Abstract:
:Bacterial overgrowth in the small bowel is known to occur in patients with persistent diarrhea, but it has been unclear if colonization alone causes fluid secretion. We studied isogenic, nontoxigenic Escherichia coli strains with colonizing factor antigen II (CFA/II) (1392+) and without CFA/II (1392-) in 18-h rabbit ileal loops. Neither strain produced fluid, but quantitative cultures of rabbit ileal loops with the CFA/II-positive strain had a mean of 10(3) more CFU of bacteria per cm2 than did cultures of rabbit ileal loops with the CFA/II-negative strain or a negative control (P less than 0.05). Of 11 rabbits given strain 1392+ via the small bowel in the reversible ileal tie model, 7 became colonized (mean, 10(10.4) +/- 1.6 CFU/cm2) over 72 h, and all 7 developed diarrhea and had gross gut fluid accumulation, versus none of 10 rabbits given strain 1392- (mean, 10(3.6) +/- 1.9 CFU/cm2) (P less than 0.05). Both strains grew equivalently in vitro. The mechanism by which this E. coli strain which colonizes small-bowel mucosa but produces no recognized toxins causes fluid accumulation and diarrhea in a rabbit model at 72 h remains to be elucidated.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Wanke CA,Guerrant RLdoi
10.1128/IAI.55.8.1924-1926.1987subject
Has Abstractpub_date
1987-08-01 00:00:00pages
1924-6issue
8eissn
0019-9567issn
1098-5522journal_volume
55pub_type
杂志文章abstract::The literature on chronic mucocutaneous candidiasis contains multiple reports which suggest that loss of cell-mediated immunity in this disease may be related in part to the presence of an inhibitory factor(s) present in patient plasma. One such inhibitory factor has been suggested to be mannan polysaccharide released...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.43.3.1041-1046.1984
更新日期:1984-03-01 00:00:00
abstract::Natural bactericidal resistance to Mycobacterium bovis BCG is under the control of a single gene, designated Bcg. Lung granuloma formation in susceptible (Bcgs) and resistant (Bcgr) mice was studied in two sets of Bcg-congenic systems, namely, the BALB/c (Bcgs)-C.D2 (BALB/c.Bcgr) pair and the B10.A (Bcgs)-B10.Ar (Bcgr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.5.1210-1216.1990
更新日期:1990-05-01 00:00:00
abstract::Pathogenic biofilms have been associated with persistent infections due to their high resistance to antimicrobial agents, while commensal biofilms often fortify the host's immune system. Hence, controlling biofilm formation of both pathogenic bacteria and commensal bacteria is important in bacterium-related diseases. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05580-11
更新日期:2011-12-01 00:00:00
abstract::The goal of this study is to evaluate the contribution of mast cells to Helicobacter pylori immunity in a model of vaccine-induced protection. Mast cell-deficient Kitl(Sl)/Kitl(Sl-d) and control mice were immunized with H. pylori sonicate plus cholera toxin and challenged with H. pylori, and the bacterial loads, infla...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00532-09
更新日期:2009-12-01 00:00:00
abstract::The effects of infection with Rowson-Parr virus (RPV), an associated virus present in Friend virus (FV) preparations, on the splenic plaque-forming cell response to sheep red cells in adult mice and on the plaque-forming cell response of peritoneal cells in vitro have been investigated. The results support the hypothe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.2.160-166.1973
更新日期:1973-02-01 00:00:00
abstract::We have developed an animal model for studying mycobacterial pathogenesis using Mycobacterium marinum and the goldfish, Carassius auratus. Goldfish are injected intraperitoneally with doses between 10(2) and 10(9) CFU of M. marinum organisms. Depending on the dose of M. marinum organisms administered, an acute or chro...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.6.2938-2942.1998
更新日期:1998-06-01 00:00:00
abstract::Virulent strains of Pseudomonas aeruginosa are either of a nonmucoid, lipopolysaccharide (LPS)-smooth or mucoid, LPS-rough phenotype, and immunity to these different variants is efficiently mediated by antibodies specific to O antigens or mucoid exopolysaccharide (also called alginate), respectively. In addition to O ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.1.21-26.1995
更新日期:1995-01-01 00:00:00
abstract::Moraxella catarrhalis is a causative agent of otitis media in children and lower respiratory tract infections in adults suffering from chronic obstructive pulmonary disease (COPD). This strict human pathogen continues to be a significant cause of disease in this broad spectrum of patients because there is no available...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00294-09
更新日期:2009-10-01 00:00:00
abstract::There is an emerging paradigm shift from coronary heart disease having a purely hereditary and nutritional causation to possibly having an infectious etiology. Recent epidemiological studies have shown a correlation between periodontal disease and coronary heart disease. However, to date, there is minimal information ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.11.5792-5798.1999
更新日期:1999-11-01 00:00:00
abstract::Thymidine kinase (TK) from herpes simplex virus type 1 (HSV-1) biochemically transformed HeLa cells, purified by affinity chromatography, has been characterized with respect to its electrophoretic mobility, molecular weight, activation energy, substrate specificity, and immunological specificity. TK purified from HSV-...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.16.2.486-492.1977
更新日期:1977-05-01 00:00:00
abstract::Pathogenic species of the spotted fever group Rickettsia are subjected to repeated exposures to the host complement system through cyclic infections of mammalian and tick hosts. The serum complement machinery is a formidable obstacle for bacteria to overcome if they endeavor to endure this endozoonotic cycle. We have ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00349-12
更新日期:2012-08-01 00:00:00
abstract::Akabane virus (a Bunyavirus) has been associated with epizootics of congenital deformities in cattle, sheep, and goats. Experimental studies using mouse-adapted virus inoculated intravenously into pregnant sheep gave an inapparent infection. Neutralizing antibodies were detected on day 5, and peaks in the titer were s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.1.254-262.1977
更新日期:1977-01-01 00:00:00
abstract::The intraerythrocytic apicomplexan Babesia microti, the primary causative agent of human babesiosis, is a major public health concern in the United States and elsewhere. Apicomplexans utilize a multiprotein complex that includes a type I membrane protein called apical membrane antigen 1 (AMA1) to invade host cells. We...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00168-15
更新日期:2015-10-01 00:00:00
abstract::Salmonella enterica serovar Pullorum is worldwide a poultry pathogen of considerable economic importance, particularly in those countries with a developing poultry industry. In addition to the characteristic high mortality rates among young chicks, one of the features of Salmonella serovar Pullorum infection is that i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.12.7873-7879.2001
更新日期:2001-12-01 00:00:00
abstract::Staphylococcus aureus is a prominent human pathogen and a leading cause of community- and hospital-acquired bacterial infections worldwide. Herein, we describe the identification and characterization of the S. aureus 67.6-kDa hypothetical protein, named for the surface factor promoting resistance to oxidative killing ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00736-10
更新日期:2011-01-01 00:00:00
abstract::Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a strong Th1 response that leads to skin lesion development. In areas where L. braziliensis transmission is endemic, up to 15% of healthy subjects have tested positive for delayed-type hypersensitivity to soluble leishmania antigen (SLA...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02404-14
更新日期:2015-03-01 00:00:00
abstract::Mycoplasma hyorhinis organisms were fractionated into lipid, carbohydrate, and protein fractions by chemical and physiochemical procedures. When all fractions were tested for complement fixation and inhibition of growth inhibition activity, only the protein fractions possessed activity. Thus, it appears that the major...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.6.937-940.1973
更新日期:1973-06-01 00:00:00
abstract::Rabbit endogenous pyrogens occurred in two forms. One was an apparently single protein with a pI of 7.3; the other was a family of proteins with pI values of 4.5 to 5.0. We selected two of the latter, with pI values of 4.6 and 4.72, as representative of the group and compared them with the pI 7.3 pyrogen. Antisera rai...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.34.1.177-183.1981
更新日期:1981-10-01 00:00:00
abstract::We investigated the cytokine/chemokine secretions and alteration of protein expression from peripheral blood mononuclear cells (PBMCs) cocultured with adult liver flukes (Opisthorchis viverrini) for 6 to 24 h. PBMC-derived proteins were identified by two-dimensional electrophoresis and mass spectrometry, and the cytok...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00901-13
更新日期:2014-05-01 00:00:00
abstract::Staphylococcus aureus is one of the pathogens most frequently isolated in device-related infections. S. aureus is equipped with surface-associated proteins promoting specific binding to matrix molecules. Clumping factor A (ClfA, encoded by clfA) mediates adhesion to fibrinogen. Whereas the contribution of ClfA to path...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.6.2758-2762.2002
更新日期:2002-06-01 00:00:00
abstract::Purified and concentrated Venezuelan equine encephalitis (VEE) virus derived from tissue cultures, rendered noninfectious by ionizing radiation with retention of in vitro serological activity, also retained a high level of immunogenicity. In mice, fluid vaccines afforded excellent protection against lethal challenge w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.3.4.574-579.1971
更新日期:1971-04-01 00:00:00
abstract::Advanced human periodontitis is considered to be a B-cell lesion, but the cellular infiltrate contains several cell types, the distribution of which has not been determined. This experiment was designed to characterize and identify the immunocompetent cells on histological sections and in eluates from diseased human g...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.1.365-374.1983
更新日期:1983-07-01 00:00:00
abstract::Neisseria lactamica, a common human pharyngeal commensal, contributes to acquired immunity to Neisseria meningitidis. To define the surface antigens shared between these two species, we used monoclonal antibodies (MAbs) to study 35 N. lactamica strains isolated in various parts of the world for cross-reactivity with m...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.2.602-608.1989
更新日期:1989-02-01 00:00:00
abstract::Invasive aspergillosis is a serious fungal infection caused by the proliferation and invasion of Aspergillus hyphae in tissue. Neutrophils (PMNs) are the most important line of defense against Aspergillus hyphae. To investigate the role of granulocyte colony-stimulating factor (G-CSF) and gamma interferon (IFN-gamma) ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.4.1185-1193.1993
更新日期:1993-04-01 00:00:00
abstract::Athymic nude mice (nu/nu), heterozygous litter mates (nu/+), and thymic reconstituted homozygous animals (nu/nu TxR) were infected with Trypanosoma rhodesiense. A reduced parasitemia and prolonged survival were observed in the nu/nu animals after infection and cure or after immunization with irradiated organisms. Thes...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.20.3.714-720.1978
更新日期:1978-06-01 00:00:00
abstract::Previous studies have shown that tumor necrosis factor alpha (TNF-alpha) plays a pathophysiologic role in sepsis induced in rat pups by group B streptococci (GBS). In this model, TNF-alpha is also partially responsible for the induction of interleukin-6 (IL-6). The present study was undertaken to investigate the role ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.11.4997-5002.1994
更新日期:1994-11-01 00:00:00
abstract::Schistosomiasis affects nearly 40 million women of reproductive age. Many of these women are infected while pregnant and lactating. Several studies have demonstrated transplacental trafficking of schistosome antigens; however, little is known regarding how these antigens affect the developing fetus and placenta. To ev...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01149-12
更新日期:2013-03-01 00:00:00
abstract::Pasteurella multocida is the causative agent of a number of diseases in animals, including fowl cholera. P. multocida strains simultaneously express two lipopolysaccharide (LPS) glycoforms (glycoforms A and B) that differ only in their inner core structure. Glycoform A contains a single 3-deoxy-d-manno-octulosonic aci...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00457-10
更新日期:2010-09-01 00:00:00
abstract::Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause of human disease. In our study, the TcI strains Colombiana (COL), SylvioX10/4 (SYL), and a cultured clone (TCC) exhibited differe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00193-16
更新日期:2016-05-24 00:00:00
abstract::The initial encounter of Leishmania cells and cells from the immune system is fundamentally important in the outcome of infection and determines disease development or resistance. We evaluated the anti-Leishmania amazonensis response of naive volunteers by using an in vitro priming (IVP) system and comparing the respo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.12.7453-7460.2001
更新日期:2001-12-01 00:00:00