Goldfish, Carassius auratus, a novel animal model for the study of Mycobacterium marinum pathogenesis.

Abstract:

:We have developed an animal model for studying mycobacterial pathogenesis using Mycobacterium marinum and the goldfish, Carassius auratus. Goldfish are injected intraperitoneally with doses between 10(2) and 10(9) CFU of M. marinum organisms. Depending on the dose of M. marinum organisms administered, an acute or chronic disease is produced. The acute disease is characterized by systemic mycobacterial infection, severe peritonitis, tissue necrosis, and a short median survival time. The chronic disease is characterized by granuloma formation in all organs and survival of animals to the end point of the experiment (56 days). Colony counts in organ homogenates showed recovery of mycobacteria from a high percentage of inoculated animals. We believe this well-characterized animal model will be useful for studying mycobacterial pathogenesis.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Talaat AM,Reimschuessel R,Wasserman SS,Trucksis M

doi

10.1128/IAI.66.6.2938-2942.1998

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

2938-42

issue

6

eissn

0019-9567

issn

1098-5522

journal_volume

66

pub_type

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