Localization of the third component of complement on the cell wall of encapsulated Staphylococcus aureus M: implications for the mechanism of resistance to phagocytosis.

abstract：:Moraxella catarrhalis expresses surface receptor proteins that specifically bind host transferrin (Tf) and lactoferrin (Lf) in the first step of the iron acquisition pathway. Acute- and convalescent-phase antisera from a series of patients with M. catarrhalis pulmonary infections were tested against Tf and Lf receptor...

journal_title：Infection and immunity

authors： Yu RH,Bonnah RA,Ainsworth S,Schryvers AB

更新日期：1999-08-01 00:00:00

abstract：:Mice infected with various strains of Salmonella enteritidis and S. typhimurium were found to be more sensitive to the cell wall lipopolysaccharide (LPS) extracted from certain strains of Salmonella than noninfected mice. This hypersensitivity was induced by those smooth or rough strains which possessed a polysacchari...

journal_title：Infection and immunity

authors： Kawakami M,Hara Y,Osawa N

更新日期：1971-11-01 00:00:00

abstract：:The interaction of Borrelia burgdorferi, the causative agent of Lyme borreliosis, with phagocytic cells induces the activation of NF-kappaB and the expression of proinflammatory cytokines including tumor necrosis factor alpha (TNF-alpha). B. burgdorferi-induced TNF-alpha production is also dependent on the activation ...

journal_title：Infection and immunity

authors： Olson CM,Hedrick MN,Izadi H,Bates TC,Olivera ER,Anguita J

更新日期：2007-01-01 00:00:00

abstract：:Sixty-one Burkholderia cepacia isolates from patients with cystic fibrosis (CF) and four plant isolates were screened for production of the siderophores salicylic acid (SA), pyochelin, cepabactin, and ornibactins and fingerprinted by a PCR-based randomly amplified polymorphic DNA (RAPD) method. Of the 24 RAPD types de...

journal_title：Infection and immunity

authors： Darling P,Chan M,Cox AD,Sokol PA

更新日期：1998-02-01 00:00:00

abstract：:Strains of Cryptococcus neoformans vary in resistance to phagocytosis in vitro. The binding of isolated capsular polysaccharide (CPS) to a capsule-free mutant of C. neoformans confers resistance to phagocytosis. The importance of capsule composition to differences among strains in susceptibility to phagocytosis was ev...

journal_title：Infection and immunity

authors： Small JM,Mitchell TG

更新日期：1989-12-01 00:00:00

abstract：:Cell-associated hemagglutinin-negative mutants were derived from cholera enterotoxin-negative Vibrio cholerae JBK70 by Tn5 mutagenesis. One of the mutants identified, SB001, was characterized in greater detail. Its ability to colonize ilea of adult rabbits was determined by feeding approximately 10(8) V. cholerae to e...

journal_title：Infection and immunity

authors： Finn TM,Reiser J,Germanier R,Cryz SJ Jr

更新日期：1987-04-01 00:00:00

abstract：:An antigenic complex has been isolated in a highly purified from from the Melvin strain of Neisseria gonorrhoeae. The complex has a molecular weight of 9.3 x 10(6) and on sodium dodecyl sulfate-polyacrylamide gel electrophoresis was found to consist of several subunits; the most predominant had the following molecular...

journal_title：Infection and immunity

authors： Karkhanis YD,Anderson RL,Zeltner JY,Carlo DJ,Stoudt TH

更新日期：1979-08-01 00:00:00

abstract：:The Th1/Th2 cytokines involved in human periodontitis remain unclear; therefore, we established a humanized mouse model to investigate this issue in Actinobacillus actinomycetemcomitans-mediated periodontal infection. Quantitative-PCR analysis clearly demonstrates a predominantly mixed Th1 and Th2 expression profile a...

journal_title：Infection and immunity

authors： Teng YT

更新日期：2002-09-01 00:00:00

abstract：:The objective of this research was to determine whether gram-negative bacteria frequently isolated from periodontally diseased sites contained polyclonal B-cell activators. Polyclonal B-cell activation, which results in nonspecific activation of multiple B-cell clones was analyzed by a hemolysis-in-gel assay designed ...

journal_title：Infection and immunity

authors： Bick PH,Carpenter AB,Holdeman LV,Miller GA,Ranney RR,Palcanis KG,Tew JG

更新日期：1981-10-01 00:00:00

abstract：:Previous experimentation has highlighted a number of difficulties in the development of carrier-based bivalent vaccines (J.-F. Viret and D. Favre, Biologicals 22:361-372, 1994) In an attempt to obviate these carrier strains. Toward this aim, a series of defined rfbInaba deletion (delta rfbInaba) mutants of the cholera...

journal_title：Infection and immunity

authors： Favre D,Cryz SJ Jr,Viret JF

更新日期：1996-02-01 00:00:00

abstract：:The type III capsular polysaccharide of group B streptococci (GBS) consists of a linear backbone with short side chains ending in residues of N-acetylneuraminic acid, or sialic acid. The presence of sialic acid on the surface of the organism inhibits activation of the alternative pathway of complement and is thought t...

journal_title：Infection and immunity

authors： Wessels MR,Haft RF,Heggen LM,Rubens CE

更新日期：1992-02-01 00:00:00

abstract：:Stimulated polymorphonuclear leukocytes have been shown by this laboratory to release a reactive-oxygen species (ROS) which is detectable in the supernatant and is capable of oxidizing reduced glutathione and reacting with methionine (Sagone et al., Blood 63:96-104, 1984). This ROS is dependent on H2O2 and heme for it...

journal_title：Infection and immunity

authors： Rao MK,Sagone AL Jr

更新日期：1984-03-01 00:00:00

abstract：:Lymphocytes from uninfected, nonimmune mice can be stimulated to proliferate and produce antibody to diverse antigens in culture when exposed to the purified protein derivative of tuberculin or unheated tuberculin culture filtrate. Lymphocytes from numerous inbred strains of mice respond to tuberculin, but no true low...

journal_title：Infection and immunity

authors： Sultzer BM,Nilsson BS,Kirschenbaum D

更新日期：1977-03-01 00:00:00

abstract：:Inoculation of herpes simplex virus on the forehead and/or snout of hairless mice resulted in a significantly lower mortality rate than inoculation of the skin in the lumbosacral area. Latent herpes simplex virus infections were detected in all forehead-inoculated and in 90% of snout-inoculated mice. Phosphonoacetic a...

journal_title：Infection and immunity

authors： Klein RJ,Friedman-Kien AE,Yellin PB

更新日期：1978-04-01 00:00:00

abstract：:Evidence is presented that the chronicity of infection in CBA mice after injection of Brucella abortus 19 is related to a number of factors: (i) the relative resistance of B. abortus to macrophage killing, which allowed some bacteria to survive the peak of macrophage activity occurring at 14 days; (ii) the decline in ...

journal_title：Infection and immunity

authors： Cheers C,Pagram F

更新日期：1979-02-01 00:00:00

abstract：:During the process of phagocytosis, human leukocytes emit a burst of luminescence which can be measured in a liquid scintillation spectrometer. The enzyme superoxide dismutase, which removes superoxide anions (O(2.)), inhibited this chemiluminescence by 70% at a concentration of 100 mug/ml. The enzyme did not inhibit ...

journal_title：Infection and immunity

authors： Webb LS,Keele BB Jr,Johnston RB Jr

更新日期：1974-06-01 00:00:00

abstract：:In vivo- and in vitro-grown Mycoplasma hyopneumoniae organisms were inoculated onto newborn piglet tracheal organ cultures to provide a model for interaction of this organism with ciliated respiratory epithelium. Ciliostasis and loss of cilia in tracheal rings were induced by M. hyopneumoniae grown in vivo and with lo...

journal_title：Infection and immunity

authors： DeBey MC,Ross RF

更新日期：1994-12-01 00:00:00

abstract：:We have previously shown that chinchillas infected with a multiply passaged laboratory strain of influenza A/NWS/33 (H1N1) develop negative middle-ear pressure; polymorphonuclear leukocyte oxidative, bactericidal, and chemotactic dysfunction; and increased susceptibility to pneumococcal otitis media. Because influenza...

journal_title：Infection and immunity

authors： Giebink GS,Wright PF

更新日期：1983-09-01 00:00:00

abstract：:Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P>0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P<0.05) over the deleted mutants....

journal_title：Infection and immunity

authors： Entenza JM,Foster TJ,Ni Eidhin D,Vaudaux P,Francioli P,Moreillon P

更新日期：2000-09-01 00:00:00

abstract：:Guinea pig and mouse peritoneal macrophages in culture transport glucose by a specific, saturable system with characteristics compatible with facilitated diffusion. Phagocytosis of killed staphylococci or polystyrene latex spheres results in a significant increase in uptake of 2-deoxy-d-glucose. Reciprocal plot analys...

journal_title：Infection and immunity

authors： Bonventre PF,Mukkada AJ

更新日期：1974-12-01 00:00:00

abstract：:The Toll-like receptor 2 (TLR2)/TLR1 receptor complex responds to amyloid fibrils, a common component of biofilm material produced by members of the phyla Firmicutes, Bacteroidetes, and Proteobacteria. To determine whether this TLR2/TLR1 ligand stimulates inflammatory responses when bacteria enter intestinal tissue, w...

journal_title：Infection and immunity

authors： Nishimori JH,Newman TN,Oppong GO,Rapsinski GJ,Yen JH,Biesecker SG,Wilson RP,Butler BP,Winter MG,Tsolis RM,Ganea D,Tükel Ç

更新日期：2012-12-01 00:00:00

abstract：:The bacterium Listeria monocytogenes causes meningoencephalitis in humans. In rodents, listeriosis is associated with granulomatous lesions in the liver and the spleen, but not with meningoencephalitis. Here, infant rats were infected intracisternally to generate experimental listeric meningoencephalitis. Dose-depende...

journal_title：Infection and immunity

authors： Remer KA,Jungi TW,Fatzer R,Täuber MG,Leib SL

更新日期：2001-06-01 00:00:00

abstract：:The concept of translational research, which aims to facilitate the application of basic scientific discoveries in clinical and community settings, is currently in vogue. While there are powerful forces driving this trend, support for translational research must be accompanied by a robust investment in basic science, ...

journal_title：Infection and immunity

authors： Fang FC,Casadevall A

更新日期：2010-02-01 00:00:00

abstract：:The recent finding that high numbers of strict anaerobes are present in the respiratory tract of cystic fibrosis (CF) patients has drawn attention to the pathogenic contribution of the CF microbiome to airway disease. In this study, we investigated the specific interactions of the most dominant bacterial CF pathogen, ...

journal_title：Infection and immunity

authors： Pustelny C,Komor U,Pawar V,Lorenz A,Bielecka A,Moter A,Gocht B,Eckweiler D,Müsken M,Grothe C,Lünsdorf H,Weiss S,Häussler S

更新日期：2015-01-01 00:00:00

abstract：:The intestinal mucosa forms the first line of defense against infections mediated by enteric pathogens such as salmonellae. Here we exploited intestinal "organoids" (iHOs) generated from human induced pluripotent stem cells (hIPSCs) to explore the interaction of Salmonella enterica serovar Typhimurium with iHOs. Imagi...

journal_title：Infection and immunity

authors： Forbester JL,Goulding D,Vallier L,Hannan N,Hale C,Pickard D,Mukhopadhyay S,Dougan G

更新日期：2015-07-01 00:00:00

abstract：:Borrelia burgdorferi, the causative agent of Lyme disease, has a complex genome consisting of a linear chromosome and up to 21 linear and circular plasmids. These plasmids encode numerous proteins critical to the spirochete's infectious cycle and many hypothetical proteins whose functions and requirements are unknown....

journal_title：Infection and immunity

authors： Bestor A,Stewart PE,Jewett MW,Sarkar A,Tilly K,Rosa PA

更新日期：2010-06-01 00:00:00

abstract：:Growth of a streptomycin-resistant strain of Escherichia coli (VL-2) in the presence of 30 microgram of streptomycin per ml resulted in the production by these bacteria of structurally altered, nonfunctional type 1 fimbriae. This strain, when grown in this subinhibitory concentration of streptomycin, became incapable ...

journal_title：Infection and immunity

authors： Eisenstein BI,Ofek I,Beachey EH

更新日期：1981-02-01 00:00:00

abstract：:Adult murine models of Cryptosporidium infection involving Cryptosporidium muris and C. parvum were used to study immunity to cryptosporidiosis in the mammalian host. Immunocompetent BALB/c or C57BL/6 mice developed a highly patent infection with the RN 66 strain of C. muris but overcame the infection and were immune ...

journal_title：Infection and immunity

authors： McDonald V,Deer R,Uni S,Iseki M,Bancroft GJ

更新日期：1992-08-01 00:00:00

abstract：:By subcutaneous treatment with an aqueous solution of 6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine [6-O-CH3-(CH2)16-CO-MurNAc-L-Ala-D-isoGln] [referred to here as L18-MDP(Ala)], an augmentation of the resistance of mice to Escherichia coli, Pseudomonas aeruginosa. Staphylococcus aureus, and Candida albicans in...

journal_title：Infection and immunity

authors： Osada Y,Mitsuyama M,Une T,Matsumoto K,Otani T,Satoh M,Ogawa H,Nomoto K

更新日期：1982-07-01 00:00:00

abstract：:The formation of water-insoluble glucan by extracellular glucosyltransferase from Streptococcus mutans 6715 found to be greatly stimulated by various mono- or divalent cations. An enzyme preparation, obtained by ethanol fractionation, was able to catalyze the formation of water-insoluble glucan from sucrose in the pre...

journal_title：Infection and immunity

authors： Mukasa H,Shimamura A,Tsumori H

更新日期：1979-03-01 00:00:00