Mixed periodontal Th1-Th2 cytokine profile in Actinobacillus actinomycetemcomitans-specific osteoprotegerin ligand (or RANK-L)- mediated alveolar bone destruction in vivo.

abstract：:The present study was performed to determine whether Histoplasma capsulatum (yeast phase) is able to activate the alternative complement pathway. H. capsulatum yeasts were shown to consume C3 in C4-deficient guinea pig serum. Immunoelectrophoretic conversion of alternative pathway component factor B confirmed that C3 ...

journal_title：Infection and immunity

authors： Ratnoff WD,Pepple JM,Winkelstein JA

更新日期：1980-10-01 00:00:00

abstract：:The bacterium Listeria monocytogenes causes meningoencephalitis in humans. In rodents, listeriosis is associated with granulomatous lesions in the liver and the spleen, but not with meningoencephalitis. Here, infant rats were infected intracisternally to generate experimental listeric meningoencephalitis. Dose-depende...

journal_title：Infection and immunity

authors： Remer KA,Jungi TW,Fatzer R,Täuber MG,Leib SL

更新日期：2001-06-01 00:00:00

abstract：:Leptospirosis can activate inflammatory responses through Toll-like receptors (TLRs) and may cause renal tubulointerstitial fibrosis characterized by the accumulation of extracellular matrix (ECM). We have previously demonstrated that Leptospira santorosai serovar Shermani detergent extract stimulates ECM accumulation...

journal_title：Infection and immunity

authors： Tian YC,Hung CC,Li YJ,Chen YC,Chang MY,Yen TH,Hsu HH,Wu MS,Phillips A,Yang CW

更新日期：2011-03-01 00:00:00

abstract：:Rocky Mountain spotted fever, a systemic tick-borne illness caused by the obligate intracellular bacterium Rickettsia rickettsii, is associated with widespread infection of the vascular endothelium. R. rickettsii infection induces a biphasic pattern of the nuclear factor-kappaB (NF-kappaB) activation in cultured human...

journal_title：Infection and immunity

authors： Clifton DR,Rydkina E,Freeman RS,Sahni SK

更新日期：2005-01-01 00:00:00

abstract：:Lyme disease (LD), the most prevalent tick-borne illness in North America, is caused by Borrelia burgdorferi The long-term survival of B. burgdorferi spirochetes in the mammalian host is achieved though VlsE-mediated antigenic variation. It is mathematically predicted that a highly variable surface antigen prolongs ba...

journal_title：Infection and immunity

authors： Rogovskyy AS,Gillis DC,Ionov Y,Gerasimov E,Zelikovsky A

更新日期：2016-12-29 00:00:00

abstract：:Chemokines (CK) are potent leukocyte activators and chemoattractants and aid in granuloma formation, functions critical for the immune response to Mycobacterium tuberculosis. We hypothesized that infection of alveolar macrophages (AM) with different strains of M. tuberculosis elicits distinct profiles of CK, which cou...

journal_title：Infection and immunity

authors： Saukkonen JJ,Bazydlo B,Thomas M,Strieter RM,Keane J,Kornfeld H

更新日期：2002-04-01 00:00:00

abstract：:Fimbrial adhesins that mediate attachment to host cells are produced by most virulent Escherichia coli isolates. These virulence factors play an important role in the initial stages of bacterial colonization and also in determination of the host and tissue specificity. Isolates belonging to serotype O78 are known to c...

journal_title：Infection and immunity

authors： Babai R,Stern BE,Hacker J,Ron EZ

更新日期：2000-10-01 00:00:00

abstract：:Intracellular multiplication of virulent Legionella pneumophila serogroup 1 was inhibited by human monocyte-derived macrophages activated by a glycoprotein extract of Klebsiella pneumoniae, RU 41.740. Macrophage cultures were infected with L. pneumophila in the presence of immune antibodies on day 7 of culture. Extrac...

journal_title：Infection and immunity

authors： Rajagopalan P,Dournon E,Vildé JL,Pocidalo JJ

更新日期：1987-09-01 00:00:00

abstract：:Exposure of PAM cells, a spontaneously transformed mouse cell line, to brain homogenates from mice infected with scrapie caused a relative decrease in total cell yield, which persisted from passage 2 or 3 to passage 18 after treatment. The effect was elicited by each of the eight independent scrapie isolates tested. L...

journal_title：Infection and immunity

authors： Carp RI,Merz GS,Licursi PC

更新日期：1976-07-01 00:00:00

abstract：:The results of a test of endotoxic potency based upon the development of histamine hypersensitivity in mice were compared with the results obtained by testing the same materials for pyrogenicity in rabbits and lethality for chicken embryos (CELD50). The results of the histamine hypersensitization test (HHT) correlated...

journal_title：Infection and immunity

authors： Bergman RK,Milner KC,Munoz JJ

更新日期：1977-11-01 00:00:00

abstract：:Borrelia burgdorferi produces potent cell-activating molecules capable of stimulating polyclonal proliferation and immunoglobulin production by murine B lymphocytes and cytokine production by a variety of cell types. These stimulatory molecules function in infected mice, resulting in elevated levels of circulating imm...

journal_title：Infection and immunity

authors： Tai KF,Ma Y,Weis JJ

更新日期：1994-02-01 00:00:00

abstract：:Toxoplasma gondii infection in pregnant women may result in abortion or in fetal teratogenesis; however, the underlying mechanisms are still unclear. In this paper, based on a murine model, we showed that maternal infection with RH strain T. gondii tachyzoites induced elevated production of reactive oxygen species (RO...

journal_title：Infection and immunity

authors： Xu X,Liu T,Zhang A,Huo X,Luo Q,Chen Z,Yu L,Li Q,Liu L,Lun ZR,Shen J

更新日期：2012-06-01 00:00:00

abstract：:Microbial survival in a host is usually dependent on the ability of a pathogen to undergo changes that promote escape from host defense mechanisms. The human-pathogenic fungus Cryptococcus neoformans undergoes phenotypic switching in vivo that promotes persistence in tissue. By microarray and real-time PCR analyses, t...

journal_title：Infection and immunity

authors： Jain N,Li L,Hsueh YP,Guerrero A,Heitman J,Goldman DL,Fries BC

更新日期：2009-01-01 00:00:00

abstract：:The nucleotide sequence of the chromosomal DNA flanking the Actinomyces naeslundii (formerly A. viscosus) T14V type 1 fimbrial structural subunit gene (fimP) was determined. Six open reading frames (ORFs), in the order 5' ORF3, ORF2, ORF1,fimP, ORF4, ORF5, ORF6 3', were identified. ORF1 encoded a protein of 408 amino ...

journal_title：Infection and immunity

authors： Yeung MK,Ragsdale PA

更新日期：1997-07-01 00:00:00

abstract：:Localized juvenile periodontitis (LJP) runs in families, and a predisposition to develop disease appears to be inherited in an autosomal dominant fashion. Patients with LJP have elevated levels of serum immunoglobulin G2 (IgG2), and this is most striking in black LJP patients. We hypothesized that the markedly elevate...

journal_title：Infection and immunity

authors： Zhang JB,Quinn SM,Rausch M,Gunsolley JC,Schenkein HA,Tew JG

更新日期：1996-06-01 00:00:00

abstract：:Escherichia coli 83972 is a clinical asymptomatia bacteriuric isolate that is able to colonize the human urinary bladder without inducing an immune response. Here we demonstrate that one of the mechanisms by which this strain has become attenuated is through the mutation of its genes encoding type 1 and P fimbriae. ...

journal_title：Infection and immunity

authors： Klemm P,Roos V,Ulett GC,Svanborg C,Schembri MA

更新日期：2006-01-01 00:00:00

abstract：:Proteolysis is a common microbial virulence mechanism that enables the destruction of host tissue and evasion from host defense mechanisms. Antimicrobial peptides, also known as host defense peptides, are effector molecules of the innate immunity that demonstrate a broad range of antimicrobial and immunoregulatory act...

journal_title：Infection and immunity

authors： Gutner M,Chaushu S,Balter D,Bachrach G

更新日期：2009-12-01 00:00:00

abstract：:There are no vaccines against boutonneuse fever and Rocky Mountain spotted fever. Previous studies have identified a Rickettsia rickettsii surface protein as a vaccine candidate and shown that an antigenically related protein is present in R. conorii, which causes boutonneuse fever. The gene encoding the R. rickettsii...

journal_title：Infection and immunity

authors： Vishwanath S,McDonald GA,Watkins NG

更新日期：1990-03-01 00:00:00

abstract：:Fusobacterium nucleatum is a common oral anaerobe involved in periodontitis that is known to translocate and cause intrauterine infections. In the oral environment, F. nucleatum adheres to a large diversity of species, facilitating their colonization and creating biological bridges that stabilize the multispecies dent...

journal_title：Infection and immunity

authors： Coppenhagen-Glazer S,Sol A,Abed J,Naor R,Zhang X,Han YW,Bachrach G

更新日期：2015-03-01 00:00:00

abstract：:Intestinal epithelial cells (IECs), including secretory goblet cells, form essential physiochemical barriers that separate luminal bacteria from underlying immune cells in the intestinal mucosa. IECs are common targets for enteric bacterial pathogens, with hosts responding to these microbes through innate toll-like re...

journal_title：Infection and immunity

authors： Bhinder G,Stahl M,Sham HP,Crowley SM,Morampudi V,Dalwadi U,Ma C,Jacobson K,Vallance BA

更新日期：2014-09-01 00:00:00

abstract：:An array of pro- and anti-inflammatory mediators of the innate immune system was analyzed in stool, urine, and rectal mucosa samples from adults and children with shigellosis to better understand their role in recovery from and in the immunopathogenesis of the disease. Increased concentrations of lactoferrin (Lf), mye...

journal_title：Infection and immunity

authors： Raqib R,Mia SM,Qadri F,Alam TI,Alam NH,Chowdhury AK,Mathan MM,Andersson J

更新日期：2000-06-01 00:00:00

abstract：:Anthrax lethal toxin (LeTx), consisting of protective antigen (PA) and lethal factor (LF), rapidly kills primary mouse macrophages and macrophage-like cell lines such as RAW 264.7. LF is translocated by PA into the cytosol of target cells, where it acts as a metalloprotease to cleave mitogen-activated protein kinase k...

journal_title：Infection and immunity

authors： Tang G,Leppla SH

更新日期：1999-06-01 00:00:00

abstract：:Chemiluminescence of human alveolar macrophages (AM) was evaluated in vitro. Unstimulated AM generated chemiluminescence that remained constant during incubation. Addition of heat-killed Staphylococcus aureus 502A (HKB) or a chemical agent, phorbol myristate acetate, produced high rates of chemiluminescence that were ...

journal_title：Infection and immunity

authors： Beall GD,Repine JE,Hoidal JR,Rasp FL

更新日期：1977-07-01 00:00:00

abstract：:A secreted nuclease, SsnA, was identified in the virulent Streptococcus suis isolate SX332 and subsequently in each of the type strains of capsular serotypes 1 through 9. Screening of 258 porcine clinical isolates from surface (nasal mucosa or palatine tonsil) or internal (joint, brain or other internal organ) locatio...

journal_title：Infection and immunity

authors： Fontaine MC,Perez-Casal J,Willson PJ

更新日期：2004-02-01 00:00:00

abstract：:By using a suckling mouse assay, heat-stable enterotoxin (ST) was purified from the culture filtrate of Yersinia enterocolitica isolated from a diarrheal patient. The purification procedures involve ultrafiltration with an Amicon HIP-10 hollow fiber, ethanol fractionation, protamine sulfate treatment, diethylaminoethy...

journal_title：Infection and immunity

authors： Okamoto K,Inoue T,Ichikawa H,Kawamoto Y,Miyama A

更新日期：1981-02-01 00:00:00

abstract：:A 75-kilodalton major protein (75K protein) was purified to homogeneity from the cell lysate fraction and the envelope of Bacteroides gingivalis 381. The 75K protein was originally present in the outer membrane or the outermost part of this organism as a large, stable complex with an apparent molecular weight of about...

journal_title：Infection and immunity

authors： Yoshimura F,Watanabe K,Takasawa T,Kawanami M,Kato H

更新日期：1989-11-01 00:00:00

abstract：:The interaction of the first component of complement with two serum-sensitive strains of Escherichia coli and Klebsiella pneumoniae was studied. It could be demonstrated that highly purified C1, free of immunoglobulin G and immunoglobulin M, binds to E. coli or K. pneumoniae. C1 binding was also found with specificall...

journal_title：Infection and immunity

authors： Loos M,Wellek B,Thesen R,Opferkuch W

更新日期：1978-10-01 00:00:00

abstract：:The yield of infectious Chlamydia trachomatis was analyzed in human (HeLa) and mouse (McCoy) cell lines treated with the human interferon (IFN) subtypes IFN-alpha A and IFN-alpha D, with their hybrids [IFN-alpha AD (BglII), IFN-alpha AD (PvuII), and IFN-alpha DA (BglII)] constructed in vitro from their expression plas...

journal_title：Infection and immunity

authors： de la Maza LM,Peterson EM,Goebel JM,Fennie CW,Czarniecki CW

更新日期：1985-03-01 00:00:00

abstract：:The effect of a deficiency in the C5 component of complement on the pathophyisology of infection with the fungal pathogen Candida albicans was studied by using the A/J inbred mouse strain and the BcA17 congenic mouse strain. Acute infection caused by intravenous injection of C. albicans blastospores is associated with...

journal_title：Infection and immunity

authors： Mullick A,Leon Z,Min-Oo G,Berghout J,Lo R,Daniels E,Gros P

更新日期：2006-08-01 00:00:00

abstract：:The effect of human-specific antibody on surface membrane antigens of trypomastigotes of Trypanosoma cruzi was studied in vitro by using immunofluorescence methods. Immune sera induced aggregation of surface antigens in trypomastigotes to form polar cell caps. ...

journal_title：Infection and immunity

authors： Schmuñis GA,Szarfman A,Langembach T,de Souza W

更新日期：1978-05-01 00:00:00