Abstract:
:Lymphocytes from uninfected, nonimmune mice can be stimulated to proliferate and produce antibody to diverse antigens in culture when exposed to the purified protein derivative of tuberculin or unheated tuberculin culture filtrate. Lymphocytes from numerous inbred strains of mice respond to tuberculin, but no true low responder strain has been found as yet. The evidence presented suggests that a subpopulation of B cells, which are distinct from those activated by lipopolysaccharide endotoxin, respond to tuberculin. The results of digestion experiments with insolubilized enzymes suggest that the nonspecific activating principles in tuberculin are protein.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Sultzer BM,Nilsson BS,Kirschenbaum Ddoi
10.1128/IAI.15.3.799-806.1977subject
Has Abstractpub_date
1977-03-01 00:00:00pages
799-806issue
3eissn
0019-9567issn
1098-5522journal_volume
15pub_type
杂志文章abstract::Group A streptococci of M protein type 5 have been epidemiologically related to acute rheumatic fever in a number of reported outbreaks. Preliminary bacteriological evidence suggests that M5 may be an important "rheumatogenic" type in Santiago, Chile. To assess further the relationship of this streptococcal serotype t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.2.573-579.1982
更新日期:1982-11-01 00:00:00
abstract::Infection with Shiga toxin (Stx)-producing bacteria and the subsequent release of Stxs and endotoxins into the bloodstream may damage blood vessels in the colon, kidneys, and central nervous system, leading to bloody diarrhea, acute renal failure, and neurological complications. The proinflammatory cytokines tumor nec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.5.2618-2627.2004
更新日期:2004-05-01 00:00:00
abstract::A 30-amino-acid peptide corresponding to variable domain IV (VD IV) of the major outer membrane protein of Chlamydia trachomatis serovar E was conjugated to keyhole limpet hemocyanin (KLH) and used to immunize mice. The resulting antisera (anti-KLH-VD IV sera) recognized all 15 serovars of C. trachomatis when assayed ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.8.3428-3432.1992
更新日期:1992-08-01 00:00:00
abstract::Thirty two anaerobic bacterial strains were screened for their in vitro inhibitory activity toward 21 Neisseria gonorrhoeae strains, including two penicillin-resistant strains. From this screening, six anaerobic bacteria belonging to the genera Bacteroides, Peptostreptococcus, and Eubacterium were selected for their l...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::In experimentally infected human volunteers, the cutaneous immune response to Haemophilus ducreyi is orchestrated by serum, polymorphonuclear leukocytes, macrophages, T cells, and myeloid dendritic cells (DC). This response either leads to spontaneous resolution of infection or progresses to pustule formation, which i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00777-07
更新日期:2007-12-01 00:00:00
abstract::Malaria infection treatment vaccine (ITV) is a promising strategy to induce homologous and heterologous protective immunity against the blood stage of the parasite. However, the underlying mechanism of protection remains largely unknown. Here, we found that a malaria-specific antibody (Ab) could mediate the protective...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02621-14
更新日期:2015-05-01 00:00:00
abstract::Inflammatory cytokines play an important role in human immune responses to malarial disease. However, the role of these mediators in disease pathogenesis, and the relationship between host protection and injury remains unclear. A total of 248 cases of severe Plasmodium falciparum malaria among children aged 3 months t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.10.5630-5637.2004
更新日期:2004-10-01 00:00:00
abstract::Acquired cellular immunity to infection with Mycobacterium tuberculosis is believed to reside in the capacity of mononuclear phagocytes of immunized animals to inhibit intracellular multiplication of the parasite. However, in macrophage tissue culture systems, it has been customary to employ streptomycin in the medium...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1970-01-01 00:00:00
abstract::Migration of the fungal pathogen Candida albicans across the endothelial cell layer is considered a prerequisite for the invasion of multiple organs occurring in systemic candidiasis. We developed an experimental system in which C. albicans migrates from a luminal compartment across a monolayer of bovine aortic endoth...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.12.5085-5091.1996
更新日期:1996-12-01 00:00:00
abstract::One aspect in a broad spectrum of possible mechanisms of cariostatic reactions of fluoride is its interaction with the metabolism of oral bacteria. Information on the mechanisms and kinetics of fluoride inhibition of essential enzymes of the glycolytic pathway of the relevant bacteria is lacking. In this work, the iso...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.4.1043-1047.1990
更新日期:1990-04-01 00:00:00
abstract::Three strains of anaerobic, dextranase-producing, gram-positive, rod-shaped bacteria were isolated from human dental plaque associated with root carious lesions. The isolates produced a molar ratio of acetate to lactate from glucose fermentation ranging from 1.1 to 1.9. Each strain also produced fructose-6-phosphate p...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.42.2.716-720.1983
更新日期:1983-11-01 00:00:00
abstract::Monoclonal antibodies have been generated to the unique distal sugar epitopes on the oligosaccharide haptens of the glycopeptidolipid antigens of clinically prominent members of the Mycobacterium avium serocomplex. Thus, antibodies are described that recognize the distal O-acetyl-alpha-L-rhamnopyranosyl residue of the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.10.3147-3158.1989
更新日期:1989-10-01 00:00:00
abstract::Ecto-5'-nucleotidase (CD73) is expressed abundantly on the apical surface of intestinal epithelial cells (IECs) and functions as the terminal enzyme in the generation of extracellular adenosine. Previous work demonstrated that adenosine signaling in IECs results in a number of tissue-protective effects during inflamma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01022-16
更新日期:2017-09-20 00:00:00
abstract::Male ICR Swiss mice (2 to 3 months old) were fed Candida albicans in their drinking water for 3 days, followed by no treatment, antibiotics in their drinking water (daily), or immunosuppressants given by intraperitoneal injection (two to three times weekly) over a 3- to 4-week period. The organs of animals were proces...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.7.1558-1563.1987
更新日期:1987-07-01 00:00:00
abstract::Exposure of hamster tracheal rings in organ culture to virulent Mycoplasma pneumoniae organisms leads to alterations in macromolecular biosynthesis and metabolic activity of the respiratory epithelial cells. Avirulent organisms derived from the same parent strain do not produce these effects. During the course of infe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.4.704-710.1975
更新日期:1975-04-01 00:00:00
abstract::Diarrhea and amebic liver abscesses due to invasive Entamoeba histolytica infections are an important cause of morbidity and mortality in the developing world. Entamoeba histolytica adherence and cell migration, two phenotypes linked to virulence, are both aberrant in trophozoites deficient in the metallosurface prote...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02490-14
更新日期:2015-02-01 00:00:00
abstract::Hookworm glutathione S-transferases (GSTs) are critical for parasite blood feeding and survival and represent potential targets for vaccination. Three cDNAs, each encoding a full-length GST protein from the human hookworm Necator americanus (and designated Na-GST-1, Na-GST-2, and Na-GST-3, respectively) were isolated ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00848-09
更新日期:2010-04-01 00:00:00
abstract::We have examined the ability of peptidoglycan (PepG) and lipoteichoic acid (LTA) isolated from Staphylococcus aureus to induce the release of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and IL-10 in whole human blood and identified the cellular origins of these cytokines. Both PepG and LTA induced t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.7.3965-3970.2000
更新日期:2000-07-01 00:00:00
abstract::Yersinia pestis, the causative agent of plague, autoaggregates within a few minutes of cessation of shaking when grown at 28 degrees C. To identify the autoaggregation factor of Y. pestis, we performed mariner-based transposon mutagenesis. Autoaggregation-defective mutants from three different pools were identified, e...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00997-09
更新日期:2010-03-01 00:00:00
abstract::Insertional inactivation of the Streptococcus mutans spaP gene was used to construct an isogenic mutant (834) of strain NG8 (serotype c) which lacked the major cell surface-associated protein referred to as P1 (15). Results of several studies suggest that P1 is involved in the adherence of S. mutans to saliva-coated a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.12.4606-4609.1991
更新日期:1991-12-01 00:00:00
abstract::Antibodies against mumps virus have been studied by using immunoglobulin class-specific indicators labeled with (125)I in the radioimmunoassay (RIA) procedure. The immunoglobulins in paired acute and convalescent sera were allowed to react with mumps virus in a solid-phase RIA system. Class-specific immunoglobulin ind...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.3.380-385.1973
更新日期:1973-03-01 00:00:00
abstract::We have previously shown that chinchillas infected with a multiply passaged laboratory strain of influenza A/NWS/33 (H1N1) develop negative middle-ear pressure; polymorphonuclear leukocyte oxidative, bactericidal, and chemotactic dysfunction; and increased susceptibility to pneumococcal otitis media. Because influenza...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.3.913-920.1983
更新日期:1983-09-01 00:00:00
abstract::This study was undertaken to determine the sequence of events in the microenvironment of the intestinal tract that culminate in the symptoms of cholera and to attempt to define more clearly the mechanisms involved in antibacterial immunity. The extent to which mucus occurs in the normal intestine of rabbits and the ap...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.1.195-203.1976
更新日期:1976-01-01 00:00:00
abstract::Highly purified protein antigens are usually poor immunogens; in practice, adjuvants are needed to obtain satisfactory immune responses. Plasmodium yoelii 19-kDa merozoite surface protein 1 (MSP1(19)) is a weak antigen, but mice vaccinated with this antigen in strong adjuvants can survive an otherwise lethal parasite ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01369-07
更新日期:2008-08-01 00:00:00
abstract::It has been proposed that a multivalent malaria vaccine is necessary to mimic the naturally acquired resistance to this disease observed in humans. A major experimental challenge is to identify the optimal components to be used in such a multivalent vaccine. Expression library immunization (ELI) is a method for screen...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.8.4506-4515.2003
更新日期:2003-08-01 00:00:00
abstract::Moraxella (Branhamella) catarrhalis is an important bacterial cause of otitis media in children and lower respiratory tract infections in adults. In this study, we describe the presence of a novel high-molecular-weight outer membrane protein (HMW-OMP). This protein varies from 350 to 720 kDa in apparent molecular mass...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.4.1150-1155.1994
更新日期:1994-04-01 00:00:00
abstract::The expression of several virulence determinants of Yersinia pestis is known to be dependent on the in vitro growth temperature. One of these, calcium dependence, is associated with the presence of a 47-megadalton plasmid. We have examined the effects of incubation temperature, calcium in the growth medium, the presen...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.42.3.1092-1101.1983
更新日期:1983-12-01 00:00:00
abstract::The Legionella pneumophila major secretory protein (Msp) is a Zn2+ metalloprotease whose function in pathogenesis is unknown. The structural gene for the Msp protease, mspA, was isolated from an L. pneumophila genomic library. In Escherichia coli which contain plasmids with the mspA gene, Msp protein and activity are ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.8.2585-2592.1990
更新日期:1990-08-01 00:00:00
abstract::Toxin preparations were obtained by growing Clostridium difficile VPI strain 10463 in 2-liter brain heart infusion dialysis flasks at 37 degrees C for 3 days. The initial step of the purification scheme involved ultrafiltration through an XM-100 membrane filter. Two toxic activities, designated toxins A and B, were se...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.3.1032-1040.1982
更新日期:1982-03-01 00:00:00
abstract::Enteropathogenic strains of Yersinia enterocolitica harbor a virulence plasmid (70 kilobases) which specifies, at 37 degrees C, a calcium requirement for growth, autoagglutinability, resistance to the bactericidal activity of human serum, and the expression of some outer membrane proteins (OMPs). To map the genes enco...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.48.3.782-786.1985
更新日期:1985-06-01 00:00:00