Genetic analysis of virulence plasmid from a serogroup 9 Yersinia enterocolitica strain: role of outer membrane protein P1 in resistance to human serum and autoagglutination.

abstract：:Pseudomonas aeruginosa is a leading cause of hospital-acquired pneumonia and chronic lung infections in cystic fibrosis patients. Iron is essential for bacterial growth, and P. aeruginosa expresses multiple iron uptake systems, whose role in lung infection deserves further investigation. P. aeruginosa Fe(3+) uptake sy...

journal_title：Infection and immunity

authors： Minandri F,Imperi F,Frangipani E,Bonchi C,Visaggio D,Facchini M,Pasquali P,Bragonzi A,Visca P

更新日期：2016-07-21 00:00:00

abstract：:Intact tissues are relatively resistant to Pseudomonas aeruginosa-induced disease, and injury predisposes tissue to infection. Intact epithelia contain polarized cells that have distinct apical and basolateral membranes with unique lipids and proteins. In this study, the role of cell polarity in epithelial cell suscep...

journal_title：Infection and immunity

authors： Fleiszig SM,Evans DJ,Do N,Vallas V,Shin S,Mostov KE

更新日期：1997-07-01 00:00:00

abstract：:Despite the widely held belief that gastric acid serves as a barrier to bacterial pathogens, there are almost no experimental data to support this hypothesis. We have developed a mouse model to quantify the effectiveness of gastric acid in mediating resistance to infection with ingested bacteria. Mice that were consti...

journal_title：Infection and immunity

authors： Tennant SM,Hartland EL,Phumoonna T,Lyras D,Rood JI,Robins-Browne RM,van Driel IR

更新日期：2008-02-01 00:00:00

abstract：:Pathogenicities of 10 temperature-sensitive mutants of Venezuelan encephalitis virus were studied using the hamster model of human virulence. The parental strain and nine of the temperature-sensitive mutants produced lethal infections in hamsters. Strain ts 126 showed reduced hamster virulence. Deaths with the lethal ...

journal_title：Infection and immunity

authors： Krieger JN,Scherer WF,Wiebe ME,Pancake BA,Harsanyi ZP

更新日期：1979-09-01 00:00:00

abstract：:The presence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs), hepatitis B e antigen (HBeAg) and antibody (anti-HBe), the nature of T-cell function, and specific cell-mediated immunity to HBsAg were determined and evaluated serially in groups of subjects with chronic HBsAg carrier states and in seronegat...

journal_title：Infection and immunity

authors： Beutner KR,Tiku ML,Ogra PL

更新日期：1978-08-01 00:00:00

abstract：:Anti-NMDA receptor (NMDAR) autoantibodies have been postulated to play a role in the pathogenesis of NMDAR hypofunction, which contributes to the etiology of psychotic symptoms. Toxoplasma gondii is a pathogen implicated in psychiatric disorders and associated with elevation of NMDAR autoantibodies. However, it remain...

journal_title：Infection and immunity

authors： Li Y,Viscidi RP,Kannan G,McFarland R,Pletnikov MV,Severance EG,Yolken RH,Xiao J

更新日期：2018-09-21 00:00:00

abstract：:While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p47(phox)(-/-) mice infected with pH-insensitive Aspergillus nidulans mutants despite a paucity of fungal growth. Fatal infection also resulted from a normally avirulent ...

journal_title：Infection and immunity

authors： Bignell E,Negrete-Urtasun S,Calcagno AM,Arst HN Jr,Rogers T,Haynes K

更新日期：2005-08-01 00:00:00

abstract：:Platelets aggregate in response to an adhesin and the platelet aggregation-associated protein (PAAP) expressed on the cell surfaces of certain strains of Streptococcus sanguis. We sought to identify the corresponding PAAP receptor and accessory adhesin binding sites on platelets. Since the adhesion(s) of S. sanguis fo...

journal_title：Infection and immunity

authors： Gong K,Wen DY,Ouyang T,Rao AT,Herzberg MC

更新日期：1995-09-01 00:00:00

abstract：:The suspected correlation between cessation of type C virus production and halt in immunoglobulin secretion by murine myeloma cells was studied. Employing two variants of the murine myeloma MOPC-315, immunoglobulin A-producing and nonproducing cells, we demonstrated that the two myelomas release similar levels of type...

journal_title：Infection and immunity

authors： Gazit A,Yaniv A,Halperin D,Ben-Efraim S

更新日期：1979-08-01 00:00:00

abstract：:Intrakingdom cell-to-cell communication and interkingdom cell-to-cell communication play essential roles in the virulence of enterohemorrhagic Escherichia coli (EHEC). Four signals, autoinducer 2 (AI-2), AI-3, and the human hormones epinephrine and norepinephrine, are important in this communication. The effect of the...

journal_title：Infection and immunity

authors： Kendall MM,Rasko DA,Sperandio V

更新日期：2007-10-01 00:00:00

abstract：:Fasciola hepatica is a prevalent helminth parasite of livestock. Infection results in polarization of the host's immune response and generation of type 2 helper (Th2) immune responses, which are known to be inhibitory to Th1 responses. Bovine tuberculosis (BTB) is a bacterial disease of economic and zoonotic importanc...

journal_title：Infection and immunity

authors： Flynn RJ,Mannion C,Golden O,Hacariz O,Mulcahy G

更新日期：2007-03-01 00:00:00

abstract：:Thirty percent of Streptococcus pneumoniae isolates contain pilus islet 1, coding for a pilus composed of the backbone subunit RrgB and two ancillary proteins, RrgA and RrgC. RrgA is the major determinant of in vitro adhesion associated with pilus 1, is protective in vivo in mouse models, and exists in two variants (c...

journal_title：Infection and immunity

authors： Moschioni M,Emolo C,Biagini M,Maccari S,Pansegrau W,Donati C,Hilleringmann M,Ferlenghi I,Ruggiero P,Sinisi A,Pizza M,Norais N,Barocchi MA,Masignani V

更新日期：2010-12-01 00:00:00

abstract：:Brucellosis is a costly disease of water buffaloes (Bubalus bubalis). Latent infections and prolonged incubation of the pathogen limit the efficacy of programs based on the eradication of infected animals. We exploited genetic selection for disease resistance as an approach to the control of water buffalo brucellosis....

journal_title：Infection and immunity

authors： Borriello G,Capparelli R,Bianco M,Fenizia D,Alfano F,Capuano F,Ercolini D,Parisi A,Roperto S,Iannelli D

更新日期：2006-04-01 00:00:00

abstract：:To explore the molecular basis of the T-cell-mediated immune response to Listeria monocytogenes, we cloned and expressed listerial antigens in Escherichia coli using the lambda-ZAP bacteriophage and Bluescript plasmid vectors. A two-stage screening strategy was implemented to identify T-cell-reactive antigens; the fir...

journal_title：Infection and immunity

authors： Beattie IA,Swaminathan B,Ziegler HK

更新日期：1990-09-01 00:00:00

abstract：:Gamma interferon (IFN-γ) induces expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial cells, the permissive cells for the obligate intracellular bacterium Chlamydia trachomatis. IDO1 depletes tryptophan by catabolizing it to kynurenine with consequences for C. trachom...

journal_title：Infection and immunity

authors： Ibana JA,Belland RJ,Zea AH,Schust DJ,Nagamatsu T,AbdelRahman YM,Tate DJ,Beatty WL,Aiyar AA,Quayle AJ

更新日期：2011-11-01 00:00:00

abstract：:Escherichia coli 83972 is a clinical asymptomatia bacteriuric isolate that is able to colonize the human urinary bladder without inducing an immune response. Here we demonstrate that one of the mechanisms by which this strain has become attenuated is through the mutation of its genes encoding type 1 and P fimbriae. ...

journal_title：Infection and immunity

authors： Klemm P,Roos V,Ulett GC,Svanborg C,Schembri MA

更新日期：2006-01-01 00:00:00

abstract：:Encapsulation of soluble protein antigens in liposomes was previously shown to result in processing of antigen via the major histocompatibility complex class I pathway, as evidenced by costaining of the trans-Golgi region of murine bone marrow-derived macrophages (BMs) by fluorophore-labeled liposomal antigen and by a...

journal_title：Infection and immunity

authors： Richards RL,Rao M,Wassef NM,Glenn GM,Rothwell SW,Alving CR

更新日期：1998-06-01 00:00:00

abstract：:FMS-like tyrosine kinase-3 ligand (Flt3L) is a dendritic cell (DC) growth and differentiation factor with potential in antitumor therapies and antibacterial immunization strategies. However, the effect of systemic Flt3L treatment on lung-protective immunity against bacterial infection is incompletely defined. Here, we...

journal_title：Infection and immunity

authors： Brumshagen C,Maus R,Bischof A,Ueberberg B,Bohling J,Osterholzer JJ,Ogunniyi AD,Paton JC,Welte T,Maus UA

更新日期：2012-12-01 00:00:00

abstract：:Factors which control the levels of catalase within yeast cells of Histoplasma capsulatum were studied. Only a small fraction of the total catalase activity could be detected in whole cells. The bulk of the activity was revealed in cell-free extracts or in cells permeabilized with acetone. The formation of the enzyme ...

journal_title：Infection and immunity

authors： Howard DH

更新日期：1983-03-01 00:00:00

abstract：:Adherence of blastoconidia to epidermal corneocytes is an early event in Candida colonization and infection of the skin. Pathogenic species adhere more avidly than nonpathogenic species, transform to hyphal growth, and invade the stratum corneum of the skin. Adherence was studied by scanning electron microscopy of exp...

journal_title：Infection and immunity

authors： Ray TL,Payne CD

更新日期：1988-08-01 00:00:00

abstract：:Tuberculosis continues to ravage humanity, killing 2 million people yearly. Most cases occur in areas of the world to which the disease is endemic, where almost everyone is vaccinated early in life with Mycobacterium bovis BCG, the currently available vaccine against tuberculosis. Thus, while more-potent vaccines are ...

journal_title：Infection and immunity

authors： Horwitz MA,Harth G,Dillon BJ,Maslesa-Galic S

更新日期：2005-08-01 00:00:00

abstract：:The role of CD8 T cells in controlling Mycobacterium tuberculosis infections in mice was confirmed by comparing the levels of growth of the organism in control, major histocompatibility complex class II knockout, and athymic mice and by transferring T-cell populations into athymic mice. By using donor mice which were ...

journal_title：Infection and immunity

authors： Tascon RE,Stavropoulos E,Lukacs KV,Colston MJ

更新日期：1998-02-01 00:00:00

abstract：:In the present investigation we studied the nature of a Shigella flexneri O antigen, the type III antigen. No structural entity has yet been attributed to this antigen. Phenol-water-extracted lipopolysaccharides (LPSs) from all S. flexneri serotypes possessing either group 6 antigen or both type III antigen and group ...

journal_title：Infection and immunity

authors： Carlin NI,Wehler T,Lindberg AA

更新日期：1986-07-01 00:00:00

abstract：:Female LSH hamsters infected with Treponema pallidum subsp, endemicum before pregnancy or during early pregnancy transmit a form of syphilis to the fetus that is similar to human congenital syphilis. The offspring develops rhinitis, skin rash, failure to thrive, and hepatosplenomegaly. T. pallidum is detectable in the...

journal_title：Infection and immunity

authors： Kajdacsy-Balla A,Howeedy A,Bagasra O

更新日期：1993-08-01 00:00:00

abstract：:Bovine digital dermatitis (BDD), an infectious disease of the bovine foot with a predominant treponemal etiology, is a leading cause of lameness in dairy and beef herds worldwide. BDD is poorly responsive to antimicrobial therapy and exhibits a relapsing clinical course; an effective vaccine is therefore urgently soug...

journal_title：Infection and immunity

authors： Staton GJ,Carter SD,Ainsworth S,Mullin J,Smith RF,Evans NJ

更新日期：2020-04-20 00:00:00

abstract：:In experimentally infected human volunteers, the cutaneous immune response to Haemophilus ducreyi is orchestrated by serum, polymorphonuclear leukocytes, macrophages, T cells, and myeloid dendritic cells (DC). This response either leads to spontaneous resolution of infection or progresses to pustule formation, which i...

journal_title：Infection and immunity

authors： Humphreys TL,Li L,Li X,Janowicz DM,Fortney KR,Zhao Q,Li W,McClintick J,Katz BP,Wilkes DS,Edenberg HJ,Spinola SM

更新日期：2007-12-01 00:00:00

abstract：:Whole-genome sequencing analysis of ∼800 strains of group A Streptococcus (GAS) found that the gene encoding the multiple virulence gene regulator of GAS (mga) is highly polymorphic in serotype M59 strains but not in strains of other serotypes. To help understand the molecular mechanism of gene regulation by Mga and i...

journal_title：Infection and immunity

authors： Sanson M,Makthal N,Gavagan M,Cantu C,Olsen RJ,Musser JM,Kumaraswami M

更新日期：2015-06-01 00:00:00

abstract：:Urinary tract infection (UTI) is the second most common infection in humans, making it a global health priority. Nearly half of all women will experience a symptomatic UTI, with uropathogenic Escherichia coli (UPEC) being the major causative agent of the infection. Although there has been extensive research on UPEC vi...

journal_title：Infection and immunity

authors： Sintsova A,Smith S,Subashchandrabose S,Mobley HL

更新日期：2018-02-20 00:00:00

abstract：:Toll-like receptors (TLRs) play a critical role in early immune recognition of Aspergillus, which can regulate host defense during invasive pulmonary Aspergillosis (IPA). However, the role of TLR7 in the pathogenesis of IPA remains unknown. In this study, an in vivo model of IPA was established to investigate the cont...

journal_title：Infection and immunity

authors： Xu B,Luo Q,Gong Y,Li J,Cao J

更新日期：2021-01-25 00:00:00

abstract：:Changes in periodontal status are associated with shifts in the composition of the bacterial community in the periodontal pocket. The relative abundances of several newly recognized microbial species, including Filifactor alocis, as-yet-unculturable organisms, and other fastidious organisms have raised questions on th...

journal_title：Infection and immunity

authors： Aruni AW,Zhang K,Dou Y,Fletcher H

更新日期：2014-08-01 00:00:00