A hamster-attenuated, temperature-sensitive mutant of Venezuelan encephalitis virus.

abstract：:Listeria monocytogenes, isolated from outbreaks in either human or nonhuman primate populations, was administered orally at doses ranging from 10(6) to 10(10) CFU. Four of 10 treated animals delivered stillborn infants. L. monocytogenes was isolated from fetal tissue, and the pathology was consistent with L. monocytog...

journal_title：Infection and immunity

authors： Smith MA,Takeuchi K,Brackett RE,McClure HM,Raybourne RB,Williams KM,Babu US,Ware GO,Broderson JR,Doyle MP

更新日期：2003-03-01 00:00:00

abstract：:We have investigated the possibility that nitric oxide (NO) synthesis may affect the course of a trypanosome infection via T-cell responses using mice deficient in inducible NO synthase (iNOS). Parasitemia levels increased at the same rate in both iNOS-deficient homozygous and control heterozygous mice, and peak paras...

journal_title：Infection and immunity

authors： Millar AE,Sternberg J,McSharry C,Wei XQ,Liew FY,Turner CM

更新日期：1999-07-01 00:00:00

abstract：:Erythrocytic malaria parasites degrade hemoglobin as a principal source of amino acids for parasite protein synthesis. We have previously shown that a Plasmodium falciparum trophozoite cysteine proteinase, now termed falcipain, is required for hemoglobin degradation, and we have hypothesized that this proteinase is re...

journal_title：Infection and immunity

authors： Salas F,Fichmann J,Lee GK,Scott MD,Rosenthal PJ

更新日期：1995-06-01 00:00:00

abstract：:3-O-methylmannose isolated from Coccidioides immitis was characterized by gas chromatographic comparison of derivatives with those of synthetic 3-O-methylmannose. Gas chromatographic behavior of three derivatives of the natural and synthetic sugars was identical. ...

journal_title：Infection and immunity

authors： Porter JF,Scheer ER,Wheat RW

更新日期：1971-11-01 00:00:00

abstract：:The mechanisms by which Mycobacterium tuberculosis elicits disease are complex, involving a large repertoire of bacterial genes that are required for in vivo growth and survival. To identify such genes, we utilized a high-throughput microarray detection method to rapidly screen hundreds of unique, genotypically define...

journal_title：Infection and immunity

authors： Lamichhane G,Tyagi S,Bishai WR

更新日期：2005-04-01 00:00:00

abstract：:Clostridium difficile causes pseudomembranous colitis through the action of Rho-modifying proteins, toxins A and B. Antibodies directed against C. difficile toxin A prevent or limit C. difficile-induced colitis. We engineered plasmid pETR14, containing the hlyB and hlyD genes of the Escherichia coli hemolysin operon, ...

journal_title：Infection and immunity

authors： Ryan ET,Butterton JR,Smith RN,Carroll PA,Crean TI,Calderwood SB

更新日期：1997-07-01 00:00:00

abstract：:Organ cultures of adult hamster trachea were used to evaluate the cytotoxic potential of cell fractions of Mycoplasma pneumoniae. Cytoplasm was essentially devoid of activity, whereas viable cells and membrane preparations, at a level of 25 mug of protein per ml, induced necrosis. Damage, as revealed by light and elec...

journal_title：Infection and immunity

authors： Gabridge MG,Johnson CK,Cameron AM

更新日期：1974-11-01 00:00:00

abstract：:Raising the magnesium level from 0.4 to 1.5 mM in a medium containing only amino acids (2.08%), salts, and vitamins increased enterotoxin B production by Staphylococcus aureus S-6 by about 80%. The level of phosphates in the medium was lowered to one-tenth (to 2.87 mM) the original amount without adversely affecting g...

journal_title：Infection and immunity

authors： Keller GM,Hanson RS,Bergdoll MS

更新日期：1978-04-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-infected individuals are predisposed to recurrent oral candidiasis, and, although it has been assumed that this is because of deficient mucosal immune responses, this has not been properly established. The present study aimed to compare the concentrations and secretion rates of immun...

journal_title：Infection and immunity

authors： Coogan MM,Sweet SP,Challacombe SJ

更新日期：1994-03-01 00:00:00

abstract：:The role of cysteine proteinases in adherence of Trichomonas vaginalis NYH 286 to HeLa and human vaginal epithelial cells was evaluated. Only pretreatment of trichomonads, but not epithelial cells, with N-alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK), an inhibitor of trichomonad cysteine proteinases, greatly dimin...

journal_title：Infection and immunity

authors： Arroyo R,Alderete JF

更新日期：1989-10-01 00:00:00

abstract：:Susceptibility of Syrian hamsters of the inbred LSH and MHA strains to injection of as few as 10 plaque-forming units of vesicular stomatitis virus (VSV) was shown to occur only after intraperitoneal and intrapleural injection and not after injection of VSV intravenously, intranasally, or in the footpads. Despite the ...

journal_title：Infection and immunity

authors： Fultz PN,Shadduck JA,Kang CY,Streilein JW

更新日期：1981-11-01 00:00:00

abstract：:Intimate attachment to the host cell leading to the formation of attaching and effacing (A/E) lesions is an essential feature of enterohemorrhagic Escherichia coli (EHEC) O157:H7 pathogenesis. In a related pathogen, enteropathogenic E. coli (EPEC), this activity is dependent upon translocation of the intimin receptor,...

journal_title：Infection and immunity

authors： DeVinney R,Stein M,Reinscheid D,Abe A,Ruschkowski S,Finlay BB

更新日期：1999-05-01 00:00:00

abstract：:Polymicrobial intra-abdominal infections (IAIs) are a significant cause of morbidity and mortality, particularly when fungal pathogens are involved. Our experimental murine model of IAI involving intraperitoneal inoculation of Candida albicans and Staphylococcus aureus results in synergistic lethality (∼80%) due to ex...

journal_title：Infection and immunity

authors： Ikeh MAC,Fidel PL Jr,Noverr MC

更新日期：2018-06-21 00:00:00

abstract：:Cell-mediated immunity is pivotal in host resistance to Blastomyces dermatitidis infection. Immunization of mice with the WI-1 adhesin enhances resistance against experimental pulmonary infection but elicits features of a mixed T-helper-cell immune response. Immune mice acquire delayed-type hypersensitivity (DTH) but ...

journal_title：Infection and immunity

authors： Wüthrich M,Finkel-Jiminez BE,Klein BS

更新日期：2000-12-01 00:00:00

abstract：:We have characterized the natural immune responses to the 19-kDa domain of merozoite surface protein 1 in individuals from an area of western Kenya in which malaria is holoendemic. We used the three known natural variant forms of the yeast-expressed recombinant 19-kDa fragment that are referred to as the E-KNG, Q-KNG,...

journal_title：Infection and immunity

authors： Shi YP,Sayed U,Qari SH,Roberts JM,Udhayakumar V,Oloo AJ,Hawley WA,Kaslow DC,Nahlen BL,Lal AA

更新日期：1996-07-01 00:00:00

abstract：:Previous studies have shown that a mutant (designated C4) of Streptococcus mutans 6715 wild type (WT) is defective in glucosyltransferase (GTF)-synthesized insoluble glucan and is avirulent in gnotobiotic rats. This study investigated the factors which would render this mutant virulent in gnotobiotic rats. Microbial a...

journal_title：Infection and immunity

authors： Hirasawa M,Kiyono H,Shiota T,Hull RA,Curtiss R 3rd,Michalek SM,McGhee JR

更新日期：1980-03-01 00:00:00

abstract：:Interferon regulatory factor 1-deficient (IRF-1(-/-)) mice infected with virulent Brucella abortus 2308 at 5 x 10(5) CFU developed acute hepatitis similar to many natural hosts but, unlike natural hosts, IRF-1(-/-) mice were unable to resolve infection and died. In contrast, IRF-1(-/-) mice survived when infected at 5...

journal_title：Infection and immunity

authors： Ko J,Gendron-Fitzpatrick A,Ficht TA,Splitter GA

更新日期：2002-12-01 00:00:00

abstract：:Normal ICR mice were infected intravenously, intraperitoneally, or aerogenically with Pasteurella multocida strains isolated from a turkey (S68), calf (V90), or rabbit (J20) lung. Both the turkey and calf isolates were highly virulent for mice and multiplied logarithmically in the lungs, liver, and spleen, resulting i...

journal_title：Infection and immunity

authors： Collins FM,Niederbuhl CJ,Campbell SG

更新日期：1983-02-01 00:00:00

abstract：:The present study was performed to determine whether Histoplasma capsulatum (yeast phase) is able to activate the alternative complement pathway. H. capsulatum yeasts were shown to consume C3 in C4-deficient guinea pig serum. Immunoelectrophoretic conversion of alternative pathway component factor B confirmed that C3 ...

journal_title：Infection and immunity

authors： Ratnoff WD,Pepple JM,Winkelstein JA

更新日期：1980-10-01 00:00:00

abstract：:Neisseria gonorrhoeae releases peptidoglycan fragments during growth, and these molecules induce an inflammatory response in the human host. The proinflammatory molecules include peptidoglycan monomers, peptidoglycan dimers, and free peptides. These molecules can be released by the actions of lytic transglycosylases o...

journal_title：Infection and immunity

authors： Schaub RE,Perez-Medina KM,Hackett KT,Garcia DL,Dillard JP

更新日期：2019-01-24 00:00:00

abstract：:In contrast to infection of superficial tissues, Streptococcus pyogenes infection of deeper tissue can be associated with a significantly diminished inflammatory response, suggesting that this bacterium has the ability to both promote and suppress inflammation. To examine this, we analyzed the behavior of an S. pyogen...

journal_title：Infection and immunity

authors： Lin A,Loughman JA,Zinselmeyer BH,Miller MJ,Caparon MG

更新日期：2009-11-01 00:00:00

abstract：:The bacterial pathogen Listeria monocytogenes causes foodborne systemic disease in pregnant women, which can lead to preterm labor, stillbirth, or severe neonatal disease. Colonization of the maternal decidua appears to be an initial step in the maternal component of the disease as well as bacterial transmission to th...

journal_title：Infection and immunity

authors： Rizzuto G,Tagliani E,Manandhar P,Erlebacher A,Bakardjiev AI

更新日期：2017-07-19 00:00:00

abstract：:While the pathological events evoked by infection are commonly described, effective host responses to bacteria and their products should primarily be protective. Heat shock protein (Hsp) expression is upregulated by many stimuli and serves to maintain intracellular protein integrity. The ability of the prototypic supe...

journal_title：Infection and immunity

authors： Musch MW,Petrof EO,Kojima K,Ren H,McKay DM,Chang EB

更新日期：2004-06-01 00:00:00

abstract：:Antiserum to a synthetic peptide, CTP3, consisting of residues 50 to 64 of the B subunit of cholera enterotoxin (CT), a sequence which is conserved in heat-labile enterotoxins from Escherichia coli strains of human (H-LT) or porcine (P-LT) origin, cross-reacted with and neutralized all three enterotoxins. It also cros...

journal_title：Infection and immunity

authors： Jacob CO,Arnon R,Finkelstein RA

更新日期：1986-05-01 00:00:00

abstract：:The chemoattraction of Propionibacterium acnes lipase for neutrophils and the effect of lipase inhibitor and two antibiotic agents on the chemotaxis were evaluated. Of the various fractions tested, partially purified lipase (fraction 2c) was the most active cytotaxin produced by P. acnes. Serum mediators were not requ...

journal_title：Infection and immunity

authors： Lee WL,Shalita AR,Suntharalingam K,Fikrig SM

更新日期：1982-01-01 00:00:00

abstract：:The parameters of a persistent-state measles virus infection in BGM/MV cells were examined. The BGM/MV cell line was established by cocultivation of measles virus-infected primary C3H mouse brain cells with a stable line of African green monkey kidney cells (BGM). Initially, a morphologically mixed population of cells...

journal_title：Infection and immunity

authors： Menna JH,Collins AR,Flanagan TD

更新日期：1975-01-01 00:00:00

abstract：:We have focused on regions of staphylococcal enterotoxin C1 (SEC1) causing immunomodulation. N-terminal deletion mutants lacking residues 6 through 13 induced T-cell proliferation similar to that induced by native toxin. However, mutants with residues deleted between positions 19 and 33, although nonmitogenic themselv...

journal_title：Infection and immunity

authors： Hoffmann ML,Jablonski LM,Crum KK,Hackett SP,Chi YI,Stauffacher CV,Stevens DL,Bohach GA

更新日期：1994-08-01 00:00:00

abstract：:Live attenuated bacteria hold great promise as multivalent mucosal vaccines against a variety of pathogens. A major challenge of this approach has been the successful delivery of sufficient amounts of vaccine antigens to adequately prime the immune system without overattenuating the live vaccine. Here we used a live a...

journal_title：Infection and immunity

authors： Galen JE,Wang JY,Carrasco JA,Lloyd SA,Mellado-Sanchez G,Diaz-McNair J,Franco O,Buskirk AD,Nataro JP,Pasetti MF

更新日期：2015-01-01 00:00:00

abstract：:The hagfish, Eptatretus stoutii, has been shown to synthesize bactericidal antibodies after injections of gram-negative organisms. These bactericidins could be detected as early as 2 days after the primary injection. Secondary responses were accelerated, although titers were not significantly higher than those reached...

journal_title：Infection and immunity

authors： Acton RT,Weinheimer PF,Hildemann WH,Evans EE

更新日期：1971-08-01 00:00:00

abstract：:Woodchuck sera were tested for antigens and antibodies with tests which detect human hepatitis virus antigens and antibodies. Data on 264 woodchuck sera are presented. ...

journal_title：Infection and immunity

authors： Millman I,Halbherr T,Simmons H

更新日期：1982-02-01 00:00:00