Abstract:
:The hagfish, Eptatretus stoutii, has been shown to synthesize bactericidal antibodies after injections of gram-negative organisms. These bactericidins could be detected as early as 2 days after the primary injection. Secondary responses were accelerated, although titers were not significantly higher than those reached in the primary response. The bactericidins of hagfish were found to react with other gramnegative enteric bacteria, but not with gram-positive strains. The bactericidins show a lesser degree of specificity and a shorter induction period than other hagfish antibodies or most antibodies induced in higher vertebrates. The bactericidal activity was temperature dependent and could be irreversibly destroyed by heating at 50 C for 20 min. Immune sera were subjected to gel filtration on Sephadex G-200, and bactericidal activity was found to be associated with the excluded peak indicating a high-molecular-weight component. Evidence indicates that inducible immune responses of this bactericidal type represent a primitive capacity which arose before the emergence of vertebrate species.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Acton RT,Weinheimer PF,Hildemann WH,Evans EEdoi
10.1128/IAI.4.2.160-166.1971subject
Has Abstractpub_date
1971-08-01 00:00:00pages
160-6issue
2eissn
0019-9567issn
1098-5522journal_volume
4pub_type
杂志文章abstract::As part of a study of virulence gene regulation in Streptococcus pneumoniae, we have identified a gene encoding a homologue of the staphylococcal catabolite control protein CcpA in the pneumococcal genome sequence. The pneumococcal protein, designated RegM, has significant similarity to members of the LacI/GalR family...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.10.5454-5461.2002
更新日期:2002-10-01 00:00:00
abstract::Vitamin D is an important regulator of the expression of antimicrobial peptides, and vitamin D deficiency is associated with respiratory infections. Regulating expression of antimicrobial peptides, such as the human cathelicidin antimicrobial peptide 18 (hCAP18)/LL-37, by vitamin D in bronchial epithelial cells requir...
journal_title:Infection and immunity
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doi:10.1128/IAI.06224-11
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.9.2308-2310.1987
更新日期:1987-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.2.407-412.1982
更新日期:1982-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.50.2.488-494.1985
更新日期:1985-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.27.3.837-841.1980
更新日期:1980-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.1.50-58.1977
更新日期:1977-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.8.3100-3106.1997
更新日期:1997-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.10.5530-5538.2000
更新日期:2000-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01388-08
更新日期:2009-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01943-06
更新日期:2007-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.1.288-293.2000
更新日期:2000-01-01 00:00:00
abstract::During the infection of mice with Listeria monocytogenes, there is a profound depletion of T (Thy-1+ Ig-) lymphocytes between days 1 and 4, followed by an increase in T cells to three times normal levels by day 9. The recovery of T cell numbers required cell proliferation, being sensitive to vinblastin and cyclophosph...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.2.694-698.1982
更新日期:1982-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.1.46-55.1983
更新日期:1983-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.9.2148-2154.1987
更新日期:1987-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.2.1032-1042.2006
更新日期:2006-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.1.127-132.1979
更新日期:1979-07-01 00:00:00
abstract::Escherichia coli 83972 is a clinical asymptomatia bacteriuric isolate that is able to colonize the human urinary bladder without inducing an immune response. Here we demonstrate that one of the mechanisms by which this strain has become attenuated is through the mutation of its genes encoding type 1 and P fimbriae. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.1.781-785.2006
更新日期:2006-01-01 00:00:00
abstract::The virulence of Neisseria gonorrhoeae for chicken embryos can be modified in a predictable manner by the addition of microbial siderophores to the inoculum. "Meningobactin" and "gonobactin," siderophores isolated from iron-limited cultures of meningococci and gonococci, respectively, enhance the virulence of the rela...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.2.609-613.1981
更新日期:1981-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.1.168-171.1991
更新日期:1991-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01572-14
更新日期:2014-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.6.3436-3443.2004
更新日期:2004-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.47.1.52-60.1985
更新日期:1985-01-01 00:00:00
abstract::Acquired cellular immunity to infection with Mycobacterium tuberculosis is believed to reside in the capacity of mononuclear phagocytes of immunized animals to inhibit intracellular multiplication of the parasite. However, in macrophage tissue culture systems, it has been customary to employ streptomycin in the medium...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1970-01-01 00:00:00
abstract::Patients with chronic mucocutaneous candidiasis (CMC) are selectively unable to clear the yeast Candida, which results in persistent debilitating infections affecting the skin, nails, and mucous membranes. The underlying defect is unknown. Recent animal studies highlighted the importance of type 1 cytokines in protect...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.10.5690-5699.2003
更新日期:2003-10-01 00:00:00
abstract::To assess the relationship between the within-host diversity of malaria infections and the susceptibility of the host to subsequent infection, we genotyped 60 children's successive infections from birth through 3 years of life. MSP-1 Block2 genotypes were used to estimate the complexity of infection (COI). Malaria tra...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.69.12.7783-7792.2001
更新日期:2001-12-01 00:00:00
abstract::Advanced human periodontitis is considered to be a B-cell lesion, but the cellular infiltrate contains several cell types, the distribution of which has not been determined. This experiment was designed to characterize and identify the immunocompetent cells on histological sections and in eluates from diseased human g...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.1.365-374.1983
更新日期:1983-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.2.4.448-452.1970
更新日期:1970-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00943-08
更新日期:2009-01-01 00:00:00