Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils.

abstract：:Previous passive antibody transfer experiments have indicated that immunity to a 46-kilodalton membrane glycoprotein (M-2) of Leishmania amazonensis may protect against infection with this parasite. In the studies described in this paper, we investigated the ability of the purified M-2 molecule to elicit a protective ...

journal_title：Infection and immunity

authors： Champsi J,McMahon-Pratt D

更新日期：1988-12-01 00:00:00

abstract：:Cell walls from Streptococcus mutans were prepared by conventional technique and subjected to a series of extraction procedures involving classical protein solvents. The extracted walls contained several non-peptidoglycan amino acids and were also amenable to radiolabeling with [125I]sodium iodide and chloramine T. Th...

journal_title：Infection and immunity

authors： Nesbitt WE,Staat RH,Rosan B,Taylor KG,Doyle RJ

更新日期：1980-04-01 00:00:00

abstract：:Cholera toxin has been widely used to obtain insight into the cellular dynamics of the antigen-specific mucosal immune response. The present study was undertaken to clarify the influence of the organized intestinal lymphoid tissue (Peyer's patches [PP]) on the distribution of anti-cholera-toxin-containing cells (ACC) ...

journal_title：Infection and immunity

authors： Enders GA,Delius M,Ballhaus S,Brendel W

更新日期：1987-09-01 00:00:00

abstract：:Vibrio parahaemolyticus, a gram-negative marine bacterium, is an important pathogen causing food-borne gastroenteritis or septicemia. Recent genome sequencing of the RIMD2210633 strain (a Kanagawa phenomenon-positive clinical isolate of serotype O3:K6) revealed that the strain has two sets of gene clusters that encode...

journal_title：Infection and immunity

authors： Ono T,Park KS,Ueta M,Iida T,Honda T

更新日期：2006-02-01 00:00:00

abstract：:The Gram-negative intracellular pathogen Burkholderia pseudomallei is the causative agent of melioidosis, an important cause of sepsis in Southeast Asia. Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is essential for an appropriate immune response during pathogen invasion. In pati...

journal_title：Infection and immunity

authors： Birnie E,Weehuizen TAF,Lankelma JM,de Jong HK,Koh GCKW,van Lieshout MHP,Roelofs JJTH,Budding AE,de Vos AF,van der Poll T,Wiersinga WJ

更新日期：2019-07-23 00:00:00

abstract：:Actinobacillus pleuropneumoniae serotype 7 strains are shown to spontaneously lose cytolytic activity with a frequency of approximately 10(-4). The phenotypic change is associated with the loss of approximately 8.5 kbp of chromosomal DNA. A genomic fragment encoding the cytolysin and its flanking sequences was cloned ...

journal_title：Infection and immunity

authors： Anderson C,Potter AA,Gerlach GF

更新日期：1991-11-01 00:00:00

abstract：:Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha 2-fucosyltransferase, and alpha 3-fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized and secreted by the liver dur...

journal_title：Infection and immunity

authors： Canonico PG,Little JS,Powanda MC,Bostian KA,Beisel WR

更新日期：1980-07-01 00:00:00

abstract：:Peptidoglycans of Leptotrichia buccalis ATCC 14201 and ATCC 19616 were isolated by extraction with sodium dodecyl sulfate and subsequent digestion of the sodium dodecyl sulfate-insoluble residue with proteases and alpha-amylase. Cell wall fractions obtained by sodium dodecyl sulfate extraction and protease digestion w...

journal_title：Infection and immunity

authors： Fukuhara H,Umemoto T,Sagawa H,Kato K,Kotani S

更新日期：1983-01-01 00:00:00

abstract：:To elucidate the mechanism of the high incidence of lower respiratory tract infections in patients with diabetes mellitus, we investigated the kinetics of production of macrophage inflammatory protein 2 (MIP-2), an important mediator of lung neutrophil recruitment, using mice with streptozotocin-induced diabetes. Intr...

journal_title：Infection and immunity

authors： Amano H,Yamamoto H,Senba M,Oishi K,Suzuki S,Fukushima K,Mukaida N,Matsushima K,Eguchi K,Nagatake T

更新日期：2000-05-01 00:00:00

abstract：:Hybridomas secreting monoclonal antibodies against an apparent strain-specific cell surface antigen of Neisseria gonorrhoeae were produced. Spleen cells from BALB/c mice immunized with whole gonococci were fused with mouse myeloma cell line Sp2/0, and hybrid cells were selected in culture. One hybridoma that secreted ...

journal_title：Infection and immunity

authors： Nachamkin I,Cannon JG,Mittler RS

更新日期：1981-05-01 00:00:00

abstract：:The protection and immune response to infection caused by the parasite Schistosoma mansoni were studied by comparison of two murine irradiated-vaccine models. Mice were exposed from 1 to 4 times to infective-stage cercariae attenuated with either a moderate dose (15 kilorads) or a high dose (50 kilorads) of radiation....

journal_title：Infection and immunity

authors： Reynolds SR,Harn DA

更新日期：1992-01-01 00:00:00

abstract：:BCG vaccines are a family of closely related daughter strains of an attenuated isolate of Mycobacterium bovis derived by in vitro passage from 1908 to 1921. During subsequent laboratory propagation of the vaccine strain until its lyophilization in 1961, BCG Pasteur underwent at least seven further genomic mutations. T...

journal_title：Infection and immunity

authors： Belley A,Alexander D,Di Pietrantonio T,Girard M,Jones J,Schurr E,Liu J,Sherman DR,Behr MA

更新日期：2004-05-01 00:00:00

abstract：:Neutrophil collagenase (matrix metalloproteinase 8 [MMP-8]) is an important mediator of tissue destruction in inflammatory diseases. Studies of anaerobic periodontal infections have shown that active MMP-8 in gingival crevicular fluid is associated with the degradation of periodontal tissues in progressive periodontit...

journal_title：Infection and immunity

authors： Romanelli R,Mancini S,Laschinger C,Overall CM,Sodek J,McCulloch CA

更新日期：1999-05-01 00:00:00

abstract：:Iron acquisition from the host is an important step in the pathogenic process. While Yersinia pestis has multiple iron transporters, the yersiniabactin (Ybt) siderophore-dependent system plays a major role in iron acquisition in vitro and in vivo. In this study, we determined that the Ybt system is required for the us...

journal_title：Infection and immunity

authors： Fetherston JD,Kirillina O,Bobrov AG,Paulley JT,Perry RD

更新日期：2010-05-01 00:00:00

abstract：:We have previously shown that a pneumococcal surface protein A (PspA)-based vaccine containing DNA plasmid encoding the Flt3 ligand (FL) gene (pFL) as a nasal adjuvant prevented nasal carriage of Streptococcus pneumoniae. In this study, we further investigated the safety and efficacy of this nasal vaccine for the indu...

journal_title：Infection and immunity

authors： Kataoka K,Fujihashi K,Oma K,Fukuyama Y,Hollingshead SK,Sekine S,Kawabata S,Ito HO,Briles DE,Oishi K

更新日期：2011-07-01 00:00:00

abstract：:Exposure of mycobacterial growth inhibitory factor (MycoIF) to trypsin, chymotrypsin, or neuraminidase decrease its ability to produce intracellular inhibition of mycobacterial growth within macrophages, suggesting that MycoIF was a glycoprotein. MycoIF was unaffected by deoxyribonuclease or ribonuclease. Supernatant ...

journal_title：Infection and immunity

authors： Cahall DL,Youmans GP

更新日期：1975-10-01 00:00:00

abstract：:Strains of Bacteroides fragilis associated with diarrhea in children (termed enterotoxigenic B. fragilis, or ETBF) produce a heat-labile ca. 20-kDa protein toxin (BFT). The purpose of this study was to examine the activity of BFT on polarized monolayers of human intestinal epithelial cells (T84 cells). In Ussing chamb...

journal_title：Infection and immunity

authors： Chambers FG,Koshy SS,Saidi RF,Clark DP,Moore RD,Sears CL

更新日期：1997-09-01 00:00:00

abstract：:Seven antigens of Borrelia hermsii, B. parkeri, and B. turicatae with isoelectric points in the range of 4.4 to 5.0 and molecular masses of 40 to 43 kilodaltons played a role in the relapse phenomenon of relapsing fever. Based upon location of the antigens in the outer envelope, the molecular weight, and Western blot ...

journal_title：Infection and immunity

authors： Kehl KS,Farmer SG,Komorowski RA,Knox KK

更新日期：1986-12-01 00:00:00

abstract：:Evidence obtained from gene knockout studies supports the role of Toll-like receptor 4 (TLR4) in intestinal inflammation and microbiota recognition. Increased epithelial TLR4 expression is observed in patients with inflammatory bowel disease. However, little is known of the effect of increased TLR4 signaling on intest...

journal_title：Infection and immunity

authors： Dheer R,Santaolalla R,Davies JM,Lang JK,Phillips MC,Pastorini C,Vazquez-Pertejo MT,Abreu MT

更新日期：2016-01-11 00:00:00

abstract：:gammadelta T cells are considered crucial to the outcome of various infectious diseases. The present study was undertaken to characterize gammadelta (T-cell receptor 1(+) [TCR1(+)]) T cells phenotypically and functionally in avian immune response. Day-old chicks were orally immunized with Salmonella enterica serovar E...

journal_title：Infection and immunity

authors： Berndt A,Pieper J,Methner U

更新日期：2006-07-01 00:00:00

abstract：:A number of polymorphonuclear leukocyte (PMN) chemotactic factors derived from complement components have been described. We sought to determine which of these factors accounted for the majority of PMN chemotactic activity in rabbit serum and guinea pig serum treated with preformed immune complexes. Normal rabbit sera...

journal_title：Infection and immunity

authors： Snyderman R,Phillips J,Mergenhagen SE

更新日期：1970-06-01 00:00:00

abstract：:The intravenous administration of hydrogen peroxide has been reported to benefit patients with pneumonia and to reduce Plasmodium parasitemia in experimentally infected mice. We assessed the antibacterial activity of intravenously infused hydrogen peroxide against hydrogen peroxide-susceptible Escherichia coli (MBC of...

journal_title：Infection and immunity

authors： Shenep JL,Stokes DC,Hughes WT

更新日期：1985-06-01 00:00:00

abstract：:Cattle are an important reservoir of Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) O157:H7 strains, foodborne pathogens that cause hemorrhagic colitis and hemolytic uremic syndrome in humans. EHEC O157:H7 strains are not pathogenic in calves >3 weeks old. Our objective was to determine if EHEC O157:H...

journal_title：Infection and immunity

authors： Dean-Nystrom EA,Bosworth BT,Cray WC Jr,Moon HW

更新日期：1997-05-01 00:00:00

abstract：:Chlamydia trachomatis is a strict human pathogen producing infections that cause medically important chronic inflammatory diseases, such as blinding trachoma and tubal factor infertility. Isolates exist as serotypes that fall into distinct biologic and pathological groups corresponding to differences in infection tiss...

journal_title：Infection and immunity

authors： Carlson JH,Hughes S,Hogan D,Cieplak G,Sturdevant DE,McClarty G,Caldwell HD,Belland RJ

更新日期：2004-12-01 00:00:00

abstract：:We show in this study that toxin production in Clostridium difficile is altered in cells which can no longer form flagellar filaments. The impact of inactivation of fliC, CD0240, fliF, fliG, fliM, and flhB-fliR flagellar genes upon toxin levels in culture supernatants was assessed using cell-based cytotoxicity assay, ...

journal_title：Infection and immunity

authors： Aubry A,Hussack G,Chen W,KuoLee R,Twine SM,Fulton KM,Foote S,Carrillo CD,Tanha J,Logan SM

更新日期：2012-10-01 00:00:00

abstract：:Burkholderia cepacia is an opportunistic pathogen that causes severe systemic infections in patients with chronic granulomatous disease (CGD) or with cystic fibrosis (CF), but its mechanisms of virulence are poorly understood. We developed a murine model of systemic infection in wild-type (WT) and gamma interferon kno...

journal_title：Infection and immunity

authors： Speert DP,Steen B,Halsey K,Kwan E

更新日期：1999-08-01 00:00:00

abstract：:Cell surface protein SSP-5 in the oral bacterium Streptococcus gordonii M5 binds human salivary agglutinin in a Ca(2+)-dependent reaction (D.R. Demuth, E.E. Golub, and D. Malamud, J. Biol. Chem. 265:7120-7126, 1990). The region of the gene encoding an N-terminal segment of a related polypeptide (SspA) in S. gordonii D...

journal_title：Infection and immunity

authors： Jenkinson HF,Terry SD,McNab R,Tannock GW

更新日期：1993-08-01 00:00:00

abstract：:Considerable evidence supports the concept that CD4(+) T cells are important in sarcoidosis pathogenesis, but the antigens responsible for the observed Th1 immunophenotype remain elusive. The epidemiologic association with bioaerosols and the presence of granulomatous inflammation support consideration of mycobacteria...

journal_title：Infection and immunity

authors： Oswald-Richter KA,Culver DA,Hawkins C,Hajizadeh R,Abraham S,Shepherd BE,Jenkins CA,Judson MA,Drake WP

更新日期：2009-09-01 00:00:00

abstract：:In previous work (Jones, Infect, Immun. 30:78-89, 1980) a major cytoplasmic antigen of Candida albicans was identified. In both humans and experimental animals, this antigen is released from C. albicans during the course of an invasive C. albicans infection and elicits a specific antibody response. In this study, we u...

journal_title：Infection and immunity

authors： Greenfield RA,Jones JM

更新日期：1981-11-01 00:00:00

abstract：:Genetically based natural resistance to brucellosis in cattle provides for novel strategies to control zoonotic diseases. Bovine NRAMP1, the homologue of a murine gene (Bcg), has been identified as a major candidate for controlling the in vivo resistant phenotype. We developed an in vitro model for expression of resis...

journal_title：Infection and immunity

authors： Barthel R,Feng J,Piedrahita JA,McMurray DN,Templeton JW,Adams LG

更新日期：2001-05-01 00:00:00