Association of protein with the cell wall of Streptococcus mutans.

abstract：:Comparative studies on the virulence of two strains of Pseudomonas aeruginosa isolated from otic pus and mink pneumonic lesion, respectively, were made by means of intranasal inoculation in mink. The minimal lethal dose of the former (strain NC-5, highly virulent for mice) was 10(10), and that of the latter (strain No...

journal_title：Infection and immunity

authors： Shimizu T,Homma JY,Aoyama T,Onodera T,Noda H

更新日期：1974-07-01 00:00:00

abstract：:Cholera toxin (CT) and related Escherichia coli enterotoxins LTI and LTIIb have a conserved hydrophobic region at the AB(5) interface postulated to be important for toxin assembly. Hydrophobic residue F223 in the A subunit of CT (CTA) as well as residues 174, L77, and T78 in the B subunit of CT (CTB) were replaced ind...

journal_title：Infection and immunity

authors： Tinker JK,Erbe JL,Hol WG,Holmes RK

更新日期：2003-07-01 00:00:00

abstract：:Henle 407 and HeLa cells were compared as hosts for Shigella dysenteriae at a low multiplicity of infection. Efficiency of attachment and invasion without centrifugation, as well as selectivity for pathogenic over nonpathogenic S. dysenteriae without Congo red, were much greater for Henle 407 cells than for HeLa cells...

journal_title：Infection and immunity

authors： Sen A,Leon MA,Palchaudhuri S

更新日期：1990-07-01 00:00:00

abstract：:Strategies to limit complement deposition on Streptococcus pneumoniae are established as virulence features for invasive disease, but their role in respiratory tract infection requires further analysis. We evaluated complement C3 protein deposition on discordant S. pneumoniae isolates of the same serotype (6A) and the...

journal_title：Infection and immunity

authors： Sabharwal V,Ram S,Figueira M,Park IH,Pelton SI

更新日期：2009-03-01 00:00:00

abstract：:The production and role of tumor necrosis factor alpha (TNF-alpha) in pneumococcal pneumonia were investigated in a mouse pneumonia model. When approximately 10(6) CFU of Streptococcus pneumoniae TUM19 were used to inoculate CBA/J mice intranasally, TNF-alpha levels in the lungs and serum began to increase from 1 and ...

journal_title：Infection and immunity

authors： Takashima K,Tateda K,Matsumoto T,Iizawa Y,Nakao M,Yamaguchi K

更新日期：1997-01-01 00:00:00

abstract：:Chronic infections play a significant role in the morbidity and mortality of patients with chronic airflow limitation. By stimulating airway inflammation, persistent infection has the potential to cause airway fibrosis. However, in patient this condition is most typically found in lungs damaged by other factors, such ...

journal_title：Infection and immunity

authors： McIntosh JC,Simecka JW,Ross SE,Davis JK,Miller EJ,Cassell GH

更新日期：1992-07-01 00:00:00

abstract：:Otitis media developed in 67% of chinchillas inoculated intranasally with type 7 Streptococcus pneumoniae and influenza A virus. Only 4% of chinchillas inoculated with influenza alone and 21% of chinchillas inoculated with S. pneumoniae alone developed otitis media. Among the chinchillas that developed otitis media af...

journal_title：Infection and immunity

authors： Giebink GS,Berzins IK,Marker SC,Schiffman G

更新日期：1980-11-01 00:00:00

abstract：:Conventional dendritic cells (cDCs) are critical for protection against pulmonary infection with the opportunistic fungal pathogen Cryptococcus neoformans; however, the role of plasmacytoid dendritic cells (pDCs) is unknown. We show for the first time that murine pDCs have direct activity against C. neoformans via rea...

journal_title：Infection and immunity

authors： Hole CR,Leopold Wager CM,Mendiola AS,Wozniak KL,Campuzano A,Lin X,Wormley FL Jr

更新日期：2016-08-19 00:00:00

abstract：:The expression of the Shigella flexneri chromosomal aerobactin genes during growth of the bacterium within tissue culture cells was assayed. During intracellular growth, aerobactin promoter activity was repressed relative to the level observed in bacteria grown extracellularly, even when the bacteria had been starved ...

journal_title：Infection and immunity

authors： Headley V,Hong M,Galko M,Payne SM

更新日期：1997-02-01 00:00:00

abstract：:EspG is a conserved protein encoded by the locus of enterocyte effacement (LEE) of attaching and effacing (A/E) pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli and Citrobacter rodentium. EspG is delivered into infected host cells by a type III secretion system. The role of EspG in virulenc...

journal_title：Infection and immunity

authors： Hardwidge PR,Deng W,Vallance BA,Rodriguez-Escudero I,Cid VJ,Molina M,Finlay BB

更新日期：2005-05-01 00:00:00

abstract：:Streptococcal pyrogenic exotoxin B (SpeB), a conserved cysteine protease expressed by virtually all Streptococcus pyogenes strains, has recently been shown to be an important virulence factor (S. Lukomski, S. Sreevatsan, C. Amberg, W. Reichardt, M. Woischnik, A. Podbielski, and J. M. Musser, J. Clin. Invest. 99:2574-2...

journal_title：Infection and immunity

authors： Lukomski S,Burns EH Jr,Wyde PR,Podbielski A,Rurangirwa J,Moore-Poveda DK,Musser JM

更新日期：1998-02-01 00:00:00

abstract：:Mice with a null deletion mutation in the gamma interferon (IFN-gamma) receptor gene were used to study the role of IFN-gamma responsiveness during experimental pulmonary cryptococcosis. Cryptococcus neoformans was inoculated intratracheally into mice lacking the IFN-gamma receptor gene (IFN-gammaR-/-) and into contro...

journal_title：Infection and immunity

authors： Chen GH,McDonald RA,Wells JC,Huffnagle GB,Lukacs NW,Toews GB

更新日期：2005-03-01 00:00:00

abstract：:Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the adjuvant effect of murine CpG ODN 1826 on the immunogenicity and protective efficacy of the Saccharomyces cerevisiae-expres...

journal_title：Infection and immunity

authors： Kumar S,Jones TR,Oakley MS,Zheng H,Kuppusamy SP,Taye A,Krieg AM,Stowers AW,Kaslow DC,Hoffman SL

更新日期：2004-02-01 00:00:00

abstract：:Two phospholipase C fractions were detected in culture supernatants from Pseudomonas aeruginosa ATCC 19660, PAO1, and D10C by preparative polyacrylamide gel electrophoresis. Both hemolytic fractions from strain ATCC 19660 were isolated by polyacrylamide gel electrophoresis and were found to cause paralysis, death, der...

journal_title：Infection and immunity

authors： Berk RS,Brown D,Coutinho I,Meyers D

更新日期：1987-07-01 00:00:00

abstract：:The HT29MTXE12 (E12) cell line harbors an adherent mucus layer, providing a novel technique to model mucosal infection in vitro. In this study, we have characterized the interaction of Campylobacter jejuni with the E12 cell line and exploited its unique mucus layer to examine the potential efficacy of probiotic treatm...

journal_title：Infection and immunity

authors： Alemka A,Clyne M,Shanahan F,Tompkins T,Corcionivoschi N,Bourke B

更新日期：2010-06-01 00:00:00

abstract：:The Streptococcus mutans serotype c gtfA gene encodes a 55-kilodalton sucrose-hydrolyzing enzyme. Analysis of S. mutans gtfA mutants revealed that the mutant strains were specifically impaired in the ability to use melibiose as a sole carbon source. S. mutans gtfA mutant strains synthesized less alpha-galactosidase ac...

journal_title：Infection and immunity

authors： Barletta RG,Curtiss R 3rd

更新日期：1989-03-01 00:00:00

abstract：:Helicobacter pylori colonizes the gastric epithelium of at least 50% of the world's human population, playing a causative role in the development of chronic gastritis, peptic ulcers, and gastric adenocarcinoma. Current evidence indicates that H. pylori can invade epithelial cells in the gastric mucosa. However, relati...

journal_title：Infection and immunity

authors： Terebiznik MR,Vazquez CL,Torbicki K,Banks D,Wang T,Hong W,Blanke SR,Colombo MI,Jones NL

更新日期：2006-12-01 00:00:00

abstract：:The antigenically variant Chlamydia trachomatis major outer membrane protein (MOMP) is a target of antibody-mediated neutralization in vitro, and it is an important protein for designing a subunit vaccine. Knowledge of MOMP T-cell determinants will be essential to elicit rapid and strong immune responses following an ...

journal_title：Infection and immunity

authors： Ishizaki M,Allen JE,Beatty PR,Stephens RS

更新日期：1992-09-01 00:00:00

abstract：:Continuous virus production is a characteristic of chicken embryo fibroblasts (CEF) infected and transformed by a nondefective Schmidt-Ruppin subgroup A Rous sarcoma virus. This virus production has been examined with particular attention to the amount of newly budded virus which remained cell-associated, and to the a...

journal_title：Infection and immunity

authors： Volkmann KR,Morgan HR

更新日期：1974-10-01 00:00:00

abstract：:The adsorption of (3)H-labeled Streptococcus mutans 6715 cells to disks of hydroxyapatite (HA) was studied. The number of streptococci that adsorbed was logarithmically related to the concentration of cells available up to at least 2 x 10(8) per ml; equilibrium occurred within 45 min. Assay reliability was verified by...

journal_title：Infection and immunity

authors： Clark WB,Gibbons RJ

更新日期：1977-11-01 00:00:00

abstract：:The Legionella pneumophila major secretory protein (Msp) is a Zn2+ metalloprotease whose function in pathogenesis is unknown. The structural gene for the Msp protease, mspA, was isolated from an L. pneumophila genomic library. In Escherichia coli which contain plasmids with the mspA gene, Msp protein and activity are ...

journal_title：Infection and immunity

authors： Szeto L,Shuman HA

更新日期：1990-08-01 00:00:00

abstract：:The presence of soybean meal in the diet of gnotobiotic mice was shown to prevent the establishment of a clostridial strain in the gastrointestinal tract. Soybean meal did not inhibit the growth of Clostridium in vitro, suggesting that the host plays a role in the observed inhibition of bacterial growth. The inhibitor...

journal_title：Infection and immunity

authors： Lhuillery C,Demarne Y,Ducluzeau R,Clara A

更新日期：1982-05-01 00:00:00

abstract：:We have previously described (L. M. Vaughan, P. R. Smith, and T. J. Foster, Infect. Immun. 61:2172-2181, 1993) the construction of a kanamycin-resistant aromatic-dependent mutant of Aeromonas salmonicida, the causative agent of furunculosis, and its use as a live vaccine. Here we describe the construction of an unmark...

journal_title：Infection and immunity

authors： Marsden MJ,Vaughan LM,Foster TJ,Secombes CJ

更新日期：1996-09-01 00:00:00

abstract：:Infection of epithelial cells by two biovars of Chlamydia trachomatis results in the tyrosine phosphorylation of several host proteins. The most prominent change in host protein tyrosine phosphorylation involves a complex of proteins with molecular masses of 75 to 85 kDa (pp75/85) and 100 kDa (pp100). The C. trachomat...

journal_title：Infection and immunity

authors： Fawaz FS,van Ooij C,Homola E,Mutka SC,Engel JN

更新日期：1997-12-01 00:00:00

abstract：:Borrelia burgdorferi, the Lyme disease pathogen, dramatically alters its protein profile when it is transmitted between ticks and mammals. Several differentially expressed proteins have been shown to be critical for the enzootic cycle of B. burgdorferi. In this study, we demonstrated that expression of the surface lip...

journal_title：Infection and immunity

authors： Xu H,He M,He JJ,Yang XF

更新日期：2010-07-01 00:00:00

abstract：:Anti-CD4 antibodies, which cause CD4(+) T-cell depletion, have been shown to increase susceptibility to infections in mice. Thus, development of anti-CD4 antibodies for clinical use raises potential concerns about suppression of host defense mechanisms against pathogens and tumors. The anti-human CD4 antibody kelixima...

journal_title：Infection and immunity

authors： Herzyk DJ,Gore ER,Polsky R,Nadwodny KL,Maier CC,Liu S,Hart TK,Harmsen AG,Bugelski PJ

更新日期：2001-02-01 00:00:00

abstract：:Inbred mouse strains differ in their susceptibility to infection with the facultative intracellular bacterium Listeria monocytogenes, largely due to delayed or deficient innate immune responses. Previous antibody depletion studies suggested that neutrophils (polymorphonuclear leukocytes [PMN]) were particularly import...

journal_title：Infection and immunity

authors： Pitts MG,Combs TA,D'Orazio SEF

更新日期：2018-03-22 00:00:00

abstract：:The Th-2 response to microfilariae of Brugia malayi in BALB/c mice is associated with peritoneal eosinophilia. These eosinophils had an activated hypodense phenotype in vivo and expressed high levels of the class II major histocompatibility complex (MHC). Interleukin 4 up-regulated the class II MHC, whereas gamma inte...

journal_title：Infection and immunity

authors： Mawhorter SD,Pearlman E,Kazura JW,Boom WH

更新日期：1993-12-01 00:00:00

abstract：:We compared the susceptibilities of Chlamydia trachomatis elementary bodies (EBs) to human defensin HNP-2 and porcine protegrin PG-1, cysteine-rich beta-sheet antimicrobial peptides produced by mammalian leukocytes. Although both peptides protected McCoy cell monolayers from infection by chlamydial EBs, protegrins wer...

journal_title：Infection and immunity

authors： Yasin B,Harwig SS,Lehrer RI,Wagar EA

更新日期：1996-03-01 00:00:00

abstract：:The method of hemagglutination inhibition was used to investigate the antigenic diversity of lipopolysaccharide (LPS) from Neisseria meningitidis and to develop a serotyping systems based on this antigen. The system uses outer membrane complex prepared by a simple extraction procedure to inhibit homologous hemagglutin...

journal_title：Infection and immunity

authors： Mandrell RE,Zollinger WD

更新日期：1977-05-01 00:00:00