Modulation of toxin production by the flagellar regulon in Clostridium difficile.

abstract：:Production of group A streptococcal pyrogenic exotoxins (SPE) type A and C was transferred from toxigenic streptococcal strains to nontoxigenic strains by lysogeny. Lysogens were tested for SPE with Ouchterlony immunodiffusion on Todd-Hewitt agar plates; toxin diffusing from isolated colonies reacted with specific hyp...

journal_title：Infection and immunity

authors： Johnson LP,Schlievert PM,Watson DW

更新日期：1980-04-01 00:00:00

abstract：:Nonimmune binding of immunoglobulin to whole bacteria was quantitated for North American isolates of Haemophilus somnus recovered from cattle with pneumonia, reproductive failure (abortion), or thromboembolic meningoencephalitis or from the vagina or prepuce of carrier cattle. Quantitative binding activity covered a w...

journal_title：Infection and immunity

authors： Widders PR,Dorrance LA,Yarnall M,Corbeil LB

更新日期：1989-02-01 00:00:00

abstract：:The role of CD8 T cells in controlling Mycobacterium tuberculosis infections in mice was confirmed by comparing the levels of growth of the organism in control, major histocompatibility complex class II knockout, and athymic mice and by transferring T-cell populations into athymic mice. By using donor mice which were ...

journal_title：Infection and immunity

authors： Tascon RE,Stavropoulos E,Lukacs KV,Colston MJ

更新日期：1998-02-01 00:00:00

abstract：:Purified cell walls representing a wide variety in teichoic acid and peptidoglycan structure prepared from eight different gram-positive bacterial species induced the production of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 from human monocytes in the presence of 10% plasma or serum. Significant amounts...

journal_title：Infection and immunity

authors： Heumann D,Barras C,Severin A,Glauser MP,Tomasz A

更新日期：1994-07-01 00:00:00

abstract：:Using a PCR-based strategy and degenerate oligonucleotides, we isolated a Legionella pneumophila gene that showed high sequence similarity to members of the fliI gene family. An insertion mutation that disrupted the fliI open reading frame was recombined onto the L. pneumophila chromosome and analyzed for its effects ...

journal_title：Infection and immunity

authors： Merriam JJ,Mathur R,Maxfield-Boumil R,Isberg RR

更新日期：1997-06-01 00:00:00

abstract：:In vitro studies have shown that enterotoxigenic Escherichia coli (ETEC) strains are capable of invading cultured epithelial cells derived from the human ileum and colon. Two separate invasion loci (tia and tib) have previously been isolated from the classical ETEC strain H10407. The tia locus has been shown to direct...

journal_title：Infection and immunity

authors： Mammarappallil JG,Elsinghorst EA

更新日期：2000-12-01 00:00:00

abstract：:Previous passive antibody transfer experiments have indicated that immunity to a 46-kilodalton membrane glycoprotein (M-2) of Leishmania amazonensis may protect against infection with this parasite. In the studies described in this paper, we investigated the ability of the purified M-2 molecule to elicit a protective ...

journal_title：Infection and immunity

authors： Champsi J,McMahon-Pratt D

更新日期：1988-12-01 00:00:00

abstract：:The relationship between the sequence of Neisseria gonorrhoeae pilin and its quaternary assembly into pilus fibers was studied with a set of site-directed antibody probes and by mapping the specificities of antipilus antisera with peptides. Buried and exposed peptides in assembled pili were identified by competitive i...

journal_title：Infection and immunity

authors： Forest KT,Bernstein SL,Getzoff ED,So M,Tribbick G,Geysen HM,Deal CD,Tainer JA

更新日期：1996-02-01 00:00:00

abstract：:Strain TG is a plasmidless exfoliative toxin (ET) producer. Strain ER201 contains a plasmid, whose loss had no apparent effect on ET production. The plasmid of ER201 was almost identical in size to the plasmid from strain UT0007, which carries an ET determinant. ...

journal_title：Infection and immunity

authors： Rosenblum ED,Tyrone S

更新日期：1976-11-01 00:00:00

abstract：:Individuals with sickle cell anemia are subject to serious infections caused by a number of bacteria, including Salmonella species and Staphylococcus aureus. It has been suggested that in sickle cell anemia, extensive erythrophagocytosis by macrophages may interfere with their antibacterial function and thereby predis...

journal_title：Infection and immunity

authors： Hand WL,King-Thompson NL

更新日期：1983-06-01 00:00:00

abstract：:Twenty monoclonal antibodies have been prepared to the erythrocytes from CBA/Ca mice infected with the rodent malaria Plasmodium chabaudi. By immunofluorescence, 15 of these antibodies recognized parasite antigens expressed only during the development of mature trophozoites to schizonts and merozoites, 2 recognized pa...

journal_title：Infection and immunity

authors： Boyle DB,Newbold CI,Smith CC,Brown KN

更新日期：1982-10-01 00:00:00

abstract：:Cryptococcus neoformans is an opportunistic fungal pathogen that primarily causes disease in immunocompromised individuals. Dendritic cells (DCs) can phagocytose C. neoformans, present cryptococcal antigen, and kill C. neoformans. However, early events following C. neoformans phagocytosis by DCs are not well defined. ...

journal_title：Infection and immunity

authors： Wozniak KL,Levitz SM

更新日期：2008-10-01 00:00:00

abstract：:Streptococcus suis is one of the most important pathogens affecting the swine industry and is also an emerging zoonotic agent for humans. Two-component signaling systems (TCSs) play important roles in the adaptation of pathogenic bacteria to host environments. In this study, we identified a novel TCS, named TCS09HKRR,...

journal_title：Infection and immunity

authors： Zhong X,Zhang Y,Zhu Y,Dong W,Ma J,Pan Z,Yao H

更新日期：2019-08-21 00:00:00

abstract：:The induction of interleukin-8 (IL-8) in vitro has been suggested to correlate with the reactogenicity of Vibrio cholerae vaccine candidates. V. cholerae vaccine candidate 638, a hemagglutinin protease/hap-defective strain, was recently reported to be well tolerated in human volunteers, suggesting a role for Hap in re...

journal_title：Infection and immunity

authors： Zhou X,Gao DQ,Michalski J,Benitez JA,Kaper JB

更新日期：2004-01-01 00:00:00

abstract：:The Haemophilus ducreyi 35000HP genome encodes a homolog of the CpxRA two-component cell envelope stress response system originally characterized in Escherichia coli. CpxR, the cytoplasmic response regulator, was shown previously to be involved in repression of the expression of the lspB-lspA2 operon (M. Labandeira-Re...

journal_title：Infection and immunity

authors： Labandeira-Rey M,Brautigam CA,Hansen EJ

更新日期：2010-11-01 00:00:00

abstract：:A crude complex containing group C polysaccharide, outer membrane proteins, and lipopolysaccharide (LPS) was isolated from the cell-free culture liquid of Neisseria meningitidis serogroup C, serotype 2a. Group C polysaccharide and LPS were removed from this complex, resulting in an outer membrane complex and a purifie...

journal_title：Infection and immunity

authors： Beuvery EC,Miedema F,van Delft RW,Haverkamp J,Leussink AB,te Pas BJ,Teppema KS,Tiesjema RH

更新日期：1983-04-01 00:00:00

abstract：:A radioimmunoprecipitation method has been devised which permits the direct identification of those proteins which are both exposed on the cell surface of Haemophilus influenzae type b and accessible to antibody. Both extrinsically and intrinsically radiolabeled cells of this organism were employed as the sources of a...

journal_title：Infection and immunity

authors： Hansen EJ,Frisch CF,Johnston KH

更新日期：1981-09-01 00:00:00

abstract：:Staphylococcus aureus is an important opportunistic pathogen and is the etiological agent of many hospital- and community-acquired infections. The golden pigment, staphyloxanthin, of S. aureus colonies distinguishes it from other staphylococci and related Gram-positive cocci. Staphyloxanthin is the product of a series...

journal_title：Infection and immunity

authors： Hall JW,Yang J,Guo H,Ji Y

更新日期：2017-01-26 00:00:00

abstract：:Carbon storage regulator A (CsrA) is an RNA binding protein that has been characterized in many bacterial species to play a central regulatory role by modulating several metabolic processes. We recently showed that a homolog of CsrA in Borrelia burgdorferi (CsrA(Bb), BB0184) was upregulated in response to propagation ...

journal_title：Infection and immunity

authors： Karna SL,Sanjuan E,Esteve-Gassent MD,Miller CL,Maruskova M,Seshu J

更新日期：2011-02-01 00:00:00

abstract：:Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonize...

journal_title：Infection and immunity

authors： Santos IK,Costa CH,Krieger H,Feitosa MF,Zurakowski D,Fardin B,Gomes RB,Weiner DL,Harn DA,Ezekowitz RA,Epstein JE

更新日期：2001-08-01 00:00:00

abstract：:Indomethacin, a nonsteroidal anti-inflammatory agent, will abolish salmonella-induced rabbit ileal secretion when given prior to the establishment of infection. In the present study, we assessed whether indomethacin can inhibit salmonella-induced intestinal secretion when administered after infection and net intestina...

journal_title：Infection and immunity

authors： Giannella RA,Rout WR,Formal SB

更新日期：1977-07-01 00:00:00

abstract：:The orotidine-5'-monophosphate decarboxylase (OMPDC) gene, encoding the final enzyme of the de novo pyrimidine biosynthesis pathway, was deleted using Toxoplasma gondii KU80 knockouts to develop an avirulent nonreverting pyrimidine auxotroph strain. Additionally, to functionally address the role of the pyrimidine salv...

journal_title：Infection and immunity

authors： Fox BA,Bzik DJ

更新日期：2010-09-01 00:00:00

abstract：:Leptospira interrogans is an important mammalian pathogen. Transmission from an environmental source requires adaptations to a range of new environmental conditions in the organs and tissues of the infected host. Since many pathogenic bacteria utilize temperature to discern their environment and regulate the synthesis...

journal_title：Infection and immunity

authors： Nally JE,Timoney JF,Stevenson B

更新日期：2001-01-01 00:00:00

abstract：:An enzyme from Treponema denticola that hydrolyzes a synthetic trypsin substrate, N-alpha-benzoyl-L-arginine-p-nitroanilide (BAPNA), was purified to near homogeneity, as judged by gel electrophoresis. The molecular weight of the enzyme was estimated to be ca. 69,000 by sodium dodecyl sulfate-polyacrylamide gel electro...

journal_title：Infection and immunity

authors： Ohta K,Makinen KK,Loesche WJ

更新日期：1986-07-01 00:00:00

abstract：:Nineteen of 22 female mice (CF1 strain) inoculated intragastrically with Treponema hyodysenteriae developed cecal and colonic lesions consisting of catarrhal inflammation, edema, and occasional hemorrhage. ...

journal_title：Infection and immunity

authors： Joens LA,Glock RD

更新日期：1979-08-01 00:00:00

abstract：:Treatment of Rickettsia prowazekii-infected L929 cells with gamma interferon (IFN-gamma) immediately after infection altered the lipid metabolism of the host cells as determined by measurement of phospholipid hydrolysis and oleic acid incorporation into phospholipids and neutral lipids. At 48 h postinfection, there wa...

journal_title：Infection and immunity

authors： Winkler HH,Day L,Daugherty R,Turco J

更新日期：1993-08-01 00:00:00

abstract：:The ability of butyric acid, an extracellular metabolite from periodontopathic bacteria, to induce apoptosis in murine WEHI 231 cells, splenic B cells, and human RAJI cells was examined. The culture filtrate of Porphyromonas gingivalis, Prevotella loescheii, and Fusobacterium nucleatum, which contains high a percentag...

journal_title：Infection and immunity

authors： Kurita-Ochiai T,Ochiai K,Fukushima K

更新日期：1998-06-01 00:00:00

abstract：:Subchronic exposure to pharmacological levels of estrogenic compounds, including 17 beta-estradiol, diethylstilbestrol, and alpha-dienestrol, significantly increased the mortality of B6C3F1 female mice after Listeria infection. Compounds with little estrogenic activity, including 5 alpha-dihydrotestosterone, progester...

journal_title：Infection and immunity

authors： Pung OJ,Luster MI,Hayes HT,Rader J

更新日期：1984-11-01 00:00:00

abstract：:Modulation of cytosolic (intracellular) Ca(2+) concentration (Ca(i)) may be an important host response when airway epithelial cells are exposed to Pseudomonas aeruginosa. We measured Ca(i) in Calu-3 cells exposed from the apical or basolateral surface to cytotoxic and noncytotoxic strains of P. aeruginosa. Apical addi...

journal_title：Infection and immunity

authors： Jacob T,Lee RJ,Engel JN,Machen TE

更新日期：2002-11-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium, similar to various facultative intracellular pathogens, has been shown to respond to the hostile conditions inside macrophages of the host organism by inducing stress proteins, such as DnaK. DnaK forms a chaperone machinery with the cochaperones DnaJ and GrpE. To elucidate the ...

journal_title：Infection and immunity

authors： Takaya A,Tomoyasu T,Matsui H,Yamamoto T

更新日期：2004-03-01 00:00:00