Purification and characterization of an enzyme produced by Treponema denticola capable of hydrolyzing synthetic trypsin substrates.

abstract：:The agent of Lyme disease, Borrelia burgdorferi, has a number of outer membrane proteins that are differentially regulated during its life cycle. In addition to their physiological functions in the organism, these proteins also likely serve different functions in invasiveness and immune evasion. In borreliae, as well ...

journal_title：Infection and immunity

authors： Toledo A,Coleman JL,Kuhlow CJ,Crowley JT,Benach JL

更新日期：2012-01-01 00:00:00

abstract：:Adoptive immunity is poorly expressed in normal syngeneic mice. This phenomenon was studied by using experimental antituberculosis immunity as a model system representing pure cell-mediated immunity. Expression of adoptive immunity was facilitated by pretreating recipients with sublethal ionizing radiation (500 rads) ...

journal_title：Infection and immunity

authors： Lefford MJ

更新日期：1983-07-01 00:00:00

abstract：:The phenotypic and functional changes of glycolipid presented by CD1d(glycolipid/CD1d) specific Valpha14+ T cells in the liver of mice at early stages of bacterial infection were investigated. After Listeria monocytogenes infection or interleukin-12 (IL-12) treatment, alpha-galactosylceramide/CD1d tetramer-reactive (a...

journal_title：Infection and immunity

authors： Emoto M,Yoshizawa I,Emoto Y,Miamoto M,Hurwitz R,Kaufmann SH

更新日期：2006-10-01 00:00:00

abstract：:Pretreatment with multiple doses of polymyxin B and colistimethate was evaluated as to its ability to sequester sufficient antibiotic in tissues to neutralize the effects of endotoxin in three animal models. Animals were challenged with endotoxin 24, 48, or 72 h after the last dose of antibiotic when there was minimal...

journal_title：Infection and immunity

authors： Craig WA,Turner JH,Kunin CM

更新日期：1974-08-01 00:00:00

abstract：:Vibrio cholerae normally inhabits aquatic habitats but can cause a severe diarrheal illness in humans. Its arsenal of virulence factors includes a secreted hemagglutinin (HA) protease. An HA protease-deficient mutant of V. cholerae was isolated and designated E7946 mpc. E7946 mpc was found to contain a point mutation ...

journal_title：Infection and immunity

authors： Vance RE,Zhu J,Mekalanos JJ

更新日期：2003-05-01 00:00:00

abstract：:To look for a possible correlation between the virulence of Rhodococcus equi and its cytokine-inducing capacity, we evaluated intracellular survival and measured cytokine induction by mouse macrophages infected with a virulent strain containing an 85-kb plasmid and expressing VapA (103+), its avirulent plasmid-cured d...

journal_title：Infection and immunity

authors： Giguère S,Prescott JF

更新日期：1998-05-01 00:00:00

abstract：:The screening of several inbred strains of mice suggested that the capacity of their spleen cells to respond to the mitogenic effect of lipopolysaccharide (LPS) of gram-negative bacteria was correlated with their resistance to intraperitoneal infection with Salmonella typhimurium. An infection of LPS into mice caused ...

journal_title：Infection and immunity

authors： von Jeney N,Günther E,Jann K

更新日期：1977-01-01 00:00:00

abstract：:Thirty two anaerobic bacterial strains were screened for their in vitro inhibitory activity toward 21 Neisseria gonorrhoeae strains, including two penicillin-resistant strains. From this screening, six anaerobic bacteria belonging to the genera Bacteroides, Peptostreptococcus, and Eubacterium were selected for their l...

journal_title：Infection and immunity

authors： Morin A,Saheb SA,Bisaillon JG,Beaudet R,Sylvestre M

更新日期：1980-06-01 00:00:00

abstract：:To define the role of nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide (LOS) in the induction of proinflammatory cytokine gene expression during otitis media, we compared the abilities of formalin-killed NTHI strain 2019 and its LOS htrB and rfaD mutants to stimulate human middle ear epithelial (HMEE) cel...

journal_title：Infection and immunity

authors： Tong HH,Chen Y,James M,Van Deusen J,Welling DB,DeMaria TF

更新日期：2001-06-01 00:00:00

abstract：:V beta 10(+) and V beta 14(+) T cells were selectively increased 7 to 14 days following infection in the lungs of naive mice infected with Histoplasma capsulatum. Following secondary challenge of immune mice, V beta 1(+) and V beta 8.1(+) cells were sporadically increased. Elimination of V beta 10(+) and V beta 14(+) ...

journal_title：Infection and immunity

authors： Deepe GS Jr,Gibbons RS,Ward SR

更新日期：2002-03-01 00:00:00

abstract：:The invasion of Rickettsia tsutsugamushi, Gilliam strain, into guinea pig polymorphonuclear leukocytes (PMNs) and the localization and distribution of tracers were followed during the process by electron microscopy. The seven tracers used were: cationized ferritin, ferritin, thorium dioxide (ThO2), carbon particles, l...

journal_title：Infection and immunity

authors： Rikihisa Y,Ito S

更新日期：1980-10-01 00:00:00

abstract：:The immunoprophylactic effect of chemically inactivated Pseudomonas aeruginosa exotoxin A in experimental pseudomonas infections was studied. Exotoxin A toxoids were prepared by Formalin (f-TXD) or glutaraldehyde (g-TXD) treatment. Immunization of mice with three or four doses (10 micrograms each) of f-TXD and the syn...

journal_title：Infection and immunity

authors： Pavlovskis OR,Edman DC,Leppla SH,Wretlind B,Lewis LR,Martin KE

更新日期：1981-05-01 00:00:00

abstract：:The antigenic relationship of six different strains of Paracoccidioides brasiliensis was investigated by the agar-gel immunodiffusion test. Soluble antigens prepared from the two morphological phases of the fungus were diffused against human sera obtained from eight patients with paracoccidioidomycosis (South American...

journal_title：Infection and immunity

authors： Restrepo-Moreno A

更新日期：1970-09-01 00:00:00

abstract：:Viral hepatitis caused by infection with murine hepatitis virus strain A59 has been shown to affect the mitotic response after partial hepatectomy in mice. Normal mice showed a delayed response, whereas nude mice did not show any response, even 5 days after partial hepatectomy. ...

journal_title：Infection and immunity

authors： Carthew P

更新日期：1981-08-01 00:00:00

abstract：:Genetic resistance to lethal infection with Rickettsia tsutsugamushi was studied in over 30 inbred strains, inbred hybrids, and outbred stocks of mice. Inbred mice infected intraperitoneally with the Gilliam strain of R. tsutsugamushi showed three patterns of response: susceptible (A/HeJ, C3H/HeDub, C3H/HeJ, C3H/HeN, ...

journal_title：Infection and immunity

authors： Groves MG,Osterman JV

更新日期：1978-02-01 00:00:00

abstract：:Neisseria gonorrhoeae enters cultured human mucosal cells following binding of a distinct gonococcal opacity (Opa) outer membrane protein to cell surface proteoglycan receptors. We examined the route of internalization that is activated by Opa-expressing gonococci (strain VP1). Microscopy of infected Chang epithelial ...

journal_title：Infection and immunity

authors： Grassmé HU,Ireland RM,van Putten JP

更新日期：1996-05-01 00:00:00

abstract：:We developed a porcine dermal explant model to determine the extent to which Staphylococcus aureus biofilm communities deplete oxygen, change pH, and produce damage in underlying tissue. Microelectrode measurements demonstrated that dissolved oxygen (DO) in biofilm-free dermal tissue was 4.45 ± 1.17 mg/liter, while DO...

journal_title：Infection and immunity

authors： Lone AG,Atci E,Renslow R,Beyenal H,Noh S,Fransson B,Abu-Lail N,Park JJ,Gang DR,Call DR

更新日期：2015-06-01 00:00:00

abstract：:Streptococcus iniae causes systemic infection characterized by meningitis and sepsis. Here, we report a larval zebrafish model of S. iniae infection. Injection of wild-type S. iniae into the otic vesicle induced a lethal infection by 24 h postinfection. In contrast, an S. iniae mutant deficient in polysaccharide capsu...

journal_title：Infection and immunity

authors： Harvie EA,Green JM,Neely MN,Huttenlocher A

更新日期：2013-01-01 00:00:00

abstract：:Microbial survival in a host is usually dependent on the ability of a pathogen to undergo changes that promote escape from host defense mechanisms. The human-pathogenic fungus Cryptococcus neoformans undergoes phenotypic switching in vivo that promotes persistence in tissue. By microarray and real-time PCR analyses, t...

journal_title：Infection and immunity

authors： Jain N,Li L,Hsueh YP,Guerrero A,Heitman J,Goldman DL,Fries BC

更新日期：2009-01-01 00:00:00

abstract：:Susceptibility of Syrian hamsters of the inbred LSH and MHA strains to injection of as few as 10 plaque-forming units of vesicular stomatitis virus (VSV) was shown to occur only after intraperitoneal and intrapleural injection and not after injection of VSV intravenously, intranasally, or in the footpads. Despite the ...

journal_title：Infection and immunity

authors： Fultz PN,Shadduck JA,Kang CY,Streilein JW

更新日期：1981-11-01 00:00:00

abstract：:The macrophage migration inhibition test was applied to the study of delayed hypersensitivity in mice vaccinated intravenously with oil-treated cell walls of Mycobacterium bovis BCG. Migration inhibition of peritoneal exudate cells from sensitized mice was demonstrated directly upon incubation of the cells with purifi...

journal_title：Infection and immunity

authors： Yamamoto K,Anacker RL

更新日期：1970-06-01 00:00:00

abstract：:Lipopolysaccharides (LPSs) of Gram-negative bacteria comprise lipid A, core, and O-polysaccharide (OPS) components. Studies have demonstrated that LPSs isolated from the pathogenic species Burkholderia pseudomallei and Burkholderia mallei and from less-pathogenic species, such as Burkholderia thailandensis, are potent...

journal_title：Infection and immunity

authors： Sengyee S,Yoon SH,West TE,Ernst RK,Chantratita N

更新日期：2019-11-18 00:00:00

abstract：:We identified nonhemolytic mutants of Listeria monocytogenes that were severely deficient in their ability to invade mammalian nonprofessional phagocytes. These mutants were generated spontaneously or by means of transposon Tn916 mutagenesis. In terms of their extracellular proteins, the noninvasive mutants were defic...

journal_title：Infection and immunity

authors： Kathariou S,Pine L,George V,Carlone GM,Holloway BP

更新日期：1990-12-01 00:00:00

abstract：:Adherence to fibrinogen and fibronectin plays a crucial role in Staphylococcus aureus experimental endocarditis. Previous genetic studies have shown that infection and carriage isolates do not systematically differ in their virulence-related genes, including genes conferring adherence, such as clfA and fnbA. We set ou...

journal_title：Infection and immunity

authors： Ythier M,Entenza JM,Bille J,Vandenesch F,Bes M,Moreillon P,Sakwinska O

更新日期：2010-04-01 00:00:00

abstract：:A nasal vaccine, consisting of outer membrane vesicles (OMVs) from group B Neisseria meningitidis, was given to 12 volunteers in the form of nose drops or nasal spray four times at weekly intervals, with a fifth dose 5 months later. Each nasal dose consisted of 250 microg of protein, equivalent to 10 times the intramu...

journal_title：Infection and immunity

authors： Haneberg B,Dalseg R,Wedege E,Høiby EA,Haugen IL,Oftung F,Andersen SR,Naess LM,Aase A,Michaelsen TE,Holst J

更新日期：1998-04-01 00:00:00

abstract：:Humans are the sole reservoir of Neisseria gonorrhoeae, an organism which undergoes a marked increase in metabolic rate after exposure to a low-molecular-weight, heat-stable component(s) of human serum. Further studies on the effect of serum on gonococcal metabolism were undertaken. Gonococcal broth (GCB) is commonly ...

journal_title：Infection and immunity

authors： Britigan BE,Chai Y,Cohen MS

更新日期：1985-12-01 00:00:00

abstract：:A model of invasive Haemophilus influenzae type b disease in rats was used to compare the net in vivo and in vitro multiplication rates of this bacterium. In both the blood of rats and in vitro cultures (fresh rat blood or enriched broth) there was an exponential increase in the number of CFU per milliliter with calcu...

journal_title：Infection and immunity

authors： Rubin LG

更新日期：1986-06-01 00:00:00

abstract：:A hamster immunization challenge assay described in the accompanying paper (M. F. Barile, D. K. F. Chandler, H. Yoshida, M. W. Grabowski, R. Harasawa, and S. Razin, Infect. Immun. 56:2443-2449, 1988) was used to examine protection against Mycoplasma pneumoniae disease by passive immunization and to evaluate the protec...

journal_title：Infection and immunity

authors： Barile MF,Chandler DK,Yoshida H,Grabowski MW,Razin S

更新日期：1988-09-01 00:00:00

abstract：:In order to construct an effector strain for the replacement therapy of dental caries, we wished to combine the properties of low-level acid production and high-level colonization potential in a strain of Streptococcus mutans. To this end, we made a deletion in the lactate dehydrogenase (LDH) gene cloned from the bact...

journal_title：Infection and immunity

authors： Hillman JD,Chen A,Duncan M,Lee SW

更新日期：1994-01-01 00:00:00

abstract：:Two proteins, HifD and HifE, have been identified as structural components of Haemophilus influenzae pili. Both are localized at the pilus tip, and HifE appears to mediate pilus adherence to host cells. In this study we examined the immunologic and structural diversity of these pilus subunits among type b H. influenza...

journal_title：Infection and immunity

authors： McCrea KW,Sauver JL,Marrs CF,Clemans D,Gilsdorf JR

更新日期：1998-10-01 00:00:00