Abstract:
:The role of CD8 T cells in controlling Mycobacterium tuberculosis infections in mice was confirmed by comparing the levels of growth of the organism in control, major histocompatibility complex class II knockout, and athymic mice and by transferring T-cell populations into athymic mice. By using donor mice which were incapable of making gamma interferon (IFN-gamma), it was shown that IFN-gamma production was essential for CD8 cell mediation of protective immunity against M. tuberculosis.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Tascon RE,Stavropoulos E,Lukacs KV,Colston MJdoi
10.1128/IAI.66.2.830-834.1998subject
Has Abstractpub_date
1998-02-01 00:00:00pages
830-4issue
2eissn
0019-9567issn
1098-5522journal_volume
66pub_type
杂志文章abstract::Streptococcus sanguis 804 (NCTC 10904) was grown ih batch culture at constant pH. and the glucosyltransferase activity of the supernatant was assayed over a 40-h growth period. The optimum pH for enzyme production was 7.0 to 7.2. During growth of the culture, three reproducible phases of enzyme activity were observed....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.1.50-58.1977
更新日期:1977-01-01 00:00:00
abstract::Strains of Cryptococcus neoformans vary in resistance to phagocytosis in vitro. The binding of isolated capsular polysaccharide (CPS) to a capsule-free mutant of C. neoformans confers resistance to phagocytosis. The importance of capsule composition to differences among strains in susceptibility to phagocytosis was ev...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.12.3751-3756.1989
更新日期:1989-12-01 00:00:00
abstract::The Yersinia enterocolitica gsrA gene is a stress protein gene which was originally identified as essential for protecting cells under both extracellular environmental stress and intracellular stress in macrophages due to phagocytosis. The gsrA gene was shown to be a member of the htrA class of genes and to possess a ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.6.2190-2196.1997
更新日期:1997-06-01 00:00:00
abstract::The immune mechanism by which hamsters acquire resistance to infection with Treponema pertenue, the causative agent of frambesia, or yaws, has not been elucidated. Serum or cells (spleen or lymph node) obtained from hamsters resistant to frambesial infection were transferred to normal syngenic recipients, who are subs...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.2.430-435.1978
更新日期:1978-08-01 00:00:00
abstract::Iron is an important element for the growth of microorganisms as well as in the defense of the host by serving as a catalyst for the generation of free radicals via the Fenton/Haber-Weiss reactions. The iron transporter natural resistance-associated macrophage protein 1 (Nramp1) confers resistance to the growth of a v...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.11.6618-6624.2001
更新日期:2001-11-01 00:00:00
abstract::Antioxidants are protective against septic shock in animal models. Recently, free radical scavengers have been found to inhibit the activation of the NF-kappa B protein in a number of cell lines. This transcriptional regulatory protein binds to the promoters of the proinflammatory cytokines tumor necrosis factor, inte...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.8.3122-3128.1994
更新日期:1994-08-01 00:00:00
abstract::Once Candida albicans comes in contact with endothelial cells, it induces cellular injury. This endothelial cell injury may be a mechanism by which blood-borne organisms escape from the intravascular compartment and invade the tissue parenchyma during hematogenous infection. We have been investigating the ability of c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.11.4714-4718.1996
更新日期:1996-11-01 00:00:00
abstract::Mortality associated with acute lung injury (ALI) induced by lipopolysaccharide (LPS) remains high in humans, warranting improved treatment and prevention strategies. ALI is characterized by the expression of proinflammatory mediators and extensive neutrophil influx into the lung, followed by severe lung damage. Under...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.12.7247-7256.2004
更新日期:2004-12-01 00:00:00
abstract::The major antigenic determinants of the lipoglycans from Acholeplasma granularum and Acholeplasma axanthum were found to be the oligosaccharide sequences Glcp(beta 1 leads to 2)-Glcp(alpha 1 leads to 4)-Glcp and Glcp(beta 1 leads to 2)-Glcp(beta 1 leads to 2)-Glcp, respectively. The disaccharides sophorose and maltose...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.2.629-632.1983
更新日期:1983-05-01 00:00:00
abstract::A series of experiments was conducted to study the influence of embryonal bursectomy (EBX) on the early and late pathogenesis of Marek's disease (MD). The early lytic infection in the lymphoid organs normally associated with oncogenic MD virus infection in intact chickens was not seen in EBX chickens. Therefore, the d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.31.1.199-207.1981
更新日期:1981-01-01 00:00:00
abstract::Group A streptococcal pyrogenic exotoxins A, B, and C (also known as scarlet fever toxins and erythrogenic toxins) were evaluated for relatedness to another streptococcus-derived lymphocyte mitogen, blastogen A. Streptococcal pyrogenic exotoxin A and blastogen A were immunologically cross-reactive and shared the same ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.6.1865-1867.1989
更新日期:1989-06-01 00:00:00
abstract::A panel of monoclonal antibodies (MAbs) specific for the heat-stable enterotoxin (STh) of enterotoxigenic Escherichia coli was produced. All four MAbs (8G7, 53-4, 11C, and SH1) bound to native STh in an enzyme-linked immunosorbent assay to various degrees, with clone SH1 showing the best affinity. The MAbs were screen...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.1.289-294.1993
更新日期:1993-01-01 00:00:00
abstract::Although certain helminth infections preferentially induce type 2 T-cell responses, the immunological mechanisms responsible for type 2 T-cell polarization remain unclear. In the present study, we investigated the effects of excretory-secretory (ES) antigen from the nematode Nippostrongylus brasiliensis on cytokine pr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.11.6233-6239.2000
更新日期:2000-11-01 00:00:00
abstract::The 34-kilodalton (kDa) antigen of Treponema pallidum subsp. pallidum (T. pallidum) is a pathogen-specific integral membrane protein. DNA sequence analysis of the cloned gene revealed an open reading frame encoding a primary product of 204 residues with a molecular mass of 22,087 daltons. Sequences that correspond to ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.11.3314-3323.1989
更新日期:1989-11-01 00:00:00
abstract::Poly-N-acetyl-glucosamine (PNAG) is a staphylococcal surface polysaccharide influencing biofilm formation that is also under investigation for its vaccine potential. Antibodies that bind to PNAG with either low (<15%) or high (>90%) levels of acetate are superior at opsonic and protective activity compared with antibo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00078-07
更新日期:2007-07-01 00:00:00
abstract::Studies of active immunization against Helicobacter pylori indicate that antibodies play a minor role in immunity. There is also evidence, however, that the translocation of antibodies in the stomach may be insufficient to achieve functional antibody levels in the gastric lumen. We have used a suckling mouse model of ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00547-09
更新日期:2009-11-01 00:00:00
abstract::The multiple antigen peptide (MAP) approach is an effective method to chemically synthesize and deliver multiple T-cell and B-cell epitopes as the constituents of a single immunogen. Here we report on the design, chemical synthesis, and immunogenicity of three Plasmodium falciparum MAP vaccines that incorporated antig...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00533-10
更新日期:2010-11-01 00:00:00
abstract::Only listeriolysin O (LLO)-producing strains of Listeria monocytogenes generate protective immunity in mice. Based on the findings that endogenous gamma interferon (IFN-gamma) production was induced only by such strains and that purified LLO could induce IFN-gamma from NK cells, we have postulated that LLO may play a ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.2.568-575.1999
更新日期:1999-02-01 00:00:00
abstract::We report here invasin-dependent and invasin-independent mechanisms in which the enteropathogen Yersinia enterocolitica is able to disseminate from the lumen of the small intestine to the spleen. The invasin-dependent route is clearly discernible in mice devoid of intestinal Peyer's patches and mesenteric lymph nodes....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.12.8453-8455.2005
更新日期:2005-12-01 00:00:00
abstract::Protamines (salmine prepared from sperm DNA of salmon and clupeine from herring sperm), which are basic peptides rich in arginine, were found to inhibit the proteolytic activity of arginine-specific cysteine protease (RC-protease) from Porphyromonas gingivalis. Lineweaver-Burk plot analysis revealed that the protamine...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.9.4917-4920.1999
更新日期:1999-09-01 00:00:00
abstract::In previous work, we identified xanthine oxidase (XO) as an important enzyme in the interaction between the host and enteropathogenic Escherichia coli(EPEC) and Shiga-toxigenic E. coli(STEC). Many of the biological effects of XO were due to the hydrogen peroxide produced by the enzyme. We wondered, however, if uric ac...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01389-15
更新日期:2016-03-24 00:00:00
abstract::A DNA microarray containing fragments of 137 Borrelia burgdorferi B31 putative lipoprotein genes was used to examine Lyme disease spirochetes. DNA from B. burgdorferi sensu stricto B31, 297, and N40; Borrelia garinii IP90; and Borrelia afzelii P/Gau was fluorescently labeled and hybridized to the microarray, demonstra...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.6.3300-3303.2002
更新日期:2002-06-01 00:00:00
abstract::Challenges with the production and suboptimal immunogenicity of malaria vaccine candidates have slowed the development of a Plasmodium falciparum multiantigen vaccine. Attempting to resolve these issues, we focused on the use of highly immunogenic merozoite surface protein 8 (MSP8) as a vaccine carrier protein. Previo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00486-17
更新日期:2017-12-19 00:00:00
abstract::The precise role of Leishmania glycoconjugate molecules including phosphoglycans (PGs) and lipophosphoglycan (LPG) on host cellular responses is still poorly defined. Here, we investigated the interaction of Leishmania major LPG2 null mutant (lpg2(-)), which lacks both PGs and LPG, with dendritic cells (DCs) and the s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01447-08
更新日期:2009-08-01 00:00:00
abstract::Borrelia burgdorferi produces potent cell-activating molecules capable of stimulating polyclonal proliferation and immunoglobulin production by murine B lymphocytes and cytokine production by a variety of cell types. These stimulatory molecules function in infected mice, resulting in elevated levels of circulating imm...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.2.520-528.1994
更新日期:1994-02-01 00:00:00
abstract::The recent finding that high numbers of strict anaerobes are present in the respiratory tract of cystic fibrosis (CF) patients has drawn attention to the pathogenic contribution of the CF microbiome to airway disease. In this study, we investigated the specific interactions of the most dominant bacterial CF pathogen, ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02234-14
更新日期:2015-01-01 00:00:00
abstract::We found that thiols reduced the amount of cholera toxin produced by Vibrio cholerae 569B in vitro. A sulfhydryl group at least was necessary for the reduction of cholera toxin production by thiols. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.53.3.700-701.1986
更新日期:1986-09-01 00:00:00
abstract::Previous reports have demonstrated that heat-stable (A-type) capsule on piliated enterotoxigenic Escherichia coli enhances colonization of enterotoxigenic E. coli in the small intestine and enhances virulence of enterotoxigenic E. coli. In this report, four encapsulated enterotoxigenic E. coli strains and one encapsul...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.3.737-740.1984
更新日期:1984-09-01 00:00:00
abstract::The present study examined the role of endogenous gamma interferon (IFN-gamma) in the formation of granulomas in mice which had been given a single intravenous injection of glycolipid-containing mycolic acid (trehalose 2,3,6'-trimycolate) purified from cell walls of Rhodococcus aurantiacus (Gordona aurantiaca) (GaGM) ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.7.2872-2878.1993
更新日期:1993-07-01 00:00:00
abstract::The two published sequences of the pertussis toxin operon differ in 3 bp in the S1 subunit gene. In this report, we provide evidence that Bordetella pertussis strains are able to produce active pertussis toxin only when they contain one of the two possible nucleotide sequences. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.3.1177-1179.1991
更新日期:1991-03-01 00:00:00