Abstract:
:A series of experiments was conducted to study the influence of embryonal bursectomy (EBX) on the early and late pathogenesis of Marek's disease (MD). The early lytic infection in the lymphoid organs normally associated with oncogenic MD virus infection in intact chickens was not seen in EBX chickens. Therefore, the damage to the immune system was minimal. EBX chickens also had lower viremia levels, higher lymphocyte responses to mitogens, and a lower or delayed MD mortality when compared with intact chickens. Furthermore, it was shown that although vaccination with SB-1 by itself did not protect against a highly virulent MD transplantable tumor, the combination of EBX and vaccination gave significant protection. All these effects could be explained by an enhanced immune response in EBX birds. In contrast, the pathogenesis of nononcogenic MD virus was not influenced by EBX. The possible mechanism(s) involved in these observed effects of EBX on MD pathogenesis are discussed.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Schat KA,Calnek BW,Fabricant Jdoi
10.1128/IAI.31.1.199-207.1981subject
Has Abstractpub_date
1981-01-01 00:00:00pages
199-207issue
1eissn
0019-9567issn
1098-5522journal_volume
31pub_type
杂志文章abstract::Sixty-one Burkholderia cepacia isolates from patients with cystic fibrosis (CF) and four plant isolates were screened for production of the siderophores salicylic acid (SA), pyochelin, cepabactin, and ornibactins and fingerprinted by a PCR-based randomly amplified polymorphic DNA (RAPD) method. Of the 24 RAPD types de...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.2.874-877.1998
更新日期:1998-02-01 00:00:00
abstract::A mutual symbiotic enhancement of growth of Porphyromonas gingivalis and Treponema denticola is described in this report. Brain heart infusion broth supplemented with vitamin K did not support the individual growth of P. gingivalis or T. denticola. However, when inoculated as a mixture, both bacterial species did grow...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.12.5298-5301.1992
更新日期:1992-12-01 00:00:00
abstract::The major antigenic determinants of the lipoglycans from Acholeplasma granularum and Acholeplasma axanthum were found to be the oligosaccharide sequences Glcp(beta 1 leads to 2)-Glcp(alpha 1 leads to 4)-Glcp and Glcp(beta 1 leads to 2)-Glcp(beta 1 leads to 2)-Glcp, respectively. The disaccharides sophorose and maltose...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.2.629-632.1983
更新日期:1983-05-01 00:00:00
abstract::Ocular inflammation is one of the consequences of infection with the protozoan parasite Toxoplasma gondii. Even if lesions are self-healing in immunocompetent persons, they pose a lifetime risk of reactivation and are a serious threat to vision. As there are virtually no immunological data on reactivating ocular toxop...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02985-14
更新日期:2015-05-01 00:00:00
abstract::Syphilis has been recognized as a disease since the late 1400s, yet there is no practical vaccine available. One impediment to the development of a vaccine is the lack of understanding of multiple reinfections in humans despite the development of robust immune responses during the first episode. It has been shown that...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.10.5605-5612.2003
更新日期:2003-10-01 00:00:00
abstract::The immunogenicity of a single dose of a whole-cell vaccine of inactivated Borrelia burgdorferi HSF (human spinal fluid isolate) was evaluated. Syrian hamsters were vaccinated subcutaneously and challenged by the intraperitoneal injection of 1,000 50% infectious doses of B. burgdorferi HSF 30 or 90 days postvaccinatio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.54.3.897-898.1986
更新日期:1986-12-01 00:00:00
abstract::We previously reported that infection by Fusobacterium nucleatum strongly induced the expression of both human beta-defensin 2 (HBD-2) and HBD-3 by gingival epithelial cells. The aim of this study was to characterize the pattern recognition receptors (PRRs) and regulatory mechanisms involved in the induction of HBD-2 ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00449-08
更新日期:2009-03-01 00:00:00
abstract::A nonclonal population of Borrelia burgdorferi N40 (passage 3) that survived protective immunity following challenge inoculation of outer surface protein (Osp) A- or B-hyperimmunized mice were characterized for the molecular basis of evasion of immunity. Two of six B. burgdorferi isolates, cultured from OspA-immunized...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.5.1658-1662.1995
更新日期:1995-05-01 00:00:00
abstract::Heterogeneic autoantibodies against axonal neurofilament proteins of mature mouse neurons grown in vitro were detected by the indirect immunofluorescence technique in 12.7% (9 of 71) of the sera from nonhuman primates infected with kuru, in 14.5% (17 of 117) and 4% (1 of 25), respectively, of the sera from nonhuman pr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.1.316-324.1982
更新日期:1982-10-01 00:00:00
abstract::The Salmonella dublin virulence plasmid mediates systemic infection in mice and cattle. Here, we analyze the interaction between wild-type and plasmid-cured Salmonella strains with phagocytes in vitro and in vivo. The intracellular recovery of S. dublin from murine peritoneal and bovine alveolar macrophages cultured i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.8.3385-3393.1996
更新日期:1996-08-01 00:00:00
abstract::Recruitment of neutrophils to lung tissue and airspaces is a hallmark of inflammatory events following inhalation of endotoxins. We studied the role of different lymphocyte subsets in this inflammation, which is assumed to primarily involve the innate immune system. Inhalation of aerosolized Escherichia coli lipopolys...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.12.6962-6969.2000
更新日期:2000-12-01 00:00:00
abstract::Isolated Bacteroides gingivalis 2561 vesicles aggregated suspensions of Actinomyces viscosus and Actinomyces naeslundii of all taxonomy clusters. Vesicles bound near A. viscosus cell walls and among its surface fibrils. Tritiated vesicles bound slightly better to saliva-coated hydroxyapatite (SHA) than to SHA coated w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.5.1618-1620.1989
更新日期:1989-05-01 00:00:00
abstract::A monoclonal immunoglobulin M antibody, HP15/36, was produced by a hybridoma cell line prepared by fusion of mouse myeloma cell line Sp2/O with spleen cells of mice immunized with Helicobacter pylori D273 (French strain). Immunoelectron microscopy of whole bacteria and ultrathin sections showed that the determinant wa...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.6.2732-2736.1993
更新日期:1993-06-01 00:00:00
abstract::Bovine NK cells have recently been characterized and the present study describes the interaction between NK cells, antigen-presenting cells, and secreted mycobacterial proteins. Gamma interferon (IFN-gamma) production by NK cells was seen in approximately 30% of noninfected calves in response to the Mycobacterium tube...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.9.5628-5635.2005
更新日期:2005-09-01 00:00:00
abstract::A dialyzable factor(s) in human serum is known to stimulate gonococcal oxygen consumption. Its effect on other human pathogens was investigated. A 10% serum solution increased peak O2 consumption for Escherichia coli and Staphylococcus aureus to 157% (P less than 0.05) and 199% (P less than 0.02), respectively, of the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.52.3.657-663.1986
更新日期:1986-06-01 00:00:00
abstract::The serotype-specific polysaccharide of Streptococcus mutans AHT (serotype a) was shown to be loosely associated with the cell surface of this organism. The antigen was extracted from whole cells by boiling in sodium acetate buffer, pH 4.0, for 10 min. The purified product was found to be a diheteroglycan of galactose...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.3.1177-1185.1979
更新日期:1979-12-01 00:00:00
abstract::Trehalose 6,6'-dimycolate (TDM) plays important roles in the development of granulomatous inflammation during infection with Mycobacterium spp., Rhodococcus spp., etc. To reveal the augmenting effect of TDM on vascular endothelial growth factor (VEGF) production and neovascularization, we investigated murine granuloma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.4.2043-2052.2000
更新日期:2000-04-01 00:00:00
abstract::A Pasteurella haemolytica mutant incapable of producing leukotoxin was created by allelic replacement. Concentrated culture supernatants from wild-type P. haemolytica, but not from the mutant, contained the 102-kDa leukotoxin protein and lysed bovine lymphoma cells and sheep erythrocytes. Wild-type P. haemolytica demo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.8.3209-3212.1995
更新日期:1995-08-01 00:00:00
abstract::Pathogenic leptospires have the ability to survive and disseminate to multiple organs after penetrating the host. Several pathogens, including spirochetes, have been shown to express surface proteins that interact with the extracellular matrix (ECM). This adhesin-mediated binding process seems to be a crucial step in ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00460-06
更新日期:2006-11-01 00:00:00
abstract::A better knowledge on how immune responses are initiated in mucosal tissues would facilitate the design of new mucosal vaccines, as well as improve our understanding on host defense against infection. We investigated the mechanisms of adjuvanticity of the Mycoplasma-derived macrophage-activating 2-kDa lipopeptide (MAL...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.12.6978-6986.2004
更新日期:2004-12-01 00:00:00
abstract::We previously reported that two surface-exposed high-molecular-weight proteins, HMW1 and HMW2, expressed by a prototypic strain of nontypeable Haemophilus influenzae (NTHI) mediate attachment to human epithelial cells. These proteins are members of a family of highly immunogenic proteins common to most nontypeable Hae...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.8.3032-3037.1996
更新日期:1996-08-01 00:00:00
abstract::A water-soluble acylpolygalactosyl (APG) of 34 kDa was obtained from the Klebsiella pneumoniae membrane by alkaline hydrolysis and delipidation. APG comprises a poly(1,3)galactose chain, a core, and a lipid moiety made of a glucosamine disaccharide with two N-linked beta OH-myristates. The monocyte binding sites for A...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.5.1520-1527.1994
更新日期:1994-05-01 00:00:00
abstract::The clinical and histopathological manifestations of syphilis and the invasive behavior of Treponema pallidum in tissue culture systems reflect the propensity for treponemes to migrate through skin, hematogenously disseminate, and invade targeted tissues. Treponemal motility is believed to be essential to this process...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.5.1701-1709.1997
更新日期:1997-05-01 00:00:00
abstract::Glucose metabolism and respiration of Candida albicans were compared under conditions which permitted either maximal filamentous or maximal yeast growth. Changes in metabolism were monitored by comparing the quantities of ethanol produced, CO2 evolved, and oxygen consumed. Filamenting cultures produced more ethanol an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.12.1.119-127.1975
更新日期:1975-07-01 00:00:00
abstract::Numerous bacterial pathogens use type III secretion systems (T3SSs) or T4SSs to inject or translocate virulence proteins into eukaryotic cells. Several different reporter systems have been developed to measure the translocation of these proteins. In this study, a peptide tag-based reporter system was developed and use...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00690-06
更新日期:2006-10-01 00:00:00
abstract::Genetically based natural resistance to brucellosis in cattle provides for novel strategies to control zoonotic diseases. Bovine NRAMP1, the homologue of a murine gene (Bcg), has been identified as a major candidate for controlling the in vivo resistant phenotype. We developed an in vitro model for expression of resis...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.5.3110-3119.2001
更新日期:2001-05-01 00:00:00
abstract::Urease activity has recently been shown to be an important virulence determinant for Helicobacter pylori, allowing it to survive the low pH of the stomach during colonization. Experimental murine infection with Helicobacter felis is now being used as a model for H. pylori infection to study the effects of vaccines, an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.3.793-798.1994
更新日期:1994-03-01 00:00:00
abstract::Recently, our laboratory and others have demonstrated that human peripheral blood T and NK lymphocytes directly inhibit the growth of Cryptococcus neoformans. In this study, we further define the conditions under which lymphocyte-mediated fungistasis against C. neoformans occurs and examine whether mechanisms implicat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.9.3550-3554.1995
更新日期:1995-09-01 00:00:00
abstract::Porphyromonas gingivalis is a periodontal pathogen capable of invading primary cultures of normal human gingival epithelial cells (NHGEC). Involvement of P. gingivalis fimbriae in the invasion process was examined. Purified P. gingivalis 33277 fimbriae blocked invasion of this organism into NHGEC in a dose-dependent m...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.1.313-316.1997
更新日期:1997-01-01 00:00:00
abstract::The she gene of Shigella flexneri 2a, which also harbors the internal enterotoxin genes set1A and set1B (F. R. Noriega, GenBank accession no. U35656, 1995) encodes a homolog of the virulence-related immunoglobulin A (IgA) protease-like family of secreted proteins, Tsh, EspC, SepA, and Hap, from an avian pathogenic Esc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.11.4606-4614.1997
更新日期:1997-11-01 00:00:00