Factors affecting filamentation in Candida albicans: changes in respiratory activity of Candida albicans during filamentation.

Abstract:

:Glucose metabolism and respiration of Candida albicans were compared under conditions which permitted either maximal filamentous or maximal yeast growth. Changes in metabolism were monitored by comparing the quantities of ethanol produced, CO2 evolved, and oxygen consumed. Filamenting cultures produced more ethanol and less CO2 than yeasts, with oxygen consumption in the former concomitantly slower than that of the latter. Studies involving cofactors and inhibitors associated with electron transport imply that a transfer of electrons away from flavoprotein is required for maintenance of yeast morphology. Conditions consistent with a buildup of reduced flavoprotein, however, favored filament formation. These changes were expressed metabolically as a shift from an aerobic to a fermentative metabolism. The results presented are consistent with hypotheses correlating filament production with changes in carbohydrate metabolism and an interruption of electron transfer within the cell.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Land GA,McDonald WC,Stjernholm RL,Friedman L

doi

10.1128/IAI.12.1.119-127.1975

keywords:

subject

Has Abstract

pub_date

1975-07-01 00:00:00

pages

119-27

issue

1

eissn

0019-9567

issn

1098-5522

journal_volume

12

pub_type

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