Measurement of effector protein injection by type III and type IV secretion systems by using a 13-residue phosphorylatable glycogen synthase kinase tag.

abstract：:Immunization of BALB/c mice with a plasmid containing the gene for Trypanosoma cruzi trans-sialidase (TS) induced antibodies that inhibited TS enzymatic activity, CD4+ Th1 and CD8+ Tc1 cells, and protective immunity against infection. We used this model to obtain basic information on the requirement of CD4 or CD8 or B...

journal_title：Infection and immunity

authors： Fujimura AE,Kinoshita SS,Pereira-Chioccola VL,Rodrigues MM

更新日期：2001-09-01 00:00:00

abstract：:Pathogenic leptospires have the ability to survive and disseminate to multiple organs after penetrating the host. Several pathogens, including spirochetes, have been shown to express surface proteins that interact with the extracellular matrix (ECM). This adhesin-mediated binding process seems to be a crucial step in ...

journal_title：Infection and immunity

authors： Barbosa AS,Abreu PA,Neves FO,Atzingen MV,Watanabe MM,Vieira ML,Morais ZM,Vasconcellos SA,Nascimento AL

更新日期：2006-11-01 00:00:00

abstract：:Monoclonal antibodies to the capsular polysaccharide of Cryptococcus neoformans produce distinct capsular reactions and have biological activities that are determined by serotype specificity. In the present study, polyclonal rabbit anticapsular antibodies were cross-absorbed to produce serotype specificities similar t...

journal_title：Infection and immunity

authors： MacGill TC,MacGill RS,Kozel TR

更新日期：2001-02-01 00:00:00

abstract：:Heat shock protein (HSP) expression was examined in murine bone marrow-derived macrophages infected with stationary-phase promastigotes of Leishmania donovani. Immunoblotting performed with a rabbit polyclonal antiserum raised against HSP60 from Heliothis virescens (moth) revealed the de novo appearance of 65- and 67-...

journal_title：Infection and immunity

authors： Rey-Ladino JA,Reiner NE

更新日期：1993-08-01 00:00:00

abstract：:Streptococcus suis serotype 2 is a porcine and human pathogen with adhesive and invasive properties. In other streptococci, large surface-associated proteins (>100 kDa) of the MSCRAMM family (microbial surface components recognizing adhesive matrix molecules) are key players in interactions with host tissue. In this s...

journal_title：Infection and immunity

authors： Baums CG,Kaim U,Fulde M,Ramachandran G,Goethe R,Valentin-Weigand P

更新日期：2006-11-01 00:00:00

abstract：:Staphylococcus aureus experimental endocarditis relies on sequential fibrinogen binding (for valve colonization) and fibronectin binding (for endothelial invasion) conferred by peptidoglycan-attached adhesins. Fibronectin-binding protein A (FnBPA) reconciles these two properties--as well as elastin binding--and promot...

journal_title：Infection and immunity

authors： Piroth L,Que YA,Widmer E,Panchaud A,Piu S,Entenza JM,Moreillon P

更新日期：2008-08-01 00:00:00

abstract：:Bacterial tyrosine kinases and their cognate protein tyrosine phosphatases are best known for regulating the biosynthesis of polysaccharides. Moreover, their roles in the stress response, DNA metabolism, cell division, and virulence have also been documented. The aim of this study was to investigate the pathogenicity ...

journal_title：Infection and immunity

authors： Ferreira AS,Silva IN,Fernandes F,Pilkington R,Callaghan M,McClean S,Moreira LM

更新日期：2015-02-01 00:00:00

abstract：:T cells are important in systemic anticryptococcal defenses, but a role in controlling an initial pulmonary infection has not been demonstrated. A murine model with intratracheal inoculation was developed to study the acquisition and expression of pulmonary T cell-mediated immunity against Cryptococcus neoformans. Inf...

journal_title：Infection and immunity

authors： Huffnagle GB,Yates JL,Lipscomb MF

更新日期：1991-04-01 00:00:00

abstract：:The complete nucleotide sequence of a 612-base-pair DNA fragment containing the gene for the major fimbrial subunit of CS3 of enterotoxigenic Escherichia coli is presented. A possible promoter region, a ribosome-binding site, and two potential signal peptidase cleavage sites are indicated. Unlike the best-studied fimb...

journal_title：Infection and immunity

authors： Boylan M,Smyth CJ,Scott JR

更新日期：1988-12-01 00:00:00

abstract：:Porphyromonas gingivalis, a bacterium associated with active chronic periodontitis lesions, produces several proteolytic enzymes that are thought to be involved in host colonization, perturbation of the immune system, and tissue destruction. The aim of the present study was to investigate the contribution of Arg- and ...

journal_title：Infection and immunity

authors： Grenier D,Imbeault S,Plamondon P,Grenier G,Nakayama K,Mayrand D

更新日期：2001-08-01 00:00:00

abstract：:Acquired cellular immunity to infection with Mycobacterium tuberculosis is believed to reside in the capacity of mononuclear phagocytes of immunized animals to inhibit intracellular multiplication of the parasite. However, in macrophage tissue culture systems, it has been customary to employ streptomycin in the medium...

journal_title：Infection and immunity

authors： Patterson RJ,Youmans GP

更新日期：1970-01-01 00:00:00

abstract：:Mycoplasma penetrans adhered to cultured human cells, forming clusters that localized to specific areas of the host cell surface. Adherence and cluster formation were inhibited by anti-M. penetrans antibodies, suggesting the involvement of specific adhesin-receptor interactions. Ultrastructural studies showed that aft...

journal_title：Infection and immunity

authors： Girón JA,Lange M,Baseman JB

更新日期：1996-01-01 00:00:00

abstract：:Relapsing fever is a rapidly progressive and severe septic disease caused by certain Borrelia spirochetes. The disease is divided into two forms, i.e., epidemic relapsing fever, caused by Borrelia recurrentis and transmitted by lice, and the endemic form, caused by several Borrelia species, such as B. duttonii, and tr...

journal_title：Infection and immunity

authors： Meri T,Cutler SJ,Blom AM,Meri S,Jokiranta TS

更新日期：2006-07-01 00:00:00

abstract：:In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor...

journal_title：Infection and immunity

authors： Delfino D,Cianci L,Lupis E,Celeste A,Petrelli ML,Curró F,Cusumano V,Teti G

更新日期：1997-06-01 00:00:00

abstract：:Human sera were examined by an enzyme-linked immunosorbent assay for immunoglobulin G (IgG) and IgM antibodies to purified type III polysaccharide of group B streptococci. The antigen-binding capacity of a reference human serum was determined by a radioimmunoassay, and the total antibody content was determined by quan...

journal_title：Infection and immunity

authors： Anthony BF,Concepcion NF,Wass CA,Heiner DC

更新日期：1984-10-01 00:00:00

abstract：:Microsporidia are obligate intracellular parasites that are ubiquitous in nature and have been recognized as causing an important emerging disease among immunocompromised individuals. Limited knowledge exists about the immune response against these organisms, and virtually nothing is known about the receptors involved...

journal_title：Infection and immunity

authors： Fischer J,Suire C,Hale-Donze H

更新日期：2008-10-01 00:00:00

abstract：:Streptococcus mutans produces several enzymes which metabolize sucrose. Three glucosyltransferase genes (gtfB, gtfC, and gtfD) and a single fructosyltransferase gene (ftf) encode enzymes which are important in formation of exopolysaccharides. Mutants of S. mutans V403 carrying single and multiple mutations of the gtfB...

journal_title：Infection and immunity

authors： Munro C,Michalek SM,Macrina FL

更新日期：1991-07-01 00:00:00

abstract：:In this report, we demonstrate that the variable antigens present on the surface of Plasmodium knowlesi-infected erythrocytes could not be found on the surface of merozoites. A number of technical problems had to be solved to make such a comparative study possible, including the purification of merozoites by affinity ...

journal_title：Infection and immunity

authors： Hommel M,David PH

更新日期：1981-07-01 00:00:00

abstract：:The pulmonary immune response protects healthy individuals against Pneumocystis pneumonia (PcP). However, the immune response also drives immunopathogenesis in patients who develop severe PcP, and it is generally accepted that optimal treatment requires combination strategies that promote fungal killing and also provi...

journal_title：Infection and immunity

authors： Hoy Z,Wright TW,Elliott M,Malone J,Bhagwat S,Wang J,Gigliotti F

更新日期：2020-01-22 00:00:00

abstract：:An LT-B-ST (LT-B/ST) fusion peptide was constructed by genetically joining the 5' terminus of a synthetic gene coding for the heat-stable enterotoxin (ST) of Escherichia coli to the 3' terminus of the gene coding for the binding subunit of the heat-labile enterotoxin (LT-B) of E. coli. An eight-amino-acid, proline-con...

journal_title：Infection and immunity

authors： Cárdenas L,Clements JD

更新日期：1993-11-01 00:00:00

abstract：:Four mouse monoclonal antibodies have been developed which react with Mycobacterium tuberculosis antigen 5. Each of these monoclonal antibodies has been used to prepare immunoabsorbents, and antigen has been isolated from unheated M. tuberculosis H37Ra culture filtrate by affinity chromatography with these absorbents....

journal_title：Infection and immunity

authors： Daniel TM,Gonchoroff NJ,Katzmann JA,Olds GR

更新日期：1984-07-01 00:00:00

abstract：:An experimental model of coxsackievirus B3 infection in newborn mice was utilized to examine the protective role of antiviral antibodies and an interferon inducer, polyinosinic acid-polycytidylic acid [poly(I:C)]. Subcutaneous administration to the infected mice of specific antiviral antibodies resulted in significant...

journal_title：Infection and immunity

authors： Cho CT,Feng KK,McCarthy VP,Lenahan MF

更新日期：1982-08-01 00:00:00

abstract：:Q fever has been associated with granulomatous changes in clinical biopsy material obtained from liver and bone marrow. Local reactions to skin testing have been described in previously sensitized humans, but histological studies of such reactions have not been reported. We note that delayed hypersensitivity reactions...

journal_title：Infection and immunity

authors： Ascher MS,Berman MA,Parker D,Turk JL

更新日期：1983-01-01 00:00:00

abstract：:Streptococcus pneumoniae is a fermentative microorganism and causes serious diseases in humans, including otitis media, bacteremia, meningitis, and pneumonia. However, the mechanisms enabling pneumococcal survival in the host and causing disease in different tissues are incompletely understood. The available evidence ...

journal_title：Infection and immunity

authors： Gaspar P,Al-Bayati FA,Andrew PW,Neves AR,Yesilkaya H

更新日期：2014-12-01 00:00:00

abstract：:The human pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 has two histidine sensor kinases, QseC and QseE, which respond to the mammalian adrenergic hormones epinephrine and norepinephrine by increasing their autophosphorylation. Although QseC and QseE are present in nonpathogenic strains of E. coli, EHEC e...

journal_title：Infection and immunity

authors： Njoroge J,Sperandio V

更新日期：2012-02-01 00:00:00

abstract：:Experiments outlined here investigate the role of nitric oxide (NO) in the pathogenesis of Plasmodium falciparum-induced malarial anemia (MA). The results show that ex vivo and in vitro NO synthase (NOS) activity in peripheral blood mononuclear cells (PBMCs) is significantly elevated in children with MA and inversely ...

journal_title：Infection and immunity

authors： Keller CC,Kremsner PG,Hittner JB,Misukonis MA,Weinberg JB,Perkins DJ

更新日期：2004-08-01 00:00:00

abstract：:Urinary tract infection (UTI) is the second most common infection in humans, making it a global health priority. Nearly half of all women will experience a symptomatic UTI, with uropathogenic Escherichia coli (UPEC) being the major causative agent of the infection. Although there has been extensive research on UPEC vi...

journal_title：Infection and immunity

authors： Sintsova A,Smith S,Subashchandrabose S,Mobley HL

更新日期：2018-02-20 00:00:00

abstract：:The route of pathogen inoculation by needle has been shown to influence the outcome of infection. Employing needle inoculation of the obligately intracellular parasite Leishmania major, which is transmitted in nature following intradermal (i.d.) deposition of parasites by the bite of an infected sand fly, we identifie...

journal_title：Infection and immunity

authors： Ribeiro-Gomes FL,Roma EH,Carneiro MB,Doria NA,Sacks DL,Peters NC

更新日期：2014-07-01 00:00:00

abstract：:Isolates of Thermoplasma acidophilum were divided into serological groups based on immunodiffusion studies of solubilized-membrane preparations. ...

journal_title：Infection and immunity

authors： Bohlool BB,Brock TD

更新日期：1974-07-01 00:00:00

abstract：:T-cell-mediated immunity is an important determinant in protection against primary infection with Coccidioides immitis, a dimorphic fungal pathogen that causes the disease coccidioidomycosis. To determine if interleukin-12 (IL-12) gene therapy could potentiate host response against C. immitis, we constructed a single-...

journal_title：Infection and immunity

authors： Jiang C,Magee DM,Cox RA

更新日期：1999-06-01 00:00:00