Construction of a single-chain interleukin-12-expressing retroviral vector and its application in cytokine gene therapy against experimental coccidioidomycosis.

abstract：:l-Arginine (1 M) eluted measles virus adsorbed on monkey erythrocytes without affecting the infectious and hemagglutinating activities of the virus. This phenomenon was also observed for encephalomyocarditis virus and Newcastle disease virus. ...

journal_title：Infection and immunity

authors： Lebon P,Protat A,Moline P

更新日期：1975-06-01 00:00:00

abstract：:The suppression of T-cell deoxyribonucleic acid (DNA) synthesis by serum from mice acutely with murine cytomegalovirus (MCMV) was investigated. Spleen cells from uninfected mice were exposed to concanavalin A in the presence of serum taken from mice at various times after infection with MCMV. The capacity of the serum...

journal_title：Infection and immunity

authors： Booss J,Wheelock EF

更新日期：1977-08-01 00:00:00

abstract：:A ruthenium red-staining capsule was observed on two pathogenic strains, but not on one nonpathogenic strain of Mycoplasma gallisepticum. The capsule appeared to mediate cytadsorption of mycoplasmas to the chicken tracheal epithelium without evidence of membrane fusion. No relationship was seen between the presence of...

journal_title：Infection and immunity

authors： Tajima M,Yagihashi T,Miki Y

更新日期：1982-05-01 00:00:00

abstract：:Legionella pneumophila organisms are able to infect and multiply within the ciliated protozoan Tetrahymena pyriformis. This ability may be associated with virulence, because an attenuated strain of L. pneumophila fails to multiply within this protozoan, whereas a virulent strain increases 10,000-fold in number when co...

journal_title：Infection and immunity

authors： Fields BS,Barbaree JM,Shotts EB Jr,Feeley JC,Morrill WE,Sanden GN,Dykstra MJ

更新日期：1986-09-01 00:00:00

abstract：:Peru-15 is a live attenuated oral vaccine derived from a Vibrio cholerae O1 El Tor Inaba strain by a series of deletions and modifications, including deletion of the entire CT genetic element. Peru-15 is also a stable, motility-defective strain and is unable to recombine with homologous DNA. We wished to determine whe...

journal_title：Infection and immunity

authors： Cohen MB,Giannella RA,Bean J,Taylor DN,Parker S,Hoeper A,Wowk S,Hawkins J,Kochi SK,Schiff G,Killeen KP

更新日期：2002-04-01 00:00:00

abstract：:Understanding the regulation of human immune responses is critical for vaccine development and treating infectious diseases. We have previously shown that simultaneous engagement of the T cell receptor (TCR) and complement regulator CD46 on human CD4(+) T cells in the presence of interleukin-2 (IL-2) induces potent se...

journal_title：Infection and immunity

authors： Truscott SM,Abate G,Price JD,Kemper C,Atkinson JP,Hoft DF

更新日期：2010-12-01 00:00:00

abstract：:An established cell line (Vero) defective in interferon production was used to evaluate the role of interferon in chronic rubella virus infections of cell cultures. Inoculation of Vero cells with a low multiplicity of virus resulted in the development of carrier cultures which had the characteristics of a regulated in...

journal_title：Infection and immunity

authors： Mifune K,Desmyter J,Rawls WE

更新日期：1970-08-01 00:00:00

abstract：:Chlamydial inclusions were demonstrated by indirect immunofluorescence (IF) with antiserum to the chlamydial group antigen when McCoy cell monolayers infected with either Chlamydia trachomatis or Chlamydia psittaci were fixed in formaldehyde or paraformaldehyde, provided the monolayer was not allowed to dry. If these ...

journal_title：Infection and immunity

authors： Richmond SJ,Stirling P

更新日期：1981-11-01 00:00:00

abstract：:The genes encoding alpha-hemolysin and mannose-resistant hemagglutination were shown to be closely linked in cloned DNA from two Escherichia coli urinary tract isolates of serotypes O4 (J96) and O6 (C1212). DNA hybridization experiments demonstrated that the hly and mrh gene clusters of other E. coli O6 serotypes were...

journal_title：Infection and immunity

authors： Low D,David V,Lark D,Schoolnik G,Falkow S

更新日期：1984-01-01 00:00:00

abstract：:Inflammatory cytokines play an important role in human immune responses to malarial disease. However, the role of these mediators in disease pathogenesis, and the relationship between host protection and injury remains unclear. A total of 248 cases of severe Plasmodium falciparum malaria among children aged 3 months t...

journal_title：Infection and immunity

authors： Lyke KE,Burges R,Cissoko Y,Sangare L,Dao M,Diarra I,Kone A,Harley R,Plowe CV,Doumbo OK,Sztein MB

更新日期：2004-10-01 00:00:00

abstract：:Listeria monocytogenes is an intracellular bacterial pathogen that invades epithelial cells by subverting two cellular receptors, E-cadherin and Met. We recently identified type II phosphatidylinositol 4-kinases alpha and beta (PI4KIIalpha and PI4KIIbeta) as being required for bacterial entry downstream of Met. In thi...

journal_title：Infection and immunity

authors： Tham TN,Gouin E,Rubinstein E,Boucheix C,Cossart P,Pizarro-Cerda J

更新日期：2010-01-01 00:00:00

abstract：:Entamoeba histolytica virulence is related to a number of amebic components (lectins, cysteine proteinases, and amebapore) and host factors, such as intestinal bacterial flora. Trophozoites are selective in their interactions with bacteria, and the parasite recognition of glycoconjugates plays an important role in ame...

journal_title：Infection and immunity

authors： Padilla-Vaca F,Ankri S,Bracha R,Koole LA,Mirelman D

更新日期：1999-05-01 00:00:00

abstract：:The selection of influenza B virus recombinants from plaques in bovine kidney cell monolayers is described. Two sets of recombinants were each derived from parents of high and low virulence for humans, respectively. Recombination frequency was apparently high, and reassortment of genes made it possible to obtain atten...

journal_title：Infection and immunity

authors： Beare AS,Sherwood JE,Callow KA,Craig JW

更新日期：1977-02-01 00:00:00

abstract：:Cryptococcus neoformans is surrounded by an antiphagocytic polysaccharide capsule whose primary constituent is glucuronoxylomannan (GXM). Three prominent structural features of GXM are single xylosyl and glucuronosyl side chains and O acetylation of the mannose backbone. Isogenic pairs of O-acetyl-positive and O-acety...

journal_title：Infection and immunity

authors： Kozel TR,Levitz SM,Dromer F,Gates MA,Thorkildson P,Janbon G

更新日期：2003-05-01 00:00:00

abstract：:The growth of Eimeria vermiformis within cultured murine fibroblastlike (L-929) or rat epithelial-like (RATEC) cells was inhibited by treatment of the cells with the appropriate recombinant gamma interferon. The effect was apparent as a reduction in both the initial numbers of intracellular sporozoites and, to a much ...

journal_title：Infection and immunity

authors： Rose ME,Smith AL,Wakelin D

更新日期：1991-02-01 00:00:00

abstract：:An impressive change in the epidemiology and severity of invasive group A streptococcal infections occurred in the 1980s, and the incidence of streptococcal toxic shock syndrome cases continues to rise. The reason for the resurgence of severe invasive cases remains a mystery-has there been a change in the pathogen or ...

journal_title：Infection and immunity

authors： Basma H,Norrby-Teglund A,Guedez Y,McGeer A,Low DE,El-Ahmedy O,Schwartz B,Kotb M

更新日期：1999-04-01 00:00:00

abstract：:In this work we immunized mice with DNA encoding full-length Tc52 or its amino- or carboxy-terminal (N- and C-term, respectively) domain carried by attenuated Salmonella as a DNA delivery system. As expected, Salmonella-mediated DNA delivery resulted in low antibody titers and a predominantly Th1 response, as shown by...

journal_title：Infection and immunity

authors： Matos MN,Cazorla SI,Bivona AE,Morales C,Guzmán CA,Malchiodi EL

更新日期：2014-10-01 00:00:00

abstract：:Our previous work suggests that one mechanism through which connective tissue breakdown might occur in periodontal diseases is the production of metalloproteinases, including collagenase, by gingival fibroblasts. In this study we investigated whether highly purified preparations of lipopolysaccharide (LPS) and lipotei...

journal_title：Infection and immunity

authors： Heath JK,Atkinson SJ,Hembry RM,Reynolds JJ,Meikle MC

更新日期：1987-09-01 00:00:00

abstract：:We have determined the amounts of specific anti-class 1 outer membrane protein antibodies in sera from 25 patients during the course of systemic meningococcal disease, using purified class 1 protein as the sensitizing antigen in an enzyme-linked immunosorbent assay. The class 1 protein was obtained from a variant of s...

journal_title：Infection and immunity

authors： Guttormsen HK,Wetzler LM,Solberg CO

更新日期：1994-04-01 00:00:00

abstract：:Development of an effective vaccine against Leishmania infection is a priority of tropical disease research. We have recently demonstrated protection against Leishmania major in the murine and nonhuman primate models with individual or combinations of purified leishmanial recombinant antigens delivered as plasmid DNA ...

journal_title：Infection and immunity

authors： Coler RN,Skeiky YA,Bernards K,Greeson K,Carter D,Cornellison CD,Modabber F,Campos-Neto A,Reed SG

更新日期：2002-08-01 00:00:00

abstract：:The chromosomal iroBCDEN gene cluster first described for Salmonella enterica is involved in the uptake of catecholate-type siderophore compounds. An orthologous gene cluster has recently been detected in Escherichia coli strains which cause extraintestinal disease. This E. coli iroBCDEN gene cluster has an impact on ...

journal_title：Infection and immunity

authors： Sorsa LJ,Dufke S,Heesemann J,Schubert S

更新日期：2003-06-01 00:00:00

abstract：:The recently introduced choleragen-induced rat foot edema model has been employed as a bioassay for evaluating the immunogenicity of three purified preparations containing cholera exo-enterotoxin antigen, choleragen, choleragenoid, and Formalin-treated choleragen (formagen). The results indicated that choleragen evoke...

journal_title：Infection and immunity

authors： Finkelstein RA,Hollingsworth RC

更新日期：1970-05-01 00:00:00

abstract：:Treatment with nontoxic monophosphoryl lipid A (MPL), which was derived from a polysaccharide-deficient, heptoseless Re mutant of Salmonella typhimurium, was found to inactivate suppressor T-cell activity, as evidenced by a decrease in the degree of low-dose immunological paralysis expressed and an increase in the mag...

journal_title：Infection and immunity

authors： Baker PJ,Hiernaux JR,Fauntleroy MB,Prescott B,Cantrell JL,Rudbach JA

更新日期：1988-05-01 00:00:00

abstract：:Murine embryo fibroblasts (MEF) were found to secrete tumor necrosis factor (TNF) in response to stimulation with endotoxin. Endotoxin-induced TNF production by MEF was inhibited by cycloheximide. However, reversal of the effect of this inhibitor on protein synthesis results in TNF being secreted in amounts equivalent...

journal_title：Infection and immunity

authors： Havell EA,Rogerson BJ

更新日期：1993-05-01 00:00:00

abstract：:Glaesserella (Haemophilus) parasuis is a commensal bacterium of the upper respiratory tract in pigs and also the causative agent of Glässer's disease, which causes significant morbidity and mortality in pigs worldwide. Isolates are characterized into 15 serovars by their capsular polysaccharide, which has shown a corr...

journal_title：Infection and immunity

authors： Eberle KC,Hau SJ,Luan SL,Weinert LA,Stasko JA,Wang J,Peters SE,Langford PR,Rycroft AN,Wren BW,Maskell DJ,Tucker AW,Brockmeier SL

更新日期：2020-04-20 00:00:00

abstract：:By crossed immunoelectrophoresis and Western blotting (immunoblotting), it was shown that Borrelia burgdorferi expresses the 60-kilodalton Common Antigen (CA) that is cross-reactive with an equivalent antigen in a wide range of remotely related bacteria. B. burgdorferi CA is strongly immunogenic. A B. burgdorferi geno...

journal_title：Infection and immunity

authors： Hansen K,Bangsborg JM,Fjordvang H,Pedersen NS,Hindersson P

更新日期：1988-08-01 00:00:00

abstract：:Salmonella enterica, a gram-negative pathogen, causes a spectrum of human infections including enterocolitis and typhoid fever. We previously showed that Salmonella flagellin played a role in suppressing intestinal mucosal inflammation in a murine model of acute enterocolitis. In this study, we examined the role of fl...

journal_title：Infection and immunity

authors： Fournier B,Williams IR,Gewirtz AT,Neish AS

更新日期：2009-09-01 00:00:00

abstract：:Acquisition of immunity to Plasmodium falciparum sexual stages is a key determinant for reducing human-mosquito transmission by preventing the fertilization and the development of the parasite in the mosquito midgut. Naturally acquired immunity against sexual stages may therefore form the basis for the development of ...

journal_title：Infection and immunity

authors： Ouédraogo AL,Roeffen W,Luty AJ,de Vlas SJ,Nebie I,Ilboudo-Sanogo E,Cuzin-Ouattara N,Teleen K,Tiono AB,Sirima SB,Verhave JP,Bousema T,Sauerwein R

更新日期：2011-12-01 00:00:00

abstract：:Vibrio cholerae accessory colonization factor genes (acfA, B, C, and D) are required for efficient intestinal colonization. Expression of acf genes is under the control of a regulatory cascade that also directs the synthesis of cholera toxin and proteins involved in the biogenesis of the toxin-coregulated pilus. The g...

journal_title：Infection and immunity

authors： Everiss KD,Hughes KJ,Kovach ME,Peterson KM

更新日期：1994-08-01 00:00:00

abstract：:Porphyromonas gingivalis, a gram-negative anaerobic bacterium associated with active lesions of chronic periodontitis, produces several proteinases which are presumably involved in host colonization, perturbation of the immune system, and tissue destruction. The aims of this study were to investigate the degradation o...

journal_title：Infection and immunity

authors： Goulet V,Britigan B,Nakayama K,Grenier D

更新日期：2004-08-01 00:00:00