Role of viremia in the suppression of T-cell function during murine cytomegalovirus infection.

abstract：:The efficacy of the innate immune system depends on its ability to mount an appropriate response to diverse infections and damaging agents. Key components of this system are pattern recognition receptors that detect pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). Nlrp1b is a pattern rec...

journal_title：Infection and immunity

authors： Liao KC,Mogridge J

更新日期：2013-02-01 00:00:00

abstract：:By subcutaneous treatment with an aqueous solution of 6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine [6-O-CH3-(CH2)16-CO-MurNAc-L-Ala-D-isoGln] [referred to here as L18-MDP(Ala)], an augmentation of the resistance of mice to Escherichia coli, Pseudomonas aeruginosa. Staphylococcus aureus, and Candida albicans in...

journal_title：Infection and immunity

authors： Osada Y,Mitsuyama M,Une T,Matsumoto K,Otani T,Satoh M,Ogawa H,Nomoto K

更新日期：1982-07-01 00:00:00

abstract：:Pertussis toxin (PT), a virulence factor secreted by Bordetella pertussis, contributes to respiratory tract infection and disease caused by this pathogen. By comparing a wild-type (WT) B. pertussis strain to a mutant strain with an in-frame deletion of the ptx genes encoding PT (DeltaPT), we recently found that the la...

journal_title：Infection and immunity

authors： Carbonetti NH,Artamonova GV,Andreasen C,Dudley E,Mays RM,Worthington ZE

更新日期：2004-06-01 00:00:00

abstract：:Human lactoferrin (hLf), a glycoprotein released from neutrophil granules during inflammation, and the lipopolysaccharide (LPS)-binding protein (LBP), an acute-phase serum protein, are known to bind to the lipid A of LPS. The LPS-binding sites are located in the N-terminal regions of both proteins, at amino acid resid...

journal_title：Infection and immunity

authors： Elass-Rochard E,Legrand D,Salmon V,Roseanu A,Trif M,Tobias PS,Mazurier J,Spik G

更新日期：1998-02-01 00:00:00

abstract：:Tuberculosis remains the leading cause of death among infectious diseases, accounting for more than two million deaths annually. The incidence of the disease is increasing globally, partially because of the resurgence of drug-resistant strains of Mycobacterium tuberculosis. Calixarenes are macrocyclic oligomers, some ...

journal_title：Infection and immunity

authors： Colston MJ,Hailes HC,Stavropoulos E,Hervé AC,Hervé G,Goodworth KJ,Hill AM,Jenner P,Hart PD,Tascon RE

更新日期：2004-11-01 00:00:00

abstract：:Interstitial lung macrophages from tuberculosis-susceptible I/St and tuberculosis-resistant A/Sn mice demonstrated significant constitutive differences in gene expression levels, whereas in vitro infection of these cells with Mycobacterium tuberculosis had only a modulatory impact on gene expression. We conclude that ...

journal_title：Infection and immunity

authors： Orlova MO,Majorov KB,Lyadova IV,Eruslanov EB,M'lan CE,Greenwood CM,Schurr E,Apt AS

更新日期：2006-06-01 00:00:00

abstract：:Immunization with the B oligomer of pertussis toxin protected neonatal mice from a lethal respiratory challenge with Bordetella pertussis. All mice immunized with 8 micrograms of B oligomer survived aerosol challenge and had peripheral leukocyte counts and weight gains similar to those of mice immunized with pertussis...

journal_title：Infection and immunity

authors： Shahin RD,Witvliet MH,Manclark CR

更新日期：1990-12-01 00:00:00

abstract：:The American opossum is the only experimental animal that regularly develops bacterial endocarditis spontaneously. There was no relation between the ability of opossums to clear bacteria from the bloodstream and the subsequent development of endocarditis. ...

journal_title：Infection and immunity

authors： Musher DM,Richie Y

更新日期：1974-06-01 00:00:00

abstract：:Toxoplasma gondii is a protozoan parasite that is able to penetrate human monocytes by either passive uptake during phagocytosis or active penetration. It is expected that immunoglobulin G (IgG) opsonization will target the parasite to macrophage Fc gamma receptors for phagocytic processing and subsequent degradation....

journal_title：Infection and immunity

authors： Fadul CE,Channon JY,Kasper LH

更新日期：1995-11-01 00:00:00

abstract：:The development of chronic and recurrent Staphylococcus aureus infections is associated with the emergence of slow-growing mutants known as small-colony variants (SCVs), which are highly tolerant of antibiotics and can survive inside host cells. However, the host and bacterial factors which underpin SCV emergence duri...

journal_title：Infection and immunity

authors： Painter KL,Strange E,Parkhill J,Bamford KB,Armstrong-James D,Edwards AM

更新日期：2015-05-01 00:00:00

abstract：:The gene encoding the 56-kDa protein of Orientia tsutsugamushi Shanxi was amplified by a nested PCR and cloned into the expression vector pQE30. The 56-kDa protein of O. tsutsugamushi Shanxi (Sxh56) was expressed as a fusion protein with the His(6)-binding protein of Escherichia coli by deleting the signal peptide-enc...

journal_title：Infection and immunity

authors： Chen WJ,Niu DS,Zhang XY,Chen ML,Cui H,Wei WJ,Wen BH,Chen XR

更新日期：2003-08-01 00:00:00

abstract：:Cholera toxin (CT) is a potent adjuvant for mucosal vaccination; however, its mechanism of action has not been clarified completely. It is well established that peripheral monocytes differentiate into dendritic cells (DCs) both in vitro and in vivo and that monocytes are the in vivo precursors of mucosal CD103(-) proi...

journal_title：Infection and immunity

authors： Veglia F,Sciaraffia E,Riccomi A,Pinto D,Negri DR,De Magistris MT,Vendetti S

更新日期：2011-03-01 00:00:00

abstract：:Glycosylation of the flagellar core proteins (FlaBs) was detected in Treponema pallidum Nichols and in the type or reference strains of seven oral Treponema species. In several nonmotile strains of oral treponemes, the FlaBs were undetectable by both antibody and glycan staining. In contrast, a spontaneous low-motilit...

journal_title：Infection and immunity

authors： Wyss C

更新日期：1998-12-01 00:00:00

abstract：:Randomly bred guinea pigs were infected with Listeria monocytogenes using the intracardial, intravenous and intraperitoneal routes of infection. Doses of Listeria ranged from 5 to 1,000 x the 50% lethal dose based on the 50% lethal dose for intracardially injected Listeria. A complete necropsy was performed on all ani...

journal_title：Infection and immunity

authors： Dustoor M,Croft W,Fulton A,Blazkovec A

更新日期：1977-03-01 00:00:00

abstract：:Feto-placental infections represent a major cause of pregnancy complications, and yet the underlying molecular and cellular mechanisms of vertical transmission are poorly understood. Listeria monocytogenes, a facultative intracellular pathogen, is one of a group of pathogens that are known to cause feto-placental infe...

journal_title：Infection and immunity

authors： Bakardjiev AI,Stacy BA,Fisher SJ,Portnoy DA

更新日期：2004-01-01 00:00:00

abstract：:Inner ear dysfunction secondary to chronic otitis media (OM), including high-frequency sensorineural hearing loss or vertigo, is not uncommon. Although chronic middle ear inflammation is believed to cause inner ear dysfunction by entry of OM pathogen components or cytokines from the middle ear into the inner ear, the ...

journal_title：Infection and immunity

authors： Moon SK,Woo JI,Lee HY,Park R,Shimada J,Pan H,Gellibolian R,Lim DJ

更新日期：2007-07-01 00:00:00

abstract：:Free-living amoebae of the genus Acanthamoeba can cause severe and chronic infections in humans, mainly localized in immune privileged sites, such as the brain and the eye. Monocytes/macrophages are thought to be involved in Acanthamoeba infections, but little is known about how these facultative parasites influence t...

journal_title：Infection and immunity

authors： Mattana A,Sanna M,Cano A,Delogu G,Erre G,Roberts CW,Henriquez FL,Fiori PL,Cappuccinelli P

更新日期：2016-09-19 00:00:00

abstract：:Antibody rises to various virus subcomponents were measured by enzyme-linked immunosorbent assay in the paired sera of volunteers experimentally infected with human coronavirus 229E group viruses. Most of the antibody made during infection was directed against the virus surface projections, with only small amounts of ...

journal_title：Infection and immunity

authors： Macnaughton MR,Hasony HJ,Madge MH,Reed SE

更新日期：1981-03-01 00:00:00

abstract：:We studied seven strains of group G streptococci isolated from clinically severe bacteremic infections in six intravenous drug abusers. These group G strains multiplied luxuriantly in fresh human blood. On electron microscopy, they exhibited surface fibrillae similar to those observed in M-protein-rich group A strepto...

journal_title：Infection and immunity

authors： Bisno AL,Craven DE,McCabe WR

更新日期：1987-03-01 00:00:00

abstract：:Exposure of hamster tracheal rings in organ culture to virulent Mycoplasma pneumoniae organisms leads to alterations in macromolecular biosynthesis and metabolic activity of the respiratory epithelial cells. Avirulent organisms derived from the same parent strain do not produce these effects. During the course of infe...

journal_title：Infection and immunity

authors： Hu PC,Collier AM,Baseman JB

更新日期：1975-04-01 00:00:00

abstract：:Scrub typhus immunogens were prepared by exposing infected yolk sac suspensions of Rickettsia tsutsugamushi to various doses of gamma radiation. Mouse lethality was abolished at doses greater than 200 krads, whereas immunogenicity of the suspensions, as shown by mouse protection tests, was diminished relatively little...

journal_title：Infection and immunity

authors： Eisenberg GH Jr,Osterman JV

更新日期：1977-01-01 00:00:00

abstract：:Many of the proinflammatory effects of gram-negative bacteria are elicited by the interaction of bacterial lipopolysaccharide (LPS) with Toll-like receptor 4 (TLR4) expressed on host cells. TLR4 signaling leads to activation of NF-kappa B and transcription of many genes involved in the inflammatory response. In this s...

journal_title：Infection and immunity

authors： Li X,Tupper JC,Bannerman DD,Winn RK,Rhodes CJ,Harlan JM

更新日期：2003-08-01 00:00:00

abstract：:Mammalian hosts often develop distinct immune response against the diverse parasitic helminths that have evolved for immune evasion. Interleukin-25 (IL-25), an IL-17 cytokine family member, plays a key role in initiating the protective immunity against several parasitic helminths; however, the involvement and underlyi...

journal_title：Infection and immunity

authors： Angkasekwinai P,Srimanote P,Wang YH,Pootong A,Sakolvaree Y,Pattanapanyasat K,Chaicumpa W,Chaiyaroj S,Dong C

更新日期：2013-10-01 00:00:00

abstract：:A zone of extracellular digestion of the mucin layer around Candida albicans blastoconidia was observed by transmission electron microscopy in the jejunum of mice inoculated intragastrically (G. T. Cole, K. R. Seshan, L. M. Pope, and R. J. Yancey, J. Med. Vet. Mycol. 26:173-185, 1988). This observation prompted the hy...

journal_title：Infection and immunity

authors： Colina AR,Aumont F,Deslauriers N,Belhumeur P,de Repentigny L

更新日期：1996-11-01 00:00:00

abstract：:In C3H gnotobiotic mice, no significant difference was observed between the translocation of nine clinical isolates of enteropathogenic Campylobacter spp. and that of seven nonisogeneic Escherichia coli strains with or without various determinants of pathogenicity. In addition, there was no correlation found between t...

journal_title：Infection and immunity

authors： Youssef M,Corthier G,Goossens H,Tancrede C,Henry-Amar M,Andremont A

更新日期：1987-04-01 00:00:00

abstract：:An apparent inhibition of induction of mouse hepatic tryptophan oxygenase by endotoxin has been reported previously, as evidenced by low catalytic activity. This could be due either to decreased tryptophan oxygenase levels or to inactivation of existing enzyme molecules. To resolve this question, the enzyme was quanti...

journal_title：Infection and immunity

authors： Rippe DF,Berry LJ

更新日期：1973-10-01 00:00:00

abstract：:Attachment of Fusobacterium nucleatum to various oral surfaces is mediated by several adhesins anchored on its outer surface. Monoclonal antibodies (MAbs) were prepared and used to identify the putative galactose-binding adhesin of F. nucleatum PK1594. Four unique MAbs, 8G7, 26B9, 28G11, and 29D4, were isolated on the...

journal_title：Infection and immunity

authors： Shaniztki B,Hurwitz D,Smorodinsky N,Ganeshkumar N,Weiss EI

更新日期：1997-12-01 00:00:00

abstract：:Binding of radiolabeled human fibrinogen and aggregated beta-microglobulin was measured in 60 strains of beta-hemolytic group B streptococci. Positive fibrinogen binding was detected in seven of the strains. Six of the group B strains showed an uptake of aggregated beta 2-microglobulin. Four individual strains carried...

journal_title：Infection and immunity

authors： Schönbeck C,Björck L,Kronvall G

更新日期：1981-03-01 00:00:00

abstract：:The presence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs), hepatitis B e antigen (HBeAg) and antibody (anti-HBe), the nature of T-cell function, and specific cell-mediated immunity to HBsAg were determined and evaluated serially in groups of subjects with chronic HBsAg carrier states and in seronegat...

journal_title：Infection and immunity

authors： Beutner KR,Tiku ML,Ogra PL

更新日期：1978-08-01 00:00:00

abstract：:The gene encoding a nitric oxide reductase has been identified in Neisseria gonorrhoeae. The norB gene product shares significant identity with the nitric oxide reductases in Ralstonia eutropha and Synechocystis sp. and, like those organisms, the gonococcus lacks a norC homolog. The gonococcal norB gene was found to b...

journal_title：Infection and immunity

authors： Householder TC,Fozo EM,Cardinale JA,Clark VL

更新日期：2000-09-01 00:00:00