Transcriptional profiling of lipopolysaccharide-induced acute lung injury.

abstract：:Following intranasal inoculation, Vibrio cholerae KFV101 (DeltactxAB DeltahapA DeltahlyA DeltartxA) colonizes and stimulates tumor necrosis factor alpha and interleukin 1beta (IL-1beta) in mice, similar to what occurs with isogenic strain P4 (DeltactxAB), but is less virulent and stimulates reduced levels of IL-6, dem...

journal_title：Infection and immunity

authors： Haines GK 3rd,Sayed BA,Rohrer MS,Olivier V,Satchell KJ

更新日期：2005-09-01 00:00:00

abstract：:Normal cell polarity protects epithelial cells against Pseudomonas aeruginosa invasion and cytotoxicity. Using epithelial cell clones with selective defects in sorting of membrane constituents, and using hepatocyte growth factor pretreatment, we found that polarized susceptibility to P. aeruginosa can be altered witho...

journal_title：Infection and immunity

authors： Fleiszig SM,Vallas V,Jun CH,Mok L,Balkovetz DF,Roth MG,Mostov KE

更新日期：1998-07-01 00:00:00

abstract：:AMA-1 of Plasmodium falciparum is a promising candidate antigen in malaria vaccine development. In this study, we have mapped the immunodominant T-cell determinants in this antigen by using synthetic peptides. From the amphipathic scores, 17 putative T-cell determinants were identified. Nine of the 17 peptides complem...

journal_title：Infection and immunity

authors： Lal AA,Hughes MA,Oliveira DA,Nelson C,Bloland PB,Oloo AJ,Hawley WE,Hightower AW,Nahlen BL,Udhayakumar V

更新日期：1996-03-01 00:00:00

abstract：:The structural gene of pneumolysin was randomly mutagenized. A screen, developed to identify mutants with reduced hemolytic activity, identified substitutions within the cysteine-containing region and also at residues toward the N terminus of the toxin. These are the first reported changes within the N-terminal region...

journal_title：Infection and immunity

authors： Hill J,Andrew PW,Mitchell TJ

更新日期：1994-02-01 00:00:00

abstract：:Rats kept under germfree conditions showed lower specific lysosomal enzyme activities in liver endothelial cells, but not in Kupffer cells. ...

journal_title：Infection and immunity

authors： Knook DL,Barkway C,Sleyster EC

更新日期：1981-08-01 00:00:00

abstract：:Understanding the regulation of human immune responses is critical for vaccine development and treating infectious diseases. We have previously shown that simultaneous engagement of the T cell receptor (TCR) and complement regulator CD46 on human CD4(+) T cells in the presence of interleukin-2 (IL-2) induces potent se...

journal_title：Infection and immunity

authors： Truscott SM,Abate G,Price JD,Kemper C,Atkinson JP,Hoft DF

更新日期：2010-12-01 00:00:00

abstract：:It has been proposed that a multivalent malaria vaccine is necessary to mimic the naturally acquired resistance to this disease observed in humans. A major experimental challenge is to identify the optimal components to be used in such a multivalent vaccine. Expression library immunization (ELI) is a method for screen...

journal_title：Infection and immunity

authors： Rainczuk A,Scorza T,Smooker PM,Spithill TW

更新日期：2003-08-01 00:00:00

abstract：:We developed an efficient electrotransformation system for the pathogenic fungus Histoplasma capsulatum and used it to examine the effects of features of the transforming DNA on transformation efficiency and fate of the transforming DNA and to demonstrate fungal expression of two recombinant Escherichia coli genes, hp...

journal_title：Infection and immunity

authors： Woods JP,Heinecke EL,Goldman WE

更新日期：1998-04-01 00:00:00

abstract：:Passive protection, the administration of antibodies to prevent infection, has garnered significant interest in recent years as a potential prophylactic countermeasure to decrease the prevalence of hospital-acquired infections. Pili, polymerized protein structures covalently anchored to the peptidoglycan wall of many ...

journal_title：Infection and immunity

authors： Pinkston KL,Singh KV,Gao P,Wilganowski N,Robinson H,Ghosh S,Azhdarinia A,Sevick-Muraca EM,Murray BE,Harvey BR

更新日期：2014-04-01 00:00:00

abstract：:Gram-negative bacterial cells exposed to a complement source may carry membrane attack complexes containing variable numbers of C9 molecules per C5b-8 site. In order to investigate the assembly of this complex, the ability of C9 molecules to bind to C5b-8 complexes was compared with the binding characteristics of C9 f...

journal_title：Infection and immunity

authors： MacKay SL,Dankert JR

更新日期：1994-07-01 00:00:00

abstract：:Nonspecific cross-reacting antigen (NCA) is a well-characterized membrane glycoprotein on granulocytes, macrophages, and lung epithelium. Structural studies at the protein and genomic levels have revealed that NCA is a member of the immunoglobulin supergene family, and hybridization studies showed that the transcript ...

journal_title：Infection and immunity

authors： Sauter SL,Rutherfurd SM,Wagener C,Shively JE,Hefta SA

更新日期：1991-07-01 00:00:00

abstract：:The role of type 1 pili in promoting bladder colonization was examined by constructing two mutant strains of a clinical Escherichia coli isolate. One mutant was isogenic to the parental strain save for a lesion in a gene required for pilus receptor binding; the other mutant was isogenic save for a lesion in the gene e...

journal_title：Infection and immunity

authors： Keith BR,Maurer L,Spears PA,Orndorff PE

更新日期：1986-09-01 00:00:00

abstract：:The genetics of resistance to a naturally occurring respiratory infection caused by Sendai virus was examined in F1, F2, and backcross progeny of resistant C57BL/6J and susceptible DBA/2J mice and in 25 recombinant inbred strains. An intranasal inoculum of 0.1 50% tissue culture infective dose (low dose) of Sendai vir...

journal_title：Infection and immunity

authors： Brownstein DG

更新日期：1983-07-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) glycoprotein gC was purified by affinity chromatography with an immunosorbent column containing monoclonal antibody to HSV-1 gC, and its reactivity with rabbit antisera was measured by enzyme-linked immunosorbent assay and sodium dodecyl sulfate-polyacrylamide gel electrophoretic an...

journal_title：Infection and immunity

authors： Zweig M,Heilman CJ Jr,Bladen SV,Showalter SD,Hampar B

更新日期：1983-08-01 00:00:00

abstract：:Rabbits immunized with group B type III, group C, and Streptococcus pneumoniae type XIV streptococcal vaccines developed autoantibodies reactive with autologous and isologous erythrocytes and human O-positive erythrocytes at reduced temperatures. The cold agglutinin antibodies were present in both the immunoglobulin M...

journal_title：Infection and immunity

authors： Colling RG,Pearson TC,Brown JC

更新日期：1983-07-01 00:00:00

abstract：:The objective of this study was to determine (i) if complementation of ureB-negative Helicobacter pylori restores colonization and (ii) if urease is a useful reporter for promoter activity in vivo. Strains used were M6, M6DeltaureB, and 10 recombinant derivatives of M6 or M6DeltaureB in which urease expression was und...

journal_title：Infection and immunity

authors： Eaton KA,Gilbert JV,Joyce EA,Wanken AE,Thevenot T,Baker P,Plaut A,Wright A

更新日期：2002-02-01 00:00:00

abstract：:Cryptococcus neoformans is surrounded by an antiphagocytic polysaccharide capsule whose primary constituent is glucuronoxylomannan (GXM). Three prominent structural features of GXM are single xylosyl and glucuronosyl side chains and O acetylation of the mannose backbone. Isogenic pairs of O-acetyl-positive and O-acety...

journal_title：Infection and immunity

authors： Kozel TR,Levitz SM,Dromer F,Gates MA,Thorkildson P,Janbon G

更新日期：2003-05-01 00:00:00

abstract：:Sera from certain animal species contain a substance(s) which binds hepatitis B surface antigen. The hepatitis B binding substance found in animals is not antibody, but appears to be a glycoprotein which reacted with antigen-coated beads and produced a "false positive" test for antibody. This glycoprotein could be sel...

journal_title：Infection and immunity

authors： Millman I,McMichael JC

更新日期：1978-09-01 00:00:00

abstract：:Escherichia coli hemolysin is considered an important virulence factor in extraintestinal E. coli infections. The present study demonstrates that cultured pulmonary artery endothelial cells are susceptible to attack by low concentrations of E. coli hemolysin (greater than or equal to 0.05 hemolytic units/ml; greater t...

journal_title：Infection and immunity

authors： Suttorp N,Flöer B,Schnittler H,Seeger W,Bhakdi S

更新日期：1990-11-01 00:00:00

abstract：:The effect of ingestion of heat-killed Histoplasma capsulatum yeast cells on the metabolism of arachidonic acid (20:4) to prostenoids and leukotrienes was examined in murine peritoneal macrophages (M phi s). H. capsulatum-containing M phi s exhibited a metabolite profile similar to that of zymosan-challenged phagocyte...

journal_title：Infection and immunity

authors： Wolf JE,Massof SE,Peters SP

更新日期：1992-07-01 00:00:00

abstract：:Pathogenicities of 10 temperature-sensitive mutants of Venezuelan encephalitis virus were studied using the hamster model of human virulence. The parental strain and nine of the temperature-sensitive mutants produced lethal infections in hamsters. Strain ts 126 showed reduced hamster virulence. Deaths with the lethal ...

journal_title：Infection and immunity

authors： Krieger JN,Scherer WF,Wiebe ME,Pancake BA,Harsanyi ZP

更新日期：1979-09-01 00:00:00

abstract：:Cells of Yersinia pestis strain EV76 are known to cease growth after a shift from 26 to 37 degrees C in neutral Ca2+-deficient medium; this effect is potentiated by Mg2+. With 2.5 mM Mg2+ and no added Ca2+, restriction was relaxed at elevated pH at which maximum cell yields occurred in the presence of 20 mM exogenous ...

journal_title：Infection and immunity

authors： Zahorchak RJ,Brubaker RR

更新日期：1982-12-01 00:00:00

abstract：:F344 rats chronically infected with Ureaplasma parvum develop two distinct profiles: asymptomatic urinary tract infection (UTI) and UTI complicated by struvite urolithiasis. To identify factors that affect disease outcome, we characterized the temporal host immune response during infection by histopathologic analysis ...

journal_title：Infection and immunity

authors： Reyes L,Alvarez S,Allam A,Reinhard M,Brown MB

更新日期：2009-10-01 00:00:00

abstract：:Salmonella enterica serovar Enteritidis is a major cause of food-borne diseases associated with consumption of shell eggs. Clinical isolates of S. enterica serovar Enteritidis exhibit a wide spectrum of virulence in mice. A highly virulent isolate (SE2472) was previously shown to be more resistant in vitro than other ...

journal_title：Infection and immunity

authors： Lu S,Killoran PB,Fang FC,Riley LW

更新日期：2002-02-01 00:00:00

abstract：:We examined the effect of host age and health status on the adherence of mannose-sensitive piliated Escherichia coli K1 to human oral epithelial cells. Mannose-sensitive piliated bacteria adhered in comparable numbers to newborn, older infant, and adult cells (125 +/- 61, 198 +/- 54, and 139 +/- 69 bacteria per cell, ...

journal_title：Infection and immunity

authors： Clegg H,Guerina N,Langermann S,Kessler TW,Guerina V,Goldmann D

更新日期：1984-07-01 00:00:00

abstract：:Clostridium perfringens type B and type C isolates, which produce beta-toxin (CPB), cause fatal diseases originating in the intestines of humans or livestock. Our previous studies demonstrated that CPB is necessary for type C isolate CN3685 to cause bloody necrotic enteritis in a rabbit ileal loop model and also showe...

journal_title：Infection and immunity

authors： Vidal JE,McClane BA,Saputo J,Parker J,Uzal FA

更新日期：2008-10-01 00:00:00

abstract：:Rabbit endogenous pyrogens were of about the same molecular size, but showed considerable heterogeneity of their isoelectric points. We attempted to show that this heterogeneity was attributable to variable glycosylation of a single polypeptide chain. When peritoneal exudate cells were stimulated to make pyrogens in t...

journal_title：Infection and immunity

authors： Murphy PA,Cebula TA,Windle BE

更新日期：1981-10-01 00:00:00

abstract：:Cytolethal distending toxins (CDT) constitute an emerging heterogeneous family of bacterial toxins whose common biological property is to inhibit the proliferation of cells in culture by blocking their cycle at G2/M phase. In this study, we investigated the molecular mechanisms underlying the block caused by CDT from ...

journal_title：Infection and immunity

authors： Comayras C,Tasca C,Pérès SY,Ducommun B,Oswald E,De Rycke J

更新日期：1997-12-01 00:00:00

abstract：:The effect of a standard regimen of cimetidine on the gastric flora of 20 male volunteers was studied in a double-blind manner and compared with the effects of a standard antacid regimen. Postprandial microbial titers in gastric aspirates were significantly higher at 4, 8, and 16 weeks of therapy in subjects taking an...

journal_title：Infection and immunity

authors： Snepar R,Poporad GA,Romano JM,Kobasa WD,Kaye D

更新日期：1982-05-01 00:00:00

abstract：:We report on the colonization of murine trigeminal ganglia after sequential infection of mice by herpes simplex viruses (HSVs). In preliminary studies, we have established that whereas the HSV-1(F) strain efficiently colonizes ganglia when inoculated by either the ear or eye routes, the HSV-1 X HSV-2 recombinant C7D c...

journal_title：Infection and immunity

authors： Meignier B,Norrild B,Roizman B

更新日期：1983-08-01 00:00:00