Colonization of murine ganglia by a superinfecting strain of herpes simplex virus.

abstract：:Humans infected with the dimorphic fungus Blastomyces dermatitidis develop strong T-lymphocyte responses to WI-1, an immunodominant antigen that has been shown to elicit protective immunity in mice. In the present study, the T-cell epitopes of WI-1 and human leukocyte antigen (HLA) restricting elements that display th...

journal_title：Infection and immunity

authors： Chang WL,Audet RG,Aizenstein BD,Hogan LH,DeMars RI,Klein BS

更新日期：2000-02-01 00:00:00

abstract：:Streptococcus mutans produces several enzymes which metabolize sucrose. Three glucosyltransferase genes (gtfB, gtfC, and gtfD) and a single fructosyltransferase gene (ftf) encode enzymes which are important in formation of exopolysaccharides. Mutants of S. mutans V403 carrying single and multiple mutations of the gtfB...

journal_title：Infection and immunity

authors： Munro C,Michalek SM,Macrina FL

更新日期：1991-07-01 00:00:00

abstract：:Infection with gram-negative monocytotropic Ehrlichia strains results in a fatal toxic shock-like syndrome characterized by a decreased number of Ehrlichia-specific CD4(+) Th1 cells, the expansion of tumor necrosis factor alpha (TNF-alpha)-producing CD8(+) T cells, and the systemic overproduction of interleukin-10 (IL...

journal_title：Infection and immunity

authors： Ismail N,Crossley EC,Stevenson HL,Walker DH

更新日期：2007-09-01 00:00:00

abstract：:Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked. Many pathogens have acquired the ability to sequester complement regulators from host plasma to evade complement attack. We describe here how Streptococcus pneumoniae adopts a st...

journal_title：Infection and immunity

authors： Haleem KS,Ali YM,Yesilkaya H,Kohler T,Hammerschmidt S,Andrew PW,Schwaeble WJ,Lynch NJ

更新日期：2018-12-19 00:00:00

abstract：:An LT-B-ST (LT-B/ST) fusion peptide was constructed by genetically joining the 5' terminus of a synthetic gene coding for the heat-stable enterotoxin (ST) of Escherichia coli to the 3' terminus of the gene coding for the binding subunit of the heat-labile enterotoxin (LT-B) of E. coli. An eight-amino-acid, proline-con...

journal_title：Infection and immunity

authors： Cárdenas L,Clements JD

更新日期：1993-11-01 00:00:00

abstract：:As an opportunistic bacterial pathogen, Pseudomonas aeruginosa mainly affects immunocompromised individuals as well as patients with cystic fibrosis. In a previous study, we showed that ExoS of P. aeruginosa, when injected into host cells through a type III secretion apparatus, functions as an effector molecule to tri...

journal_title：Infection and immunity

authors： Jia J,Alaoui-El-Azher M,Chow M,Chambers TC,Baker H,Jin S

更新日期：2003-06-01 00:00:00

abstract：:When spleen cells derived from C57BL/6 mice immunized with L cells 7 days previously were cocultured with antigenic cells, immune interferon appeared in the culture fluid. We analyzed the tissue distribution of the immune interferon-producing cells (IIPC) which appeared in various lymphoid organs after allogeneic stim...

journal_title：Infection and immunity

authors： Ito Y,Aoki H,Kimura Y,Takano M,Maeno K,Shimokata K

更新日期：1980-08-01 00:00:00

abstract：:Fab fragments prepared from the immunoglobulin G monoclonal antibody (MAb) 4C12, which reacts with a determinant expressed on the hyphal extension of germ tubes of Candida albicans, inhibited germ tube formation, but intact MAb 4C12 did not. Indirect immunofluorescence showed a punctate binding pattern on cells incuba...

journal_title：Infection and immunity

authors： Casanova M,Martínez JP,Chaffin WL

更新日期：1990-11-01 00:00:00

abstract：:Recombinant adenylate cyclase toxoids are shown to deliver inserted foreign CD4(+)-T-cell epitopes into the major histocompatibility complex class II presentation pathway, inducing a specific CD4(+)-T-cell response in vivo and yielding in vitro stimulation of specific CD4(+) T cells at a 100-times-higher molar efficie...

journal_title：Infection and immunity

authors： Loucká J,Schlecht G,Vodolánová J,Leclerc C,Sebo P

更新日期：2002-02-01 00:00:00

abstract：:The yield of infectious Chlamydia trachomatis was analyzed in human (HeLa) and mouse (McCoy) cell lines treated with the human interferon (IFN) subtypes IFN-alpha A and IFN-alpha D, with their hybrids [IFN-alpha AD (BglII), IFN-alpha AD (PvuII), and IFN-alpha DA (BglII)] constructed in vitro from their expression plas...

journal_title：Infection and immunity

authors： de la Maza LM,Peterson EM,Goebel JM,Fennie CW,Czarniecki CW

更新日期：1985-03-01 00:00:00

abstract：:Vibrio cholerae normally inhabits aquatic habitats but can cause a severe diarrheal illness in humans. Its arsenal of virulence factors includes a secreted hemagglutinin (HA) protease. An HA protease-deficient mutant of V. cholerae was isolated and designated E7946 mpc. E7946 mpc was found to contain a point mutation ...

journal_title：Infection and immunity

authors： Vance RE,Zhu J,Mekalanos JJ

更新日期：2003-05-01 00:00:00

abstract：:The objective of these studies was to determine the role of macrophage inflammatory protein 1alpha/CCL3 in pulmonary host defense during Klebsiella pneumoniae infection. Following intratracheal inoculation, 7-day survival of CCL3(-/-) mice was less than 10%, compared to 60% for CCL3(+/+) mice. Survival of CCR5(-/-) mi...

journal_title：Infection and immunity

authors： Lindell DM,Standiford TJ,Mancuso P,Leshen ZJ,Huffnagle GB

更新日期：2001-10-01 00:00:00

abstract：:Cholera toxin (CT) and related Escherichia coli enterotoxins LTI and LTIIb have a conserved hydrophobic region at the AB(5) interface postulated to be important for toxin assembly. Hydrophobic residue F223 in the A subunit of CT (CTA) as well as residues 174, L77, and T78 in the B subunit of CT (CTB) were replaced ind...

journal_title：Infection and immunity

authors： Tinker JK,Erbe JL,Hol WG,Holmes RK

更新日期：2003-07-01 00:00:00

abstract：:Streptococcus pneumoniae contains an inhibitor of human neutrophil elastase. The agent does not inhibit other proteases, including neutrophil cathepsin G and pancreatic elastase. It is active in the presence of insoluble elastin as well as synthetic elastase substrates. The inhibitor is present in the pneumococcal cel...

journal_title：Infection and immunity

authors： Vered M,Simon SR,Janoff A

更新日期：1985-07-01 00:00:00

abstract：:Antisera were raised in rabbits with acid-treated Re mutant bacteria from Salmonella minnesota and Escherichia coli and tested in a passive hemolysis assay with di- and monophosphorylated free lipid A of E. coli (LipA-Ac and LipA-HCl, respectively) coated onto sheep erythrocytes. Depending on the acid used to prepare ...

journal_title：Infection and immunity

authors： Brade L,Brade H

更新日期：1985-06-01 00:00:00

abstract：:Bacillary angiomatosis (BA), one of the many clinical manifestations resulting from infection with the facultative intracellular bacterium Bartonella henselae, is characterized by angiogenic lesions. Macrophages have been identified as important effector cells contributing to the angiogenic process during B. henselae ...

journal_title：Infection and immunity

authors： McCord AM,Burgess AW,Whaley MJ,Anderson BE

更新日期：2005-09-01 00:00:00

abstract：:Plasma cells are common in chronically inflamed sites, including periodontal lesions. The aim of this study was to determine which factors contribute to this local accumulation of plasma cells. Specifically, we sought to evaluate the effects of specific antigen and nonspecific activators from an infectious agent assoc...

journal_title：Infection and immunity

authors： Mallison SM 3rd,Smith JP,Schenkein HA,Tew JG

更新日期：1991-11-01 00:00:00

abstract：:To elucidate the mechanism of the high incidence of lower respiratory tract infections in patients with diabetes mellitus, we investigated the kinetics of production of macrophage inflammatory protein 2 (MIP-2), an important mediator of lung neutrophil recruitment, using mice with streptozotocin-induced diabetes. Intr...

journal_title：Infection and immunity

authors： Amano H,Yamamoto H,Senba M,Oishi K,Suzuki S,Fukushima K,Mukaida N,Matsushima K,Eguchi K,Nagatake T

更新日期：2000-05-01 00:00:00

abstract：:Science has a critical role to play in addressing humanity's most important challenges in the twenty-first century. However, the contemporary scientific enterprise has developed in ways that prevent it from reaching maximum effectiveness and detract from the appeal of a research career. To be effective, the methodolog...

journal_title：Infection and immunity

authors： Fang FC,Casadevall A

更新日期：2012-03-01 00:00:00

abstract：:The ability of Streptococcus salivarius strain TOVE-R to inhibit the ecological emergence of virulent representatives of the most prevalent human mutans streptococci on the teeth of specific pathogen-free Osborne-Mendel rats was studied. Rats which were infected by TOVE-R, or either S. mutans 10449S or S. sobrinus 671...

journal_title：Infection and immunity

authors： Tanzer JM,Kurasz AB,Clive J

更新日期：1985-07-01 00:00:00

abstract：:A monoclonal antibody (MAb) was raised against Shiga toxin 2 (Stx2) of Escherichia coli O157:H7. MAb VTm1.1 belonged to the immunoglobulin G1 subclass and had a kappa light chain, and it could neutralize the cytotoxic activity of Stx2 and variants derived from patient strains but not that of variants derived from anim...

journal_title：Infection and immunity

authors： Nakao H,Kiyokawa N,Fujimoto J,Yamasaki S,Takeda T

更新日期：1999-11-01 00:00:00

abstract：:The ability of a pathogen to evade neutrophil phagocytic killing mechanisms is critically important for dissemination and establishment of a systemic infection. Understanding how pathogens overcome these innate defenses is essential for the development of optimal therapeutic strategies for invasive infections. CpsY is...

journal_title：Infection and immunity

authors： Allen JP,Neely MN

更新日期：2012-05-01 00:00:00

abstract：:The Lyme disease spirochete, Borrelia burgdorferi, exists in a zoonotic cycle involving an arthropod tick and mammalian host. Dissemination of the organism within and between these hosts depends upon the spirochete's ability to traverse through complex tissues. Additionally, the spirochete outruns the host immune cell...

journal_title：Infection and immunity

authors： Sultan SZ,Manne A,Stewart PE,Bestor A,Rosa PA,Charon NW,Motaleb MA

更新日期：2013-06-01 00:00:00

abstract：:Previous studies have demonstrated that animals exposed to Streptococcus pneumoniae while recovering from influenza A virus infection exhibit exacerbated disease symptoms. However, many of the current animal models exploring dual viral and bacterial synergistic exacerbations of respiratory disease have utilized mouse-...

journal_title：Infection and immunity

authors： Speshock JL,Doyon-Reale N,Rabah R,Neely MN,Roberts PC

更新日期：2007-06-01 00:00:00

abstract：:Trypanosoma cruzi is a protozoan parasite that can initiate mucosal infection after conjunctival exposure. The anatomical route of T. cruzi invasion and spread after conjunctival parasite contamination remains poorly characterized. In the present work we have identified the sites of initial invasion and replication af...

journal_title：Infection and immunity

authors： Giddings OK,Eickhoff CS,Smith TJ,Bryant LA,Hoft DF

更新日期：2006-10-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) and its two ligands, CCL17 and CCL22, are critically involved in different immune processes. In models of lipopolysaccharide-induced shock, CCR4-deficient (CCR4(-/-)) mice showed improved survival rates associated with attenuated proinflammatory cytokine release. Using CCR4(-/-) mice wit...

journal_title：Infection and immunity

authors： Traeger T,Kessler W,Assfalg V,Cziupka K,Koerner P,Dassow C,Breitbach K,Mikulcak M,Steinmetz I,Pfeffer K,Heidecke CD,Maier S

更新日期：2008-11-01 00:00:00

abstract：:Hookworm glutathione S-transferases (GSTs) are critical for parasite blood feeding and survival and represent potential targets for vaccination. Three cDNAs, each encoding a full-length GST protein from the human hookworm Necator americanus (and designated Na-GST-1, Na-GST-2, and Na-GST-3, respectively) were isolated ...

journal_title：Infection and immunity

authors： Zhan B,Perally S,Brophy PM,Xue J,Goud G,Liu S,Deumic V,de Oliveira LM,Bethony J,Bottazzi ME,Jiang D,Gillespie P,Xiao SH,Gupta R,Loukas A,Ranjit N,Lustigman S,Oksov Y,Hotez P

更新日期：2010-04-01 00:00:00

abstract：:Staphylococcus aureus is an important pathogen of humans and other animals, causing bacteremia, abscesses, endocarditis, and other infectious syndromes. A signature-tagged mutagenesis (STM) system was adapted for use in studying the genes required for in vivo survival of S. aureus. An STM library was ultimately create...

journal_title：Infection and immunity

authors： Schwan WR,Coulter SN,Ng EY,Langhorne MH,Ritchie HD,Brody LL,Westbrock-Wadman S,Bayer AS,Folger KR,Stover CK

更新日期：1998-02-01 00:00:00

abstract：:Current evidence indicates that Mycobacterium avium infection in patients with AIDS is acquired mostly through the gastrointestinal (GI) tract and that M. avium binds to and invades GI mucosal cells in vitro. Since M. avium is exposed to specific environmental conditions in the GI tract such as changes in pH, low oxyg...

journal_title：Infection and immunity

authors： Bermudez LE,Petrofsky M,Goodman J

更新日期：1997-09-01 00:00:00

abstract：:Female C57BL/6J mice were infected with Trypanosoma cruzi and subsequently given macrophages or lymphocytes from syngeneic donors which had recovered from the acute infection. Mice which received immune peritoneal macrophages, splenic lymphocytes, or lymph node lymphocytes developed lower mean parasitemias and cumulat...

journal_title：Infection and immunity

authors： Burgess DE,Hanson WL

更新日期：1979-09-01 00:00:00