Exposure to low oxygen tension and increased osmolarity enhance the ability of Mycobacterium avium to enter intestinal epithelial (HT-29) cells.

abstract：:Cytomegalovirus (CMV) infections are common in renal transplant recipients. We studied 23 recipients prospectively to determine whether infections by other herpes-group and non-herpes-group viruses were also present. Sera, obtained at the time of surgery and periodically thereafter, were tested for antibody to CMV, he...

journal_title：Infection and immunity

authors： Armstrong JA,Evans AS,Rao N,Ho M

更新日期：1976-10-01 00:00:00

abstract：:Saccharomyces boulardii is a nonpathogenic yeast used in the treatment of Clostridium difficile diarrhea and colitis. We have reported that S. boulardii inhibits C. difficile toxin A enteritis in rats by releasing a 54-kDa protease which digests the toxin A molecule and its brush border membrane (BBM) receptor (I. Cas...

journal_title：Infection and immunity

authors： Castagliuolo I,Riegler MF,Valenick L,LaMont JT,Pothoulakis C

更新日期：1999-01-01 00:00:00

abstract：:We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria m...

journal_title：Infection and immunity

authors： Reid SD,Montgomery AG,Musser JM

更新日期：2004-03-01 00:00:00

abstract：:The pulmonary immune response protects healthy individuals against Pneumocystis pneumonia (PcP). However, the immune response also drives immunopathogenesis in patients who develop severe PcP, and it is generally accepted that optimal treatment requires combination strategies that promote fungal killing and also provi...

journal_title：Infection and immunity

authors： Hoy Z,Wright TW,Elliott M,Malone J,Bhagwat S,Wang J,Gigliotti F

更新日期：2020-01-22 00:00:00

abstract：:Pregnant mice, guinea pigs, rats, and rabbits responded to injections of Moraxella bovis strain EPP-63(300) with abortion, death, embryo resorption, and production of small litters. The nature of response appeared to depend primarily on the number of viable cells injected and to some extent on the species of animal an...

journal_title：Infection and immunity

authors： Norman JO,Elissalde MH

更新日期：1979-05-01 00:00:00

abstract：:Streptococcus pneumoniae remains a major causative agent of serious human diseases. The worldwide increase of antibiotic resistant strains revealed the importance of horizontal gene transfer in this pathogen, a scenario that results in the modulation of the species-specific gene pool. We investigated genomic variation...

journal_title：Infection and immunity

authors： Hakenbeck R,Balmelle N,Weber B,Gardès C,Keck W,de Saizieu A

更新日期：2001-04-01 00:00:00

abstract：:Organ cultures of adult hamster trachea were used to evaluate the cytotoxic potential of cell fractions of Mycoplasma pneumoniae. Cytoplasm was essentially devoid of activity, whereas viable cells and membrane preparations, at a level of 25 mug of protein per ml, induced necrosis. Damage, as revealed by light and elec...

journal_title：Infection and immunity

authors： Gabridge MG,Johnson CK,Cameron AM

更新日期：1974-11-01 00:00:00

abstract：:The toxicity of Chlamydia trachomatis was studied with mouse peritoneal macrophage culture. Inoculation of 30 inclusion-forming units of trachoma B/TW-5/OT organisms and 250 inclusion-forming units of lymphogranuloma venereum L2/434/Bu organisms per cell caused immediated toxicity, with the killing of 40 to 90% of the...

journal_title：Infection and immunity

authors： Kuo CC

更新日期：1978-06-01 00:00:00

abstract：:Intrauterine infections lead to serious complications for mother and fetus, including preterm birth, maternal and fetal death, and neurological sequelae in the surviving offspring. Improving maternal and child heath is a global priority. Yet, the development of strategies to prevent and treat pregnancy-related disease...

journal_title：Infection and immunity

authors： Lowe DE,Robbins JR,Bakardjiev AI

更新日期：2018-05-22 00:00:00

abstract：:Burkholderia cenocepacia strain K56-2 typically has rough colony morphology on agar medium; however, shiny colony variants (shv) can appear spontaneously. These shv all had a minimum of 50% reduction in biomass formation and were generally avirulent in an alfalfa seedling infection model. Three shv-K56-2 S15, K56-2 S7...

journal_title：Infection and immunity

authors： Bernier SP,Nguyen DT,Sokol PA

更新日期：2008-01-01 00:00:00

abstract：:A superoxide dismutase (SOD) gene from the obligate intracellular bacterium Coxiella burnetii has been cloned, and its DNA sequence has been determined and expressed in Escherichia coli. The gene was identified on pSJR50, a pHC79-derived genomic clone, by using the polymerase chain reaction with degenerate oligonucleo...

journal_title：Infection and immunity

authors： Heinzen RA,Frazier ME,Mallavia LP

更新日期：1992-09-01 00:00:00

abstract：:The two published sequences of the pertussis toxin operon differ in 3 bp in the S1 subunit gene. In this report, we provide evidence that Bordetella pertussis strains are able to produce active pertussis toxin only when they contain one of the two possible nucleotide sequences. ...

journal_title：Infection and immunity

authors： Pizza M,Bugnoli M,Pucci P,Siciliano R,Marino G,Rappuoli R

更新日期：1991-03-01 00:00:00

abstract：:The bundle-forming pilus (BFP) of enteropathogenic Escherichia coli (EPEC) is an important virulence factor. We examined the role of divergent alleles of bfpA encoding bundlin, the BFP pilin protein, in pilus biogenesis, pilus interactions, and immune responses. We found that the BFP biogenesis machine from an EPEC st...

journal_title：Infection and immunity

authors： Fernandes PJ,Guo Q,Donnenberg MS

更新日期：2007-10-01 00:00:00

abstract：:Human gamma delta T cells are known to respond at high frequencies to pathogenic mycobacteria. Here we show that opportunistic strains of mycobacteria share with pathogenic mycobacteria the ability to trigger at high frequencies human V gamma 9V delta 2 T-cell-receptor-positive T lymphocytes. Stimulating ligands were ...

journal_title：Infection and immunity

authors： Häcker G,Kromer S,Heeg K,Ivanyi J,Wagner H,Pfeffer K

更新日期：1992-07-01 00:00:00

abstract：:Colonization of the large bowel of healthy infants by Clostridium difficile was studied. Feces were collected from five breast-fed aand five formula-fed infants throughout the first year of life, and levels of C. difficile were quantitated. Three breast-fed and five formula-fed infants were colonized for periods of be...

journal_title：Infection and immunity

authors： Stark PL,Lee A,Parsonage BD

更新日期：1982-03-01 00:00:00

abstract：:Infectious pancreatic necrosis virus was stable for 10 days at 4 C in stream and well water, after which the virus had a half-life of 7.5 days. At 15 C, the virus was stable for 5 days, and then had a half-life between 5 and 6 days. Viral antigen in infected cells developed much more slowly at 4 C than at 20 C. Infect...

journal_title：Infection and immunity

authors： Tu KC,Spendlove RS,Goede RW

更新日期：1975-06-01 00:00:00

abstract：:N-Acetyl-muramyl-L-alanyl-D-isoglutamine (MDP), a structurally defined fragment of bacterial peptidoglycan, stimulated significant release of previously incorporated 45Ca from fetal rat bones in tissue culture over the concentration range of 0.1 to 10.0 micrograms/ml. MDP-Stimulated bone resorption was not inhibited b...

journal_title：Infection and immunity

authors： Dewhirst FE

更新日期：1982-01-01 00:00:00

abstract：:Gamma interferon (IFN-γ) induces expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial cells, the permissive cells for the obligate intracellular bacterium Chlamydia trachomatis. IDO1 depletes tryptophan by catabolizing it to kynurenine with consequences for C. trachom...

journal_title：Infection and immunity

authors： Ibana JA,Belland RJ,Zea AH,Schust DJ,Nagamatsu T,AbdelRahman YM,Tate DJ,Beatty WL,Aiyar AA,Quayle AJ

更新日期：2011-11-01 00:00:00

abstract：:A virus, 78-238, isolated from the cerebrospinal fluid of a dog with neurological dysfunction, was characterized as a paramyxovirus. This conclusion was supported by viral cytopathic effects and morphological appearance of virions and nucleocapsids in infected cells. Nucleocapsids were found in the cytoplasm of all in...

journal_title：Infection and immunity

authors： Baumgärtner WK,Metzler AE,Krakowka S,Koestner A

更新日期：1981-03-01 00:00:00

abstract：:The derivative toxins purified from cultures of proteolytic strains of Clostridium botulinum types A and F were found to have been only partially nicked but were fully activated. Trypsinization of C. botulinum type B derivative toxin at pH 6.0 resulted in simultaneous activation and nicking, whereas at pH 4.5, activat...

journal_title：Infection and immunity

authors： Ohishi I,Sakaguchi G

更新日期：1977-08-01 00:00:00

abstract：:Modulation of myelopoiesis by three synthetic muramyl peptides was investigated in vivo. Two adjuvant-active compounds (N-acetylmuramyl dipeptide [MDP] and MDP-butyl-ester) elicited significant responses in DBA/2 mice characterized by a rise in the level of monocyte-macrophage colony-stimulating activity in serum, a p...

journal_title：Infection and immunity

authors： Galelli A,Chedid L

更新日期：1983-12-01 00:00:00

abstract：:Mycoplasma pneumoniae is a leading, worldwide cause of death and disability due to pneumonia. Mycoplasma pulmonis infection in mice is an invaluable model for the study of host defenses against respiratory mycoplasmas in vivo. C3H/HeN mice are much more susceptible to acute inflammatory lung disease due to M. pulmonis...

journal_title：Infection and immunity

authors： Cartner SC,Simecka JW,Lindsey JR,Cassell GH,Davis JK

更新日期：1995-10-01 00:00:00

abstract：:Studies of active immunization against Helicobacter pylori indicate that antibodies play a minor role in immunity. There is also evidence, however, that the translocation of antibodies in the stomach may be insufficient to achieve functional antibody levels in the gastric lumen. We have used a suckling mouse model of ...

journal_title：Infection and immunity

authors： Gorrell RJ,Robins-Browne RM

更新日期：2009-11-01 00:00:00

abstract：:We studied apoptosis in a human ileocecal adenocarcinoma tumor cell line (HCT-8) infected with Cryptosporidium parvum, from 2 to 72 h postinfection (h.p.i.). At 2 h.p.i., the percentage of annexin V-positive cells in the cell culture had increased to 10% compared to 2.5% in noninfected control culture; sorted infected...

journal_title：Infection and immunity

authors： Mele R,Gomez Morales MA,Tosini F,Pozio E

更新日期：2004-10-01 00:00:00

abstract：:The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in ...

journal_title：Infection and immunity

authors： Lembo A,Kalis C,Kirschning CJ,Mitolo V,Jirillo E,Wagner H,Galanos C,Freudenberg MA

更新日期：2003-10-01 00:00:00

abstract：:The mechanism by which capsular polysaccharides inhibit phagocytosis is not clearly understood. We investigated the association between a negative surface charge and inhibition of phagocytosis by the capsular polysaccharide of Cryptococcus neoformans. A two-polymer aqueous-phase system containing phosphate ions was us...

journal_title：Infection and immunity

authors： Kozel TR,Reiss E,Cherniak R

更新日期：1980-08-01 00:00:00

abstract：:Staphylococcus aureus infections are an important public health concern due to their increasing incidence and high rates of mortality. The success of S. aureus as a pathogen is highly related to its enormous capacity to evade the host immune response. The critical role of tumor necrosis factor alpha (TNF-α) in the ini...

journal_title：Infection and immunity

authors： Giai C,Gonzalez C,Ledo C,Garofalo A,Di Genaro MS,Sordelli DO,Gomez MI

更新日期：2013-11-01 00:00:00

abstract：:An enhanced memory response, as shown by increased titers of specific immunoglobulin A (IgA), was seen in intestinal secretions from isolated Thiry-Vella loops in rabbits primed orally with live, locally invasive Shigella sp. X16 and challenged 60 days later with a single oral dose of the same antigen. Heat-killed shi...

journal_title：Infection and immunity

authors： Keren DF,McDonald RA,Scott PJ,Rosner AM,Strubel E

更新日期：1985-01-01 00:00:00

abstract：:The purpose of our experiment was to evaluate the destructive potential of a strain of Actinomyces viscosus on the periodontium of sensitized rodents, describing the induced lesions on the basis of quantitative cytology. The experimental design comprised in principle the following procedures. Young germfree rats were ...

journal_title：Infection and immunity

authors： Guggenheim B,Schroeder HE

更新日期：1974-09-01 00:00:00

abstract：:Exposure of mononuclear cells from the mouse peritoneal cavity to interferon (IF)-containing mouse sera enhanced phagocytosis of colloidal carbon particles by the cells. The same effect was observed when the cells were exposed to IF-containing cell culture harvest free of serum. The magnitude of this effect of IF-cont...

journal_title：Infection and immunity

authors： Huang KY,Donahoe RM,Gordon FB,Dressler HR

更新日期：1971-11-01 00:00:00