Abstract:
:The purpose of our experiment was to evaluate the destructive potential of a strain of Actinomyces viscosus on the periodontium of sensitized rodents, describing the induced lesions on the basis of quantitative cytology. The experimental design comprised in principle the following procedures. Young germfree rats were immunized either by intravenous or intradermal injections with heat-killed cells of A. viscosus Ny 1 or sham immunized intradermally with physiological saline. After a period suitable for activation of the humoral and cell-mediated immune systems, Ny 1 was monoassociated in all animals by oral implantation. During the ensuing 42 days the animals were allowed to react against the continuous peripheral oral antigen challenge. Since A. viscosus is known as a heavy dental plaque-forming organism, the animals could be expected to develop local immunopathological lesions in the periodontal tissues. These lesions were then studied by quantitative cytology after sampling procedures allowing optimal tissue preservation. The degree of bone loss observed in all treatments was unrelated to the destructive capacity of the infiltrates, suggesting the presence of distinct mechanisms responsible for the activation of osteoclasts and factors interfering with fibroblast activity. Although the cellular composition of the infiltrated tissues was analyzed at the end of the experiment only, distinct stages of the lesions in the different treatments allowed reconstruction of the sequence of events. After an acute inflammatory phase, a classic delayed hypersensitivity reaction developed which was transformed after some time by a large superimposed plasma cell accumulation. The particular but undefined immune status was the significant factor determining the final type of peripheral infiltrative reaction.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Guggenheim B,Schroeder HEdoi
10.1128/IAI.10.3.565-577.1974subject
Has Abstractpub_date
1974-09-01 00:00:00pages
565-77issue
3eissn
0019-9567issn
1098-5522journal_volume
10pub_type
杂志文章abstract::Transforming growth factor beta (TGF-beta) has been shown to be a central immunomodulator used by leishmaniae to escape effective mechanisms of protection in human and murine infections with these parasites. However, all the information is derived from studies of established infection, while little is known about TGF-...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.9.5908-5914.2005
更新日期:2005-09-01 00:00:00
abstract::A major ceramide monohexoside (CMH) was purified from lipidic extracts of Cryptococcus neoformans. This molecule was analyzed by high-performance thin-layer chromatography (HPTLC), gas chromatography coupled with mass spectrometry, and fast atom bombardment-mass spectrometry. The cryptococcal CMH is a beta-glucosylcer...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.12.7049-7060.2000
更新日期:2000-12-01 00:00:00
abstract::A novel immunobiologically active fraction was prepared from a phenol-water extract of Prevotella intermedia ATCC 25611 by Sephadex G-100 column chromatography. The fraction consisted mainly of carbohydrate and protein and was devoid of fatty acid. The fraction showed high-molecular-weight bands (10,000 to 12,000) on ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.11.4531-4538.1997
更新日期:1997-11-01 00:00:00
abstract::Upon infection of a host, the pathogenic fungus Aspergillus fumigatus is attacked by the reactive oxygen species produced by phagocytic cells. Detoxification of hydrogen peroxide by catalases was proposed as a way to overcome this host response. A. fumigatus produces three active catalases; one is produced by conidia,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.6.3551-3562.2003
更新日期:2003-06-01 00:00:00
abstract::The complete nucleotide sequence of a 612-base-pair DNA fragment containing the gene for the major fimbrial subunit of CS3 of enterotoxigenic Escherichia coli is presented. A possible promoter region, a ribosome-binding site, and two potential signal peptidase cleavage sites are indicated. Unlike the best-studied fimb...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.12.3297-3300.1988
更新日期:1988-12-01 00:00:00
abstract::Cytomegalovirus (CMV) infection is common after renal transplantation, and cytomegaloviruria occurs in about two-thirds of the recipients. These observations suggest that the allografts may be a site of latent infection with CMV and its reactivation may be the source of viruria. To investigate this possibility, 130 ki...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.19.2.699-703.1978
更新日期:1978-02-01 00:00:00
abstract::The level of type-specific antigen (that covalently associated with the cell wall peptidoglycan and that released extracellularly) synthesized by virulent and avirulent strains of type III group B streptococci was quantitated and compared. Additionally, the effect of the physiological age of the cells and the influenc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.2.217-221.1984
更新日期:1984-05-01 00:00:00
abstract::Blastomyces dermatitidis is a thermally induced dimorphic fungus capable of causing lung and systemic infections in immunocompetent animal hosts. With the publication of genomic sequences from three different strains of B. dermatitidis and the development of RNA interference as a gene-silencing tool, it has become pos...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01328-09
更新日期:2010-06-01 00:00:00
abstract::A gene from Haemophilus influenzae encoding an outer membrane lipoprotein of about 15,000 daltons and which comigrates with the peptidoglycan-associated lipoprotein (PAL) of H. influenzae on sodium dodecyl sulfate-polyacrylamide gel electrophoresis has been previously reported and designated pcp gene, and its product ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.10.3388-3393.1990
更新日期:1990-10-01 00:00:00
abstract::The influence of D-alanine and carbohydrate substitution of lipoteichoic acids (LTAs) on the binding of antibody directed to the polyglycerol phosphate (PGP) portion was found to be at least partially dependent upon the mode of presentation of the antigen. There were greater differences in binding of anti-PGP immunogl...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.2.549-555.1983
更新日期:1983-08-01 00:00:00
abstract::The production of interleukin-6 (IL-6) and its possible relationship to host resistance and inflammatory response to Pneumocystis carinii infection were examined in mice with severe combined immunodeficiency (SCID mice). IL-6 activity was detected in the serum and lungs of P. carinii-infected mice but not in mice free...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.1.97-102.1993
更新日期:1993-01-01 00:00:00
abstract::The effect of continuous exposure to 80% oxygen on newborn mice with Ureaplasma urealyticum pneumonia was determined. Mice were inoculated intranasally with either U. urealyticum or sterile broth and then housed in either 80% oxygen or room air (21% oxygen). The mice were sacrificed at either 7 or 14 days after inocul...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.11.3487-3493.1990
更新日期:1990-11-01 00:00:00
abstract::The data presented indicate that in experimental Pseudomonas aeruginosa infection of mice, protease enhances the virulence of the organism. Anesthetized CBA/Lü mice were subjected to a 15-s flame burn and infected with a wild-type protease-producing strain and two of its protease-deficient mutants. The average bacteri...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.24.1.181-187.1979
更新日期:1979-04-01 00:00:00
abstract::Despite the high prevalence of cutaneous infections, little is known about the role of host immune responsiveness during Staphylococcus aureus dermatitis. We have recently described a murine model of infectious dermatitis induced by superantigen-producing S. aureus. To assess the role of neutrophils in staphylococcal ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.11.6162-6167.2000
更新日期:2000-11-01 00:00:00
abstract::Oral inoculation of calves and steers with 10(10) CFU of Escherichia coli O157:H7 induced prompt and sustained increases in serum antibodies to O157 lipopolysaccharide. Neutralizing antibodies to verotoxin 1 also increased rapidly in most steers but more gradually in calves. None of the animals developed neutralizing ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.5.1879-1883.1996
更新日期:1996-05-01 00:00:00
abstract::Lipopolysaccharides obtained from Brucella abortus, B. melitensis, and B. suis, but not B. canis, were found to contain amino sugars identified as glucosamine and quinovosamine by cation exchange and thin-layer cellulose chromatography and ninhydrin degradation. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.4.772-774.1974
更新日期:1974-04-01 00:00:00
abstract::Subchronic exposure to pharmacological levels of estrogenic compounds, including 17 beta-estradiol, diethylstilbestrol, and alpha-dienestrol, significantly increased the mortality of B6C3F1 female mice after Listeria infection. Compounds with little estrogenic activity, including 5 alpha-dihydrotestosterone, progester...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.2.301-307.1984
更新日期:1984-11-01 00:00:00
abstract::Cultures of Serpulina pilosicoli 95/1000, isolated from a pig with porcine intestinal spirochetosis (PIS), and S. pilosicoli WesB, isolated from an Aboriginal child with diarrhea, were used to infect 5-week-old newly weaned pigs. Four of 12 pigs infected with strain 95/1000 and 2 of 12 pigs infected with strain WesB b...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.11.4648-4654.1996
更新日期:1996-11-01 00:00:00
abstract::Athymic BALB/c nude mice and euthymic BALB/c mice were infected with Rickettsia akari by the intraperitoneal route. The rickettsialpox infection was terminated in euthymic mice with only two intraperitoneal injections of the antibiotic oxytetracycline, whereas prolonged treatment was necessary to terminate the infecti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract::ExoU, a phospholipase injected into host cells by the type III secretion system of Pseudomonas aeruginosa, leads to rapid cytolytic cell death. Although the importance of ExoU in infection is well established, the mechanism by which this toxin kills host cells is less clear. To gain insight into how ExoU causes cell d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.5.2552-2561.2006
更新日期:2006-05-01 00:00:00
abstract::The adipocytokine leptin links nutritional status to immune function. Leptin signaling protects from amebiasis, but the molecular mechanism is not understood. We developed an in vitro model of ameba-host cell interaction to test the hypothesis that leptin prevents ameba-induced apoptosis in host epithelial cells. We d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06140-11
更新日期:2012-05-01 00:00:00
abstract::The effector mechanism, which operates against challenge parasites in the lungs of C57BL/6 mice vaccinated once with irradiated cercariae of Schistosoma mansoni, is mediated by CD4+ T helper lymphocytes. However, adoptive transfer of immunity from vaccinated donors to naive recipients by using sensitized T cells has n...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.1.42-48.1997
更新日期:1997-01-01 00:00:00
abstract::Cholera toxin has been widely used to obtain insight into the cellular dynamics of the antigen-specific mucosal immune response. The present study was undertaken to clarify the influence of the organized intestinal lymphoid tissue (Peyer's patches [PP]) on the distribution of anti-cholera-toxin-containing cells (ACC) ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.9.1997-1999.1987
更新日期:1987-09-01 00:00:00
abstract::Mycobacterial growth inhibitory factor (MycoIF), found in supernatant fluids of mouse spleen cell cultures that have been stimulated in vitro with homologous antigen, inhibited the intracellular multiplication of virulent tubercle bacilli within normal mouse peritoneal macrophages in vitro. Antigenically stimulated H...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.12.4.833-840.1975
更新日期:1975-10-01 00:00:00
abstract::An experimental model of "chronic" diphtheria intoxication in the guinea pig was developed. Adult guinea pigs, subjected to a regimen of multiple sublethal doses of purified diphtheria toxin (total of 1.4 minimum lethal doses divided equally in four daily doses), developed a toxemia which terminated in death between 6...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.4.556-560.1973
更新日期:1973-04-01 00:00:00
abstract::Utilization of the technique of immune electron microscopy has enabled the detection of a coronavirus in organ culture harvests derived from a washing from an adult with an acute upper respiratory tract illness; convalescent serum was the source of specific antibody. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.1.111-116.1973
更新日期:1973-01-01 00:00:00
abstract::Escherichia coli F-18, isolated from the feces of a healthy human in 1977, is an excellent colonizer of the streptomycin-treated mouse large intestine and displays normal motility and chemotaxis ability. A chemotaxis-defective derivative of E. coli F-18, E, coli F-18 CheA-, and a nonflagellated derivative, E. coli F-1...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.9.2957-2961.1990
更新日期:1990-09-01 00:00:00
abstract::Cells of several strains of Streptococcus gordonii attached in much higher numbers to experimental pellicles formed from samples of submandibular or parotid saliva on hydroxyapatite (HA) beads than to buffer controls. The nature of the salivary components responsible were investigated by preparing experimental pellicl...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.9.2948-2954.1991
更新日期:1991-09-01 00:00:00
abstract::Potassium thiocyanate extracts of a virulent Pasteurella multocida 3:A rabbit isolate were prepared and used as a vaccine in rabbits. The extract contained protein, carbohydrate, hyaluronic acid, lipopolysaccharide, DNA, and RNA. The protein and lipopolysaccharide profiles of the extract were similar to those of the P...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.12.2967-2976.1987
更新日期:1987-12-01 00:00:00
abstract::Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA fragmentation characteristic of apoptosis. Macrophage lysis was dependent on a subset of caspases and an intact sipB gene...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.6.3744-3747.2000
更新日期:2000-06-01 00:00:00