A potassium thiocyanate extract vaccine prepared from Pasteurella multocida 3:A protects rabbits against homologous challenge.

abstract：:In this study, a novel recombinant attenuated Yersinia pseudotuberculosis PB1+ strain (χ10069) engineered with ΔyopK ΔyopJ Δasd triple mutations was used to deliver a Y. pestis fusion protein, YopE amino acid 1 to 138-LcrV (YopENt138-LcrV), to Swiss Webster mice as a protective antigen against infections by yersiniae....

journal_title：Infection and immunity

authors： Singh AK,Curtiss R 3rd,Sun W

更新日期：2019-09-19 00:00:00

abstract：:Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections. These bacteria undertake a multistage infection cycle involving invasion of and proliferation within urinary tract epithelial cells, leading to the rupture of the host cell and dispersal of the bacteria, some of which have a highly...

journal_title：Infection and immunity

authors： Iosifidis G,Duggin IG

更新日期：2020-08-19 00:00:00

abstract：:Escherichia coli strains isolated from newborn infants were injected intraperitoneally into infant rats. Strains possessing the K1 capsular polysaccharide antigen were significantly more virulent than strains lacking this antigen. When 5-day-old animals were injected with 1.2 X 10(1) colony forming units of a K1 E. co...

journal_title：Infection and immunity

authors： Bortolussi R,Ferrieri P,Wannamaker LW

更新日期：1978-11-01 00:00:00

abstract：:Porphyromonas gingivalis forms communities with antecedent oral biofilm constituent streptococci. P. gingivalis major fimbriae bind to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) present on the streptococcal surface, and this interaction plays an important role in P. gingivalis colonization. This study identified...

journal_title：Infection and immunity

authors： Nagata H,Iwasaki M,Maeda K,Kuboniwa M,Hashino E,Toe M,Minamino N,Kuwahara H,Shizukuishi S

更新日期：2009-11-01 00:00:00

abstract：:Whereas infections of macrophages by promastigote forms of Leishmania mexicana pifanoi induce the production of superoxide, infections by amastigotes barely induce superoxide production. Several approaches were employed to gain insight into the mechanism by which amastigotes avoid eliciting superoxide production. Firs...

journal_title：Infection and immunity

authors： Pham NK,Mouriz J,Kima PE

更新日期：2005-12-01 00:00:00

abstract：:Infection with the protozoan parasite Toxoplasma gondii is transmitted to humans from infected animals by tissue cysts and oocysts excreted by cats. Immunization with inactivated parasites or recombinant proteins has at best shown partial protection. We constructed a plasmid expressing the SAG1 surface antigen of T. g...

journal_title：Infection and immunity

authors： Nielsen HV,Lauemøller SL,Christiansen L,Buus S,Fomsgaard A,Petersen E

更新日期：1999-12-01 00:00:00

abstract：:Platelets aggregate in response to an adhesin and the platelet aggregation-associated protein (PAAP) expressed on the cell surfaces of certain strains of Streptococcus sanguis. We sought to identify the corresponding PAAP receptor and accessory adhesin binding sites on platelets. Since the adhesion(s) of S. sanguis fo...

journal_title：Infection and immunity

authors： Gong K,Wen DY,Ouyang T,Rao AT,Herzberg MC

更新日期：1995-09-01 00:00:00

abstract：:Vitamin D is an important regulator of the expression of antimicrobial peptides, and vitamin D deficiency is associated with respiratory infections. Regulating expression of antimicrobial peptides, such as the human cathelicidin antimicrobial peptide 18 (hCAP18)/LL-37, by vitamin D in bronchial epithelial cells requir...

journal_title：Infection and immunity

authors： Schrumpf JA,van Sterkenburg MA,Verhoosel RM,Zuyderduyn S,Hiemstra PS

更新日期：2012-12-01 00:00:00

abstract：:The enteric pathogen Shigella is one of the leading causes of moderate-to-severe diarrhea and death in young children in developing countries. Transformed cell lines and animal models have been widely used to study Shigella pathogenesis. In addition to altered physiology, transformed cell lines are composed of a singl...

journal_title：Infection and immunity

authors： Ranganathan S,Doucet M,Grassel CL,Delaine-Elias B,Zachos NC,Barry EM

更新日期：2019-03-25 00:00:00

abstract：:Treatment with nontoxic monophosphoryl lipid A (MPL), which was derived from a polysaccharide-deficient, heptoseless Re mutant of Salmonella typhimurium, was found to inactivate suppressor T-cell activity, as evidenced by a decrease in the degree of low-dose immunological paralysis expressed and an increase in the mag...

journal_title：Infection and immunity

authors： Baker PJ,Hiernaux JR,Fauntleroy MB,Prescott B,Cantrell JL,Rudbach JA

更新日期：1988-05-01 00:00:00

abstract：:Oral spirochetes possess many potential virulence factors, including the capacity for tissue invasion and persistence despite a vigorous host immune response. In an attempt to identify treponemal immunoreactive components, sera derived from individuals with advanced periodontal disease were used as a reagent to isolat...

journal_title：Infection and immunity

authors： Heinzerling HF,Olivares M,Burne RA

更新日期：1997-06-01 00:00:00

abstract：:Lewis (Le) antigens have been implicated in the pathogenesis of atrophic gastritis and gastric cancer in the setting of Helicobacter pylori infection, and H. pylori-induced anti-Le antibodies have been described that cross-react with the gastric mucosa of both mice and humans. The aim of this study was to examine the ...

journal_title：Infection and immunity

authors： Heneghan MA,McCarthy CF,Janulaityte D,Moran AP

更新日期：2001-08-01 00:00:00

abstract：:Performing patch-clamp experiments on human macrophages, we show that the K(+) channel MaxiK is activated by lipopolysaccharide, peptidoglycan, and interleukin-1. Cytokine production initiated by several Toll-like receptor (TLR) ligands and by interleukin-1 is inhibited by MaxiK blockade. This provides evidence for fu...

journal_title：Infection and immunity

authors： Scheel O,Papavlassopoulos M,Blunck R,Gebert A,Hartung T,Zähringer U,Seydel U,Schromm AB

更新日期：2006-07-01 00:00:00

abstract：:Staphylococcus epidermidis is a leading cause of infections associated with indwelling medical devices, including prosthetic joint infection. While biofilm formation is assumed to be the main mechanism underlying the chronic infections S. epidermidis causes, we hypothesized that S. epidermidis also evades immune killi...

journal_title：Infection and immunity

authors： Perez K,Patel R

更新日期：2018-09-21 00:00:00

abstract：:The clinical and histopathological manifestations of syphilis and the invasive behavior of Treponema pallidum in tissue culture systems reflect the propensity for treponemes to migrate through skin, hematogenously disseminate, and invade targeted tissues. Treponemal motility is believed to be essential to this process...

journal_title：Infection and immunity

authors： Hagman KE,Porcella SF,Popova TG,Norgard MV

更新日期：1997-05-01 00:00:00

abstract：:During bacterial infection of the bovine mammary gland, large numbers of leukocytes migrate into the udder, resulting in the establishment of a host response against the pathogen. Currently, the specific leukocyte populations mediating this immune response are not well defined. In the studies described here, we analyz...

journal_title：Infection and immunity

authors： Soltys J,Quinn MT

更新日期：1999-12-01 00:00:00

abstract：:The ability to bind and utilize hemin is a trait common to many human pathogens. Nevertheless, the relationship between Legionella pneumophila, the agent of Legionnaires' disease, and hemin has received little attention. Thus, we explored the capacity of a virulent, serogroup 1 strain of L. pneumophila to bind hemin a...

journal_title：Infection and immunity

authors： O'Connell WA,Hickey EK,Cianciotto NP

更新日期：1996-03-01 00:00:00

abstract：:The goal of this study was to determine the roles of eosinophils and neutrophils in innate and adaptive protective immunity to larval Strongyloides stercoralis in mice. The experimental approach used was to treat mice with an anti-CCR3 monoclonal antibody to eliminate eosinophils or to use CXCR2-/- mice, which have a ...

journal_title：Infection and immunity

authors： Galioto AM,Hess JA,Nolan TJ,Schad GA,Lee JJ,Abraham D

更新日期：2006-10-01 00:00:00

abstract：:A significant depression in the phagocytic capacity of elicited peritoneal macrophages, pulmonary alveolar macrophages, and elicited peritoneal polymorphonucleated neutrophils was manifested when the cells were incubated in medium containing cadmium chloride. With the exception of the neutrophils, a similar influence ...

journal_title：Infection and immunity

authors： Loose LD,Silkworth JB,Simpson DW

更新日期：1978-11-01 00:00:00

abstract：:Rabbit endogenous pyrogens were of about the same molecular size, but showed considerable heterogeneity of their isoelectric points. We attempted to show that this heterogeneity was attributable to variable glycosylation of a single polypeptide chain. When peritoneal exudate cells were stimulated to make pyrogens in t...

journal_title：Infection and immunity

authors： Murphy PA,Cebula TA,Windle BE

更新日期：1981-10-01 00:00:00

abstract：:Considerable evidence supports the concept that CD4(+) T cells are important in sarcoidosis pathogenesis, but the antigens responsible for the observed Th1 immunophenotype remain elusive. The epidemiologic association with bioaerosols and the presence of granulomatous inflammation support consideration of mycobacteria...

journal_title：Infection and immunity

authors： Oswald-Richter KA,Culver DA,Hawkins C,Hajizadeh R,Abraham S,Shepherd BE,Jenkins CA,Judson MA,Drake WP

更新日期：2009-09-01 00:00:00

abstract：:The role of capsule in the adherence of Haemophilus influenzae type b to human epithelial cells in vitro was examined. A group of 30 nonadherent isolates did not differ in degree of encapsulation compared with their respective adherent variants. Furthermore, capsule-deficient mutants of both nonadherent and adherent v...

journal_title：Infection and immunity

authors： LiPuma JJ,Gilsdorf JR

更新日期：1987-09-01 00:00:00

abstract：:Avian pathogenic Escherichia coli (APEC) cause extraintestinal disease in avian species via respiratory tract infection. Virulence factors associated with APEC include type 1 and P fimbriae, curli, aerobactin, lipopolysaccharide (LPS), K1 capsular antigen, temperature-sensitive hemagglutinin (Tsh), and an uncharacteri...

journal_title：Infection and immunity

authors： Mellata M,Dho-Moulin M,Dozois CM,Curtiss R 3rd,Lehoux B,Fairbrother JM

更新日期：2003-01-01 00:00:00

abstract：:Infectious agents are often considered potential triggers of chronic inflammatory disease, including autoimmunity; however, direct evidence is usually lacking. Here we show that following control of acute infection of mice with the myotropic Colombiana strain of Trypanosoma cruzi, parasites persisted in tissue at low ...

journal_title：Infection and immunity

authors： Roffê E,Marino APMP,Weaver J,Wan W,de Araújo FF,Hoffman V,Santiago HC,Murphy PM

更新日期：2016-03-24 00:00:00

abstract：:Type 1 fimbrial phase-locked mutants of uropathogenic Escherichia coli cystitis isolate F11 were used to assess the role of the invertible element during urinary tract infection. Compared to the wild type, the phase-locked off mutant was attenuated, and constitutive production of type 1 fimbriae by the phase-locked on...

journal_title：Infection and immunity

authors： Snyder JA,Lloyd AL,Lockatell CV,Johnson DE,Mobley HL

更新日期：2006-02-01 00:00:00

abstract：:To evaluate the roles of the infectious agent and the host in the pathogensis of Salmonella-associated arthritis (SAA), 1O(3) to 10(6) heat-killed Salmonella enteritidis were injected directly into involved carpal joints in normal and actively immunized rats and in hosts adoptively immunized by the intravenous transfe...

journal_title：Infection and immunity

authors： Volkman A,Collins FM

更新日期：1976-04-01 00:00:00

abstract：:In gram-negative sepsis, the activation of polymorphonuclear leukocytes (PMN) by lipopolysaccharide (LPS) and the resulting production of superoxide and other oxygen radicals may be an important cause of tissue damage. A suppression of the PMN response to LPS stimulation would be therapeutically beneficial. The aim of...

journal_title：Infection and immunity

authors： Wagner DR,Heinrich D

更新日期：1994-10-01 00:00:00

abstract：:An "immunogenic" ribonucleic acid (Im-RNA) has been extracted from peritoneal exudate (PE) cells of rats that were immunized with sheep erythrocytes (SRBC). Following multiple phenol extractions and deoxyribonuclease treatment, the material obtained from PE cells was eluted from diethylaminoethyl-cellulose at 0.55 M N...

journal_title：Infection and immunity

authors： Archer SJ,Wust CJ

更新日期：1973-08-01 00:00:00

abstract：:The major antigenic determinants of the lipoglycans from Acholeplasma granularum and Acholeplasma axanthum were found to be the oligosaccharide sequences Glcp(beta 1 leads to 2)-Glcp(alpha 1 leads to 4)-Glcp and Glcp(beta 1 leads to 2)-Glcp(beta 1 leads to 2)-Glcp, respectively. The disaccharides sophorose and maltose...

journal_title：Infection and immunity

authors： Al-Samarrai TH,Smith PF,Lynn RJ

更新日期：1983-05-01 00:00:00

abstract：:Guinea pig peritoneal or alveolar macrophages were inoculated with Mycoplasma pneumoniae cells. Extracellular mycoplasms were killed by complement treatment, and the effect of macrophage action on the number of the remaining viable mycoplasmas was observed. The complement killing was to some extent inhibited by the pr...

journal_title：Infection and immunity

authors： Erb P,Bredt W

更新日期：1979-07-01 00:00:00