Preliminary characterization of "immunogenic" ribonucleic acid derived from rat peritoneal exudate cells.

abstract：:We have developed an in vitro assay to study the intramacrophage replication of Mycobacterium tuberculosis or Mycobacterium bovis BCG. In this assay, extracellular mycobacterial replication was avoided by using a small infecting inoculum and a new method for efficiently removing nonphagocytocytized bacilli. The abilit...

journal_title：Infection and immunity

authors： Zlotnik A,Crowle AJ

更新日期：1982-08-01 00:00:00

abstract：:Mapping vectors containing antibiotic resistance markers inserted adjacent to or within different cloned genes from Streptococcus mutans were used to determine the relative positions of these genes on the chromosome. The gtfA, ftf, and scrB genes were inserted into streptococcal mapping vector pVA891 adjacent to an Em...

journal_title：Infection and immunity

authors： Perry D,Kuramitsu HK

更新日期：1989-03-01 00:00:00

abstract：:The objective of this study was to identify disease-related changes in lymphocyte populations within ileal mucosae of calves with cryptosporidiosis. Groups of five neonatal calves were orally infected at 3 days of age with 10(8) oocysts and maintained in enteric-pathogen-free conditions until clinical disease was esta...

journal_title：Infection and immunity

authors： Wyatt CR,Brackett EJ,Perryman LE,Rice-Ficht AC,Brown WC,O'Rourke KI

更新日期：1997-01-01 00:00:00

abstract：:Glucan-binding protein B (GbpB) from Streptococcus mutans has been shown to induce protective immunity to dental caries in experimental models. Having recently sequenced the gbpB gene, our objective in this study was to identify immunogenic regions within the GbpB sequence for use in subunit vaccines. Potential region...

journal_title：Infection and immunity

authors： Smith DJ,King WF,Barnes LA,Peacock Z,Taubman MA

更新日期：2003-03-01 00:00:00

abstract：:Twenty-six Pseudomonas aeruginosa strains from patients with cystic fibrosis were typed by the Fisher immunotyping scheme. Only 6 strains were agglutinated by a single typing serum, whereas 15 strains were agglutinated with more than one serum and 5 were not agglutinated by any serum. Neither the polyagglutinable nor ...

journal_title：Infection and immunity

authors： Hancock RE,Mutharia LM,Chan L,Darveau RP,Speert DP,Pier GB

更新日期：1983-10-01 00:00:00

abstract：:The gene products from an 8-kb region adjacent to the 3' end of the ptx operon are required by Bordetella pertussis for the export of pertussis holotoxin. At least one of these gene products (PtlC) is specifically required for the export of assembled holotoxin from the periplasmic space. ptlC mutants exhibit a 20-fold...

journal_title：Infection and immunity

authors： Baker SM,Masi A,Liu DF,Novitsky BK,Deich RA

更新日期：1995-10-01 00:00:00

abstract：:Chronic infections play a significant role in the morbidity and mortality of patients with chronic airflow limitation. By stimulating airway inflammation, persistent infection has the potential to cause airway fibrosis. However, in patient this condition is most typically found in lungs damaged by other factors, such ...

journal_title：Infection and immunity

authors： McIntosh JC,Simecka JW,Ross SE,Davis JK,Miller EJ,Cassell GH

更新日期：1992-07-01 00:00:00

abstract：:The genome of Borrelia burgdorferi, the etiologic agent of Lyme disease, is composed of a linear chromosome and more than 20 linear and circular plasmids. Typically, plasmid content analysis has been carried out by pulsed-field gel electrophoresis and confirmed by Southern hybridization. However, multiple plasmids of ...

journal_title：Infection and immunity

authors： Iyer R,Kalu O,Purser J,Norris S,Stevenson B,Schwartz I

更新日期：2003-07-01 00:00:00

abstract：:The protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide (CP5) was examined in a modified model of catheter-induced endocarditis. Rats were catheterized by surgically passing a polyethylene catheter through the right carotid artery and aortic valve into the left ventricle. The ...

journal_title：Infection and immunity

authors： Lee JC,Park JS,Shepherd SE,Carey V,Fattom A

更新日期：1997-10-01 00:00:00

abstract：:Although certain helminth infections preferentially induce type 2 T-cell responses, the immunological mechanisms responsible for type 2 T-cell polarization remain unclear. In the present study, we investigated the effects of excretory-secretory (ES) antigen from the nematode Nippostrongylus brasiliensis on cytokine pr...

journal_title：Infection and immunity

authors： Uchikawa R,Matsuda S,Arizono N

更新日期：2000-11-01 00:00:00

abstract：:Escherichia coli strain RDEC-1 causes a diarrheagenic infection in rabbits with AF/R1 fimbriae, which have been identified as an important colonization factor in RDEC-1 adherence leading to disease. The AF/R1-mediated RDEC-1 adherence model has been used as a model systems for E. coli diarrheal diseases. In this study...

journal_title：Infection and immunity

authors： Ryu H,Kim YS,Grange PA,Cassels FJ

更新日期：2001-02-01 00:00:00

abstract：:Four isolates of Staphylococcus aureus from patients with endocarditis and bacteremia were capable of secreting high-molecular-weight soluble peptidoglycans when grown in a minimal cell wall medium containing penicillin G. Vancomycin was not able to substitute for penicillin G in triggering this secretion. Secretion r...

journal_title：Infection and immunity

authors： Zeiger AR,Wong W,Chatterjee AN,Young FE,Tuazon CU

更新日期：1982-09-01 00:00:00

abstract：:Dissemination of Leishmania within the host is related to parasites undergoing unchecked proliferation. We therefore studied the effects of oxidant generating systems on promastigote multiplication by (i) direct determinations of organism proliferation and (ii) the incorporation of [3H]uracil into promastigote nucleop...

journal_title：Infection and immunity

authors： Reiner NE,Kazura JW

更新日期：1982-06-01 00:00:00

abstract：:Experiments were performed to study the effect of antibody to Streptococcus mutans glucosyltransferase (GTF) on the implantation of these organisms in hamsters. Salivary (immunoglobulin A) and serum (immunoglobulin G) antibodies to GTF and GTF-inhibiting activity were elicited by injection of GTF in Freund complete ad...

journal_title：Infection and immunity

authors： Smith DJ,Taubman MA,Ebersole JL

更新日期：1982-08-01 00:00:00

abstract：:The agent of Lyme disease, Borrelia burgdorferi, has a number of outer membrane proteins that are differentially regulated during its life cycle. In addition to their physiological functions in the organism, these proteins also likely serve different functions in invasiveness and immune evasion. In borreliae, as well ...

journal_title：Infection and immunity

authors： Toledo A,Coleman JL,Kuhlow CJ,Crowley JT,Benach JL

更新日期：2012-01-01 00:00:00

abstract：:Susceptibility to Coccidioides spp. varies widely in humans and other mammals and also among individuals within a species. Among strains of mice with various susceptibilities, immunohistopathology revealed that C57BL/6 mice were highly susceptible to the disease following intranasal infection, DBA/2n mice were interme...

journal_title：Infection and immunity

authors： Shubitz LF,Dial SM,Perrill R,Casement R,Galgiani JN

更新日期：2008-12-01 00:00:00

abstract：:Human gamma delta T cells are known to respond at high frequencies to pathogenic mycobacteria. Here we show that opportunistic strains of mycobacteria share with pathogenic mycobacteria the ability to trigger at high frequencies human V gamma 9V delta 2 T-cell-receptor-positive T lymphocytes. Stimulating ligands were ...

journal_title：Infection and immunity

authors： Häcker G,Kromer S,Heeg K,Ivanyi J,Wagner H,Pfeffer K

更新日期：1992-07-01 00:00:00

abstract：:Virus population dynamics in the lungs, trachea, and nasopharynx of Swiss-ICR mice were studied after respiratory challenge with mouse-adapted preparations of strain A2/Aichi/2/68 influenza virus. Markedly higher doses of virus were required to produce infection with nasopharyngeal challenge than with bronchoalveolar ...

journal_title：Infection and immunity

authors： Larson EW,Dominik JW,Rowberg AH,Higbee GA

更新日期：1976-02-01 00:00:00

abstract：:To evaluate the roles of the infectious agent and the host in the pathogensis of Salmonella-associated arthritis (SAA), 1O(3) to 10(6) heat-killed Salmonella enteritidis were injected directly into involved carpal joints in normal and actively immunized rats and in hosts adoptively immunized by the intravenous transfe...

journal_title：Infection and immunity

authors： Volkman A,Collins FM

更新日期：1976-04-01 00:00:00

abstract：:gamma delta T cells have variously been implicated in the protection against, and the pathogenesis of, malaria, but few studies have examined the gamma delta T-cell response to malaria in African children, who suffer the large majority of malaria-associated morbidity and mortality. This is unfortunate, since available...

journal_title：Infection and immunity

authors： Hviid L,Kurtzhals JA,Adabayeri V,Loizon S,Kemp K,Goka BQ,Lim A,Mercereau-Puijalon O,Akanmori BD,Behr C

更新日期：2001-05-01 00:00:00

abstract：:Brucella species can cause brucellosis, a zoonotic disease that causes serious livestock economic losses and represents a public health threat. The mechanism of virulence of Brucella spp. is not yet fully understood. Therefore, it is crucial to identify new molecules that serve as virulence factors to better understan...

journal_title：Infection and immunity

authors： de Souza Filho JA,de Paulo Martins V,Campos PC,Alves-Silva J,Santos NV,de Oliveira FS,Menezes GB,Azevedo V,Cravero SL,Oliveira SC

更新日期：2015-04-01 00:00:00

abstract：:Several strains of group B Streptococcus agalactiae were found to be lethal for young adult rats. When bacteria were heat killed and then injected intraperitoneally into rats, rapid death (14 to 18 h) of the rats occurred, characterized by labored breathing, hemolyzed serum, hemoglobinuria, and subungual hemorrhages. ...

journal_title：Infection and immunity

authors： Warejcka DJ,Goodrum KJ,Spitznagel JK

更新日期：1985-05-01 00:00:00

abstract：:Polyinosinate-polycytidylate [poly(I).poly(C)]-induced interferon production in cultures of human foreskin fibroblast strains was increased by ultraviolet irradiation of cells at the time of exposure to inducer or at 2 h after induction. Incubation of cells with interferon prior to induction (priming) and ultraviolet ...

journal_title：Infection and immunity

authors： Mozes LW,Havell EA,Gradoville ML,Vilcek J

更新日期：1974-11-01 00:00:00

abstract：:Colonization by Bordetella bronchiseptica results in a variety of inflammatory respiratory infections, including canine kennel cough, porcine atrophic rhinitis, and a whooping cough-like disease in humans. For successful colonization, B. bronchiseptica must acquire iron (Fe) from the infected host. A vast amount of Fe...

journal_title：Infection and immunity

authors： Mocny JC,Olson JS,Connell TD

更新日期：2007-10-01 00:00:00

abstract：:Whole blood and plasma from animals in the acute stage of leptospirosis contained a toxic factor which produced a cytopathic effect on fibroblastic L cell monolayers. Firm adsorption of cytotoxic factor (CTF) to L cells occurred within 1 h. The highest titer of CTF in plasma was reached at 24 h and declined after 48 h...

journal_title：Infection and immunity

authors： Knight LL,Miller NG,White RJ

更新日期：1973-09-01 00:00:00

abstract：:We measured the microbicidal peptides MCP-1 and MCP-2 in rabbit alveolar macrophages (AM), comparing rabbits pretreated with complete Freund adjuvant with untreated control animals. Levels of MCP-1 increased from 4.7 +/- 0.6 microgram/10(7) resident AM to 13.2 +/- 0.1 microgram/10(7) complete Freund adjuvant-elicited ...

journal_title：Infection and immunity

authors： Lehrer RI,Szklarek D,Selsted ME,Fleischmann J

更新日期：1981-09-01 00:00:00

abstract：:The adenylate cyclase-hemolysin of Bordetella pertussis consists of a cell-invasive N-terminal adenylate cyclase domain linked to a C-terminal RTX hemolysin containing extensive glycine-rich repeats. The toxin is an essential virulence factor required in the initial stages of infection. Adenylate cyclase-hemolysin was...

journal_title：Infection and immunity

authors： Betsou F,Sebo P,Guiso N

更新日期：1995-09-01 00:00:00

abstract：:After intranasal inoculation, Brucella melitensis chronically infects the mononuclear phagocyte system in BALB/c mice, but it causes no apparent illness. Adaptive immunity, which can be transferred by either T cells or antibody from immune to naive animals, confers resistance to challenge infection. The role of innate...

journal_title：Infection and immunity

authors： Izadjoo MJ,Polotsky Y,Mense MG,Bhattacharjee AK,Paranavitana CM,Hadfield TL,Hoover DL

更新日期：2000-09-01 00:00:00

abstract：:In Brucella abortus, a gene encoding a major cell envelope protein, omp2, is duplicated within a short segment of the large chromosomal DNA. Although both genes contain open reading frames, encoding proteins of high identity, expression from only one, omp2b, has been detected in laboratory-grown B. abortus. In the pre...

journal_title：Infection and immunity

authors： Marquis H,Ficht TA

更新日期：1993-09-01 00:00:00

abstract：:Vaccination has been proposed for the prevention of disease due to enterohemorrhagic Escherichia coli (EHEC), but the immune response following human infection, including the choice of potential antigens, has not been well characterized. To study this, sera were obtained from five pediatric patients with acute diarrhe...

journal_title：Infection and immunity

authors： Li Y,Frey E,Mackenzie AM,Finlay BB

更新日期：2000-09-01 00:00:00