Abstract:
:To evaluate the roles of the infectious agent and the host in the pathogensis of Salmonella-associated arthritis (SAA), 1O(3) to 10(6) heat-killed Salmonella enteritidis were injected directly into involved carpal joints in normal and actively immunized rats and in hosts adoptively immunized by the intravenous transfer of spleen cells from syngeneic donors with ongoing SAA. As many as 10(6) living Salmonellae invariably failed to generate more than a transient inflammatory response in normal rats. The regression of acute joint swelling was accelerated in both types of immunized hosts. The intensity and duration of acute inflammation evoked in normal rats by 10(6) and 10(9) heat-killed Salmonellae did not exceed the response elicited by 10(3) living organisms. In sharply contrasting results, however, a chronic arthritis became established in a significant number of actively and adoptively sensitized rats after the intra-articular injection of 10(9) heat-killed organisms. No Salmonellae were recovered from these adoptively sensitized rats although small numbers of organisms has been present among the spleen cells in the transfer inocula. Taken together, these results indicate the obligatory involvement of host factors in the mediation of this chronic arthritis and virtually eliminate any likelihood that joint damage in SAA is due to the directly destructive effects of intra-articular infection.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Volkman A,Collins FMdoi
10.1128/IAI.13.4.1155-1160.1976subject
Has Abstractpub_date
1976-04-01 00:00:00pages
1155-60issue
4eissn
0019-9567issn
1098-5522journal_volume
13pub_type
杂志文章abstract::Several trivalent cations, including lanthanum (La3+), inhibited the secretion (enterosorption) induced by the enterotoxins of Vibrio cholerae and Escherichia coli in the rabbit ileum in vivo. High concentrations (greater than 10 mM) of La3+ were required to inhibit cholera enterotoxin (CE)-induced enterosorption, pro...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.5.1038-1044.1975
更新日期:1975-05-01 00:00:00
abstract::A monoclonal antibody was used to characterize a 135-kDa surface-located membrane protein (Lmp1) generally present in Mycoplasma hominis strains. The monoclonal antibody, 552, was applied to identify the corresponding gene in an expression library of M. hominis PG21 DNA. The M. hominis PG21 lmp1 gene was sequenced, an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.1.212-223.1995
更新日期:1995-01-01 00:00:00
abstract::Mycoplasma salivarium cells propagated in PPLO broth (Difco Laboratories, Detroit, Mich.) supplemented with rabbit serum (10% [vol/vol]) and harvested by centrifugation were shown to contain rabbit immunoglobulin G (IgG) (approximately 4 to 10% of total cell proteins) and to produce IgM autoantibodies to IgG when inoc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.1.263-265.1987
更新日期:1987-01-01 00:00:00
abstract::Several strains of group B Streptococcus agalactiae were found to be lethal for young adult rats. When bacteria were heat killed and then injected intraperitoneally into rats, rapid death (14 to 18 h) of the rats occurred, characterized by labored breathing, hemolyzed serum, hemoglobinuria, and subungual hemorrhages. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.48.2.560-564.1985
更新日期:1985-05-01 00:00:00
abstract::Fractionation of the culture medium showed that Streptococcus salivarius ATCC 25975 secreted a glucosyltransferase (Gtf) that was primer independent. On the basis of this observation, a gene library of S. salivarius chromosomal DNA cloned into lambda L47.1 was screened for a gene(s) coding for such an activity. As a r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.2.609-621.1995
更新日期:1995-02-01 00:00:00
abstract::We have previously shown that splenocytes from mice acutely infected with Trypanosoma cruzi exhibit high levels of nitric oxide (NO)-mediated apoptosis. In the present study, we used the gamma interferon (IFN-gamma)-knockout (IFN-gamma(-/-)) mice to investigate the role of IFN-gamma in modulating apoptosis induction a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.8.3864-3871.1999
更新日期:1999-08-01 00:00:00
abstract::In this communication, we examine the specificity of anti-herpes simplex virus (HSV) cytotoxic T lymphocytes (CTL). Serological studies of the two related HSV serotypes (HSV-1 and HSV-2) have revealed both type-specific and cross-reactive antigenic determinants in the viral envelope and on the surface of infected cell...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.34.3.795-803.1981
更新日期:1981-12-01 00:00:00
abstract::The diarrheagenic pathogen enteropathogenic Escherichia coli (EPEC) is responsible for significant infant mortality and morbidity, particularly in developing countries. EPEC pathogenesis relies on a type III secretion system-mediated transfer of virulence effectors into host cells. EPEC modulates host cell survival an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01690-06
更新日期:2007-05-01 00:00:00
abstract::The purpose of the present study was to determine the extent of immunologic responses, particularly immunopathologic responses, within the upper and lower respiratory tracts after intranasal immunization using the mucosal adjuvant cholera toxin (CT). BALB/c mice were nasally immunized with influenza virus vaccine comb...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.4.2328-2338.2001
更新日期:2001-04-01 00:00:00
abstract::The primary antibody response of BALB/c splenocytes to sheep erythrocytes in vitro was suppressed by infection with Friend leukemia virus (FLV), with the response capacity decreasing with increasing duration of infection. The acquisition of normal antibody responses was amplified by macrophage-produced antibody respon...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.39.3.1260-1264.1983
更新日期:1983-03-01 00:00:00
abstract::The Legionella pneumophila major secretory protein (Msp) is a Zn2+ metalloprotease whose function in pathogenesis is unknown. The structural gene for the Msp protease, mspA, was isolated from an L. pneumophila genomic library. In Escherichia coli which contain plasmids with the mspA gene, Msp protein and activity are ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.8.2585-2592.1990
更新日期:1990-08-01 00:00:00
abstract::The effects of phagocytosis-stimulating factor (PSF) derived from polymorphonuclear neutrophils on macrophage functions were studied. PSF enhanced the initial rate of phagocytosis of serum-opsonized zymosan particles by macrophages, whereas it did not affect the phagocytosis of immunoglobulin G-sensitized and inert zy...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.8.1762-1766.1987
更新日期:1987-08-01 00:00:00
abstract::Minicells are small, anucleate cells resulting from aberrant cell divisions at the polar ends of bacilli. We have isolated minicell-producing mutant strains of Shigella flexneri 2a (MC-I) and Shigella dysenteriae 1 (MC-V) after mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. Microscopically, broth cultures of M...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.30.1.297-302.1980
更新日期:1980-10-01 00:00:00
abstract::Pneumocystis pneumonia (PcP) is a life-threatening infection that affects immunocompromised individuals. Nearly half of all PcP cases occur in those prescribed effective chemoprophylaxis, suggesting that additional preventive methods are needed. To this end, we have identified a unique mouse Pneumocystis surface prote...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00850-16
更新日期:2017-03-23 00:00:00
abstract::In vivo accumulation of D-serine by Escherichia coli CFT073 leads to elevated expression of PAP fimbriae and hemolysin by an unknown mechanism. Loss of D-serine catabolism by CFT073 leads to a competitive advantage during murine urinary tract infection (UTI), but loss of both D- and L-serine catabolism results in atte...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00618-08
更新日期:2008-12-01 00:00:00
abstract::The Plasmodium falciparum liver-stage antigen 3 (LSA3), a recently identified preerythrocytic antigen, induces protection against malaria in chimpanzees. Using antibodies from individuals with hyperimmunity to malaria affinity purified on recombinant or synthetic polypeptides of LSA3, we identified four non-cross-reac...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.6.3845-3952.2001
更新日期:2001-06-01 00:00:00
abstract::Antibody levels in sera and respiratory secretions and resistance to respiratory infections were examined in mice given live infuenza virus in small-particle (2 mum) aerosols, large-particle (10 mum) aerosols, intraperitoneally, and subcutaneously. After parenteral administration antibody was found primarily in the se...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.3.696-703.1976
更新日期:1976-03-01 00:00:00
abstract::We have studied the ability of outer membrane vesicle (OMV) vaccines from Neisseria meningitidis serogroup B to induce vaccine-specific antibody and spleen cell proliferative responses in mice after being administered intranasally (i.n.) and/or subcutaneously (s.c.). A series of four weekly i.n. doses (25 microg) with...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.8.5010-5015.2001
更新日期:2001-08-01 00:00:00
abstract::Whole-genome sequencing analysis of ∼800 strains of group A Streptococcus (GAS) found that the gene encoding the multiple virulence gene regulator of GAS (mga) is highly polymorphic in serotype M59 strains but not in strains of other serotypes. To help understand the molecular mechanism of gene regulation by Mga and i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.03023-14
更新日期:2015-06-01 00:00:00
abstract::Vibrio cholerae is a monoflagellated gram-negative bacterium that causes the severe diarrheal disease cholera. In contrast to Salmonella enterica serovar Typhimurium infection, which is accompanied by both acute diarrhea and high-level inflammation, V. cholerae infection is largely noninflammatory in human hosts. Bact...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00736-07
更新日期:2008-03-01 00:00:00
abstract::Experimental Helicobacter pylori infection was studied in Mongolian gerbils with fresh human isolates that carry or do not carry cagA (cagA-positive or cagA-negative, respectively), multiply passaged laboratory strains, wild-type strain G1.1, or isogenic ureA, cagA, or vacA mutants of G1.1. Animals were sacrificed 1 t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.10.4856-4866.1998
更新日期:1998-10-01 00:00:00
abstract::Archival gastric tissues from 10 of 39 gnotobiotic piglets colonized with Helicobacter pylori 26695 contained stromal leukocytic inflammation along with ulcers and erosions. In contrast, gastric tissues from 54 archival control piglets were devoid of both inflammation and ulcers. These data confirm the hypothesis that...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.6.2352-2355.1995
更新日期:1995-06-01 00:00:00
abstract::Fab fragments prepared from the immunoglobulin G monoclonal antibody (MAb) 4C12, which reacts with a determinant expressed on the hyphal extension of germ tubes of Candida albicans, inhibited germ tube formation, but intact MAb 4C12 did not. Indirect immunofluorescence showed a punctate binding pattern on cells incuba...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.11.3810-3812.1990
更新日期:1990-11-01 00:00:00
abstract::Bacterial superantigens (SAgs) have been implicated in inflammatory disease, and SAg-treated mice have increased jejunal T cells. Here we show that T84 cells (a human epithelial cell line) display increased MCP-1 and RANTES mRNA expression and protein production in response to conditioned medium from Staphylococcus au...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.11.6198-6202.1999
更新日期:1999-11-01 00:00:00
abstract::Growing Streptococcus gordonii Spp+ phase variants, which have normal levels of glucosyltransferase (GTF) activity, use sucrose to promote their accumulation on surfaces by forming a cohesive bacterium-insoluble glucan polymer mass (BPM). Spp- phase variants, which have lower levels of GTF activity, do not form BPMs a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.10.4301-4308.1992
更新日期:1992-10-01 00:00:00
abstract::The ability to bind Congo red (Crb+) is associated with virulence of Shigella flexneri and is encoded by a large, 220-kilobase plasmid. We cloned fragments of this plasmid to isolate the sequences encoding Congo red binding, to determine the degree of conservation of these sequences among S. flexneri strains, and to s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.54.2.435-443.1986
更新日期:1986-11-01 00:00:00
abstract::The levels of protection found in vaccine studies of murine visceral leishmaniasis are significantly lower than for cutaneous leishmaniasis; whether this is due to the high-challenge murine model employed and/or is a consequence of differences required in tissue-specific local immune responses is not understood. Conse...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.1.401-410.2003
更新日期:2003-01-01 00:00:00
abstract::Staphylococcus aureus is an important pathogen of humans and other animals, causing bacteremia, abscesses, endocarditis, and other infectious syndromes. A signature-tagged mutagenesis (STM) system was adapted for use in studying the genes required for in vivo survival of S. aureus. An STM library was ultimately create...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.2.567-572.1998
更新日期:1998-02-01 00:00:00
abstract::The relative immunogenicities of three forms of the Escherichia coli heatlabile enterotoxin (LT), the holotoxin, its B subunit, and the polymyxin-release form (PM LT) were compared by immunizing rats with various dosages of each given exclusively by the parenteral (IP/IP) or peroral (PO/PO) routes or by a combination ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.31.1.144-150.1981
更新日期:1981-01-01 00:00:00
abstract::Counts of acid-fast bacilli were made on homogenates of whole liver, whole spleen, and two femurs of CBA mice killed at various time intervals after intravenous infection with Mycobacterium lepraemurium. The growth curves so obtained showed that the bacillus multiplied faster in bone marrow than in liver or spleen. No...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.2.480-486.1976
更新日期:1976-02-01 00:00:00