The C-terminal domain is essential for protective activity of the Bordetella pertussis adenylate cyclase-hemolysin.

abstract：:Immunocompromised patients are more susceptible to recurrent nontyphoidal Salmonella (NTS) bacteremia. A key manifestation of HIV infection is the loss of CD4 T cells, which are crucial for immunity to Salmonella infection. We characterized the consequences of CD4 T cell depletion in mice where virulent Salmonella est...

journal_title：Infection and immunity

authors： Loomis WP,Delaney MA,Johnson ML,Cookson BT

更新日期：2020-12-15 00:00:00

abstract：:Immunization with live Plasmodium sporozoites under chloroquine prophylaxis (Spz plus CQ) induces sterile immunity against sporozoite challenge in rodents and, more importantly, in humans. Full protection is obtained with substantially fewer parasites than with the classic immunization with radiation-attenuated sporoz...

journal_title：Infection and immunity

authors： Mauduit M,Tewari R,Depinay N,Kayibanda M,Lallemand E,Chavatte JM,Snounou G,Rénia L,Grüner AC

更新日期：2010-05-01 00:00:00

abstract：:Phagocytosis and mechanisms of killing of Aspergillus fumigatus conidia by murine alveolar macrophages (AM), which are the main phagocytic cells of the innate immunity of the lung, were investigated. Engulfment of conidia by murine AM lasts 2 h. Killing of A. fumigatus conidia by AM begins after 6 h of phagocytosis. S...

journal_title：Infection and immunity

authors： Philippe B,Ibrahim-Granet O,Prévost MC,Gougerot-Pocidalo MA,Sanchez Perez M,Van der Meeren A,Latgé JP

更新日期：2003-06-01 00:00:00

abstract：:Yersinia pseudotuberculosis inv mutant strains cured of the virulence plasmid exhibit thermoinducible adhesion to cultured mammalian cells. To identify the genes responsible for this phenotype, Y. pseudotuberculosis homologs of the Y. enterocolitica ail and the Y. pestis psa loci were identified. Mutations in the Y. p...

journal_title：Infection and immunity

authors： Yang Y,Merriam JJ,Mueller JP,Isberg RR

更新日期：1996-07-01 00:00:00

abstract：:Shigella flexneri is a gram-negative bacterium that causes bacillary dysentery in humans that is characterized by an acute inflammatory response of the colon. The fate of phagocytes that are infected in vitro with virulent Shigella has been the subject of some investigation and debate. In this study we found that viru...

journal_title：Infection and immunity

authors： Koterski JF,Nahvi M,Venkatesan MM,Haimovich B

更新日期：2005-01-01 00:00:00

abstract：:We examined the immunobiological responses to Histoplasma capsulatum in lungs of gamma interferon (IFN-gamma) knockout mice (GKO mice). Naive GKO mice succumbed by day 9 to intranasal challenge with 2.5 x 10(6) yeasts, whereas all wild-type (WT) mice survived for 45 days. Compared to lungs of WT mice, the lungs of acu...

journal_title：Infection and immunity

authors： Allendoerfer R,Deepe GS Jr

更新日期：1997-07-01 00:00:00

abstract：:The possibility that preexisting specific serum antibody could suppress a defined mucosal immune response to a topically applied antigen was studied in rats. Hyperimmune serum antibody induced by parenteral immunization of rats with cholera toxoid markedly suppressed the mucosal immune response to enterically applied ...

journal_title：Infection and immunity

authors： Pierce NF

更新日期：1980-10-01 00:00:00

abstract：:Urogenital Chlamydia serovars replicating in reproductive epithelium pose a unique challenge to host immunity and vaccine development. Previous studies have shown that CD4 T cells are necessary and sufficient to clear primary Chlamydia muridarum genital tract infections in the mouse model, making a protective CD4 T ce...

journal_title：Infection and immunity

authors： Johnson RM,Yu H,Kerr MS,Slaven JE,Karunakaran KP,Brunham RC

更新日期：2012-06-01 00:00:00

abstract：:The adherence mechanism of Aeromonas caviae Sch3N to HEp-2 cells was initially investigated through four mini-Tn5 mutants that showed a 10-fold decrease in adherence. These mutants lost motility, flagella, and their lipopolysaccharide (LPS) O antigen (O-Ag). Three genes, flmB-neuA-flmD, were found to be interrupted by...

journal_title：Infection and immunity

authors： Gryllos I,Shaw JG,Gavín R,Merino S,Tomás JM

更新日期：2001-01-01 00:00:00

abstract：:Chlamydia trachomatis is an obligately intracellular bacterial parasite of eucaryotic cells that undergoes a biphasic life cycle within a parasitophorous vacuole (PV) called an inclusion. The parasitophorous vacuolar membrane (PVM) constitutes a barrier between the replicating bacteria and the nutrient-rich environmen...

journal_title：Infection and immunity

authors： Heinzen RA,Hackstadt T

更新日期：1997-03-01 00:00:00

abstract：:Deciphering the mechanisms by which Borrelia burgdorferi controls the synthesis of proteins associated with mammalian infection will be an important step toward understanding the pathogenic properties of Lyme disease-causing bacteria. We present results of studies indicating that B. burgdorferi senses a wide variety o...

journal_title：Infection and immunity

authors： Babb K,El-Hage N,Miller JC,Carroll JA,Stevenson B

更新日期：2001-06-01 00:00:00

abstract：:A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinylpyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1beta (IL-1beta) production was f...

journal_title：Infection and immunity

authors： Boelens JJ,Zaat SA,Murk JL,Weening JJ,van Der Poll T,Dankert J

更新日期：2000-03-01 00:00:00

abstract：:Groups of specific pathogen-free Hartley strain guinea pigs were vaccinated with viable Mycobacterium bovis BCG and maintained on isocaloric purified diets containing either 30 or 10% protein (ovalbumin) combined with either 50 ppm (microgram/g) or no added zinc. Seven weeks later the guinea pigs were skin tested with...

journal_title：Infection and immunity

authors： McMurray DN,Yetley EA

更新日期：1983-02-01 00:00:00

abstract：:A 2.9-kilobase pair locus in Neisseria meningitidis was identified as containing transcriptionally linked open reading frames encoding TolC- and HlyD-like proteins. Although the meningococcal TolC protein was required for extracellular production of the repeats-in-toxin (RTX) FrpC toxin, it could not functionally repl...

journal_title：Infection and immunity

authors： Kamal N,Rouquette-Loughlin C,Shafer WM

更新日期：2007-12-01 00:00:00

abstract：:It was found that cells of Nocardia asteroides GUH-2 (virulent) were approximately 10 times more virulent than cells of N. asteroides 14759 (intermediate) and greater that 500 times more virulent than N. asteroides 10905 (avirulent) cells when early-stationary-phase cultures suspended in saline were injected intraven...

journal_title：Infection and immunity

authors： Beaman BL,Maslan S

更新日期：1977-06-01 00:00:00

abstract：:The ability of intracellular pathogens to sense and adapt to the hostile environment of the host is an important factor governing virulence. We have sequenced the operon encoding the major heat shock proteins GroES and GroEL in the gram-positive food-borne pathogen Listeria monocytogenes. The operon has a conserved or...

journal_title：Infection and immunity

authors： Gahan CG,O'Mahony J,Hill C

更新日期：2001-06-01 00:00:00

abstract：:Although often considered a strict human pathogen, Streptococcus pneumoniae has been reported to infect and cause pneumonia in horses, although the pathology appears restricted compared to that of human infections. Here we report on the molecular characterization of a group of S. pneumoniae isolates obtained from hors...

journal_title：Infection and immunity

authors： Whatmore AM,King SJ,Doherty NC,Sturgeon D,Chanter N,Dowson CG

更新日期：1999-06-01 00:00:00

abstract：:Salmonella choleraesuis chi 3781, an attenuated [delta cya-12 delta(crp-cdt)19] mutant, was electroporated with the plasmid pBA31-R7, which codes for the expression of a 31-kDa protein from Brucella abortus (BCSP31). Recombinant S. choleraesuis chi 3781 stably maintained the pBA31-R7 plasmid and continued to express t...

journal_title：Infection and immunity

authors： Stabel TJ,Mayfield JE,Morfitt DC,Wannemuehler MJ

更新日期：1993-02-01 00:00:00

abstract：:Toxigenic Vibrio cholerae strains are lysogens of CTXPhi, a filamentous phage which encodes cholera toxin. The receptor for CTXPhi for invading V. cholerae cells is the toxin-coregulated pilus (TCP), the genes for which reside in a larger genetic element, the TCP pathogenicity island. We analyzed 146 CTX-negative stra...

journal_title：Infection and immunity

authors： Faruque SM,Asadulghani,Saha MN,Alim AR,Albert MJ,Islam KM,Mekalanos JJ

更新日期：1998-12-01 00:00:00

abstract：:Previously, we identified five genes (Cj1321 to Cj1326, of which Cj1325 and Cj1326 are a single gene) in the O-linked flagellin glycosylation island that are highly prevalent in Campylobacter jejuni isolates from chickens. We report mutagenesis, functional, and structural data to confirm that this locus, and Cj1324 in...

journal_title：Infection and immunity

authors： Howard SL,Jagannathan A,Soo EC,Hui JP,Aubry AJ,Ahmed I,Karlyshev A,Kelly JF,Jones MA,Stevens MP,Logan SM,Wren BW

更新日期：2009-06-01 00:00:00

abstract：:The cellular origins of type I and type II interferons released into the circulation of mice with delayed hypersensitivity were investigated. We determined the effect of treatment with various immunosuppressive agents, including cyclophosphamide, cycloheximide, antithymocyte serum, and whole-body X-irradiation, on the...

journal_title：Infection and immunity

authors： Sonnenfeld G,Salvin SB,Youngner JS

更新日期：1977-11-01 00:00:00

abstract：:It was shown in this work that the infectivity of metacyclic forms of Trypanosoma cruzi was affected upon interaction with the monoclonal antibody (10D8), which reacts with a carbohydrate epitope of the 35- and 50-kilodalton (kDa) surface glycoconjugates. The invasion of Vero cells by metacyclic forms of strains Tulah...

journal_title：Infection and immunity

authors： Yoshida N,Mortara RA,Araguth MF,Gonzalez JC,Russo M

更新日期：1989-06-01 00:00:00

abstract：:Human enterotoxigenic Escherichia coli (ETEC) producing colonization factor antigen III (CFA/III) and coli surface antigens 4, 5, and 6 (CS4, CS5, and CS6) of CFA/IV were examined ultrastructurally and for ability to adhere to human small intestinal enterocytes and to cultured human intestinal mucosa. Strains of serot...

journal_title：Infection and immunity

authors： Knutton S,McConnell MM,Rowe B,McNeish AS

更新日期：1989-11-01 00:00:00

abstract：:A zone of extracellular digestion of the mucin layer around Candida albicans blastoconidia was observed by transmission electron microscopy in the jejunum of mice inoculated intragastrically (G. T. Cole, K. R. Seshan, L. M. Pope, and R. J. Yancey, J. Med. Vet. Mycol. 26:173-185, 1988). This observation prompted the hy...

journal_title：Infection and immunity

authors： Colina AR,Aumont F,Deslauriers N,Belhumeur P,de Repentigny L

更新日期：1996-11-01 00:00:00

abstract：:Salmonella strains that lack or overproduce DNA adenine methylase (Dam) elicit a protective immune response to different Salmonella species. To generate vaccines against other bacterial pathogens, the dam genes of Yersinia pseudotuberculosis and Vibrio cholerae were disrupted but found to be essential for viability. O...

journal_title：Infection and immunity

authors： Julio SM,Heithoff DM,Provenzano D,Klose KE,Sinsheimer RL,Low DA,Mahan MJ

更新日期：2001-12-01 00:00:00

abstract：:To assess the humoral immunological responses at the subclass level in shigellosis, specific antibody responses against Shigella dysenteriae 1 lipopolysaccharide (LPS), S. flexneri Y LPS, invasion plasmid-coded protein antigens (Ipa), and Shiga toxin were analyzed. Antibody responses of 41 patients with S. dysenteriae...

journal_title：Infection and immunity

authors： Islam D,Wretlind B,Ryd M,Lindberg AA,Christensson B

更新日期：1995-05-01 00:00:00

abstract：:The gastric spirillum Helicobacter felis, originally isolated from the cat stomach, colonizes the stomachs of germfree rats. Studies were designed to examine the pathological and serological responses of germfree rats inoculated orally with H. felis. At 2 weeks postinoculation, the gastric mucosa of germfree rats had ...

journal_title：Infection and immunity

authors： Fox JG,Lee A,Otto G,Taylor NS,Murphy JC

更新日期：1991-03-01 00:00:00

abstract：:On incubation of rabbit polymorphonuclear leukocytes with the S component of staphylococcal leukocidin at 37 degrees C, the 3H-labeled methyl group of S-adenosyl[methyl-3H]methionine was rapidly incorporated into phospholipid. Subsequently, the methylated phosphatidylcholine was degraded by activated phospholipase A2....

journal_title：Infection and immunity

authors： Noda M,Hirayama T,Matsuda F,Kato I

更新日期：1985-10-01 00:00:00

abstract：:Gram-negative bacterial pathogens utilize virulence-associated secretion systems to inject, or translocate, effector proteins into host cells to manipulate cellular processes and promote bacterial replication. However, translocated bacterial products are sensed by nucleotide binding domain and leucine-rich repeat-cont...

journal_title：Infection and immunity

authors： Zwack EE,Feeley EM,Burton AR,Hu B,Yamamoto M,Kanneganti TD,Bliska JB,Coers J,Brodsky IE

更新日期：2017-09-20 00:00:00

abstract：:Comparison of the susceptibility of outbred OF1 and inbred BALB/c, C57BL/6, DBA/2, and CBA mice to heat-stable toxin (STa) of enterotoxigenic Escherichia coli was made at different levels of induced secretion. STa was able to elicit fluid accumulation into the intestine of each strain of mice; however, quantitatively ...

journal_title：Infection and immunity

authors： Bertin A

更新日期：1992-08-01 00:00:00