PmpG303-311, a protective vaccine epitope that elicits persistent cellular immune responses in Chlamydia muridarum-immune mice.

abstract：:Mice were infected with Chlamydia trachomatis (L2/434) and at various intervals after infection their lymphoid cells were tested directly for cytotoxic activity against Chlamydia-infected L929 cells. In a modified cell-mediated lympholysis assay, splenic, lymph node, and peritoneal exudate cells did not significantly ...

journal_title：Infection and immunity

authors： Pavia CS,Schachter J

更新日期：1983-03-01 00:00:00

abstract：:Burkholderia cenocepacia, a member of the B. cepacia complex, is an opportunistic pathogen that causes serious infections in patients with cystic fibrosis. We identified a six-gene cluster in chromosome 1 encoding a two-component regulatory system (BCAL2831 and BCAL2830) and an HtrA protease (BCAL2829) hypothesized to...

journal_title：Infection and immunity

authors： Flannagan RS,Aubert D,Kooi C,Sokol PA,Valvano MA

更新日期：2007-04-01 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a prominent, food-borne cause of diarrhea, bloody diarrhea, and the hemolytic uremic syndrome in industrialized countries. Most strains of EHEC carry the locus for enterocyte effacement (LEE) pathogenicity island, but a proportion of isolates from patients with severe disea...

journal_title：Infection and immunity

authors： Leyton DL,Sloan J,Hill RE,Doughty S,Hartland EL

更新日期：2003-11-01 00:00:00

abstract：:Previous studies have noted that the prevalence of certain gonococcal colony types is influenced by the physiological state of the human host. Consequently eight different gonococcal strains were passed on clear typing medium, and opaque (Op) and transparent (Tr) variants of heavily pilated (P++) bacteria were selecte...

journal_title：Infection and immunity

authors： Salit IE,Gotschlich EC

更新日期：1978-11-01 00:00:00

abstract：:Natural heterogeneity in the structure of the lipid A portion of lipopolysaccharide (LPS) produces differential effects on the innate immune response. Gram-negative bacterial species produce LPS structures that differ from the classic endotoxic LPS structures. These differences include hypoacylation and hypophosphoryl...

journal_title：Infection and immunity

authors： Chilton PM,Hadel DM,To TT,Mitchell TC,Darveau RP

更新日期：2013-09-01 00:00:00

abstract：:Group A streptococci (GAS) are highly prevalent human pathogens whose primary ecological niche is the superficial epithelial layers of the throat and/or skin. Many GAS strains with a strong tendency to cause pharyngitis are distinct from strains that tend to cause impetigo; thus, genetic differences between them may c...

journal_title：Infection and immunity

authors： Rouchon CN,Ly AT,Noto JP,Luo F,Lizano S,Bessen DE

更新日期：2017-10-18 00:00:00

abstract：:Gender is a significant factor in determining the susceptibility to and severity of pulmonary diseases in both humans and animals. Murine respiratory mycoplasmosis (MRM), due to Mycoplasma pulmonis infection, is an excellent animal model for evaluation of the role of various host factors on the development of acute or...

journal_title：Infection and immunity

authors： Yancey AL,Watson HL,Cartner SC,Simecka JW

更新日期：2001-05-01 00:00:00

abstract：:Using the indirect fluorescein-labeled and indirect peroxidase-antiperoxidase-labeled immunohistochemical techniques, and utilizing both antiserum specific for the beta-subunit of choriogonadotropin and antiserum for the total hormone, we have demonstrated the presence of a choriogonadotropin-like immunoreactive mater...

journal_title：Infection and immunity

authors： Acevedo HF,Slifkin M,Pouchet-Melvin GR,Campbell-Acevedo EA

更新日期：1979-06-01 00:00:00

abstract：:Brucella abortus is recognized by several Toll-like receptor (TLR)-associated pathways triggering proinflammatory responses that affect both the nature and intensity of the immune response. Previously, we demonstrated that B. abortus-mediated dendritic cell (DC) maturation and control of infection are dependent on the...

journal_title：Infection and immunity

authors： de Almeida LA,Macedo GC,Marinho FA,Gomes MT,Corsetti PP,Silva AM,Cassataro J,Giambartolomei GH,Oliveira SC

更新日期：2013-05-01 00:00:00

abstract：:Several monoclonal antibodies directed against gonococcal pili have been used to investigate the potential contribution of anti-pilus antibodies to host defense against gonococcal infection. Included were two antibodies (SM1 and SM2) which reacted with conserved determinants present on pili from all strains tested and...

journal_title：Infection and immunity

authors： Virji M,Heckels JE

更新日期：1985-09-01 00:00:00

abstract：:Immunoglobulin A1 (IgA1) proteases are produced by a number of different species of bacteria which cause infection at human mucosal surfaces. The sole substrate of these proteases is human IgA1. Cleavage is within the hinge region of IgA1, although there is variability in the exact peptide bond within the hinge region...

journal_title：Infection and immunity

authors： Grundy FJ,Plaut AG,Wright A

更新日期：1990-02-01 00:00:00

abstract：:Tuberculosis remains a leading killer worldwide, and new approaches for its treatment and prevention are urgently needed. This effort will benefit greatly from a better understanding of gene regulation in Mycobacterium tuberculosis, particularly with respect to this pathogen's response to its host environment. We exam...

journal_title：Infection and immunity

authors： Purkayastha A,McCue LA,McDonough KA

更新日期：2002-03-01 00:00:00

abstract：:Based upon the lipopolysaccharide (LPS) structure and antigenicity of Shigella group B, a strategy for broad cross-protection against 14 Shigella flexneri serotypes was designed. This strategy involves the use of two S. flexneri serotypes (2a and 3a), which together bear the all of the major antigenic group factors of...

journal_title：Infection and immunity

authors： Noriega FR,Liao FM,Maneval DR,Ren S,Formal SB,Levine MM

更新日期：1999-02-01 00:00:00

abstract：:Immune responses in the guinea pig model are understudied because of a lack of commercial reagents. We have developed a custom-made guinea pig oligonucleotide microarray (81 spots) and have examined the gene expression profile of splenocytes restimulated in vitro from Mycobacterium bovis BCG-vaccinated and naive anima...

journal_title：Infection and immunity

authors： Tree JA,Elmore MJ,Javed S,Williams A,Marsh PD

更新日期：2006-02-01 00:00:00

abstract：:Guinea pigs sensitized by repeated skin testing with potent, merthiolated coccidioidin, equal to Smith standard, exhibited erythema, edema, and an induration-like reaction to intradermal injection of the preparation. No statistically significant migration inhibition of peritoneal exudate macrophages from these animals...

journal_title：Infection and immunity

authors： Sinski JT,Reed GL,Kelley LM,LeFebvre R

更新日期：1973-02-01 00:00:00

abstract：:In this study, the role of the hepatobiliary system in the early pathogenesis of Salmonella enteritidis infection was investigated in a rat model. Intravenous (i.v.) challenge with lipopolysaccharide (LPS) has previously been shown to enhance the translocation of normal gut flora. We first confirmed that LPS can simil...

journal_title：Infection and immunity

authors： Islam AF,Moss ND,Dai Y,Smith MS,Collins AM,Jackson GD

更新日期：2000-01-01 00:00:00

abstract：:Sephadex G-200 filtration was used for fractionating dengue type 2 (DEN-2)-infected suckling mouse brain (SMB) supernatant fluids. The high-molecular-weight fraction, which was eluted in the void volume, showed no increase in type specificity when tested against immune ascitic fluid to the four prototype dengue viruse...

journal_title：Infection and immunity

authors： Cornesky RA,Hammon WM,Atchison RW,Sather GE

更新日期：1972-12-01 00:00:00

abstract：:In its canonical role the reverse transcriptase telomerase recovers the telomeric repeats that are lost during DNA replication. Other locations and activities have been recently described for the telomerase protein subunit TERT in mammalian cells. In the present work, using biochemistry, molecular biology, and electro...

journal_title：Infection and immunity

authors： Campelo R,Díaz Lozano I,Figarella K,Osuna A,Ramírez JL

更新日期：2015-01-01 00:00:00

abstract：:The chemoattraction of Propionibacterium acnes lipase for neutrophils and the effect of lipase inhibitor and two antibiotic agents on the chemotaxis were evaluated. Of the various fractions tested, partially purified lipase (fraction 2c) was the most active cytotaxin produced by P. acnes. Serum mediators were not requ...

journal_title：Infection and immunity

authors： Lee WL,Shalita AR,Suntharalingam K,Fikrig SM

更新日期：1982-01-01 00:00:00

abstract：:Phenethyl alcohol, at the maximum concentration which did not inhibit growth (0.3% [vol/vol]), inhibited the production of alpha-lysin and exoproteases but not that of delta-lysin in Staphylococcus aureus Wood 46. The inhibition of alpha-lysin was reversible, and transient accumulation of cell-associated alpha-lysin o...

journal_title：Infection and immunity

authors： Lee KY,Birkbeck TH

更新日期：1985-01-01 00:00:00

abstract：:Chitinases of pathogens have been proposed as potential targets of vaccines or specific inhibitors. We studied the genomic organization, transcript levels, developmental expression, and biological function of chitinases in the rodent filarial nematode Acanthocheilonema viteae, a model organism for human-pathogenic fil...

journal_title：Infection and immunity

authors： Tachu B,Pillai S,Lucius R,Pogonka T

更新日期：2008-01-01 00:00:00

abstract：:We evaluated sexual recombination in the apicomplexan parasite Theileria parva using genome-wide marker analysis of haploid sporozoite populations obtained from infected Rhipicephalus appendiculatus ticks. Analysis of 231 parasite clones derived by in vitro infection of bovine lymphocytes revealed 48 distinct combinat...

journal_title：Infection and immunity

authors： Katzer F,Ngugi D,Oura C,Bishop RP,Taracha EL,Walker AR,McKeever DJ

更新日期：2006-10-01 00:00:00

abstract：:Rabbit endogenous pyrogens were of about the same molecular size, but showed considerable heterogeneity of their isoelectric points. We attempted to show that this heterogeneity was attributable to variable glycosylation of a single polypeptide chain. When peritoneal exudate cells were stimulated to make pyrogens in t...

journal_title：Infection and immunity

authors： Murphy PA,Cebula TA,Windle BE

更新日期：1981-10-01 00:00:00

abstract：:The selC tRNA gene is a common site for the insertion of pathogenicity islands in a variety of bacterial enteric pathogens. We demonstrate here that Escherichia coli that produces Shiga toxin 2d and does not harbor the locus of enterocyte effacement (LEE) contains, instead, a novel genomic island. In one representativ...

journal_title：Infection and immunity

authors： Schmidt H,Zhang WL,Hemmrich U,Jelacic S,Brunder W,Tarr PI,Dobrindt U,Hacker J,Karch H

更新日期：2001-11-01 00:00:00

abstract：:We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate ...

journal_title：Infection and immunity

authors： Delogu G,Sanguinetti M,Posteraro B,Rocca S,Zanetti S,Fadda G

更新日期：2006-05-01 00:00:00

abstract：:Yersinia pestis evolved from Y. pseudotuberculosis to become the causative agent of bubonic and pneumonic plague. We identified a homolog of the Salmonella enterica serovar Typhimurium lipoprotein (lpp) gene in Yersinia species and prepared lpp gene deletion mutants of Y. pseudotuberculosis YPIII, Y. pestis KIM/D27 (p...

journal_title：Infection and immunity

authors： Sha J,Agar SL,Baze WB,Olano JP,Fadl AA,Erova TE,Wang S,Foltz SM,Suarez G,Motin VL,Chauhan S,Klimpel GR,Peterson JW,Chopra AK

更新日期：2008-04-01 00:00:00

abstract：:Four monoclonal antibodies against Escherichia coli J5 were studied. Each of these monoclonal antibodies reacted with purified lipopolysaccharides from E. coli J5, the deep rough mutant Salmonella minnesota Re595, Agrobacterium tumefaciens, and Pseudomonas aeruginosa PAO1 as well as with the purified lipid A of P. aer...

journal_title：Infection and immunity

authors： Mutharia LM,Crockford G,Bogard WC Jr,Hancock RE

更新日期：1984-09-01 00:00:00

abstract：:Purified Escherichia coli type 1 fimbriae have been shown previously to stimulate T-cell-independent proliferation of human B lymphocytes. The response is mediated by the mannose-specific, lectin-like adhesin protein FimH. Here we show that type 1 fimbriae also stimulate immunoglobulin (Ig) secretion by B cells. The r...

journal_title：Infection and immunity

authors： Ponniah S,Abraham SN,Endres RO

更新日期：1992-12-01 00:00:00

abstract：:Gonococci from opaque colonies have cell wall outer membrane proteins that are lacking from organisms which form transparent colonies. These "colony opacity-associated" proteins are among a group of "minor" proteins that exhibit heat modification of their apparent subunit molecular sizes, are easily extracted by deoxy...

journal_title：Infection and immunity

authors： Swanson J

更新日期：1980-04-01 00:00:00

abstract：:Strains of Corynebacterium ulcerans and Corynebacterium pseudotuberculosis (Corynebacterium ovis) were examined for the production of diphtheria toxin. A majority of C. ulcerans strains (25 of 37) and 1 C. pseudotuberculosis strain (1 of 14) gave a positive Elek test for diphtheria toxin, and for all strains but 1, pr...

journal_title：Infection and immunity

authors： Groman N,Schiller J,Russell J

更新日期：1984-08-01 00:00:00