Abstract:
:Mice were infected with Chlamydia trachomatis (L2/434) and at various intervals after infection their lymphoid cells were tested directly for cytotoxic activity against Chlamydia-infected L929 cells. In a modified cell-mediated lympholysis assay, splenic, lymph node, and peritoneal exudate cells did not significantly cause the destruction of the infected targets, although infection did result in the formation of antichlamydial antibodies. Whereas chlamydial antigens are capable of activating cell-mediated immunity in other experimental models, our results show that either this chlamydial infection does not induce the generation of cytotoxic effector cells or chlamydial antigens are absent from the surface of infected cells.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Pavia CS,Schachter Jdoi
10.1128/IAI.39.3.1271-1274.1983subject
Has Abstractpub_date
1983-03-01 00:00:00pages
1271-4issue
3eissn
0019-9567issn
1098-5522journal_volume
39pub_type
杂志文章abstract::It was previously determined that the type II secretion system (T2SS) promotes the ability of Legionella pneumophila to grow in coculture with amoebae. Here, we discerned the stage of intracellular infection that is potentiated by comparing the wild-type and T2SS mutant legionellae for their capacity to parasitize Aca...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00374-19
更新日期:2019-10-18 00:00:00
abstract::Immunization with the B oligomer of pertussis toxin protected neonatal mice from a lethal respiratory challenge with Bordetella pertussis. All mice immunized with 8 micrograms of B oligomer survived aerosol challenge and had peripheral leukocyte counts and weight gains similar to those of mice immunized with pertussis...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.12.4063-4068.1990
更新日期:1990-12-01 00:00:00
abstract::We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria m...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.3.1799-1803.2004
更新日期:2004-03-01 00:00:00
abstract::Immunoglobulin M antibody to hepatitis A virus (IgM anti-HAV) is found in most patients with acute type A hepatitis. To determine the duration of this IgM response as well as to confirm that IgM anti-HAV is a specific marker for acute infection, we developed a solid-phase radioimmunoassay for IgM anti-HAV. This new as...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::The effect of bile on the expression of cholera toxin (CT) and the major subunit of the toxin-coregulated pilus (TcpA) and on motility was examined in the Vibrio cholerae O1 classical-biotype strains 0395 and 569B. Although the motility of the cells increased significantly in the presence of bile, transcription of the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.3.1131-1134.1997
更新日期:1997-03-01 00:00:00
abstract::Immunoglobulin binding proteins are one of several pathogenicity factors which have been associated with invasive disease caused by group A streptococci. The surface-bound M and M-like proteins of Streptococcus pyogenes are the most characterized of these immunoglobulin binding proteins, and in most cases they bind on...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.8.4851-4857.2001
更新日期:2001-08-01 00:00:00
abstract::The addition of a sonic extract of Capnocytophaga sputigena to the culture fluid to human fibroblasts resulted in an inhibition of cell proliferation. The inhibition was dose-related (200 micrograms/ml caused a 90% inhibition, and 1,000 micrograms/ml caused a complete cessation of growth). The growth inhibition was no...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.27.1.271-275.1980
更新日期:1980-01-01 00:00:00
abstract::In an attempt to understand the mechanism of serum resistance in Actinobacillus pleuropneumoniae, in the present study we examined various interactions among the bacterial surface constituents, serum antibodies, and complement. Analysis of swine sera revealed the presence of anticapsular antibodies in convalescent-pha...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.9.3852-3860.1992
更新日期:1992-09-01 00:00:00
abstract::Ribosomal subunits from Mycobacterium smegmatis were analyzed by using sedimentation velocity, sedimentation equilibrium, and acrylamide gel electrophoresis experiments. These s(20.w) values for the subunits are 48.7S and 28.1S. The molecular weight of the 49S subunit is about 1.65 x 10(6), and that of the 28S subunit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.3.489-496.1974
更新日期:1974-03-01 00:00:00
abstract::Temperate bacteriophage can transfer toxin-encoding genes between bacteria, often resulting in acquired pathogenicity. However, little is known regarding the effects of the eukaryotic host on the phage-pathogen interaction. Using Streptococcus pyogenes as a model, we demonstrate, both in vitro and in vivo, that the eu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.7.3782-3786.2003
更新日期:2003-07-01 00:00:00
abstract::To assess the humoral immunological responses at the subclass level in shigellosis, specific antibody responses against Shigella dysenteriae 1 lipopolysaccharide (LPS), S. flexneri Y LPS, invasion plasmid-coded protein antigens (Ipa), and Shiga toxin were analyzed. Antibody responses of 41 patients with S. dysenteriae...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.5.2054-2061.1995
更新日期:1995-05-01 00:00:00
abstract::We demonstrate that a mucoid, alginate-producing strain of Pseudomonas aeruginosa isolated from the lungs of a cystic fibrosis (CF) patient secretes multiple enzymes with nucleoside diphosphate kinase (Ndk), ATPase, adenylate kinase, 5'-nucleotidase, and ATP-modifying enzymatic activities. The secretion is triggered a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.10.5231-5242.1999
更新日期:1999-10-01 00:00:00
abstract::Cryptococcus neoformans is surrounded by a capsular polysaccharide. There are at least four known serotypes of the polysaccharide. The objective of this study was to produce monoclonal antibodies (MAbs) that could be used to study the distribution of epitopes among the serotypes of C. neoformans. BALB/c mice were immu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.8.1895-1899.1987
更新日期:1987-08-01 00:00:00
abstract::Cytotoxic T lymphocytes (CTL) against herpes simplex virus (HSV) were induced in vitro from human peripheral blood lymphocytes by stimulation with HSV antigen. CTL generated by HSV type 1 (HSV-1) antigen stimulation killed not only HSV-1-infected target cells but also HSV type 2 (HSV-2)-infected target cells, though a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.1.190-197.1983
更新日期:1983-04-01 00:00:00
abstract::Escherichia coli heat-stable enterotoxin (ST) binds to receptors on rat intestinal cells and brush border membranes (BBM). We devised experiments to examine the reversibility of ST binding. We found that both 125I-labeled ST and native ST were spontaneously dissociable from the BBM receptor. Radiolabeled ST bound to B...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.2.329-334.1987
更新日期:1987-02-01 00:00:00
abstract::Porphyromonas gingivalis, a bacterium associated with active chronic periodontitis lesions, produces several proteolytic enzymes that are thought to be involved in host colonization, perturbation of the immune system, and tissue destruction. The aim of the present study was to investigate the contribution of Arg- and ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.8.5166-5172.2001
更新日期:2001-08-01 00:00:00
abstract::Impaired erythropoiesis causes anemia during genetic disorders, chronic disease, and infection. In studies of the underlying mechanisms researchers have increasingly focused on gamma interferon (IFN-gamma). Here, we identified a previously unrecognized role for interleukin-15 (IL-15) in red blood cell homeostasis and ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01836-06
更新日期:2007-05-01 00:00:00
abstract::Although the suckling mouse assay is widely used for the detection of heat-stable Escherichia coli enterotoxin (ST), few data have been published concerning the reproducibility, optimal growth, and test conditions of this assay. Four strains of toxigenic E. coli known to elaborate both heat-labile enterotoxin and ST o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.14.1.95-99.1976
更新日期:1976-07-01 00:00:00
abstract::We have isolated plasma cell hybridomas which secrete monoclonal antibodies directed against Haemophilus ducreyi. Two of these monoclonal antibodies recognize all strains of H. ducreyi tested to date and are capable of detecting the presence of H. ducreyi in skin lesions produced by this pathogen in experimental anima...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.1.196-198.1984
更新日期:1984-04-01 00:00:00
abstract::The cellular origins of type I and type II interferons released into the circulation of mice with delayed hypersensitivity were investigated. We determined the effect of treatment with various immunosuppressive agents, including cyclophosphamide, cycloheximide, antithymocyte serum, and whole-body X-irradiation, on the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.18.2.283-290.1977
更新日期:1977-11-01 00:00:00
abstract::Mycobacterium leprae are killed by myeloperoxidase (or eosinophil peroxidase), H2O2, and a halide, thus suggesting a mechanism for their destruction by peroxidase-containing phagocytes. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.2.534-536.1984
更新日期:1984-05-01 00:00:00
abstract::Interferon regulatory factor 1-deficient (IRF-1(-/-)) mice infected with virulent Brucella abortus 2308 at 5 x 10(5) CFU developed acute hepatitis similar to many natural hosts but, unlike natural hosts, IRF-1(-/-) mice were unable to resolve infection and died. In contrast, IRF-1(-/-) mice survived when infected at 5...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.12.7004-7012.2002
更新日期:2002-12-01 00:00:00
abstract::A simple and convenient method was developed for the preparation of Streptococcus pneumoniae type 14 polysaccharide (Pn14PS)-tetanus toxoid (TT) conjugate vaccines, using terminally linked Pn14PS fragments of different lengths. Native Pn14PS was simultaneously depolymerized and activated for conjugation by partial N-d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.6.2441-2446.1998
更新日期:1998-06-01 00:00:00
abstract::Host-adapted Gram-negative bacterial pathogens from the Pasteurellaceae, Neisseriaceae, and Moraxellaceae families normally reside in the upper respiratory or genitourinary tracts of their hosts and rely on utilizing iron from host transferrin (Tf) for growth and survival. The surface receptor proteins that mediate th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02572-14
更新日期:2015-03-01 00:00:00
abstract::Genetic resistance to lethal infection with Rickettsia tsutsugamushi was studied in over 30 inbred strains, inbred hybrids, and outbred stocks of mice. Inbred mice infected intraperitoneally with the Gilliam strain of R. tsutsugamushi showed three patterns of response: susceptible (A/HeJ, C3H/HeDub, C3H/HeJ, C3H/HeN, ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.19.2.583-588.1978
更新日期:1978-02-01 00:00:00
abstract::Agglutinogen 1 of Bordetella pertussis strain 353/Z (serotype 1) was separated from protective antigen and histamine-sensitizing factor by starch-block electrophoresis. Most of the agglutinogen 1 migrated towards the cathode in starch-block electrophoresis, although some remained near the origin. Fractions containing ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.3.2.243-248.1971
更新日期:1971-02-01 00:00:00
abstract::Growing Streptococcus gordonii Spp+ phase variants, which have normal levels of glucosyltransferase (GTF) activity, use sucrose to promote their accumulation on surfaces by forming a cohesive bacterium-insoluble glucan polymer mass (BPM). Spp- phase variants, which have lower levels of GTF activity, do not form BPMs a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.10.4301-4308.1992
更新日期:1992-10-01 00:00:00
abstract::Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection (STI) gonorrhea, is a growing public health threat for which a vaccine is urgently needed. We characterized the functional role of the gonococcal MetQ protein, which is the methionine binding component of an ABC transporter system, and as...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00898-16
更新日期:2017-01-26 00:00:00
abstract::Moraxella catarrhalis is a causative agent of otitis media in children and lower respiratory tract infections in adults suffering from chronic obstructive pulmonary disease (COPD). This strict human pathogen continues to be a significant cause of disease in this broad spectrum of patients because there is no available...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00294-09
更新日期:2009-10-01 00:00:00
abstract::The immunoprophylactic effect of chemically inactivated Pseudomonas aeruginosa exotoxin A in experimental pseudomonas infections was studied. Exotoxin A toxoids were prepared by Formalin (f-TXD) or glutaraldehyde (g-TXD) treatment. Immunization of mice with three or four doses (10 micrograms each) of f-TXD and the syn...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.2.681-689.1981
更新日期:1981-05-01 00:00:00