Type II Secretion Promotes Bacterial Growth within the Legionella-Containing Vacuole in Infected Amoebae.

abstract：:Two fragments with molecular weights of 111,000 (fragment I) and 59,000 (fragment II) were separated from each other by gel filtration of dithiothreitol and urea-treated, trypsinized derivative toxin (molecular weight, 170,000) of the proteolytic Okra strain of Clostridium botulinum type B on a column of Sephadex G-20...

journal_title：Infection and immunity

authors： Kozaki S,Miyazaki S,Sakaguchi G

更新日期：1977-12-01 00:00:00

abstract：:The mannose-resistant, Proteus-like (MR/P) fimbria, responsible for mannose-resistant hemagglutination, is a virulence factor for uropathogenic Proteus mirabilis. Based on known fimbrial gene organization, we postulated that MrpG, a putative minor subunit of the MR/P fimbria, functions as an adhesin responsible for he...

journal_title：Infection and immunity

authors： Li X,Zhao H,Geymonat L,Bahrani F,Johnson DE,Mobley HL

更新日期：1997-04-01 00:00:00

abstract：:Oral or intravenous inoculation of previously unexposed juvenile and adult ferrets with Campylobacter jejuni uniformly resulted in intestinal colonization lasting 2 to 12 days. Disease varied from mild to moderate diarrhea, which resolved in 2 to 3 days. Orally infected animals developed agglutinin titers of 8 to 256 ...

journal_title：Infection and immunity

authors： Bell JA,Manning DD

更新日期：1990-06-01 00:00:00

abstract：:Rabbits are not usually susceptible to intestinal Shigella infection without extensive pretreatment, including starvation and administration of antimicrobial, antimotility, and toxic agents (carbon tetrachloride). Most animals infected this way die rapidly and do not always develop colonic lesions and signs of dysente...

journal_title：Infection and immunity

authors： Rabbani GH,Albert MJ,Rahman H,Islam M,Mahalanabis D,Kabir I,Alam K,Ansaruzzaman M

更新日期：1995-11-01 00:00:00

abstract：:A murine respiratory infection model was used to study the mechanism of protective immunity to Bordetella pertussis. We found that nude mice, which are deficient in T cells, developed a persistent infection and failed to clear the bacteria after aerosol inoculation. In contrast, normal adult nonimmune mice cleared a r...

journal_title：Infection and immunity

authors： Mills KH,Barnard A,Watkins J,Redhead K

更新日期：1993-02-01 00:00:00

abstract：:Murine monoclonal and rabbit, murine, and human polyclonal antibodies against chlamydial lipopolysaccharide (LPS) were characterized by the passive hemolysis and passive hemolysis inhibition assays and by absorption experiments with LPSs of Chlamydia psittaci, Chlamydia trachomatis, and a recombinant strain of Salmone...

journal_title：Infection and immunity

authors： Brade L,Holst O,Kosma P,Zhang YX,Paulsen H,Krausse R,Brade H

更新日期：1990-01-01 00:00:00

abstract：:Treatment of mouse embryo fibroblasts (MEF) grown in vitro with purified staphylococcal exfoliative toxin (ET) increased the concanavalin A (Con A) agglutinability of MEF 3.5-fold over control cells. Possible explanations for this phenomenon were investigated. ET lacked proteolytic activity on denatured casein. Con A,...

journal_title：Infection and immunity

authors： Rogolsky M,Wiley BB,Keyhani M,Glasgow LA

更新日期：1974-12-01 00:00:00

abstract：:The rate of clearance of Vibrio fetus var. venerealis was measured by using in vivo and in vitro methods. The rate of clearance from the circulating blood increased in immune rabbits and reached a plateau 4 days after immunization. Thereafter in vivo clearance did not increase further despite rising agglutinin titers....

journal_title：Infection and immunity

authors： Carrier SP,Kramer TT

更新日期：1971-06-01 00:00:00

abstract：:The vast majority of cases of gram-negative meningitis in neonates are caused by K1-encapsulated Escherichia coli. The role of the K1 capsule in the pathogenesis of E. coli meningitis was examined with an in vivo model of experimental hematogenous E. coli K1 meningitis and an in vitro model of the blood-brain barrier....

journal_title：Infection and immunity

authors： Hoffman JA,Wass C,Stins MF,Kim KS

更新日期：1999-07-01 00:00:00

abstract：:Ers has been qualified as the PrfA-like transcriptional regulator of Enterococcus faecalis. In a previous study we reported that Ers is important for the survival within macrophages of this opportunist pathogenic bacterium. In the present work we have used proteomic and microarray expression profiling of E. faecalis J...

journal_title：Infection and immunity

authors： Riboulet-Bisson E,Sanguinetti M,Budin-Verneuil A,Auffray Y,Hartke A,Giard JC

更新日期：2008-07-01 00:00:00

abstract：:The skin microenvironment at the site of infection plays a role in the early events that determine protective T helper 1/type 1 immune responses during cutaneous leishmaniasis (CL) infection. During CL in nonhealing BALB/c mice, early interleukin-4 (IL-4) can instruct dendritic cells for protective Th1 immunity. Addit...

journal_title：Infection and immunity

authors： Govender M,Hurdayal R,Martinez-Salazar B,Gqada K,Pillay S,Gcanga L,Passelli K,Nieuwenhuizen NE,Tacchini-Cottier F,Guler R,Brombacher F

更新日期：2018-11-20 00:00:00

abstract：:Subtilase cytotoxin (SubAB) is a recently identified AB5 subunit toxin produced by Shiga-toxigenic Escherichia coli. The A subunit is thought to be a subtilase-like, serine protease, whereas the B subunit binds to the toxin receptor on the cell surface. We cloned the genes from a clinical isolate; the toxin was produc...

journal_title：Infection and immunity

authors： Morinaga N,Yahiro K,Matsuura G,Watanabe M,Nomura F,Moss J,Noda M

更新日期：2007-01-01 00:00:00

abstract：:Encapsulated Staphylococcus aureus strains are more virulent than unencapsulated staphylococci, and this phenomenon has been associated with decreased opsonization of encapsulated bacteria by normal human serum. Peptidoglycan, a major cell wall component of S. aureus, has been shown to promote opsonization of this bac...

journal_title：Infection and immunity

authors： Wilkinson BJ,Sisson SP,Kim Y,Peterson PK

更新日期：1979-12-01 00:00:00

abstract：:Staphylococcus aureus is a pathogen often found in pneumonia and sepsis. In the context of the resistance of this organism to conventional antibiotics, an understanding of the regulation of natural endogenous antimicrobial molecules is of paramount importance. Previous studies have shown that both human and mouse airw...

journal_title：Infection and immunity

authors： McMichael JW,Maxwell AI,Hayashi K,Taylor K,Wallace WA,Govan JR,Dorin JR,Sallenave JM

更新日期：2005-06-01 00:00:00

abstract：:Studies have implicated Gardnerella vaginalis as an important etiological agent in bacterial vaginosis (BV). It produces a cholesterol-dependent cytolysin, vaginolysin (VLY). In this study, we sought to characterize the interaction between vaginal epithelium, G. vaginalis, and VLY using EpiVaginal tissues from MatTek....

journal_title：Infection and immunity

authors： Garcia EM,Kraskauskiene V,Koblinski JE,Jefferson KK

更新日期：2019-03-25 00:00:00

abstract：:Major research efforts are directed towards the development of a better antimycobacterial vaccine. But progress in the field of tuberculosis vaccine development has been hampered by the lack of human in vitro models to assess vaccine immunogenicity and efficacy. New candidate vaccines will have to be evaluated against...

journal_title：Infection and immunity

authors： Kampmann B,Tena GN,Mzazi S,Eley B,Young DB,Levin M

更新日期：2004-11-01 00:00:00

abstract：:Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display little or no attenuation in cultured murine macrophages or mice. These experimental findings conf...

journal_title：Infection and immunity

authors： Alcantara RB,Read RD,Valderas MW,Brown TD,Roop RM 2nd

更新日期：2004-08-01 00:00:00

abstract：:Immunization with Plasmodium sporozoites can elicit high levels of sterile immunity, and neutralizing antibodies from protected hosts are known to target the repeat region of the circumsporozoite (CS) protein on the parasite surface. CS-based subunit vaccines have been hampered by suboptimal immunogenicity and the req...

journal_title：Infection and immunity

authors： Carapau D,Mitchell R,Nacer A,Shaw A,Othoro C,Frevert U,Nardin E

更新日期：2013-12-01 00:00:00

abstract：:EspC is an autotransporter protein secreted by enteropathogenic Escherichia coli (EPEC). The pathogenic role of EspC in EPEC infection is unknown. We have shown that the purified EspC produces enterotoxicity and cytotoxicity; for the latter effect, EspC must be internalized. However, the internalization mechanism is u...

journal_title：Infection and immunity

authors： Vidal JE,Navarro-García F

更新日期：2006-04-01 00:00:00

abstract：:Mucins are high-molecular-weight glycoproteins and major constituents of the mucus layer which covers the airway surface. We have studied the interactions between bacteria, mucins, and epithelial cells from the human respiratory tract. Nontypeable strains of Haemophilus influenzae were found to bind to purified airway...

journal_title：Infection and immunity

authors： Davies J,Carlstedt I,Nilsson AK,Håkansson A,Sabharwal H,van Alphen L,van Ham M,Svanborg C

更新日期：1995-07-01 00:00:00

abstract：:Current efforts to develop plague vaccines focus on LcrV, a polypeptide that resides at the tip of type III secretion needles. LcrV-specific antibodies block Yersinia pestis type III injection of Yop effectors into host immune cells, thereby enabling phagocytes to kill the invading pathogen. Earlier work reported that...

journal_title：Infection and immunity

authors： Miller NC,Quenee LE,Elli D,Ciletti NA,Schneewind O

更新日期：2012-04-01 00:00:00

abstract：:The pathogenesis of Staphylococcus aureus infections is influenced by multiple virulence factors that are expressed under variable conditions, and this has complicated the design of an effective vaccine. Clinical trials that targeted the capsule or clumping factor A (ClfA) failed to protect the recipients against stap...

journal_title：Infection and immunity

authors： Tuchscherr LP,Buzzola FR,Alvarez LP,Lee JC,Sordelli DO

更新日期：2008-12-01 00:00:00

abstract：:Escherichia coli O157:H7 causes food and waterborne enteric infections that can result in hemorrhagic colitis and life-threatening hemolytic uremic syndrome. Intimate adherence of the bacteria to intestinal epithelial cells is mediated by intimin, but E. coli O157:H7 also possess several other putative adhesins, inclu...

journal_title：Infection and immunity

authors： Lloyd SJ,Ritchie JM,Rojas-Lopez M,Blumentritt CA,Popov VL,Greenwich JL,Waldor MK,Torres AG

更新日期：2012-03-01 00:00:00

abstract：:Mice with a null deletion mutation in the gamma interferon (IFN-gamma) receptor gene were used to study the role of IFN-gamma responsiveness during experimental pulmonary cryptococcosis. Cryptococcus neoformans was inoculated intratracheally into mice lacking the IFN-gamma receptor gene (IFN-gammaR-/-) and into contro...

journal_title：Infection and immunity

authors： Chen GH,McDonald RA,Wells JC,Huffnagle GB,Lukacs NW,Toews GB

更新日期：2005-03-01 00:00:00

abstract：:Staphylococcus aureus is an important pathogen of humans and other animals, causing bacteremia, abscesses, endocarditis, and other infectious syndromes. A signature-tagged mutagenesis (STM) system was adapted for use in studying the genes required for in vivo survival of S. aureus. An STM library was ultimately create...

journal_title：Infection and immunity

authors： Schwan WR,Coulter SN,Ng EY,Langhorne MH,Ritchie HD,Brody LL,Westbrock-Wadman S,Bayer AS,Folger KR,Stover CK

更新日期：1998-02-01 00:00:00

abstract：:Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause of human disease. In our study, the TcI strains Colombiana (COL), SylvioX10/4 (SYL), and a cultured clone (TCC) exhibited differe...

journal_title：Infection and immunity

authors： Zago MP,Hosakote YM,Koo SJ,Dhiman M,Piñeyro MD,Parodi-Talice A,Basombrio MA,Robello C,Garg NJ

更新日期：2016-05-24 00:00:00

abstract：:Adhesion of Trichomonas vaginalis is believed to be dependent on four adhesion proteins, which are thought to bind to vaginal epithelial cells in a specific manner with a ligand-receptor type of interaction. However, the specific receptors on the host cell have not yet been identified. In this work, the ability of the...

journal_title：Infection and immunity

authors： Addis MF,Rappelli P,Fiori PL

更新日期：2000-07-01 00:00:00

abstract：:The interaction of Borrelia burgdorferi, the causative agent of Lyme borreliosis, with phagocytic cells induces the activation of NF-kappaB and the expression of proinflammatory cytokines including tumor necrosis factor alpha (TNF-alpha). B. burgdorferi-induced TNF-alpha production is also dependent on the activation ...

journal_title：Infection and immunity

authors： Olson CM,Hedrick MN,Izadi H,Bates TC,Olivera ER,Anguita J

更新日期：2007-01-01 00:00:00

abstract：:Vibrio cholerae causes human infection through ingestion of contaminated food and water, leading to the devastating diarrheal disease cholera. V. cholerae forms matrix-encased aggregates, known as biofilms, in the native aquatic environment. While the formation of V. cholerae biofilms has been well studied, little is ...

journal_title：Infection and immunity

authors： Hay AJ,Zhu J

更新日期：2015-01-01 00:00:00

abstract：:We examined the intracellular growth of 20 strains within six species of Legionella in thioglycolate-elicited peritoneal macrophages from A/J and C57BL/6 mice and a congenic strain derived from them (A.B Lgn1). With the exception of Legionella pneumophila Togus-1 and Bloomington-2, the intracellular growth of the 15 L...

journal_title：Infection and immunity

authors： Miyamoto H,Maruta K,Ogawa M,Beckers MC,Gros P,Yoshida S

更新日期：1996-05-01 00:00:00