Spectrum of Legionella species whose intracellular multiplication in murine macrophages is genetically controlled by Lgn1.


:We examined the intracellular growth of 20 strains within six species of Legionella in thioglycolate-elicited peritoneal macrophages from A/J and C57BL/6 mice and a congenic strain derived from them (A.B Lgn1). With the exception of Legionella pneumophila Togus-1 and Bloomington-2, the intracellular growth of the 15 L. pneumophila strains tested was controlled by Lgn1. However, the intracellular growth of five Legionella species other than L. pneumophila was not under Lgn1's control.


Infect Immun


Infection and immunity


Miyamoto H,Maruta K,Ogawa M,Beckers MC,Gros P,Yoshida S




Has Abstract


1996-05-01 00:00:00












  • Immune response to sheep red blood cells in mice pretreated with mycobacterial fractions.

    abstract::Ten micrograms of trehalose-6,6' -dimycolate (cord factor) injected into the footpads of mice increased the antibody response to sheep red blood cells (SRBC) subsequently injected into the same sites. There is a relationship between the antibody response and the cellular reaction induced locally and in the draining ly...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bekierkunst A,Yarkoni E,Flechner I,Morecki S,Vilkas E,Lederer E

    更新日期:1971-09-01 00:00:00

  • Cellular source of interferons in the circulation of mice with delayed hypersensitivity.

    abstract::The cellular origins of type I and type II interferons released into the circulation of mice with delayed hypersensitivity were investigated. We determined the effect of treatment with various immunosuppressive agents, including cyclophosphamide, cycloheximide, antithymocyte serum, and whole-body X-irradiation, on the...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sonnenfeld G,Salvin SB,Youngner JS

    更新日期:1977-11-01 00:00:00

  • Lipopolysaccharide-induced lethality and cytokine production in aged mice.

    abstract::This study was designed to define the lipopolysaccharide (LPS) sensitivity of aged mice in terms of lethality and cytokine production and to determine down-regulating responses of corticosterone and interleukin 10 (IL-10). The 50% lethal doses of LPS in young (6- to 7-week-old) and aged (98- to 102-week-old) mice were...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Tateda K,Matsumoto T,Miyazaki S,Yamaguchi K

    更新日期:1996-03-01 00:00:00

  • Immunoglobulin E, a pathogenic factor in Plasmodium falciparum malaria.

    abstract::Most children and adults living in areas where the endemicity of Plasmodium falciparum malaria is high have significantly elevated levels of both total immunoglobulin E (IgE) and IgE antimalarial antibodies in blood. This elevation is highest in patients with cerebral malaria, suggesting a pathogenic role for this imm...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Perlmann P,Perlmann H,Flyg BW,Hagstedt M,Elghazali G,Worku S,Fernandez V,Rutta AS,Troye-Blomberg M

    更新日期:1997-01-01 00:00:00

  • Interactions of gonococci with HeLa cells: attachment, detachment, replication, penetration, and the role of protein II.

    abstract::Colony variants of Neisseria gonorrhoeae differ in their interactions with eucaryotic cells. When gonococci were cultivated with HeLa cell monolayers, the opacity phenotype (Op) became increasingly dominant in the subpopulation of organisms which adhered to the HeLa cells. Once bound, Op organisms displayed very low l...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bessen D,Gotschlich EC

    更新日期:1986-10-01 00:00:00

  • Long-term humoral and cellular immune responses elicited by a heterologous Plasmodium vivax apical membrane antigen 1 protein prime/adenovirus boost immunization protocol.

    abstract::Apical membrane antigen 1 (AMA-1) is an invasion-related Plasmodium antigen that is expressed during both intracellular and extracellular asexual stages of the parasite's life cycle, making it an ideal target for induction of humoral and cellular immune responses that can protect against malaria. We show here that whe...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bouillet LÉ,Dias MO,Dorigo NA,Moura AD,Russell B,Nosten F,Renia L,Braga EM,Gazzinelli RT,Rodrigues MM,Soares IS,Bruna-Romero O

    更新日期:2011-09-01 00:00:00

  • Participation of normal human immunoglobulins M, G, and A in opsonophagocytosis and intracellular killing of Bacteroides fragilis and Bacteroides thetaiotaomicron by human polymorphonuclear leukocytes.

    abstract::Restoration of the ability of hypogammaglobulinemic serum to support opsonophagocytosis and intracellular killing of Bacteroides fragilis and Bacteroides thetaiotaomicron by human polymorphonuclear leukocytes was achieved by supplementation with normal human immunoglobulin M, but not with normal human immunoglobulin G...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bjornson AB,Bjornson HS,Kitko BP

    更新日期:1980-05-01 00:00:00

  • Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by formalin-killed Haemophilus influenzae or its lipooligosaccharide htrB and rfaD mutants.

    abstract::To define the role of nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide (LOS) in the induction of proinflammatory cytokine gene expression during otitis media, we compared the abilities of formalin-killed NTHI strain 2019 and its LOS htrB and rfaD mutants to stimulate human middle ear epithelial (HMEE) cel...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Tong HH,Chen Y,James M,Van Deusen J,Welling DB,DeMaria TF

    更新日期:2001-06-01 00:00:00

  • espC pathogenicity island of enteropathogenic Escherichia coli encodes an enterotoxin.

    abstract::At least five proteins are secreted extracellularly by enteropathogenic Escherichia coli (EPEC), a leading cause of infant diarrhea in developing countries. However only one, EspC, is known to be secreted independently of the type III secretion apparatus encoded by genes located within the 35.6-kb locus of enterocyte ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Mellies JL,Navarro-Garcia F,Okeke I,Frederickson J,Nataro JP,Kaper JB

    更新日期:2001-01-01 00:00:00

  • Mannan-binding lectin enhances susceptibility to visceral leishmaniasis.

    abstract::Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonize...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Santos IK,Costa CH,Krieger H,Feitosa MF,Zurakowski D,Fardin B,Gomes RB,Weiner DL,Harn DA,Ezekowitz RA,Epstein JE

    更新日期:2001-08-01 00:00:00

  • Caspase-1 activation in macrophages infected with Yersinia pestis KIM requires the type III secretion system effector YopJ.

    abstract::Pathogenic Yersinia species utilize a type III secretion system (T3SS) to translocate effectors called Yersinia outer proteins (Yops) into infected host cells. Previous studies demonstrated a role for effector Yops in the inhibition of caspase-1-mediated cell death and secretion of interleukin-1beta (IL-1beta) in naïv...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Lilo S,Zheng Y,Bliska JB

    更新日期:2008-09-01 00:00:00

  • Regulation of virulence by environmental signals in group A streptococci: influence of osmolarity, temperature, gas exchange, and iron limitation on emm transcription.

    abstract::Transcription of the gene encoding the antiphagocytic M protein (emm) of the group A streptococci has been shown to be regulated by CO2 (M. G. Caparon, R. T. Geist, J. Perez-Casal, and J. R. Scott, J. Bacteriol. 174:5693-5701, 1992). We tested the influence of additional environmental growth conditions on emm expressi...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: McIver KS,Heath AS,Scott JR

    更新日期:1995-11-01 00:00:00

  • The phenotypically variable surface protein of Trichomonas vaginalis has a single, tandemly repeated immunodominant epitope.

    abstract::Trichomonas vaginalis is a sexually transmitted protozoan parasite that undergoes phenotypic variation for numerous surface proteins. A monoclonal antibody (MAb) was used to isolate an approximately 400-bp cDNA encoding a fragment of an important phenotypically varying immunogen of T. vaginalis (Mr = 270 kDa; P270). T...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Dailey DC,Alderete JF

    更新日期:1991-06-01 00:00:00

  • Flow microfluorometry analysis of alterations in T-lymphocyte subsets during murine listeriosis.

    abstract::C57BL/6 mice were infected intravenously with 6 X 10(3) Listeria monocytogenes organisms. As early as day 3 of infection, there was a marked reduction in the number of lymphocytes recovered from the peripheral blood, bone marrow, and thymuses of infected animals. Concomitantly, there was an increase in the number of s...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Watson SR,Redington TJ,Miller TB,Bullock WE

    更新日期:1984-08-01 00:00:00

  • Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria.

    abstract::The host immune response plays an important role in the onset and progression of cerebral malaria (CM). The complement system is an essential component of the innate immune response to malaria, and its activation generates the anaphylatoxin C5a. To test the hypothesis that C5a signaling contributes to the pathogenesis...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kim H,Erdman LK,Lu Z,Serghides L,Zhong K,Dhabangi A,Musoke C,Gerard C,Cserti-Gazdewich C,Liles WC,Kain KC

    更新日期:2014-01-01 00:00:00

  • Studies on the effect of starvation on mycobacteria.

    abstract::Ten cultures of Mycobacterium tuberculosis, one of Mycobacterium kansasii (nonsignificant), and one of Mycobacterium phlei were submitted to starvation. As a result they lost first their acid fastness and then all other staining affinities but, in this chromophobic state, they survived for at least 2 years and, after ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Nyka W

    更新日期:1974-05-01 00:00:00

  • Intraspleen delivery of a DNA vaccine coding for superoxide dismutase (SOD) of Brucella abortus induces SOD-specific CD4+ and CD8+ T cells.

    abstract::In the development of vaccines capable of providing immunity against brucellosis, Cu-Zn superoxide dismutase (SOD) has been demonstrated to be one of the protective immunogens of Brucella abortus. In an earlier study, we provided strong evidence that intramuscular injection with a plasmid DNA carrying the SOD gene (pc...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Muñoz-Montesino C,Andrews E,Rivers R,González-Smith A,Moraga-Cid G,Folch H,Céspedes S,Oñate AA

    更新日期:2004-04-01 00:00:00

  • Viral infections in renal transplant recipients.

    abstract::Cytomegalovirus (CMV) infections are common in renal transplant recipients. We studied 23 recipients prospectively to determine whether infections by other herpes-group and non-herpes-group viruses were also present. Sera, obtained at the time of surgery and periodically thereafter, were tested for antibody to CMV, he...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Armstrong JA,Evans AS,Rao N,Ho M

    更新日期:1976-10-01 00:00:00

  • Experimental cryptococcosis in normal and B-cell-deficient mice.

    abstract::B-cell-deficient mice were prepared by administration of rabbit anti-mouse-mu antiserum to newborn animals within 12 h of birth onwards. Such immunodeficient animals, along with the normal controls, were infected intravenously with Cryptococcus neoformans. There was no difference in the mortality pattern, viable count...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Monga DP,Kumar R,Mohapatra LN,Malaviya AN

    更新日期:1979-10-01 00:00:00

  • Functional transfer of Salmonella pathogenicity island 2 to Salmonella bongori and Escherichia coli.

    abstract::The type III secretion system (T3SS) encoded by the Salmonella pathogenicity island 2 (SPI2) has a central role in systemic infections by Salmonella enterica and for the intracellular phenotype. Intracellular S. enterica uses the SPI2-encoded T3SS to translocate a set of effector proteins into the host cell, which mod...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Hansen-Wester I,Chakravortty D,Hensel M

    更新日期:2004-05-01 00:00:00

  • New type of exfoliatin obtained from staphylococcal strains, belonging to phage groups other than group II, isolated from patients with impetigo and Ritter's disease.

    abstract::Four strains of Staphylococcus aureus of a phage type other than the second group, isolated from patients with impetigo and Ritter's disease, were found to produce an exotoxin similar to those reported by Melish et al. (1972), Kapral and Miller (1971), and Arbuthnott et al. (1973). This toxin could elicit a general ex...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kondo I,Sakurai S,Sarai Y

    更新日期:1974-10-01 00:00:00

  • B cell activating factor inhibition impairs bacterial immunity by reducing T cell-independent IgM secretion.

    abstract::B cell activating factor of the tumor necrosis factor family (BAFF) is an essential survival factor for B cells and has been shown to regulate T cell-independent (TI) IgM production. During Ehrlichia muris infection, TI IgM secretion in the spleen was BAFF dependent, and antibody-mediated BAFF neutralization led to an...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Jones DD,Jones M,DeIulio GA,Racine R,MacNamara KC,Winslow GM

    更新日期:2013-12-01 00:00:00

  • Adhesion-dependent activation of mucosal interleukin-6 production.

    abstract::Mucosal exposure to Escherichia coli elicits an inflammatory response in the urinary tract. Interleukin-6 (IL-6) is secreted into the urine, and polymorphonuclear leukocytes (PMNLs) are recruited to the site of infection. This study analyzed the ability of mucosally administered bacterial components to activate IL-6 a...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Linder H,Engberg I,Hoschützky H,Mattsby-Baltzer I,Svanborg C

    更新日期:1991-12-01 00:00:00

  • Role of Nramp1 deletion in Chlamydia infection in mice.

    abstract::Elicited macrophages from 129sv mice with a functional deletion of the natural-resistance-associated macrophage protein 1 gene (Nramp1) were shown to be as susceptible as wild-type mice to infection with the Chlamydia trachomatis mouse pneumonitis and L3 serovars and to Chlamydia pneumoniae. Furthermore, the two group...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Pal S,Peterson EM,de La Maza LM

    更新日期:2000-08-01 00:00:00

  • Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates.

    abstract::Phagocytosis and mechanisms of killing of Aspergillus fumigatus conidia by murine alveolar macrophages (AM), which are the main phagocytic cells of the innate immunity of the lung, were investigated. Engulfment of conidia by murine AM lasts 2 h. Killing of A. fumigatus conidia by AM begins after 6 h of phagocytosis. S...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Philippe B,Ibrahim-Granet O,Prévost MC,Gougerot-Pocidalo MA,Sanchez Perez M,Van der Meeren A,Latgé JP

    更新日期:2003-06-01 00:00:00

  • Glucosyltransferases of viridans streptococci are modulins of interleukin-6 induction in infective endocarditis.

    abstract::The glucosyltransferases (GTFs) of viridans streptococci, common pathogens of infective endocarditis, are extracellular proteins that convert sucrose into exopolysaccharides and glucans. GTFs B, C, and D of Streptococcus mutans are modulins that induce, in vitro and in vivo, the production of cytokines, in particular ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Shun CT,Lu SY,Yeh CY,Chiang CP,Chia JS,Chen JY

    更新日期:2005-06-01 00:00:00

  • Factors affecting filamentation in Candida albicans: changes in respiratory activity of Candida albicans during filamentation.

    abstract::Glucose metabolism and respiration of Candida albicans were compared under conditions which permitted either maximal filamentous or maximal yeast growth. Changes in metabolism were monitored by comparing the quantities of ethanol produced, CO2 evolved, and oxygen consumed. Filamenting cultures produced more ethanol an...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Land GA,McDonald WC,Stjernholm RL,Friedman L

    更新日期:1975-07-01 00:00:00

  • Human response to Escherichia coli O157:H7 infection: antibodies to secreted virulence factors.

    abstract::Vaccination has been proposed for the prevention of disease due to enterohemorrhagic Escherichia coli (EHEC), but the immune response following human infection, including the choice of potential antigens, has not been well characterized. To study this, sera were obtained from five pediatric patients with acute diarrhe...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Li Y,Frey E,Mackenzie AM,Finlay BB

    更新日期:2000-09-01 00:00:00

  • Purification and characterization of a high-molecular-weight outer membrane protein of Moraxella (Branhamella) catarrhalis.

    abstract::Moraxella (Branhamella) catarrhalis is an important bacterial cause of otitis media in children and lower respiratory tract infections in adults. In this study, we describe the presence of a novel high-molecular-weight outer membrane protein (HMW-OMP). This protein varies from 350 to 720 kDa in apparent molecular mass...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Klingman KL,Murphy TF

    更新日期:1994-04-01 00:00:00

  • Macrophage cytophilic antibody in mice: mechanism of action of bacterial lipopolysaccharide on the uptake of immunoglobulins by mouse peritoneal cells.

    abstract::The action of injected bacterial lipopolysaccharide upon the uptake of cytophilic antibodies by macrophages was found to be unrelated either to changes in surface charge or to the rate of anaerobic glycolysis of these cells. It is apparently mediated by alterations in the levels of material in the serum which enhances...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Tizard IR

    更新日期:1971-10-01 00:00:00