Cell-mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model.

abstract：:Cathepsin G (CatG) is a serine protease found in the azurophilic granules of monocytes that is known to have antimicrobial properties, but its role in Mycobacterium tuberculosis infection is unknown. We found that M. tuberculosis infection of human THP-1 monocytic cells induced the down-regulation of CatG mRNA express...

journal_title：Infection and immunity

authors： Rivera-Marrero CA,Stewart J,Shafer WM,Roman J

更新日期：2004-10-01 00:00:00

abstract：:The cell surface of Chlamydia psittaci seems important for establishing infection since (i) UV-treated elementary bodies (EB) attach to and are ingested by L cells and (ii) heat or antibody treatment decreases attachment to L cells and promotes the fusion of chlamydiae-containing phagosomes with lysosomes in macrophag...

journal_title：Infection and immunity

authors： Eissenberg LG,Wyrick PB,Davis CH,Rumpp JW

更新日期：1983-05-01 00:00:00

abstract：:A major problem in the study of chlamydial genital infections in animal models has been the use of varied doses of chlamydiae for infection in different laboratories. It is clearly desirable to use a dose which approximates that of natural sexual infection, but that dose to date has not been determined because of the ...

journal_title：Infection and immunity

authors： Rank RG,Bowlin AK,Reed RL,Darville T

更新日期：2003-11-01 00:00:00

abstract：:Resistance to phagocytosis is a hallmark of virulent Streptococcus pyogenes (group A streptococcus). Surface-bound C5a peptidase reduces recruitment of phagocytes to the site of infection, and hyaluronic acid capsules and/or the M protein limit the uptake of streptococci. In this study the relative impact of M and M-l...

journal_title：Infection and immunity

authors： Ji Y,Schnitzler N,DeMaster E,Cleary P

更新日期：1998-11-01 00:00:00

abstract：:Cryptococcus neoformans is surrounded by an antiphagocytic polysaccharide capsule whose primary constituent is glucuronoxylomannan (GXM). Three prominent structural features of GXM are single xylosyl and glucuronosyl side chains and O acetylation of the mannose backbone. Isogenic pairs of O-acetyl-positive and O-acety...

journal_title：Infection and immunity

authors： Kozel TR,Levitz SM,Dromer F,Gates MA,Thorkildson P,Janbon G

更新日期：2003-05-01 00:00:00

abstract：:Affinity-purified rabbit polyclonal (PAB96-1) and mouse monoclonal (1G9-1C2) antibodies to synthetic H-DDDDDDD-OH, an antimicrobial anionic peptide (AP) originally isolated from ovine pulmonary surfactant, were prepared and used to assess the concentrations of AP-like molecules in human respiratory tract samples. In b...

journal_title：Infection and immunity

authors： Brogden KA,Ackermann MR,McCray PB Jr,Huttner KM

更新日期：1999-08-01 00:00:00

abstract：:To analyze the role of interleukin-10 (IL-10) in bacterial cerebral infections, we studied cerebral listeriosis in IL-10-deficient (IL-10(-/-)) and wild-type (WT) mice, the latter of which express high levels of IL-10 in both primary and secondary cerebral listeriosis. IL-10(-/-) mice succumbed to primary as well as s...

journal_title：Infection and immunity

authors： Deckert M,Soltek S,Geginat G,Lütjen S,Montesinos-Rongen M,Hof H,Schlüter D

更新日期：2001-07-01 00:00:00

abstract：:ExoU is a potent effector protein that causes rapid host cell death upon injection by the type III secretion system of Pseudomonas aeruginosa. The N-terminal half of ExoU contains a patatin-like phospholipase A(2) (PLA(2)) domain that requires the host cell cofactor superoxide dismutase 1 (SOD1) for activation, while ...

journal_title：Infection and immunity

authors： Veesenmeyer JL,Howell H,Halavaty AS,Ahrens S,Anderson WF,Hauser AR

更新日期：2010-08-01 00:00:00

abstract：:Passive protection, the administration of antibodies to prevent infection, has garnered significant interest in recent years as a potential prophylactic countermeasure to decrease the prevalence of hospital-acquired infections. Pili, polymerized protein structures covalently anchored to the peptidoglycan wall of many ...

journal_title：Infection and immunity

authors： Pinkston KL,Singh KV,Gao P,Wilganowski N,Robinson H,Ghosh S,Azhdarinia A,Sevick-Muraca EM,Murray BE,Harvey BR

更新日期：2014-04-01 00:00:00

abstract：:Staphylococcus aureus biofilm formation is induced in iron-restricted growth conditions in vitro. In this study, we showed that Emp and Eap play important roles in low-iron-induced biofilm formation of S. aureus Newman. Eap and Emp are secreted proteins which are non-covalently attached to the S. aureus cell surface a...

journal_title：Infection and immunity

authors： Johnson M,Cockayne A,Morrissey JA

更新日期：2008-04-01 00:00:00

abstract：:Hamster (Mesocricetus auratus) neutrophil granules contain at least four microbicidal peptides belonging to the defensin family. These compounds were purified from granule acid extracts by reverse-phase chromatography and termed HaNP-1 to -4 (hamster neutrophil peptide). HaNP-1 and HaNP-3 revealed the most bactericida...

journal_title：Infection and immunity

authors： Mak P,Wójcik K,Thogersen IB,Dubin A

更新日期：1996-11-01 00:00:00

abstract：:Four glycoproteins of Treponema pallidum were identified by intrinsic [14C]glucosamine labeling. Only two glycoproteins were demonstrated in T. phagedenis biotype Reiter with the same technique. Glycoproteins of both treponemes were characterized as antigens and shown to be localized within the outer membranes of the ...

journal_title：Infection and immunity

authors： Moskophidis M,Müller F

更新日期：1984-12-01 00:00:00

abstract：:Normal bacteria can translocate (migrate) across an intact intestinal mucosa, but the anatomical site of bacterial translocation has not been defined. Gastrointestinal (GI) cross-sections were obtained from mice monoassociated with high cecal concentrations of Escherichia coli, Proteus mirabilis, or Enterococcus faeca...

journal_title：Infection and immunity

authors： Wells CL,Erlandsen SL

更新日期：1991-12-01 00:00:00

abstract：:gamma delta T cells have variously been implicated in the protection against, and the pathogenesis of, malaria, but few studies have examined the gamma delta T-cell response to malaria in African children, who suffer the large majority of malaria-associated morbidity and mortality. This is unfortunate, since available...

journal_title：Infection and immunity

authors： Hviid L,Kurtzhals JA,Adabayeri V,Loizon S,Kemp K,Goka BQ,Lim A,Mercereau-Puijalon O,Akanmori BD,Behr C

更新日期：2001-05-01 00:00:00

abstract：:Whooping cough results from infection of the respiratory tract with Bordetella pertussis, and the secreted adenylate cyclase toxin (ACT) is essential for the bacterium to establish infection. Despite extensive study of the mechanism of ACT cytotoxicity and its effects over a range of concentrations in vitro, ACT has n...

journal_title：Infection and immunity

authors： Eby JC,Gray MC,Warfel JM,Paddock CD,Jones TF,Day SR,Bowden J,Poulter MD,Donato GM,Merkel TJ,Hewlett EL

更新日期：2013-05-01 00:00:00

abstract：:Leishmania amastigotes are intracellular protozoan parasites of mononuclear phagocytes which reside within parasitophorous vacuoles of phagolysosomal origin. The pH of these compartments was studied with the aim of elucidating strategies used by these microorganisms to evade the microbicidal mechanisms of their host c...

journal_title：Infection and immunity

authors： Antoine JC,Prina E,Jouanne C,Bongrand P

更新日期：1990-03-01 00:00:00

abstract：:Recent preclinical and epidemiologic studies have suggested that certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity. To investigate the strain specificity of BCG-induced protective respon...

journal_title：Infection and immunity

authors： Jeon BY,Derrick SC,Lim J,Kolibab K,Dheenadhayalan V,Yang AL,Kreiswirth B,Morris SL

更新日期：2008-11-01 00:00:00

abstract：:The human gastric pathogen Helicobacter pylori modifies host cholesterol via glycosylation and incorporates the glycosylated cholesterol into its membrane; however, the benefits of cholesterol to H. pylori are largely unknown. We speculated that cholesterol in the H. pylori membrane might alter the susceptibility of t...

journal_title：Infection and immunity

authors： Trainor EA,Horton KE,Savage PB,Testerman TL,McGee DJ

更新日期：2011-01-01 00:00:00

abstract：:Mice injected intravenously with a commercially available extract of Coxiella burnetii prepared for use as the antigen in the complement fixation diagnostic test for Q fever were subsequently resistant to infection with Babesia microti, Babesia rodhaini, and Plasmodium vinckei petteri. The parasites appeared to die in...

journal_title：Infection and immunity

authors： Clark IA

更新日期：1979-05-01 00:00:00

abstract：:Yersinia pestis, the causative agent of plague, autoaggregates within a few minutes of cessation of shaking when grown at 28 degrees C. To identify the autoaggregation factor of Y. pestis, we performed mariner-based transposon mutagenesis. Autoaggregation-defective mutants from three different pools were identified, e...

journal_title：Infection and immunity

authors： Felek S,Muszyński A,Carlson RW,Tsang TM,Hinnebusch BJ,Krukonis ES

更新日期：2010-03-01 00:00:00

abstract：:Seven cathepsin B-like cysteine proteases (CBLs) were identified from the immunoprotective excretory-secretory products of Haemonchus contortus. Two-dimensional (2-D) zymography and biotinylated inhibitors were employed to localize active CBLs in 2-D protein gels. Mass spectrometry provided the identification of AC-4,...

journal_title：Infection and immunity

authors： Yatsuda AP,Bakker N,Krijgsveld J,Knox DP,Heck AJ,de Vries E

更新日期：2006-03-01 00:00:00

abstract：:The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced ...

journal_title：Infection and immunity

authors： Barr TA,Heath AW

更新日期：1999-07-01 00:00:00

abstract：:Shigella flexneri is a gram-negative bacterium that causes bacillary dysentery in humans that is characterized by an acute inflammatory response of the colon. The fate of phagocytes that are infected in vitro with virulent Shigella has been the subject of some investigation and debate. In this study we found that viru...

journal_title：Infection and immunity

authors： Koterski JF,Nahvi M,Venkatesan MM,Haimovich B

更新日期：2005-01-01 00:00:00

abstract：:Serotype b-specific polysaccharide antigen (SPA) was extracted from whole cells of Actinobacillus actinomycetemcomitans Y4 by autoclaving and purified by chromatography on DEAE-Sephadex A-25 and Sephacryl S-300. SPA induced the release of monocyte and leukocyte chemotactic factors by human monocytes. Polymyxin B had a...

journal_title：Infection and immunity

authors： Yamaguchi N,Yamashita Y,Ikeda D,Koga T

更新日期：1996-07-01 00:00:00

abstract：:Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA fragmentation characteristic of apoptosis. Macrophage lysis was dependent on a subset of caspases and an intact sipB gene...

journal_title：Infection and immunity

authors： Watson PR,Gautier AV,Paulin SM,Bland AP,Jones PW,Wallis TS

更新日期：2000-06-01 00:00:00

abstract：:Serotypes A and B of the relapsing fever spirochete Borrelia turicatae produce different disease manifestations in infected mice. Whereas serotype B causes more severe arthritis and reaches higher densities in the blood of mice than serotype A, serotype A invades the central nervous system earlier than serotype B duri...

journal_title：Infection and immunity

authors： Pennington PM,Cadavid D,Barbour AG

更新日期：1999-09-01 00:00:00

abstract：:The hydrolysis of urea by ureases of oral bacteria in dental plaque can cause a considerable increase in plaque pH, which can inhibit the development of dental caries. There is also indirect evidence that urea metabolism may promote the formation of calculus and that ammonia release from urea could exacerbate periodon...

journal_title：Infection and immunity

authors： Morou-Bermudez E,Burne RA

更新日期：2000-12-01 00:00:00

abstract：:A series of experiments was conducted to study the influence of embryonal bursectomy (EBX) on the early and late pathogenesis of Marek's disease (MD). The early lytic infection in the lymphoid organs normally associated with oncogenic MD virus infection in intact chickens was not seen in EBX chickens. Therefore, the d...

journal_title：Infection and immunity

authors： Schat KA,Calnek BW,Fabricant J

更新日期：1981-01-01 00:00:00

abstract：:Antibody rises to various virus subcomponents were measured by enzyme-linked immunosorbent assay in the paired sera of volunteers experimentally infected with human coronavirus 229E group viruses. Most of the antibody made during infection was directed against the virus surface projections, with only small amounts of ...

journal_title：Infection and immunity

authors： Macnaughton MR,Hasony HJ,Madge MH,Reed SE

更新日期：1981-03-01 00:00:00

abstract：:Oligopeptides play important roles in bacterial nutrition and signaling. Using sequences from the available genome database for Mycobacterium tuberculosis H37Rv, the oligopeptide permease operon (oppBCDA) of Mycobacterium bovis BCG was cloned from a cosmid library. An opp mutant strain was constructed by homologous re...

journal_title：Infection and immunity

authors： Green RM,Seth A,Connell ND

更新日期：2000-02-01 00:00:00