Isolation, antimicrobial activities, and primary structures of hamster neutrophil defensins.

abstract：:Swine were infected orally with pure cultures of Treponema hyodysenteriae, and the humoral antibody response was measured by a passive hemolysis test (passive hemagglutination test with the use of complement). Antibody to T. hyodysenteriae was detected as early as 1 week and later on at 4 months after exposure. Howeve...

journal_title：Infection and immunity

authors： Jenkins EM,Sinha PP,Vance RT,Reese GL

更新日期：1976-10-01 00:00:00

abstract：:One-day-old chicks were infected orally with two strains of weakly hemolytic spirochetes isolated from a human and a pig with intestinal spirochetosis. These spirochetosis both colonized birds, attached end-on to their cecal enterocytes, induced watery diarrhea, and significantly depressed growth rates. Cultures of Se...

journal_title：Infection and immunity

authors： Trott DJ,McLaren AJ,Hampson DJ

更新日期：1995-09-01 00:00:00

abstract：:Random-bred mice were immunized with a nonliving antigen prepared from mixed-blood forms of Plasmodium berghei, strain NYU-2, in combination with Corynebacterium parvum and/or living BCG. A high proportion of intravenously immunized mice survived virulent challenge, but subcutaneous vaccination was less effective. Vac...

journal_title：Infection and immunity

authors： Murphy JR,Lefford MJ

更新日期：1978-12-01 00:00:00

abstract：:Neisseria meningitidis is the causative agent of meningococcal disease. Onset of meningococcal disease can be extremely rapid and can kill within a matter of hours. However, although a much-feared pathogen, Neisseria meningitidis is frequently found in the nasopharyngeal mucosae of healthy carriers. The bacterial fact...

journal_title：Infection and immunity

authors： Ren X,MacKichan JK

更新日期：2014-12-01 00:00:00

abstract：:Stimulation of the rabbit reticuloendothelial system with viable Mycobacterium bovis (strain BCG), and other agents, had no effect on the development of syphilitic lesions after intradermal or intravenous inoculation with graded doses of Treponema pallidum (virulent Nichol's strain; mean infective doses less than 10)....

journal_title：Infection and immunity

authors： Graves SR,Johnson RC

更新日期：1975-11-01 00:00:00

abstract：:Helicobacter pylori mutants deficient in 6-phosphogluconate dehydratase (6PGD) were constructed. Colonization densities were lower and minimum infectious doses were higher for mutant strains than for wild-type strains. In spite of better colonization, however, wild-type strains did not displace the mutant in cocoloniz...

journal_title：Infection and immunity

authors： Wanken AE,Conway T,Eaton KA

更新日期：2003-05-01 00:00:00

abstract：:We describe here a Sprague-Dawley rat model for chronic osteomyelitis. Staphylococcus aureus and sodium morrhuate were implanted by either microdrilling or direct needle injection into the tibiae of rats. Of 107 rats, 87 (81%) developed osteomyelitis when a high-speed drill was used for implantation, and 27 (51%) of 5...

journal_title：Infection and immunity

authors： Rissing JP,Buxton TB,Weinstein RS,Shockley RK

更新日期：1985-03-01 00:00:00

abstract：:Treatment of Rickettsia prowazekii-infected L929 cells with gamma interferon (IFN-gamma) immediately after infection altered the lipid metabolism of the host cells as determined by measurement of phospholipid hydrolysis and oleic acid incorporation into phospholipids and neutral lipids. At 48 h postinfection, there wa...

journal_title：Infection and immunity

authors： Winkler HH,Day L,Daugherty R,Turco J

更新日期：1993-08-01 00:00:00

abstract：:In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously, we showed a transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) concentration in serum during systemic Salmonella enterica serovar T...

journal_title：Infection and immunity

authors： Bourgeois JS,Zhou D,Thurston TLM,Gilchrist JJ,Ko DC

更新日期：2018-08-22 00:00:00

abstract：:Gonococci do not readily cause disseminated infection in mice. To simulate some of the conditions leading to disseminated gonococcal infection in women, we suspended gonococci in mucin plus hemoglobin and studied the development of gonococcal bacteremia. The mucin-hemoglobin mixture was used because the menstruum appe...

journal_title：Infection and immunity

authors： Corbeil LB,Wunderlich AC,Corbeil RR,McCutchan JA,Ito JI Jr,Braude AI

更新日期：1979-12-01 00:00:00

abstract：:Pseudomonas aeruginosa is a leading cause of hospital-acquired pneumonia and chronic lung infections in cystic fibrosis patients. Iron is essential for bacterial growth, and P. aeruginosa expresses multiple iron uptake systems, whose role in lung infection deserves further investigation. P. aeruginosa Fe(3+) uptake sy...

journal_title：Infection and immunity

authors： Minandri F,Imperi F,Frangipani E,Bonchi C,Visaggio D,Facchini M,Pasquali P,Bragonzi A,Visca P

更新日期：2016-07-21 00:00:00

abstract：:A preparation procedure for scanning electron microscopy was developed by which gononcoccal colonies can be studied directly on the agar surface. After glutaraldehyde fixation directly in petri dishes, small agar pieces were cut out and dehydrated stepwise in increasing concentrations of ethanol. The blocks were there...

journal_title：Infection and immunity

authors： Elmros T,Hörstedt P,Winblad B

更新日期：1975-09-01 00:00:00

abstract：:Fusobacterium nucleatum is a common oral anaerobe involved in periodontitis that is known to translocate and cause intrauterine infections. In the oral environment, F. nucleatum adheres to a large diversity of species, facilitating their colonization and creating biological bridges that stabilize the multispecies dent...

journal_title：Infection and immunity

authors： Coppenhagen-Glazer S,Sol A,Abed J,Naor R,Zhang X,Han YW,Bachrach G

更新日期：2015-03-01 00:00:00

abstract：:The intravascular trematode Schistosoma mansoni is a causative agent of schistosomiasis, a disease that constitutes a major health problem globally. In this study we cloned and characterized the schistosome tegumental phosphodiesterase SmNPP-5 and evaluated its role in parasite virulence. SmNPP-5 is a 52.5-kDa protein...

journal_title：Infection and immunity

authors： Bhardwaj R,Krautz-Peterson G,Da'dara A,Tzipori S,Skelly PJ

更新日期：2011-10-01 00:00:00

abstract：:Tuberculosis remains a leading killer worldwide, and new approaches for its treatment and prevention are urgently needed. This effort will benefit greatly from a better understanding of gene regulation in Mycobacterium tuberculosis, particularly with respect to this pathogen's response to its host environment. We exam...

journal_title：Infection and immunity

authors： Purkayastha A,McCue LA,McDonough KA

更新日期：2002-03-01 00:00:00

abstract：:Pathogen attachment to host cells is a key process during infection, and inhibition of pathogen adhesion is a promising approach to the prevention of infectious disease. We have previously shown that multivalent adhesion molecules (MAMs) are abundant in both pathogenic and commensal bacterial species, mediate early at...

journal_title：Infection and immunity

authors： Al-Saedi F,Stones DH,Vaz DP,Krachler AM

更新日期：2016-05-24 00:00:00

abstract：:Humans infected with the dimorphic fungus Blastomyces dermatitidis develop strong T-lymphocyte responses to WI-1, an immunodominant antigen that has been shown to elicit protective immunity in mice. In the present study, the T-cell epitopes of WI-1 and human leukocyte antigen (HLA) restricting elements that display th...

journal_title：Infection and immunity

authors： Chang WL,Audet RG,Aizenstein BD,Hogan LH,DeMars RI,Klein BS

更新日期：2000-02-01 00:00:00

abstract：:The addition of a sonic extract of Capnocytophaga sputigena to the culture fluid to human fibroblasts resulted in an inhibition of cell proliferation. The inhibition was dose-related (200 micrograms/ml caused a 90% inhibition, and 1,000 micrograms/ml caused a complete cessation of growth). The growth inhibition was no...

journal_title：Infection and immunity

authors： Stevens RH,Sela MN,Shapira J,Hammond BF

更新日期：1980-01-01 00:00:00

abstract：:Vibrio mimicus 61892, isolated in 1977 from a case of watery diarrhea in Bangladesh, produces an enterotoxin which possesses activity in Y-1 mouse adrenal cells and in rabbit ileal loops which is identical to the prototype cholera toxin (CT) produced by Vibrio cholerae 569B. The neutralization of the adrenal cell acti...

journal_title：Infection and immunity

authors： Spira WM,Fedorka-Cray PJ

更新日期：1983-11-01 00:00:00

abstract：:The in vitro effects of Pseudomonas aeruginosa elastase (P. aeruginosa E) and of human leukocyte elastase on human airway lysozyme (HAL) were investigated. P. aeruginosa E inactivated and cleaved HAL, whereas human leukocyte elastase had no effect. Total inactivation of HAL by P. aeruginosa E was observed after 120 mi...

journal_title：Infection and immunity

authors： Jacquot J,Tournier JM,Puchelle E

更新日期：1985-02-01 00:00:00

abstract：:All of the Salmonella enteritidis strains isolated from diseased animals (61 strains) and from beef (2 strains) in Japan and in West Germany (1 strain), except for 2 strains isolated from ducks, harbored either a 36-megadalton (Md) plasmid alone or in combination with several other plasmids of different sizes. It is l...

journal_title：Infection and immunity

authors： Nakamura M,Sato S,Ohya T,Suzuki S,Ikeda S

更新日期：1985-03-01 00:00:00

abstract：:Spleen cell cultures from guinea pigs given legionella pneumophila vaccine in complete Freund adjuvant or as a sublethal infection were inhibited in their migration activity in vitro when incubated with specific antigen. Both direct and indirect migration inhibition assays revealed sensitization of the guinea pigs to ...

journal_title：Infection and immunity

authors： Friedman H,Widen R,Lee I,Klein T

更新日期：1983-09-01 00:00:00

abstract：:Interleukin-1 receptor (IL1R)-associated kinase 4 (IRAK4) is a member of the IRAK family and has an important role in inducing the production of inflammatory mediators. This kinase is downstream of MyD88, an adaptor protein essential for Toll-like receptor (TLR) function. We investigated the role of this kinase in IRA...

journal_title：Infection and immunity

authors： Béla SR,Dutra MS,Mui E,Montpetit A,Oliveira FS,Oliveira SC,Arantes RM,Antonelli LR,McLeod R,Gazzinelli RT

更新日期：2012-12-01 00:00:00

abstract：:Development of an effective vaccine against Leishmania infection is a priority of tropical disease research. We have recently demonstrated protection against Leishmania major in the murine and nonhuman primate models with individual or combinations of purified leishmanial recombinant antigens delivered as plasmid DNA ...

journal_title：Infection and immunity

authors： Coler RN,Skeiky YA,Bernards K,Greeson K,Carter D,Cornellison CD,Modabber F,Campos-Neto A,Reed SG

更新日期：2002-08-01 00:00:00

abstract：:Purified beta-toxin from Clostridium perfringens type C was found to be a single polypeptide chain protein with a molecular weight of approximately 30,000. The toxin was heat labile, with 75% of its activity being inactivated by incubation at 50 degrees C for 5 min. Biological activity of the purified toxin was comple...

journal_title：Infection and immunity

authors： Sakurai J,Duncan CL

更新日期：1978-08-01 00:00:00

abstract：:Bordetella dermonecrotizing toxin (DNT) stimulates the assembly of actin stress fibers and focal adhesions by deamidating Gln63 of the small GTPase Rho. To clarify the functional and structural organization of DNT, we cloned and sequenced the DNT gene and examined the functions of various DNT mutants. Our analyses of ...

journal_title：Infection and immunity

authors： Kashimoto T,Katahira J,Cornejo WR,Masuda M,Fukuoh A,Matsuzawa T,Ohnishi T,Horiguchi Y

更新日期：1999-08-01 00:00:00

abstract：:Salmonella enterica serovar Paratyphi A O-specific polysaccharide (O-SP) was activated with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) and bound to tetanus toxoid (TT) with adipic acid dihydrazide as a linker (SPA-TT(1)) or directly (SPA-TT(2)). In mice, these two conjugates elicited high levels of imm...

journal_title：Infection and immunity

authors： Konadu EY,Lin FY,Hó VA,Thuy NT,Van Bay P,Thanh TC,Khiem HB,Trach DD,Karpas AB,Li J,Bryla DA,Robbins JB,Szu SC

更新日期：2000-03-01 00:00:00

abstract：:Two hybrid clones producing monoclonal antibodies (MAbs) raised against the purified enterotoxic hemolysin-phospholipase C (HlyPC) bifunctional molecule of a Vibrio cholerae O139 strain were used to study its enterotoxicity in relation to its hemolytic and enzymatic activities. Fab fragments of MAbs from ascites produ...

journal_title：Infection and immunity

authors： Pal S,Datta A,Nair GB,Guhathakurta B

更新日期：1998-08-01 00:00:00

abstract：:Resistance to cutaneous syphilitic reinfection in strain 2 and strain 13 guinea pigs developed gradually 3 to 7 months after primary infection and reached maximum levels at 6 to 7 months after the induction of primary cutaneous disease. Associated with this acquired resistance was the occurrence of Arthus reactions an...

journal_title：Infection and immunity

authors： Pavia CS,Niederbuhl CJ

更新日期：1985-10-01 00:00:00

abstract：:After oral feeding of mice with avirulent Salmonella, Escherichia coli, or hybrid strains, only certain bacterial strains were able to multiply and persist within the small intestinal Peyer's patches. After oral vaccination alone, or oral priming and subsequent parenteral boosting, antibody class and titers were detec...

journal_title：Infection and immunity

authors： Hohmann A,Schmidt G,Rowley D

更新日期：1979-07-01 00:00:00