Abstract:
:Recent preclinical and epidemiologic studies have suggested that certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity. To investigate the strain specificity of BCG-induced protective responses in a murine model of pulmonary tuberculosis, C57BL/6 mice were vaccinated with BCG vaccine and then challenged 2 months later with one of nine M. tuberculosis isolates. Four of these strains were from the W-Beijing lineage (HN878, N4, NHN5, and ChS) while four were non-Beijing-type isolates (C913, CDC1551, NY669, and NY920). As a control, the WHO standard M. tuberculosis Erdman strain was evaluated in these vaccination/challenge experiments. To assess the protective responses evoked by BCG immunization, organ bacterial burdens and lung pathology were assessed in vaccinated and naïve mice at 4, 12, and 20 weeks postchallenge as well as during the day of infection. At 4 weeks after the aerosol challenge with each of these strains, significantly reduced bacterial growth in the lungs and spleens and significantly improved lung pathology were seen in all vaccinated animals compared to naïve controls. After 12 weeks, reduced organ bacterial burdens were detected in vaccinated animals infected with six of nine challenge strains. Although lung CFU values were lower in vaccinated mice for only three of nine groups at 20 weeks postchallenge, significantly decreased lung inflammation was seen in all immunized animals relative to controls at 20 weeks postchallenge. Taken together, these data demonstrate that BCG vaccination protects against infection with diverse M. tuberculosis strains in the mouse model of pulmonary tuberculosis and suggest that strain-specific resistance to BCG-induced protective immunity may be uncommon.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Jeon BY,Derrick SC,Lim J,Kolibab K,Dheenadhayalan V,Yang AL,Kreiswirth B,Morris SLdoi
10.1128/IAI.00019-08subject
Has Abstractpub_date
2008-11-01 00:00:00pages
5173-80issue
11eissn
0019-9567issn
1098-5522pii
IAI.00019-08journal_volume
76pub_type
杂志文章abstract::The adherence of Plasmodium falciparum-infected red blood cells (IRBCs) in the human placenta is mediated by chondroitin-4-sulfate (C4S). Although IRBC binding to C4S has been unequivocally established, the adherence characteristics of IRBCs at different stages of parasite development and through successive parasite g...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00478-07
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abstract::Hemolytic-uremic syndrome (HUS) results from infection by Shiga toxin (Stx)-producing Escherichia coli and is the most common cause of acute renal failure in children. We have developed a mouse model of HUS by administering endotoxin-free Stx2 in multiple doses over 7 to 8 days. At sacrifice, moribund animals demonstr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00592-08
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.5.2241-2249.1999
更新日期:1999-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.9.3753-3760.1994
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.3.867-869.1984
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.3.764-775.1991
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.5.2.203-212.1972
更新日期:1972-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.4.2344-2350.2005
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journal_title:Infection and immunity
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更新日期:2005-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.10.3993-3999.1996
更新日期:1996-10-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01339-09
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.8.1924-1926.1987
更新日期:1987-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.9.5817-5826.2005
更新日期:2005-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.10.3187-3193.1990
更新日期:1990-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.3.1194-1200.1999
更新日期:1999-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.7.4242-4247.2001
更新日期:2001-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.2.458-463.1984
更新日期:1984-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.2.739-744.1982
更新日期:1982-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.2.396-401.1977
更新日期:1977-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.1.127-135.1982
更新日期:1982-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.12.7247-7256.2004
更新日期:2004-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.5.1747-1755.1992
更新日期:1992-05-01 00:00:00
abstract::The results of a test of endotoxic potency based upon the development of histamine hypersensitivity in mice were compared with the results obtained by testing the same materials for pyrogenicity in rabbits and lethality for chicken embryos (CELD50). The results of the histamine hypersensitization test (HHT) correlated...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.18.2.352-355.1977
更新日期:1977-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.34.3.1008-1017.1981
更新日期:1981-12-01 00:00:00
abstract::Human serum at low concentrations inhibits the growth of Cryptococcus neoformans in vitro. Fractionation of serum yielded a purified inhibitory protein with a molecular mass of approximately 81.8 kDa, a pI of approximately 6.2, and an amino acid sequence that matched that of human transferrin. The inhibitory activity ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.6.3787-3791.2000
更新日期:2000-06-01 00:00:00
abstract::Conventionally raised suckling mice were injected intragastrically with 10(5) spores of a Clostridium botulinum type A culture. Botulism was not observed, but 80% or more of mice challenged when 8 to 11 days old had botulinum toxin in the large intestine 3 days later. Mice younger than 7 days or older than 15 days wer...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.1.59-63.1978
更新日期:1978-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.2.757-758.1994
更新日期:1994-02-01 00:00:00