Targeting pili in enterococcal pathogenesis.

abstract：:Streptococcus pneumoniae is the most frequent microbe causing middle ear infection. The pathophysiology of pneumococcal otitis media has been characterized by measurement of local inflammatory mediators such as inflammatory cells, lysozyme, oxidative metabolic products, and inflammatory cytokines. The role of cytokine...

journal_title：Infection and immunity

authors： Sato K,Liebeler CL,Quartey MK,Le CT,Giebink GS

更新日期：1999-04-01 00:00:00

abstract：:Understanding the extent to which genetic factors influence the immune response is important in the development of subunit vaccines. Associations with HLA gene polymorphisms appear insufficient to explain the range of variation in immune responses to vaccines and to infections by major pathogens. In this study of Gamb...

journal_title：Infection and immunity

authors： Jepson A,Banya W,Sisay-Joof F,Hassan-King M,Nunes C,Bennett S,Whittle H

更新日期：1997-03-01 00:00:00

abstract：:In C3H gnotobiotic mice, no significant difference was observed between the translocation of nine clinical isolates of enteropathogenic Campylobacter spp. and that of seven nonisogeneic Escherichia coli strains with or without various determinants of pathogenicity. In addition, there was no correlation found between t...

journal_title：Infection and immunity

authors： Youssef M,Corthier G,Goossens H,Tancrede C,Henry-Amar M,Andremont A

更新日期：1987-04-01 00:00:00

abstract：:A2G mice are genetically resistant to lethal infection with neurotropic and pneumotropic influenza viruses. A possible immunological explanation for this resistance was sought by assessing the effect of cyclophosphamide and X irradiation immunosuppression on the infection of A2G mice with lethal doses of neurovirulent...

journal_title：Infection and immunity

authors： Fiske RA,Klein PA

更新日期：1975-03-01 00:00:00

abstract：:Previously, we isolated a high-molecular-weight immunogenic polysaccharide (designated PS) from Pseudomonas aeruginosa immunotype 1 (IT-1). The method which we used was modified to permit the isolation of a similar PS from P. aeruginosa IT-2. This antigen was composed primarily of carbohydrate, had a complex monosacch...

journal_title：Infection and immunity

authors： Pier GB,Sidberry HF,Sadoff JC

更新日期：1981-11-01 00:00:00

abstract：:Alveolar bone destruction is a characteristic feature of periodontitis. Treponema denticola is known to be involved in periodontitis. To elucidate the role of T. denticola in alveolar bone destruction in periodontitis, the effects of lipooligosaccharide (LOS) from T. denticola on osteoclast formation and on expression...

journal_title：Infection and immunity

authors： Choi BK,Lee HJ,Kang JH,Jeong GJ,Min CK,Yoo YJ

更新日期：2003-01-01 00:00:00

abstract：:Inactivated Marek's disease virus-infected chicken kidney cells and inactivated MSB-1 lymphoblastoid Marek's disease tumor cells were used to immunize chickens as virus- and tumor-associated antigens, respectively. Immune and nonimmune birds were then challenged by exposure to live virulent Marek's disease virus. Both...

journal_title：Infection and immunity

authors： Murthy KK,Calnek BW

更新日期：1979-11-01 00:00:00

abstract：:Helicobacter pylori infection causes severe gastroduodenal diseases in humans. Its virulence is strongly increased by the presence of the cag pathogenicity island (cag PAI). It has been shown that CagA, a major antigen in humans, is translocated to the host cell via a secretion system encoded by the cag PAI. The roles...

journal_title：Infection and immunity

authors： Seydel A,Tasca E,Berti D,Rappuoli R,Del Giudice G,Montecucco C

更新日期：2002-11-01 00:00:00

abstract：:Deoxyribonucleic acid (DNA) base composition, as measured by guanine plus cytosine (G + C) content, was determined in 17 strains of Sporothrix schenckii and Ceratocystis species. The average G + C content for S. schenckii was 54.7 +/- 0.2 mol%. No strain of Ceratocystis, with the exception of C. minor, gave values for...

journal_title：Infection and immunity

authors： Mendonça-Hagler LC,Travassos LR,Lloyd KO,Phaff HJ

更新日期：1974-05-01 00:00:00

abstract：:The initial encounter of Leishmania cells and cells from the immune system is fundamentally important in the outcome of infection and determines disease development or resistance. We evaluated the anti-Leishmania amazonensis response of naive volunteers by using an in vitro priming (IVP) system and comparing the respo...

journal_title：Infection and immunity

authors： Pompeu MM,Brodskyn C,Teixeira MJ,Clarêncio J,Van Weyenberg J,Coelho IC,Cardoso SA,Barral A,Barral-Netto M

更新日期：2001-12-01 00:00:00

abstract：:Antimicrobial peptides (AMPs), such as β-defensins and cathelicidins, are essential components of innate and adaptive immunity owing to their extensive multifunctional activities. However, their role in fungal infection in vivo remains elusive. In this study, we investigated the protective effect of murine β-defensin ...

journal_title：Infection and immunity

authors： Kolar SS,Baidouri H,Hanlon S,McDermott AM

更新日期：2013-08-01 00:00:00

abstract：:We examined the effect of host age and health status on the adherence of mannose-sensitive piliated Escherichia coli K1 to human oral epithelial cells. Mannose-sensitive piliated bacteria adhered in comparable numbers to newborn, older infant, and adult cells (125 +/- 61, 198 +/- 54, and 139 +/- 69 bacteria per cell, ...

journal_title：Infection and immunity

authors： Clegg H,Guerina N,Langermann S,Kessler TW,Guerina V,Goldmann D

更新日期：1984-07-01 00:00:00

abstract：:Recent reports have suggested that oral vaccination of mice against Helicobacter pylori is dependent on a Th1-mediated immune response. However, oral vaccination in mice neither induces sterilizing immunity nor leads to complete protection from disease. Therefore, in this study we investigated whether a systemic subcu...

journal_title：Infection and immunity

authors： Sommer F,Wilken H,Faller G,Lohoff M

更新日期：2004-02-01 00:00:00

abstract：:By crossed immunoelectrophoresis and Western blotting (immunoblotting), it was shown that Borrelia burgdorferi expresses the 60-kilodalton Common Antigen (CA) that is cross-reactive with an equivalent antigen in a wide range of remotely related bacteria. B. burgdorferi CA is strongly immunogenic. A B. burgdorferi geno...

journal_title：Infection and immunity

authors： Hansen K,Bangsborg JM,Fjordvang H,Pedersen NS,Hindersson P

更新日期：1988-08-01 00:00:00

abstract：:In vivo accumulation of D-serine by Escherichia coli CFT073 leads to elevated expression of PAP fimbriae and hemolysin by an unknown mechanism. Loss of D-serine catabolism by CFT073 leads to a competitive advantage during murine urinary tract infection (UTI), but loss of both D- and L-serine catabolism results in atte...

journal_title：Infection and immunity

authors： Anfora AT,Halladin DK,Haugen BJ,Welch RA

更新日期：2008-12-01 00:00:00

abstract：:In vitro, Clostridium perfringens enterotoxin (CPE) binds to human ileal epithelium and induces morphological damage concurrently with reduced short-circuit current, transepithelial resistance, and net water absorption. CPE also binds to the human colon in vitro but causes only slight morphological and transport chang...

journal_title：Infection and immunity

authors： Fernández Miyakawa ME,Pistone Creydt V,Uzal FA,McClane BA,Ibarra C

更新日期：2005-12-01 00:00:00

abstract：:Mortality associated with acute lung injury (ALI) induced by lipopolysaccharide (LPS) remains high in humans, warranting improved treatment and prevention strategies. ALI is characterized by the expression of proinflammatory mediators and extensive neutrophil influx into the lung, followed by severe lung damage. Under...

journal_title：Infection and immunity

authors： Jeyaseelan S,Chu HW,Young SK,Worthen GS

更新日期：2004-12-01 00:00:00

abstract：:The coaggregation-defective (COG-) mutant Actinomyces viscosus T14V(PK455), which is unable to participate in lactose-sensitive adherence, and its COG+ parent were compared to structurally define the mutational loss of cell-associated lectin activity. Immunoelectrophoretic comparisons of crude extracts or isolated fim...

journal_title：Infection and immunity

authors： Cisar JO,Curl SH,Kolenbrander PE,Vatter AE

更新日期：1983-05-01 00:00:00

abstract：:A mutual symbiotic enhancement of growth of Porphyromonas gingivalis and Treponema denticola is described in this report. Brain heart infusion broth supplemented with vitamin K did not support the individual growth of P. gingivalis or T. denticola. However, when inoculated as a mixture, both bacterial species did grow...

journal_title：Infection and immunity

authors： Grenier D

更新日期：1992-12-01 00:00:00

abstract：:Cryptococcus neoformans NIH 409 was cultured in a defined medium containing D-[1-13C]xylose (Xyl), D-[1-13C]mannose (Man), or D-[1-13C]mannitol as the sole carbon source. The distribution of 13C in the Man, Xyl, glucuronic acid (GlcA), and O-acetyl constituents of native and de-O-acetylated glucuronoxylomannan (GXM) w...

journal_title：Infection and immunity

authors： Cherniak R,O'Neill EB,Sheng S

更新日期：1998-06-01 00:00:00

abstract：:Helicobacter pylori infection of the stomach causes an active immune response that includes stimulation of inducible nitric oxide (NO) synthase (iNOS) expression. Although NO can kill H. pylori, the bacterium persists indefinitely, suggesting that NO production is inadequate. We determined if the NO derived from iNOS ...

journal_title：Infection and immunity

authors： Chaturvedi R,Asim M,Lewis ND,Algood HM,Cover TL,Kim PY,Wilson KT

更新日期：2007-09-01 00:00:00

abstract：:Recurrent urinary tract infections (UTIs) are a significant clinical problem for many women; however, host susceptibility factors have not been completely defined. The mouse model of induced UTI provides an experimental environment in which to identify specific host characteristics that are important in initial bacter...

journal_title：Infection and immunity

authors： Hopkins WJ,Gendron-Fitzpatrick A,Balish E,Uehling DT

更新日期：1998-06-01 00:00:00

abstract：:The development of immunological responsiveness to a soluble cercarial antigenic preparation (CAP) from Schistosoma mansoni was analyzed in inbred CBA/J mice infected with cercariae, one or multiple times, or sensitized using CAP. Repeated exposure to 75 cercariae at three weekly intervals (3X-75) or subcutaneous admi...

journal_title：Infection and immunity

authors： Katz SP,Colley DG

更新日期：1976-08-01 00:00:00

abstract：:The addition of a sonic extract of Capnocytophaga sputigena to the culture fluid to human fibroblasts resulted in an inhibition of cell proliferation. The inhibition was dose-related (200 micrograms/ml caused a 90% inhibition, and 1,000 micrograms/ml caused a complete cessation of growth). The growth inhibition was no...

journal_title：Infection and immunity

authors： Stevens RH,Sela MN,Shapira J,Hammond BF

更新日期：1980-01-01 00:00:00

abstract：:Natural antibodies are those immunoglobulin molecules found in mammalian serum that arise in the absence of exposure to environmental pathogens and may comprise an early host defense against invading pathogens. The spirochete Borrelia burgdorferi first encounters natural antibodies when its arthropod vector, Ixodes sc...

journal_title：Infection and immunity

authors： Belperron AA,Bockenstedt LK

更新日期：2001-10-01 00:00:00

abstract：:Streptococcus mutans Ingbritt was grown anaerobically in a chemostat, at a rate (mean generation time, 13 h) similar to that in dental plaque, in a complex medium with excess glucose and at pH values of 6.5, 6.0, and 5.5. The yield of cells was constant at pH 6.5 and 6.0 (2.00 mg/ml) but fell to 1.25 at pH 5.5; Y(gluc...

journal_title：Infection and immunity

authors： Hamilton IR,Ellwood DC

更新日期：1978-02-01 00:00:00

abstract：:Both interleukin-17A (IL-17A) and IL-17F are proinflammatory cytokines that have an important role in intestinal homeostasis via receptor signaling. These cytokines have been characterized in chickens, but very little is known about their receptors and their functional activity. We provide here the first description o...

journal_title：Infection and immunity

authors： Kim WH,Jeong J,Park AR,Yim D,Kim S,Chang HH,Yang SH,Kim DH,Lillehoj HS,Min W

更新日期：2014-09-01 00:00:00

abstract：:A total of 224 strains were serogrouped by coagglutination (COA) and serotyped by protein I enzyme-linked immunosorbent assay (ELISA). Of these strains, 61 were from patients with disseminated gonococcal infection, 21 were from patients with pelvic inflammatory disease, and 115 were from patients with uncomplicated go...

journal_title：Infection and immunity

authors： Sandstrom EG,Knapp JS,Buchanan TB

更新日期：1982-01-01 00:00:00

abstract：:Fibronectin binds to Streptococcus pyogenes, and this binding is inhibited by lipoteichoic acid (LTA). Previous studies have shown that LTA can be released from S. pyogenes by treatment with penicillin. Penicillin released LTA from both S. pyogenes and Staphylococcus aureus; however, the binding of fibronectin correla...

journal_title：Infection and immunity

authors： Nealon TJ,Beachey EH,Courtney HS,Simpson WA

更新日期：1986-02-01 00:00:00

abstract：:Bordetella pertussis fimbriae are composed of a major subunit, Fim2 or Fim3, and the minor subunit FimD. Using immunoelectron microscopy, we provide evidence that FimD is located at the fimbrial tip. The role of FimD in colonization of the mouse respiratory tract was studied by using two fimbrial mutants: a mutant com...

journal_title：Infection and immunity

authors： Geuijen CA,Willems RJ,Bongaerts M,Top J,Gielen H,Mooi FR

更新日期：1997-10-01 00:00:00