Systemic Th1 immunization of mice against Helicobacter pylori infection with CpG oligodeoxynucleotides as adjuvants does not protect from infection but enhances gastritis.

abstract：:Cytokine mRNA expression in biopsies of Mycobacterium ulcerans-infected human tissue was investigated using real-time PCR, and the findings were correlated with the clinical stages of disease and histopathologies. A broad range of cytokine mRNAs were detected in 16 early nodules and 28 late-stage ulcers, including tho...

journal_title：Infection and immunity

authors： Phillips R,Horsfield C,Mangan J,Laing K,Etuaful S,Awuah P,Nyarko K,Osei-Sarpong F,Butcher P,Lucas S,Wansbrough-Jones M

更新日期：2006-05-01 00:00:00

abstract：:Pathogenic strains of Yersinia spp. inject a set of Yop effector proteins into eukaryotic cells by using a plasmid-encoded type III secretion system. In this study, we analyzed the inflammatory response of human umbilical vein endothelial cells (HUVECs) after infection with different Yersinia enterocolitica strains. W...

journal_title：Infection and immunity

authors： Denecker G,Tötemeyer S,Mota LJ,Troisfontaines P,Lambermont I,Youta C,Stainier I,Ackermann M,Cornelis GR

更新日期：2002-07-01 00:00:00

abstract：:The genetics of resistance to a naturally occurring respiratory infection caused by Sendai virus was examined in F1, F2, and backcross progeny of resistant C57BL/6J and susceptible DBA/2J mice and in 25 recombinant inbred strains. An intranasal inoculum of 0.1 50% tissue culture infective dose (low dose) of Sendai vir...

journal_title：Infection and immunity

authors： Brownstein DG

更新日期：1983-07-01 00:00:00

abstract：:Representative strains of oral streptococci were tested for Fc immunoglobulin G (IgG) reactivity by two different techniques, agglutination of rabbit-IgG sensitized sheep erythrocytes and uptake of human and rabbit 125I-radiolabeled IgG. None of the S. mutans serotypes a through e reacted with the Fc region of either ...

journal_title：Infection and immunity

authors： Shea C,Ferretti JJ

更新日期：1981-12-01 00:00:00

abstract：:It has been shown previously that serum from chronically infected patients with cystic fibrosis inhibits the phagocytosis of Pseudomonas aeruginosa by both normal and cystic fibrosis alveolar macrophages. In the present study, the ability of peripheral monocytes and polymorphonuclear leukocytes from normal volunteers ...

journal_title：Infection and immunity

authors： Thomassen MJ,Demko CA,Wood RE,Sherman JM

更新日期：1982-11-01 00:00:00

abstract：:The mechanism of complement-mediated killing of seven serum-sensitive Pseudomonas aeruginosa strains was examined. All seven strains were sensitive to the bactericidal activity of 20% pooled normal human serum (PNHS) containing magnesium EGTA, which blocks the classical complement pathway (CCP), or 20% PNHS preheated ...

journal_title：Infection and immunity

authors： Schiller NL

更新日期：1988-03-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium employs two different type III secretion systems (TTSS) encoded within Salmonella pathogenicity islands 1 and 2 (SPI1 and SPI2) for targeting of effector proteins into the cytosol of eukaryotic cells during different stages of the infection cycle. The SPI1 TTSS translocates viru...

journal_title：Infection and immunity

authors： Panthel K,Meinel KM,Domènech VE,Retzbach H,Igwe EI,Hardt WD,Rüssmann H

更新日期：2005-01-01 00:00:00

abstract：:We demonstrate that transcription of the Staphylococcus aureus collagen adhesin gene (cna) is temporally regulated, with expression being highest in exponentially growing cultures and falling to almost undetectable levels as cultures enter the post-exponential-growth phase. The temporal regulation of cna transcription...

journal_title：Infection and immunity

authors： Gillaspy AF,Patti JM,Smeltzer MS

更新日期：1997-04-01 00:00:00

abstract：:The Toll-like receptor 2 (TLR2)/TLR1 receptor complex responds to amyloid fibrils, a common component of biofilm material produced by members of the phyla Firmicutes, Bacteroidetes, and Proteobacteria. To determine whether this TLR2/TLR1 ligand stimulates inflammatory responses when bacteria enter intestinal tissue, w...

journal_title：Infection and immunity

authors： Nishimori JH,Newman TN,Oppong GO,Rapsinski GJ,Yen JH,Biesecker SG,Wilson RP,Butler BP,Winter MG,Tsolis RM,Ganea D,Tükel Ç

更新日期：2012-12-01 00:00:00

abstract：:Three monoclonal antibodies (MAbs), all of the immunoglobulin G1 subclass, were raised against Cryptococcus neoformans by using the technique of cyclophosphamide ablation of B-cell responses against shared epitopes of the cross-reactive fungus Trichosporon beigelii. MAb 3C2 was reactive against the encapsulated and no...

journal_title：Infection and immunity

authors： Hamilton AJ,Jeavons L,Hobby P,Hay RJ

更新日期：1992-01-01 00:00:00

abstract：:Salmonella species utilize type III secretion systems (T3SSs) to translocate effectors into the cytosol of mammalian host cells, subverting cell signaling and facilitating the onset of gastroenteritis. In this study, we compared a draft genome assembly of Salmonella enterica subsp. salamae strain 3588/07 against the g...

journal_title：Infection and immunity

authors： Pollard DJ,Young JC,Covarelli V,Herrera-León S,Connor TR,Fookes M,Walker D,Echeita A,Thomson NR,Berger CN,Frankel G

更新日期：2016-11-18 00:00:00

abstract：:Mice infected with various strains of Salmonella enteritidis and S. typhimurium were found to be more sensitive to the cell wall lipopolysaccharide (LPS) extracted from certain strains of Salmonella than noninfected mice. This hypersensitivity was induced by those smooth or rough strains which possessed a polysacchari...

journal_title：Infection and immunity

authors： Kawakami M,Hara Y,Osawa N

更新日期：1971-11-01 00:00:00

abstract：:The interaction of Borrelia burgdorferi, the causative agent of Lyme borreliosis, with phagocytic cells induces the activation of NF-kappaB and the expression of proinflammatory cytokines including tumor necrosis factor alpha (TNF-alpha). B. burgdorferi-induced TNF-alpha production is also dependent on the activation ...

journal_title：Infection and immunity

authors： Olson CM,Hedrick MN,Izadi H,Bates TC,Olivera ER,Anguita J

更新日期：2007-01-01 00:00:00

abstract：:Although Streptococcus intermedius and Streptococcus mutans are regarded as members of the commensal microflora of the body, S. intermedius is often associated with deep-seated purulent infections, whereas S. mutans is frequently associated with dental caries. In this study, we investigated the roles of the S. mutans ...

journal_title：Infection and immunity

authors： Petersen FC,Assev S,van der Mei HC,Busscher HJ,Scheie AA

更新日期：2002-01-01 00:00:00

abstract：:Pertussis toxin is secreted from Bordetella pertussis with the assistance of the Ptl transport system, a member of the type IV family of macromolecular transporters. The S1 subunit and the B oligomer combine to form the holotoxin prior to export from the bacterial cell, although the site of assembly is not known. To b...

journal_title：Infection and immunity

authors： Farizo KM,Fiddner S,Cheung AM,Burns DL

更新日期：2002-03-01 00:00:00

abstract：:The absolute requirement for elemental iron and the porphyrin nucleus for growth of Haemophilus influenzae led us to investigate the role of iron and hemin in regulation of expression of the H. influenzae transferrin receptor. H. influenzae type b strain H1689 was grown in brain heart infusion broth supplemented with ...

journal_title：Infection and immunity

authors： Morton DJ,Musser JM,Stull TL

更新日期：1993-10-01 00:00:00

abstract：:Mice with disrupted beta 2-microglobulin (beta 2m-/-), I-A (class II-/-), or CD4 (CD4-/-) genes were examined for their capacity to resolve Chlamydia trachomatis genital tract infection. C57BL/6 and beta 2m-/- mice resolved infection similarly and were culture negative by 4 to 5 weeks following infection. Conversely, ...

journal_title：Infection and immunity

authors： Morrison RP,Feilzer K,Tumas DB

更新日期：1995-12-01 00:00:00

abstract：:An immunogenic aminopeptidase was purified from Brucella melitensis strain VTRM1. The purification procedure consisted of ammonium sulfate fractionation and three chromatographic steps. This procedure resulted in a yield of 29% and a 144-fold increase in specific activity. The aminopeptidase appeared to be a monomeric...

journal_title：Infection and immunity

authors： Contreras-Rodriguez A,Ramirez-Zavala B,Contreras A,Schurig GG,Sriranganathan N,Lopez-Merino A

更新日期：2003-09-01 00:00:00

abstract：:The antigens of Haemophilus somnus recognized by convalescent bovine serum were studied by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting with a protein A-peroxidase conjugate. The same two 76K and 40K antigens were predominant in whole-bacterium preparations and in outer-membrane-enric...

journal_title：Infection and immunity

authors： Corbeil LB,Arthur JE,Widders PR,Smith JW,Barbet AF

更新日期：1987-06-01 00:00:00

abstract：:It is not clear how the host initially recognizes and responds to infection by gram-negative pathogenic Brucella spp. It was previously shown (D. S. Weiss, B. Raupach, K. Takeda, S. Akira, and A. Zychlinsky, J. Immunol. 172:4463-4469, 2004) that the early macrophage response against gram-negative bacteria is mediated ...

journal_title：Infection and immunity

authors： Weiss DS,Takeda K,Akira S,Zychlinsky A,Moreno E

更新日期：2005-08-01 00:00:00

abstract：:Extracytoplasmic proteins were released from Serpulina (Treponema) hyodysenteriae (strain B204) by treatment of whole cells with a nonionic detergent (Tween 20). Centrifugation of the Tween 20-released proteins at 100,000 x g sedimented 10 major extracytoplasmic proteins with approximate molecular masses of 44, 43.5, ...

journal_title：Infection and immunity

authors： Gabe JD,Chang RJ,Slomiany R,Andrews WH,McCaman MT

更新日期：1995-01-01 00:00:00

abstract：:Iron starvation conditions limited the growth of Salmonella typhi, as evidenced by an increase in the lag phase of a culture and a decrease in the number of bacteria reached in the stationary phase. The analysis of the outer membrane of bacteria grown under these conditions identified new protein components with appar...

journal_title：Infection and immunity

authors： Fernandez-Beros ME,Gonzalez C,McIntosh MA,Cabello FC

更新日期：1989-04-01 00:00:00

abstract：:Strains of Bacteroides fragilis associated with diarrhea in children (termed enterotoxigenic B. fragilis, or ETBF) produce a heat-labile ca. 20-kDa protein toxin (BFT). The purpose of this study was to examine the activity of BFT on polarized monolayers of human intestinal epithelial cells (T84 cells). In Ussing chamb...

journal_title：Infection and immunity

authors： Chambers FG,Koshy SS,Saidi RF,Clark DP,Moore RD,Sears CL

更新日期：1997-09-01 00:00:00

abstract：:Complement-fixing antibodies were first detected in mice 7 days after intravenous injection with Mycoplasma arthritidis. Peak titers were observed at 21 days, and high levels of antibody persisted through 293 days. The metabolism-inhibiting antibody response was minimal. On fractionation of mouse sera, only 7S antibod...

journal_title：Infection and immunity

authors： Coke BC,Ward JR,Golightly-Rowland C,Trapp GA

更新日期：1971-10-01 00:00:00

abstract：:Culture filtrate from Mycobacterium tuberculosis contains protective antigens of relevance for the generation of a new antituberculosis vaccine. We have identified two previously uncharacterized M. tuberculosis proteins (TB7.3 and TB10.4) from the highly active low-mass fraction of culture filtrate. The molecules were...

journal_title：Infection and immunity

authors： Skjøt RL,Oettinger T,Rosenkrands I,Ravn P,Brock I,Jacobsen S,Andersen P

更新日期：2000-01-01 00:00:00

abstract：:Chemiluminescence of human alveolar macrophages (AM) was evaluated in vitro. Unstimulated AM generated chemiluminescence that remained constant during incubation. Addition of heat-killed Staphylococcus aureus 502A (HKB) or a chemical agent, phorbol myristate acetate, produced high rates of chemiluminescence that were ...

journal_title：Infection and immunity

authors： Beall GD,Repine JE,Hoidal JR,Rasp FL

更新日期：1977-07-01 00:00:00

abstract：:Vibrio cholerae responds to environmental changes by altering the protein composition of its outer membrane. In rich medium, V. cholerae expresses almost exclusively the outer membrane porin OmpU, whereas in minimal medium, OmpT is the dominant porin. The supplementation of a minimal medium with a mixture of asparagin...

journal_title：Infection and immunity

authors： Mey AR,Craig SA,Payne SM

更新日期：2012-02-01 00:00:00

abstract：:In this study we used Escherichia coli strain F11(P155) of porcine origin. The heat-stable enterotoxin (ST) was produced with a batch fermentor under agitation (500 rpm) and forced aeration (5 liters/min) in Casamino Acids yeast extract medium containing 0.2% glucose. The pH varied from 7.2 to 7.8. The maximum amount ...

journal_title：Infection and immunity

authors： Lallier R,Lariviere S,St-Pierre S

更新日期：1980-05-01 00:00:00

abstract：:By using a suckling mouse assay, heat-stable enterotoxin (ST) was purified from the culture filtrate of Yersinia enterocolitica isolated from a diarrheal patient. The purification procedures involve ultrafiltration with an Amicon HIP-10 hollow fiber, ethanol fractionation, protamine sulfate treatment, diethylaminoethy...

journal_title：Infection and immunity

authors： Okamoto K,Inoue T,Ichikawa H,Kawamoto Y,Miyama A

更新日期：1981-02-01 00:00:00

abstract：:Bartonella bacilliformis is the etiologic agent of Oroya fever in humans. Flagellum-mediated motility has been postulated as a major virulence factor for invasion of host cells. To address this hypothesis, we purified and characterized flagella from strain KC584 and then assessed their role in human erythrocyte associ...

journal_title：Infection and immunity

authors： Scherer DC,DeBuron-Connors I,Minnick MF

更新日期：1993-12-01 00:00:00