Phagocytosis of Pseudomonas aeruginosa by polymorphonuclear leukocytes and monocytes: effect of cystic fibrosis serum.

abstract：:Mutation of tryptophan-101 in Clostridium difficile toxin A, a 308-kDa glucosyltransferase, resulted in a 50-fold-reduced cytopathic activity in cell culture experiments. The mutant toxin A was characterized and applied to distinguish between glucosyltransferase-dependent and -independent effects with respect to RhoB ...

journal_title：Infection and immunity

authors： Teichert M,Tatge H,Schoentaube J,Just I,Gerhard R

更新日期：2006-10-01 00:00:00

abstract：:Vitamin D is an important regulator of the expression of antimicrobial peptides, and vitamin D deficiency is associated with respiratory infections. Regulating expression of antimicrobial peptides, such as the human cathelicidin antimicrobial peptide 18 (hCAP18)/LL-37, by vitamin D in bronchial epithelial cells requir...

journal_title：Infection and immunity

authors： Schrumpf JA,van Sterkenburg MA,Verhoosel RM,Zuyderduyn S,Hiemstra PS

更新日期：2012-12-01 00:00:00

abstract：:Most Escherichia coli isolates can express type 1 fimbriae with mannose-specific adhesins. These adhesins bind to the oligosaccharide chains of secretory immunoglobulin A (IgA). Thus, in addition to specific antibody activity, secretory IgA possesses a broad reactivity with bacteria expressing type 1 fimbriae. The abs...

journal_title：Infection and immunity

authors： Friman V,Adlerberth I,Connell H,Svanborg C,Hanson LA,Wold AE

更新日期：1996-07-01 00:00:00

abstract：:Amebic erythrophagocytosis is characteristic of invasive amebiasis, and mutants deficient in erythrocyte ingestion are avirulent. We sought to understand the molecular mechanisms underlying erythrocyte phagocytosis by Entamoeba histolytica. Following adherence to amebae, erythrocytes became round and crenulated, and p...

journal_title：Infection and immunity

authors： Boettner DR,Huston CD,Sullivan JA,Petri WA Jr

更新日期：2005-06-01 00:00:00

abstract：:Pseudomonas aeruginosa, an important opportunistic pathogen of humans, exploits epithelial damage to establish infection. We have rigorously explored the role of N-glycoproteins and heparan sulfate proteoglycans (HSPGs) in P. aeruginosa-mediated attachment and subsequent downstream events at the apical (AP) and basola...

journal_title：Infection and immunity

authors： Bucior I,Mostov K,Engel JN

更新日期：2010-03-01 00:00:00

abstract：:Biofilm formation by the periodontal pathogen Aggregatibacter actinomycetemcomitans is dependent upon autoinducer-2 (AI-2)-mediated quorum sensing. However, the components that link the detection of the AI-2 signal to downstream gene expression have not been determined. One potential regulator is the QseBC two-compone...

journal_title：Infection and immunity

authors： Novak EA,Shao H,Daep CA,Demuth DR

更新日期：2010-07-01 00:00:00

abstract：:Hamster respiratory epithelial cells were cultured in a monolayer format, and 20% of the cells were ciliated. Mycoplasma pneumoniae attached to the epithelial cells in a neuraminidase-specific fashion and induced ciliostasis and cytonecrosis. ...

journal_title：Infection and immunity

authors： Gabridge MG,Gunderson H,Schaeffer SL,Barden-Stahl YD

更新日期：1978-07-01 00:00:00

abstract：:A major problem in the study of chlamydial genital infections in animal models has been the use of varied doses of chlamydiae for infection in different laboratories. It is clearly desirable to use a dose which approximates that of natural sexual infection, but that dose to date has not been determined because of the ...

journal_title：Infection and immunity

authors： Rank RG,Bowlin AK,Reed RL,Darville T

更新日期：2003-11-01 00:00:00

abstract：:In previous work (Jones, Infect, Immun. 30:78-89, 1980) a major cytoplasmic antigen of Candida albicans was identified. In both humans and experimental animals, this antigen is released from C. albicans during the course of an invasive C. albicans infection and elicits a specific antibody response. In this study, we u...

journal_title：Infection and immunity

authors： Greenfield RA,Jones JM

更新日期：1981-11-01 00:00:00

abstract：:Antigen 2 (Ag2), a major immunoreactive component of Coccidioides immitis mycelium- and spherule-phase cell walls, was recently cloned in our laboratory and was shown to elicit T-cell responses in Coccidioides-immune mice. In this investigation, we evaluated recombinant Ag2 (rAg2) and PCR-generated Ag2 truncations for...

journal_title：Infection and immunity

authors： Zhu Y,Tryon V,Magee DM,Cox RA

更新日期：1997-08-01 00:00:00

abstract：:Stimulated polymorphonuclear leukocytes have been shown by this laboratory to release a reactive-oxygen species (ROS) which is detectable in the supernatant and is capable of oxidizing reduced glutathione and reacting with methionine (Sagone et al., Blood 63:96-104, 1984). This ROS is dependent on H2O2 and heme for it...

journal_title：Infection and immunity

authors： Rao MK,Sagone AL Jr

更新日期：1984-03-01 00:00:00

abstract：:Upon infection of a host, the pathogenic fungus Aspergillus fumigatus is attacked by the reactive oxygen species produced by phagocytic cells. Detoxification of hydrogen peroxide by catalases was proposed as a way to overcome this host response. A. fumigatus produces three active catalases; one is produced by conidia,...

journal_title：Infection and immunity

authors： Paris S,Wysong D,Debeaupuis JP,Shibuya K,Philippe B,Diamond RD,Latgé JP

更新日期：2003-06-01 00:00:00

abstract：:Mortality associated with acute lung injury (ALI) induced by lipopolysaccharide (LPS) remains high in humans, warranting improved treatment and prevention strategies. ALI is characterized by the expression of proinflammatory mediators and extensive neutrophil influx into the lung, followed by severe lung damage. Under...

journal_title：Infection and immunity

authors： Jeyaseelan S,Chu HW,Young SK,Worthen GS

更新日期：2004-12-01 00:00:00

abstract：:Cure of amebic liver abscess is associated with resistance to recurrent invasive amebiasis and the development of a humoral and cell-mediated immune response. We determined whether human immune sera contain blocking antibody for the 170-kilodalton (kDa) galactose or N-acetylgalactosamine (Gal/GalNAc)-binding lectin of...

journal_title：Infection and immunity

authors： Petri WA Jr,Joyce MP,Broman J,Smith RD,Murphy CF,Ravdin JI

更新日期：1987-10-01 00:00:00

abstract：:Synthetic oligosaccharides derived from the capsular polysaccharide (PRP) of Haemophilus influenzae type b were conjugated to carrier proteins via a thioether linkage. Conjugates were made of trimeric and tetrameric ribose-ribitol-phosphate and tetanus toxoid or diphtheria toxin. All conjugates elicited anti-PRP antib...

journal_title：Infection and immunity

authors： Peeters CC,Evenberg D,Hoogerhout P,Käyhty H,Saarinen L,van Boeckel CA,van der Marel GA,van Boom JH,Poolman JT

更新日期：1992-05-01 00:00:00

abstract：:Mycobacterium tuberculosis grows within the phagocytic vacuoles of macrophages, where it encounters a moderately acidic and possibly nutrient-restricted environment. Other mycobacterial species encounter acidic conditions in soil and aquatic environments. We have evaluated the influence of pH and divalent cation level...

journal_title：Infection and immunity

authors： Piddington DL,Kashkouli A,Buchmeier NA

更新日期：2000-08-01 00:00:00

abstract：:Treponema hyodysenteriae was shown to attach to mouse peritoneal cells in the absence of serum opsonins in vitro. If serotype-specific antiserum from pigs was added to the media and treponemes of that corresponding serotype were employed in the assay, the amount of attachment increased an average of 3.7 times that of ...

journal_title：Infection and immunity

authors： Nuessen ME,Joens LA

更新日期：1982-12-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in controlling several aspects of immune responses, including the activation and differentiation of specific T cell subsets and antigen-presenting cells, thought to be relevant in the context of experimental Trypanosoma cruzi infec...

journal_title：Infection and immunity

authors： Barroso A,Gualdrón-López M,Esper L,Brant F,Araújo RR,Carneiro MB,Ávila TV,Souza DG,Vieira LQ,Rachid MA,Tanowitz HB,Teixeira MM,Machado FS

更新日期：2016-09-19 00:00:00

abstract：:Little data are available regarding L-form phagocyte interactions. Due to difficulty with more conventional methods, a serum-free technique of surface phagocytosis employing cellulose ester micropore filters, fluorochrome staining, and reflecting fluorescence microscopy was developed. Intracellular localization of L-f...

journal_title：Infection and immunity

authors： Harwick HJ,Barajas L,Montgomerie JZ,Kalmanson GM,Guze LB

更新日期：1972-06-01 00:00:00

abstract：:To explore the molecular basis of the T-cell-mediated immune response to Listeria monocytogenes, we cloned and expressed listerial antigens in Escherichia coli using the lambda-ZAP bacteriophage and Bluescript plasmid vectors. A two-stage screening strategy was implemented to identify T-cell-reactive antigens; the fir...

journal_title：Infection and immunity

authors： Beattie IA,Swaminathan B,Ziegler HK

更新日期：1990-09-01 00:00:00

abstract：:Recent efforts to develop a vaccine against the diarrheal disease cholera have focused on the use of live attenuated strains of the causative organism, Vibrio cholerae. The Ogawa lipopolysaccharide phenotype is expressed by many epidemic strains, and motility defects reduce the risk of reactive diarrhea in vaccine rec...

journal_title：Infection and immunity

authors： Chiang SL,Mekalanos JJ

更新日期：2000-11-01 00:00:00

abstract：:Infection of resistant or susceptible mice with Trichuris muris provokes mesenteric lymph node responses which are polarized towards Th2 or Th1, respectively. These responses are well documented in the literature. In contrast, little is known about the local responses occurring within the infected intestine. Through m...

journal_title：Infection and immunity

authors： Datta R,deSchoolmeester ML,Hedeler C,Paton NW,Brass AM,Else KJ

更新日期：2005-07-01 00:00:00

abstract：:Borrelia burgdorferi, the Lyme disease-causing spirochete, can persistently infect its vertebrate hosts for years. B. burgdorferi is often found associated with host connective tissue, where it interacts with components of the extracellular matrix, including fibronectin. Some years ago, a borrelial surface protein, na...

journal_title：Infection and immunity

authors： Brissette CA,Bykowski T,Cooley AE,Bowman A,Stevenson B

更新日期：2009-07-01 00:00:00

abstract：:Lung dendritic cells were identified by immunohistochemistry in lung tissue sections from C57BL/6 mice. Following isolation from the lungs using CD11c magnetic beads, the flow cytometric analysis of I-A(b+) and CD11c(+) cells indicated a mixed population of dendritic cells at different stages of maturation, with most ...

journal_title：Infection and immunity

authors： Gonzalez-Juarrero M,Orme IM

更新日期：2001-02-01 00:00:00

abstract：:Once Candida albicans comes in contact with endothelial cells, it induces cellular injury. This endothelial cell injury may be a mechanism by which blood-borne organisms escape from the intravascular compartment and invade the tissue parenchyma during hematogenous infection. We have been investigating the ability of c...

journal_title：Infection and immunity

authors： Fratti RA,Ghannoum MA,Edwards JE Jr,Filler SG

更新日期：1996-11-01 00:00:00

abstract：:Toxic shock syndrome-associated staphylococcal and streptococcal exotoxins were tested for an ability to induce the production of tumor necrosis factor (TNF). Staphylococcal enterotoxins B and C1, along with streptococcal pyrogenic exotoxin A, all induced TNF production in a dose-dependent manner, with production peak...

journal_title：Infection and immunity

authors： Fast DJ,Schlievert PM,Nelson RD

更新日期：1989-01-01 00:00:00

abstract：:A fibronectin (Fn)-binding adhesin of Staphylococcus aureus contains three tandem 37- or 38-amino-acid motifs (D1, D2, and D3), which function to bind Fn. Plasma from patients with S. aureus infections contain antibodies that preferentially recognize ligand induced binding sites in the D motifs and do not inhibit Fn b...

journal_title：Infection and immunity

authors： Huesca M,Sun Q,Peralta R,Shivji GM,Sauder DN,McGavin MJ

更新日期：2000-03-01 00:00:00

abstract：:Organisms of the Mycobacterium avium complex are associated with disseminated infection in patients with AIDS. The mechanisms that account for the survival of the intracellular bacteria are unknown. We document here that infection of C57BL/6 black mice with M. avium 101 triggered interleukin-10 (IL-10) production. The...

journal_title：Infection and immunity

authors： Bermudez LE,Champsi J

更新日期：1993-07-01 00:00:00

abstract：:Neutrophil serine proteases cathepsin G (CG), neutrophil elastase (NE), and proteinase 3 (PR3) have recently been shown to contribute to killing of Streptococcus pneumoniae in vitro. However, their relevance in lung-protective immunity against different serotypes of S. pneumoniae in vivo has not been determined so far...

journal_title：Infection and immunity

authors： Hahn I,Klaus A,Janze AK,Steinwede K,Ding N,Bohling J,Brumshagen C,Serrano H,Gauthier F,Paton JC,Welte T,Maus UA

更新日期：2011-12-01 00:00:00

abstract：:Colony counts and light microscopy were used to assess the capacity of Candida albicans to colonize, infect the alimentary tract, and cause disseminated disease in athymic (nu/nu), euthymic (nu/+), beige (bg/bg), black (bg/+), beige athymic (bg/bg nu/nu), or beige euthymic (bg/bg nu/+) germfree mice. The alimentary tr...

journal_title：Infection and immunity

authors： Cantorna MT,Balish E

更新日期：1990-04-01 00:00:00