Abstract:
:Hamster respiratory epithelial cells were cultured in a monolayer format, and 20% of the cells were ciliated. Mycoplasma pneumoniae attached to the epithelial cells in a neuraminidase-specific fashion and induced ciliostasis and cytonecrosis.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Gabridge MG,Gunderson H,Schaeffer SL,Barden-Stahl YDdoi
10.1128/IAI.21.1.333-336.1978subject
Has Abstractpub_date
1978-07-01 00:00:00pages
333-6issue
1eissn
0019-9567issn
1098-5522journal_volume
21pub_type
杂志文章abstract::Sera from certain animal species contain a substance(s) which binds hepatitis B surface antigen. The hepatitis B binding substance found in animals is not antibody, but appears to be a glycoprotein which reacted with antigen-coated beads and produced a "false positive" test for antibody. This glycoprotein could be sel...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.3.879-885.1978
更新日期:1978-09-01 00:00:00
abstract::Monoclonal antibodies against Ureaplasma urealyticum serotype 4 were produced by immunizing BALB/c mice with whole-cell antigens of the U. urealyticum serotype 4 reference strain. Ten monoclonal antibodies differentiated into two groups were found: one group included five monoclonal antibodies recognizing a band in im...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.5.2253-2256.1993
更新日期:1993-05-01 00:00:00
abstract::Subunits of a proline-rich coccidioidal antigen (Ag2/PRA) of Coccidioides immitis were analyzed by comparison as vaccines in mice. The optimal dose of plasmid vaccine encoding full-length Ag2/PRA was determined to be between 10 and 100 microg. Mice vaccinated with plasmids encoding amino acids (aa) 1 to 106 were as pr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.7.3330-3335.2002
更新日期:2002-07-01 00:00:00
abstract::Four mouse monoclonal antibodies have been developed which react with Mycobacterium tuberculosis antigen 5. Each of these monoclonal antibodies has been used to prepare immunoabsorbents, and antigen has been isolated from unheated M. tuberculosis H37Ra culture filtrate by affinity chromatography with these absorbents....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.1.52-55.1984
更新日期:1984-07-01 00:00:00
abstract::Susceptibility of Syrian hamsters of the inbred LSH and MHA strains to injection of as few as 10 plaque-forming units of vesicular stomatitis virus (VSV) was shown to occur only after intraperitoneal and intrapleural injection and not after injection of VSV intravenously, intranasally, or in the footpads. Despite the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.34.2.540-549.1981
更新日期:1981-11-01 00:00:00
abstract::Studies of meningococcal pathogenesis have been severely restricted due to the absence of an adequate animal model. Given the significance of iron in meningococcal pathogenesis, we developed a model of Neisseria meningitidis colonization in outbred adult mice that included daily administration of iron dextran. While r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.1849-1855.2003
更新日期:2003-04-01 00:00:00
abstract::Peroral immunization with a live strain of Escherichia coli O6K13H1 against experimental ascending pyelonephritis caused by the same strain was studied in rats, and the effect of immunization on antibody titers against the O and K antigens and lipid A was determined. Peroral immunization with live bacteria protected s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.2.647-653.1982
更新日期:1982-02-01 00:00:00
abstract::Help from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01328-06
更新日期:2007-05-01 00:00:00
abstract::Helicobacter pylori infection causes severe gastroduodenal diseases in humans. Its virulence is strongly increased by the presence of the cag pathogenicity island (cag PAI). It has been shown that CagA, a major antigen in humans, is translocated to the host cell via a secretion system encoded by the cag PAI. The roles...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.11.6468-6470.2002
更新日期:2002-11-01 00:00:00
abstract::The innate immune response to Pneumocystis infection is not well understood. In this study, normal C57BL/6 mouse alveolar macrophages were found to respond to Pneumocystis murina organisms through Toll-like receptor 2 (TLR2), leading to the nuclear translocation of NF-kappaB and the production of proinflammatory cytok...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.3.1857-1864.2006
更新日期:2006-03-01 00:00:00
abstract::Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1beta (IL-1beta), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.3.1244-1247.1998
更新日期:1998-03-01 00:00:00
abstract::A soluble hemagglutinin/protease produced by Vibrio cholerae, which has previously been shown to hydrolyze fibronectin and ovomucin and to cleave lactoferrin and the A subunit of the heat-labile enterotoxin of Escherichia coli, appears to be a zinc metalloendopeptidase. Both its hemagglutinative and protease functions...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.42.2.639-644.1983
更新日期:1983-11-01 00:00:00
abstract::Because of the association of the group A streptococcal pyrogenic exotoxins (SPEs) with erythrogenic toxin used in the classical Dick test, the involvement of the SPEs in production of erythematous skin reactions was assessed. Unless they had been presensitized, young adult rabbits failed to show skin reactions after ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.2.467-472.1979
更新日期:1979-11-01 00:00:00
abstract::The immunodominant proteins and glycoproteins of Borrelia burgdorferi were analyzed by one-dimensional (1D) and 2D gel electrophoresis. More than 100 polypeptide species could be detected on silver-stained 2D gels. Separation of sonic extracts of the organism by differential centrifugation (100,000 X g) revealed sever...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.11.3637-3645.1989
更新日期:1989-11-01 00:00:00
abstract::Helicobacter mustelae is a urease-rich bacterium associated with gastritis in ferrets. The ureases of H. mustelae and Helicobacter pylori, a bacterium implicated in human gastritis, share many characteristics. Helicobacter sp. ureases appear to be unique among bacterial enzymes in exhibiting submillimolar Km values an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.9.3343-3345.1991
更新日期:1991-09-01 00:00:00
abstract::The population structure of the Bacillus cereus group (52 strains of B. anthracis, B. cereus, and B. thuringiensis) was investigated by sequencing seven gene fragments (rpoB, gyrB, pycA, mdh, mbl, mutS, and plcR). Most of the strains were classifiable into two large subgroups in six housekeeping gene trees but not in ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.9.5253-5261.2004
更新日期:2004-09-01 00:00:00
abstract::Immunochemically identical components were isolated from water-soluble phases of five Staphylococcus aureus strains by affinity chromatography on fibrinogen-linked Sepharose 4B. The elution was performed with 1 M MgCl2. The component could be isolated from sonicated preparations of whole cells, cell walls, and extrace...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.49.3.700-708.1985
更新日期:1985-09-01 00:00:00
abstract::Black melanin-like pigments are produced by several neurotropic fungi, including Cryptococcus neoformans. Pigment production is associated with virulence. In media containing phenolic substrates such as L-dopa, C. neoformans cells become black as a result of pigment accumulation. Pigmented and nonpigmented C. neoforma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.8.3131-3136.1995
更新日期:1995-08-01 00:00:00
abstract::Pathogenic strains of Yersinia spp. inject a set of Yop effector proteins into eukaryotic cells by using a plasmid-encoded type III secretion system. In this study, we analyzed the inflammatory response of human umbilical vein endothelial cells (HUVECs) after infection with different Yersinia enterocolitica strains. W...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.7.3510-3520.2002
更新日期:2002-07-01 00:00:00
abstract::By using in vitro assays, a group of related, filamentous gram-negative bacteria isolated from subgingival plaque deposits of patients with periodontal disease were found to colonize intact teeth. Tentatively identified as members of the genus Cytophaga, these isolates exhibited a preference for colonizing the cementu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.1.15-18.1979
更新日期:1979-10-01 00:00:00
abstract::The nitrate dissimilation pathway is important for anaerobic growth in Pseudomonas aeruginosa. In addition, this pathway contributes to P. aeruginosa virulence by using the nematode Caenorhabditis elegans as a model host, as well as biofilm formation and motility. We used a set of nitrate dissimilation pathway mutants...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00822-09
更新日期:2009-10-01 00:00:00
abstract::Erythrocytic malaria parasites degrade hemoglobin as a principal source of amino acids for parasite protein synthesis. We have previously shown that a Plasmodium falciparum trophozoite cysteine proteinase, now termed falcipain, is required for hemoglobin degradation, and we have hypothesized that this proteinase is re...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.6.2120-2125.1995
更新日期:1995-06-01 00:00:00
abstract::Infection with Mycobacterium avium subsp. paratuberculosis is associated with high levels of morbidity, decreased production, and early culling in dairy cattle. Clinical symptoms of Johne's disease include persistent diarrhea, inappetence, and resultant weight loss due to chronic inflammation of the small intestine. A...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.11.6479-6486.2003
更新日期:2003-11-01 00:00:00
abstract::Mycobacterium leprae are killed by myeloperoxidase (or eosinophil peroxidase), H2O2, and a halide, thus suggesting a mechanism for their destruction by peroxidase-containing phagocytes. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.2.534-536.1984
更新日期:1984-05-01 00:00:00
abstract::We have examined the ability of peptidoglycan (PepG) and lipoteichoic acid (LTA) isolated from Staphylococcus aureus to induce the release of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and IL-10 in whole human blood and identified the cellular origins of these cytokines. Both PepG and LTA induced t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.7.3965-3970.2000
更新日期:2000-07-01 00:00:00
abstract::The chlamydial inclusion occupies a unique niche within the eukaryotic cell that does not interact with endocytic compartments but instead is fusogenic with a subset of sphingomyelin-containing exocytic vesicles. The Chlamydia trachomatis inclusion acquires these distinctive properties by as early as 2 h postinfection...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.2.973-984.2003
更新日期:2003-02-01 00:00:00
abstract::The mouse system provides an excellent model for studying host resistance to Naegleria fowleri, the agent of primary amoebic meningoencephalitis. Innate resistance to infection with N. fowleri was examined with respect to infecting dose and the age, sex, and strain of mice. Intravenous inoculation with 10(7) amoebae p...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.20.1.73-77.1978
更新日期:1978-04-01 00:00:00
abstract::Neisseria gonorrhoeae is the causative agent of the sexually transmitted disease gonorrhea, and infection with this organism is typically associated with an intense inflammatory response. In many individuals, however, the infection is asymptomatic and can progress to serious secondary complications. The type IV pili o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.1.442-448.2006
更新日期:2006-01-01 00:00:00
abstract::Six strains of Rickettsia rickettsii from Montana and North Carolina were examined in an effort to identify rickettsial constituents associated with virulence. Fever responses, scrotal reactions, and mortalities of male guinea pigs inoculated intraperitoneally with 1,000 PFU of rickettsial strains revealed that the tw...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.3.559-564.1984
更新日期:1984-06-01 00:00:00
abstract::Bacillus anthracis, the causal agent of anthrax, synthesizes two surface layer (S-layer) proteins, EA1 and Sap, which account for 5 to 10% of total protein and are expressed in vivo. A recombinant B. anthracis strain was constructed by integrating into the chromosome a translational fusion harboring the DNA fragments ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.9.4847-4850.1999
更新日期:1999-09-01 00:00:00