Abstract:
:Sera from certain animal species contain a substance(s) which binds hepatitis B surface antigen. The hepatitis B binding substance found in animals is not antibody, but appears to be a glycoprotein which reacted with antigen-coated beads and produced a "false positive" test for antibody. This glycoprotein could be selectively and quantitatively removed by reaction with purified hepatitis B surface antigen and centrifugation. Pili fractions isolated from Neisseria gonorrhoeae and Escherichia coli bound to hepatitis B surface antigen and produced false positive anti-hepatitis B surface antigen reactions. Mouse anti-bovine hepatitis B binding substance and rabbit anti-E. coli pili were capable of neutralizing bovine hepatitis B binding substance.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Millman I,McMichael JCdoi
10.1128/IAI.21.3.879-885.1978subject
Has Abstractpub_date
1978-09-01 00:00:00pages
879-85issue
3eissn
0019-9567issn
1098-5522journal_volume
21pub_type
杂志文章abstract::Several group B streptococcal products have been previously found to stimulate human monocytes to produce tumor necrosis factor alpha. In order to identify the receptors involved in these responses, monocytes were stimulated with purified group- or type-specific carbohydrates or lipoteichoic acid in the presence of an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.2.994-998.2000
更新日期:2000-02-01 00:00:00
abstract::The in vivo role of endogenous interleukin 12 (IL-12) in modulating intrapulmonary growth of Legionella pneumophila was assessed by using a murine model of replicative L. pneumophila lung infection. Intratracheal inoculation of A/J mice with virulent bacteria (10(6) L. pneumophila cells per mouse) resulted in inductio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.1.65-69.1998
更新日期:1998-01-01 00:00:00
abstract::The majority of strains of Actinobacillus actinomycetemcomitans isolated from patients with periodontal diseases secrete a leukotoxin that destroys human myeloid cells within minutes but has no effect on viability of peripheral blood lymphocytes in culture for 1.5 h. However, since this organism persists in the gingiv...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.9.3267-3272.1991
更新日期:1991-09-01 00:00:00
abstract::It was demonstrated that complement-coated sheep erythrocytes bind to Candida albicans cells grown in serum-free RPMI 1640 medium. Testing of purified complement components proved that iC3b and C3d were responsible for the reaction, whereas C3b and C3b-H reacted only slightly if at all. Binding occurred only to C. alb...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.50.2.598-600.1985
更新日期:1985-11-01 00:00:00
abstract::Galectin-3 (Gal-3) is a multifunctional beta-galactoside-binding lectin that senses self-derived and microbial glycoconjugates. Although Gal-3 is important in immune reactions and host defense in some experimental models, the function of Gal-3 during helminthic diseases (e.g., schistosomiasis) is still elusive. We sho...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02006-06
更新日期:2007-11-01 00:00:00
abstract::Neutralizing antibodies were raised in mice that had been inoculated repeatedly with moderate quantities of human leukocyte interferon highly purified by affinity chromatography on immobilized anti-interferon globulins. Interferon preparations of lesser purity sensitized the mice to subsequent inoculations of interfer...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.19.2.570-574.1978
更新日期:1978-02-01 00:00:00
abstract::The interaction between bacteria and fibronectin is believed to play an important role in the pathogenicity of clinically important Gram-positive cocci. In the present study, we identified a gene encoding a predicted fibronectin-binding protein of Enterococcus faecium (fnm), a homologue of Streptococcus pneumoniae pav...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00885-15
更新日期:2015-12-01 00:00:00
abstract::The effect of iron concentration during growth on the physicochemical surface properties of the colonial variants of Neisseria gonorrhoeae has been assessed by aqueous two-phase partitioning in a dextran-polyethyleneglycol system containing positively charged trimethylamino-polyethyleneglycol or hydrophobic polyethyle...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.2.402-407.1979
更新日期:1979-11-01 00:00:00
abstract::The data presented indicate that in experimental Pseudomonas aeruginosa infection of mice, protease enhances the virulence of the organism. Anesthetized CBA/Lü mice were subjected to a 15-s flame burn and infected with a wild-type protease-producing strain and two of its protease-deficient mutants. The average bacteri...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.24.1.181-187.1979
更新日期:1979-04-01 00:00:00
abstract::Heat-labile enterotoxins from Escherichia coli strains of porcine and human origin polymerize on heating to form high-molecular-weight aggregates, "procoligenoids," analogous to procholeragenoid derived from the cholera enterotoxin. This aggregation is accompanied by loss of biological activity (toxicity). Further hea...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.2.518-521.1984
更新日期:1984-08-01 00:00:00
abstract::Otitis media developed in 67% of chinchillas inoculated intranasally with type 7 Streptococcus pneumoniae and influenza A virus. Only 4% of chinchillas inoculated with influenza alone and 21% of chinchillas inoculated with S. pneumoniae alone developed otitis media. Among the chinchillas that developed otitis media af...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00
abstract::The genes for outer membrane protein P2 of four nontypeable Haemophilus influenzae strains were cloned and sequenced. The derived amino acid sequences were compared with the outer membrane protein P2 sequence from H. influenzae type b MinnA and the sequences of P2 from three additional nontypeable H. influenzae strain...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.6.2639-2643.1994
更新日期:1994-06-01 00:00:00
abstract::Group A streptococci of M protein type 5 have been epidemiologically related to acute rheumatic fever in a number of reported outbreaks. Preliminary bacteriological evidence suggests that M5 may be an important "rheumatogenic" type in Santiago, Chile. To assess further the relationship of this streptococcal serotype t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.2.573-579.1982
更新日期:1982-11-01 00:00:00
abstract::Humoral immune responses in experimental African trypanosomiasis were assessed in rabbits infected with Trypanosoma rhodesiense. Immune complexes as measured by a Clq binding assay or a Clq solid-phase assay were detected by day 10 and increased progressively through day 28. Immune complexes analyzed by double diffusi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.33.2.407-414.1981
更新日期:1981-08-01 00:00:00
abstract::Intracellular bacterial infections affect all vertebrates. Cultured fish are particularly vulnerable because no effective protection measures have been established since such infections emerged approximately 50 years ago. As in other vertebrates, the induction of cell-mediated immunity (CMI) plays an important role in...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00459-19
更新日期:2019-10-18 00:00:00
abstract::Toll-like receptor (TLR)-based signaling pathways in the host may be modulated by pathogens during the course of infection. We describe a novel immunomodulatory mechanism in which Aspergillus fumigatus conidia induce attenuation of TLR2- and TLR4-mediated interleukin (IL)-6 and IL-1beta proinflammatory responses in hu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01455-08
更新日期:2009-05-01 00:00:00
abstract::Hamster trachea organ cultres were shown to consume measurable amounts of oxygen when incubated in a closed micro-chamber. Several simple and complex media were evaluated, and the optimal system involved incubating 2 to 4 mg of tracheal tissue in Tyrodes balanced salt solution at 37 C for 60 min, with oxygen activity ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.12.3.544-549.1975
更新日期:1975-09-01 00:00:00
abstract::Immunoglobulin M antibody to hepatitis A virus (IgM anti-HAV) is found in most patients with acute type A hepatitis. To determine the duration of this IgM response as well as to confirm that IgM anti-HAV is a specific marker for acute infection, we developed a solid-phase radioimmunoassay for IgM anti-HAV. This new as...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::Leishmania amastigotes are intracellular protozoan parasites of mononuclear phagocytes which reside within parasitophorous vacuoles of phagolysosomal origin. The pH of these compartments was studied with the aim of elucidating strategies used by these microorganisms to evade the microbicidal mechanisms of their host c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.3.779-787.1990
更新日期:1990-03-01 00:00:00
abstract::Attenuated Yersinia pestis pgm strains, such as KIM5, lack the siderophore yersiniabactin. Strain KIM5 does not induce significant pneumonia when delivered intranasally. In this study, mice were found to develop pneumonia after intranasal challenge with strain KIM5 when they were injected intraperitoneally with iron d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00382-10
更新日期:2010-08-01 00:00:00
abstract::Escherichia coli O157:H7 carries a chromosomal msbB1 and a plasmid-encoded msbB2 gene. We characterized msbB2 function as a homologue of msbB1 by examination of wild-type organisms and mutant strains that lacked functional msbB1, msbB2, and both msbB1 and msbB2. The msbB double-mutant strain generated pentaacyl lipid ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.2.1174-1180.2004
更新日期:2004-02-01 00:00:00
abstract::Peritoneal exudate T lymphocytes from Listeria monocytogenes-immune mice in the presence of the homologous antigen (heat-killed L. monocytogenes) and normal macrophages showed L. monocytogenes-specific proliferative responses. Proliferation was inhibited by macrophages from L. monocytogenes- or Corynebacterium parvum-...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.3.907-913.1982
更新日期:1982-12-01 00:00:00
abstract::The bacterial pathogen Listeria monocytogenes causes foodborne systemic disease in pregnant women, which can lead to preterm labor, stillbirth, or severe neonatal disease. Colonization of the maternal decidua appears to be an initial step in the maternal component of the disease as well as bacterial transmission to th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00153-17
更新日期:2017-07-19 00:00:00
abstract::Legionella pneumophila is ingested by both human macrophages and amoebae, and it multiplies within similar endocytic compartments in both eukaryotic species. Inhibitors of eukaryotic protein synthesis, such as cycloheximide and emetine, had no effect on the uptake of L. pneumophila by macrophages but completely abolis...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.5.1860-1866.1994
更新日期:1994-05-01 00:00:00
abstract::Mycobacterial growth inhibitory factor (MycoIF), found in supernatant fluids of mouse spleen cell cultures that have been stimulated in vitro with homologous antigen, inhibited the intracellular multiplication of virulent tubercle bacilli within normal mouse peritoneal macrophages in vitro. Antigenically stimulated H...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.12.4.833-840.1975
更新日期:1975-10-01 00:00:00
abstract::Tick saliva has potent immunomodulatory properties. In arthropod-borne diseases, this effect is largely used by microorganisms to increase their pathogenicity and to evade host immune responses. We show that in Lyme borreliosis, tick salivary gland extract and a tick saliva protein, Salp15, inhibit in vitro keratinocy...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00482-10
更新日期:2011-02-01 00:00:00
abstract::The expression of the Shigella flexneri chromosomal aerobactin genes during growth of the bacterium within tissue culture cells was assayed. During intracellular growth, aerobactin promoter activity was repressed relative to the level observed in bacteria grown extracellularly, even when the bacteria had been starved ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.2.818-821.1997
更新日期:1997-02-01 00:00:00
abstract::Lipopolysaccharide (LPS) can induce mouse macrophages to produce a number of cytokines and other inflammatory mediators. Our laboratory previously reported that LPS-dependent macrophage-derived tumor necrosis factor alpha (TNF-alpha) production could be significantly potentiated by pretreatment with LPS at substimulat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.3.1011-1015.1996
更新日期:1996-03-01 00:00:00
abstract::Gamma interferon (IFN-gamma) is produced in response to circulating lipopolysaccharide (LPS) and contributes to the lethality of endotoxic shock. To address the cellular source of IFN-gamma production in vivo, T cells and B cells were magnetically purified from C57BL/6 mouse spleens 5 h following endotoxin injection. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.10.4244-4249.1994
更新日期:1994-10-01 00:00:00
abstract::Natural killer (NK) cells are considered to be key players in the early innate responses to protozoan infections, primarily indirectly by producing gamma interferon (IFN-gamma) in response to cytokines, like interleukin 12 (IL-12). We demonstrate that live, as well as heat-inactivated, tachyzoites of Neospora caninum,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.2.953-960.2006
更新日期:2006-02-01 00:00:00