Innate resistance of mice to experimental infection with Naegleria fowleri.

abstract：:Pathogenic Leptospira spp. are likely to encounter higher concentrations of reactive oxygen species induced by the host innate immune response. In this study, we characterized Leptospira interrogans catalase (KatE), the only annotated catalase found within pathogenic Leptospira species, by assessing its role in resist...

journal_title：Infection and immunity

authors： Eshghi A,Lourdault K,Murray GL,Bartpho T,Sermswan RW,Picardeau M,Adler B,Snarr B,Zuerner RL,Cameron CE

更新日期：2012-11-01 00:00:00

abstract：:In the present study, the immunodepressive effects of canine distemper virus (CDV) infection of dogs on two parameters of lymphocyte function, namely phytomitogen-induced cellular proliferation and skin allograft rejection, were investigated. Infection of susceptible gnotobiotic dogs with virulent R252-CDV resulted in...

journal_title：Infection and immunity

authors： Krakowka S,Cockerell G,Koestner A

更新日期：1975-05-01 00:00:00

abstract：:Isolates of Thermoplasma acidophilum were divided into serological groups based on immunodiffusion studies of solubilized-membrane preparations. ...

journal_title：Infection and immunity

authors： Bohlool BB,Brock TD

更新日期：1974-07-01 00:00:00

abstract：:Active immunization with Escherichia coli-expressed recombinant outer surface protein C (OspC) of Borrelia burgdorferi has been demonstrated to confer protection against a tick-transmitted infection on laboratory animals. A previous study in this laboratory showed that OspC antibody raised against a denatured immunoge...

journal_title：Infection and immunity

authors： Gilmore RD Jr,Mbow ML

更新日期：1999-10-01 00:00:00

abstract：:Infectious agents are often considered potential triggers of chronic inflammatory disease, including autoimmunity; however, direct evidence is usually lacking. Here we show that following control of acute infection of mice with the myotropic Colombiana strain of Trypanosoma cruzi, parasites persisted in tissue at low ...

journal_title：Infection and immunity

authors： Roffê E,Marino APMP,Weaver J,Wan W,de Araújo FF,Hoffman V,Santiago HC,Murphy PM

更新日期：2016-03-24 00:00:00

abstract：:Virulent Treponema pallidum organisms, extracted from infected rabbit testes, were subjected to velocity sedimentation in discontinuous gradients of Hypaque, a high density, low viscosity material. After centrifugation of extracts at 20 C for 45 min at 100,000 x g, treponemes separated into two distinct bands based up...

journal_title：Infection and immunity

authors： Baseman JB,Nichols JC,Rumpp JW,Hayes NS

更新日期：1974-11-01 00:00:00

abstract：:Exoantigens of Plasmodium vivax-parasitized erythrocytes stimulated macrophages to secrete tumor necrosis factor, and antisera raised against the exoantigens inhibited this secretion. The antisera also inhibited the activity of Plasmodium falciparum and Plasmodium yoelii exoantigens, and conversely, antisera against t...

journal_title：Infection and immunity

authors： Bate CA,Taverne J,Karunaweera ND,Mendis KN,Kwiatkowski D,Playfair JH

更新日期：1992-03-01 00:00:00

abstract：:A live, attenuated, recombinant influenza vaccine (Alice strain) administered intranasally was evaluated in high school students and compared with intranasal placebo and subcutaneous, inactivated, bivalent influenza vaccine. The Alice strain was antigenic, increasing the geometric mean titer (GMT) from a prestudy leve...

journal_title：Infection and immunity

authors： Schiff GM,Linnemann CC Jr,shea L,Lange B,Rotte T

更新日期：1975-04-01 00:00:00

abstract：:Cultured L929 cells infected with Rickettsia prowazekii had a greatly increased rate of hydrolysis of fatty acid from the oleic acid-radiolabeled phospholipids of the host cell membranes. The incorporation of fatty acid into phospholipid in an infected cell was only moderately inhibited relative to a mock-infected cel...

journal_title：Infection and immunity

authors： Winkler HH,Daugherty RM

更新日期：1989-01-01 00:00:00

abstract：:The energy-dependent adsorption of radioiodinated rickettsiae to sheep erythrocytes was demonstrated. The iodination procedure, however, decreased the hemolytic activity of the rickettsiae. No desorption of rickettsiae from isolated rickettsia-erythrocyte complexes (prevented from lysing by NaF) could be measured. On ...

journal_title：Infection and immunity

authors： Winkler HH

更新日期：1977-09-01 00:00:00

abstract：:Pasteurella multocida is the causative agent of fowl cholera in birds. In a previous study using signature-tagged mutagenesis, we identified a mutant, AL251, which was attenuated for virulence in mice and in the natural chicken host. Sequence analysis indicated that AL251 had an insertional inactivation of the gene wa...

journal_title：Infection and immunity

authors： Harper M,Cox AD,St Michael F,Wilkie IW,Boyce JD,Adler B

更新日期：2004-06-01 00:00:00

abstract：:The bacterial pathogen Burkholderia pseudomallei invades host cells, escapes from endocytic vesicles, multiplies intracellularly, and induces the formation of actin tails and membrane protrusions, leading to direct cell-to-cell spreading. This study was aimed at the identification of B. pseudomallei genes responsible ...

journal_title：Infection and immunity

authors： Pilatz S,Breitbach K,Hein N,Fehlhaber B,Schulze J,Brenneke B,Eberl L,Steinmetz I

更新日期：2006-06-01 00:00:00

abstract：:When type I Candida stellatoidea is plated onto sucrose agar at levels in excess of 10(8) cells, some isolates spontaneously form sucrose-positive colonies. These isolates do not display typical type I phenotypes but instead exhibit phenotypes intermediate between type I C. stellatoidea and C. albicans. Also, this phe...

journal_title：Infection and immunity

authors： Wickes BL,Golin JE,Kwon-Chung KJ

更新日期：1991-05-01 00:00:00

abstract：:High levels of Treponema denticola in subgingival dental plaque are associated with severe periodontal disease. T. denticola, along with Porphyromonas gingivalis and Bacteroides forsythus, are the only cultivatable oral microorganisms that produce significant amounts of "trypsin-like" peptidase activity. The ability o...

journal_title：Infection and immunity

authors： Fenno JC,Lee SY,Bayer CH,Ning Y

更新日期：2001-10-01 00:00:00

abstract：:Two distinct types of granulomas were produced in the draining lymph nodes by immunizing guinea pigs with Mycobacterium bovis BCG or Mycobacterium leprae, as reported earlier (Narayanan et al., J. Pathol. 134:253-265, 1981). In the BCG-induced granuloma there is successful containment, killing, and degradation of the ...

journal_title：Infection and immunity

authors： Mathew RC,Katayama I,Gupta SK,Curtis J,Turk JL

更新日期：1983-01-01 00:00:00

abstract：:L-phase variants and small colony (G-phase) variants derived from penicillinase-producing Staphylococcus aureus strains were tested for penicillinase (beta lactamase) production. A refined variation of the modified Gots test for penicillinase was used to demonstrate penicillinase synthesis. Penicillinase synthesis was...

journal_title：Infection and immunity

authors： Simon HJ,Yin EJ

更新日期：1970-11-01 00:00:00

abstract：:To characterize the mechanism by which interleukin 10 (IL-10) inhibits Th1 responses to intracellular pathogens, we evaluated the interaction between IL-10 and Mycobacterium tuberculosis-induced gamma interferon (IFN-gamma) production by peripheral blood mononuclear cells from persons across the spectrum of tuberculou...

journal_title：Infection and immunity

authors： Gong JH,Zhang M,Modlin RL,Linsley PS,Iyer D,Lin Y,Barnes PF

更新日期：1996-03-01 00:00:00

abstract：:Protective immunity against pulmonary tuberculosis (TB) is characterized by the formation in the lungs of granulomas consisting of macrophages and activated T cells producing tumor necrosis factor alpha and gamma interferon, both required for the activation of the phagocytes. In 90% of immunocompetent humans, this res...

journal_title：Infection and immunity

authors： Kaplan G,Post FA,Moreira AL,Wainwright H,Kreiswirth BN,Tanverdi M,Mathema B,Ramaswamy SV,Walther G,Steyn LM,Barry CE 3rd,Bekker LG

更新日期：2003-12-01 00:00:00

abstract：:A secreted nuclease, SsnA, was identified in the virulent Streptococcus suis isolate SX332 and subsequently in each of the type strains of capsular serotypes 1 through 9. Screening of 258 porcine clinical isolates from surface (nasal mucosa or palatine tonsil) or internal (joint, brain or other internal organ) locatio...

journal_title：Infection and immunity

authors： Fontaine MC,Perez-Casal J,Willson PJ

更新日期：2004-02-01 00:00:00

abstract：:The gastric pathogen helicobacter pylori is one of a number of bacteria which bind specifically to gangliotetraosylceramide, gangliotriaosylceramide, and phosphatidylethanolamine in vitro at neutral pH. Since this organism encounters an acid pH during initial infection of the stomach, we have monitored the effect of p...

journal_title：Infection and immunity

authors： Huesca M,Borgia S,Hoffman P,Lingwood CA

更新日期：1996-07-01 00:00:00

abstract：:Secreted and surface-exposed antigens of intracellular pathogens are thought to provide target structures for detection by the host immune system. The major secreted product of intracellular Leishmania mexicana amastigotes, a proteophosphoglycan (aPPG), is known to contribute to the establishment of the parasitophorou...

journal_title：Infection and immunity

authors： Aebischer T,Harbecke D,Ilg T

更新日期：1999-10-01 00:00:00

abstract：:Groups of specific pathogen-free Hartley strain guinea pigs were vaccinated with viable Mycobacterium bovis BCG and maintained on isocaloric purified diets containing either 30 or 10% protein (ovalbumin) combined with either 50 ppm (microgram/g) or no added zinc. Seven weeks later the guinea pigs were skin tested with...

journal_title：Infection and immunity

authors： McMurray DN,Yetley EA

更新日期：1983-02-01 00:00:00

abstract：:In vivo accumulation of D-serine by Escherichia coli CFT073 leads to elevated expression of PAP fimbriae and hemolysin by an unknown mechanism. Loss of D-serine catabolism by CFT073 leads to a competitive advantage during murine urinary tract infection (UTI), but loss of both D- and L-serine catabolism results in atte...

journal_title：Infection and immunity

authors： Anfora AT,Halladin DK,Haugen BJ,Welch RA

更新日期：2008-12-01 00:00:00

abstract：:Human multidrug efflux transporters are known for their ability to extrude antibiotics and toxic compounds out of cells, yet accumulating data indicate they have additional functions in diverse physiological processes not related to drug efflux. Here, we show that the human multidrug transporter P-glycoprotein (P-gp) ...

journal_title：Infection and immunity

authors： Sigal N,Kaplan Zeevi M,Weinstein S,Peer D,Herskovits AA

更新日期：2015-06-01 00:00:00

abstract：:Borrelia burgdorferi, the Lyme disease pathogen, dramatically alters its protein profile when it is transmitted between ticks and mammals. Several differentially expressed proteins have been shown to be critical for the enzootic cycle of B. burgdorferi. In this study, we demonstrated that expression of the surface lip...

journal_title：Infection and immunity

authors： Xu H,He M,He JJ,Yang XF

更新日期：2010-07-01 00:00:00

abstract：:A major virulence factor of group A streptococci is M protein, a surface-exposed fibrillar molecule of which there exist more than 80 distinct serological types. Antigenic variability resides largely in the amino-terminal region of M protein, whereas the carboxy-terminal half of the molecule is highly conserved among ...

journal_title：Infection and immunity

authors： Bessen D,Fischetti VA

更新日期：1988-10-01 00:00:00

abstract：:The study of how bacteria respond to and obtain divalent metal ions provides insight into the regulation of virulence factors in the host environment. Regulation of metal permease operons in gram-positive bacteria may involve the binding of metal-responsive repressors to palindromic domains in their control regions. T...

journal_title：Infection and immunity

authors： Oetjen J,Fives-Taylor P,Froeliger EH

更新日期：2002-10-01 00:00:00

abstract：:The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced ...

journal_title：Infection and immunity

authors： Barr TA,Heath AW

更新日期：1999-07-01 00:00:00

abstract：:Experiments outlined here investigate the role of nitric oxide (NO) in the pathogenesis of Plasmodium falciparum-induced malarial anemia (MA). The results show that ex vivo and in vitro NO synthase (NOS) activity in peripheral blood mononuclear cells (PBMCs) is significantly elevated in children with MA and inversely ...

journal_title：Infection and immunity

authors： Keller CC,Kremsner PG,Hittner JB,Misukonis MA,Weinberg JB,Perkins DJ

更新日期：2004-08-01 00:00:00

abstract：:Cells of Candida albicans strain WO-1 and related strains switch frequently and reversibly between a white-colony-forming unit (white phase) and a gray-colony-forming unit (opaque phase). Cells in the budding white phase exhibit the usual smooth round phenotype observed in other C. albicans strains, but cells in the b...

journal_title：Infection and immunity

authors： Anderson J,Cundiff L,Schnars B,Gao MX,Mackenzie I,Soll DR

更新日期：1989-02-01 00:00:00