Vibrio cholerae soluble hemagglutinin/protease is a metalloenzyme.

abstract：:Nasopharyngeal colonization is a necessary first step in the pathogenesis of Streptococcus pneumoniae. Using isolates containing defined mutations in the S. pneumoniae capsule locus, we found that expression of the capsular polysaccharide is essential for colonization by the type 2 strain D39 and the type 3 strains A6...

journal_title：Infection and immunity

authors： Magee AD,Yother J

更新日期：2001-06-01 00:00:00

abstract：:Cathepsin G (CatG) is a serine protease found in the azurophilic granules of monocytes that is known to have antimicrobial properties, but its role in Mycobacterium tuberculosis infection is unknown. We found that M. tuberculosis infection of human THP-1 monocytic cells induced the down-regulation of CatG mRNA express...

journal_title：Infection and immunity

authors： Rivera-Marrero CA,Stewart J,Shafer WM,Roman J

更新日期：2004-10-01 00:00:00

abstract：:Screening of a Mycobacterium tuberculosis genomic DNA library in the lambda gt11 expression vector was carried out by using, as probes, sera from tuberculous patients and murine monoclonal antibody H61.3 recognizing a mycobacterial 35-kilodalton protein present only on the M. tuberculosis complex. The recombinant beta...

journal_title：Infection and immunity

authors： Vismara D,Mezzopreti MF,Gilardini Montani MS,Del Porto P,Lombardi G,Piccolella E,Damiani G,Rappuoli R,Colizzi V

更新日期：1990-01-01 00:00:00

abstract：:Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the adjuvant effect of murine CpG ODN 1826 on the immunogenicity and protective efficacy of the Saccharomyces cerevisiae-expres...

journal_title：Infection and immunity

authors： Kumar S,Jones TR,Oakley MS,Zheng H,Kuppusamy SP,Taye A,Krieg AM,Stowers AW,Kaslow DC,Hoffman SL

更新日期：2004-02-01 00:00:00

abstract：:The antigenic relationship of glucosyltransferases (GTF) produced by different serotypes of Streptococcus mutans was studied by using a functional inhibition assay. Rat, rabbit, or hamster immune fluids, directed to cell-associated or supernatant-derived GTF, were tested against ammonium sulfate-precipitated culture s...

journal_title：Infection and immunity

authors： Smith DJ,Taubman MA

更新日期：1977-01-01 00:00:00

abstract：:The generation of nitric oxide (NO) by activated macrophages is believed to control mycobacterial infection in the murine system. In this study we examined the effect of Mycobacterium bovis BCG infection on the L-arginine-dependent NO pathway in J774.1 murine macrophages. We have confirmed previous results by demonstr...

journal_title：Infection and immunity

authors： Peteroy-Kelly M,Venketaraman V,Connell ND

更新日期：2001-09-01 00:00:00

abstract：:A rapid and reproducible method of bacteriocin typing is described based on leakage of ultraviolet light-absorbing material (UVAM), detectable in supernatants of bacteriocin-sensitive cultures, by means of a spectrophotometer. The prerequisites for reproducible results, with nonsignificant fluctuations in standard err...

journal_title：Infection and immunity

authors： Farkas-Himsley H,Pagel A

更新日期：1977-04-01 00:00:00

abstract：:Porphyromonas gingivalis is a periodontal pathogen capable of invading primary cultures of normal human gingival epithelial cells (NHGEC). Involvement of P. gingivalis fimbriae in the invasion process was examined. Purified P. gingivalis 33277 fimbriae blocked invasion of this organism into NHGEC in a dose-dependent m...

journal_title：Infection and immunity

authors： Weinberg A,Belton CM,Park Y,Lamont RJ

更新日期：1997-01-01 00:00:00

abstract：:Respiratory epithelial cells play an active part in the host response to respiratory pathogens, such as Streptococcus pneumoniae, by releasing chemokines responsible for neutrophil recruitment. In order to investigate the role of specific pneumococcal virulence factors in eliciting CXC chemokine responses, type II pne...

journal_title：Infection and immunity

authors： Graham RM,Paton JC

更新日期：2006-12-01 00:00:00

abstract：:We have previously demonstrated that fibronectin mediates streptococcal adhesion to host cells and that streptococci interact primarily with the N-terminal domain of fibronectin. FBP54 is a 54-kDa protein from group A streptococci that binds fibronectin. In this report, we show that the N-terminal domain of fibronecti...

journal_title：Infection and immunity

authors： Courtney HS,Dale JB,Hasty DI

更新日期：1996-07-01 00:00:00

abstract：:Clostridium difficile toxins A and B (TcdA and TcdB) are the causative agents of antibiotic-associated pseudomembranous colitis. Mucosal mast cells play a crucial role in the inflammatory processes underlying this disease. We studied the direct effects of TcdA and TcdB on the human mast cell line HMC-1 with respect to...

journal_title：Infection and immunity

authors： Meyer GK,Neetz A,Brandes G,Tsikas D,Butterfield JH,Just I,Gerhard R

更新日期：2007-08-01 00:00:00

abstract：:The properties of two candidate Salmonella typhi-based live oral typhoid vaccine strains, BRD691 (S. typhi Ty2 harboring mutations in aroA and aroC) and BRD1116 (S. typhi Ty2 harboring mutations in aroA, aroC, and htrA), were compared in a number of in vitro and in vivo assays. BRD1116 exhibited an increased susceptib...

journal_title：Infection and immunity

authors： Lowe DC,Savidge TC,Pickard D,Eckmann L,Kagnoff MF,Dougan G,Chatfield SN

更新日期：1999-02-01 00:00:00

abstract：:Suitability of the rhesus monkey (Macaca mulatta) as an experimental host for evaluation of vaccines against airborne infection with Mycobacterium tuberculosis strain H37Rv was investigated. Nonvaccinated monkeys were exposed to estimated doses of 12, 25, or 49 units of H37Rv in a modified Henderson apparatus, and the...

journal_title：Infection and immunity

authors： Barclay WR,Anacker RL,Brehmer W,Leif W,Ribi E

更新日期：1970-11-01 00:00:00

abstract：:The mechanism by which capsular polysaccharides inhibit phagocytosis is not clearly understood. We investigated the association between a negative surface charge and inhibition of phagocytosis by the capsular polysaccharide of Cryptococcus neoformans. A two-polymer aqueous-phase system containing phosphate ions was us...

journal_title：Infection and immunity

authors： Kozel TR,Reiss E,Cherniak R

更新日期：1980-08-01 00:00:00

abstract：:The development and course of normally lethal parasitemias in mice inoculated intraperitoneally with erythrocytic stages of Plasmodium yoelii or Plasmodium berghei were markedly affected by treatment with the antilymphoid drug cyclosporin A (CS-A). When the first of four daily subcutaneous 25-mg/kg doses of CS-A was g...

journal_title：Infection and immunity

authors： Nickell SP,Scheibel LW,Cole GA

更新日期：1982-09-01 00:00:00

abstract：:Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglob...

journal_title：Infection and immunity

authors： Collin M,Olsén A

更新日期：2001-11-01 00:00:00

abstract：:Cholera toxin (CT) is a potent adjuvant for mucosal vaccination; however, its mechanism of action has not been clarified completely. It is well established that peripheral monocytes differentiate into dendritic cells (DCs) both in vitro and in vivo and that monocytes are the in vivo precursors of mucosal CD103(-) proi...

journal_title：Infection and immunity

authors： Veglia F,Sciaraffia E,Riccomi A,Pinto D,Negri DR,De Magistris MT,Vendetti S

更新日期：2011-03-01 00:00:00

abstract：:Toxicity of lipopolysaccharide (LPS) (endotoxin) is, to a large extent, mediated by the activation of monocytes/macrophages and subsequent release of monokines, such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha). It is known that LPS binds readily to serum lipoproteins and that LPS-lipoprotein co...

journal_title：Infection and immunity

authors： Flegel WA,Wölpl A,Männel DN,Northoff H

更新日期：1989-07-01 00:00:00

abstract：:Mice infected with various strains of Salmonella enteritidis and S. typhimurium were found to be more sensitive to the cell wall lipopolysaccharide (LPS) extracted from certain strains of Salmonella than noninfected mice. This hypersensitivity was induced by those smooth or rough strains which possessed a polysacchari...

journal_title：Infection and immunity

authors： Kawakami M,Hara Y,Osawa N

更新日期：1971-11-01 00:00:00

abstract：:The influence of bile acids on adenosine 3',5'-phosphate-induced intestinal secretion was studied in mice. Bile flow was stopped by ligation of the common bile duct, and secretion was induced in ligated loops of the small intestine. The decrease of bile led to inhibition of hypersecretion after challenge with heat-lab...

journal_title：Infection and immunity

authors： Lange S,Lönnroth I

更新日期：1982-02-01 00:00:00

abstract：:Transposon Tn916 was used to insertionally inactivate a coaggregation-relevant locus of Streptococcus gordonii DL1 (Challis). One mutant (F11) was isolated that lost the ability to coaggregate with the streptococcal partners of DL1 but retained the ability to coaggregate with partners belonging to other genera. A prob...

journal_title：Infection and immunity

authors： Whittaker CJ,Clemans DL,Kolenbrander PE

更新日期：1996-10-01 00:00:00

abstract：:In order to further understand Epstein-Barr virus (EBV)-lymphocyte interactions, we investigated a chain of events including: (i) EBV binding to human lymphocyte subpopulations; (ii) the earliest appearance of EBV-determined nuclear antigen (EBNA) in the lymphocytes after EBV infection; and (iii) establishment of cont...

journal_title：Infection and immunity

authors： Menezes J,Jondal M,Leibold W,Dorval G

更新日期：1976-02-01 00:00:00

abstract：:Cell-mediated immune (CMI) responses and tumor necrosis factor alpha (TNF-alpha) have been shown to be essential in acquired protection against Cryptococcus neoformans. Induction of a protective anticryptococcal CMI response includes increases in dendritic cells (DC) and activated CD4(+) T cells in draining lymph node...

journal_title：Infection and immunity

authors： Bauman SK,Huffnagle GB,Murphy JW

更新日期：2003-01-01 00:00:00

abstract：:A complex of trehalose-6, 6'-dimycolate (cord factor) and methylated bovine serum albumin was prepared, and its effect on the toxicity of cord factor in mice was studied. Either the active immunization with cord factor-methylated bovine serum albumin complex or the passive transfer of sera of rabbits vaccinated with t...

journal_title：Infection and immunity

authors： Kato M

更新日期：1972-02-01 00:00:00

abstract：:Several bacterial species recruit the complement regulators C4b-binding protein, factor H, and vitronectin, resulting in resistance against the bactericidal activity of human serum. It was recently demonstrated that bacteria also bind plasminogen, which is converted to plasmin that degrades C3b and C5. In this study, ...

journal_title：Infection and immunity

authors： Singh B,Al-Jubair T,Voraganti C,Andersson T,Mukherjee O,Su YC,Zipfel P,Riesbeck K

更新日期：2015-09-01 00:00:00

abstract：:In this communication, we examine the specificity of anti-herpes simplex virus (HSV) cytotoxic T lymphocytes (CTL). Serological studies of the two related HSV serotypes (HSV-1 and HSV-2) have revealed both type-specific and cross-reactive antigenic determinants in the viral envelope and on the surface of infected cell...

journal_title：Infection and immunity

authors： Eberle R,Russell RG,Rouse BT

更新日期：1981-12-01 00:00:00

abstract：:The Syrian golden hamster (Mesocricetus auratus) is uniquely susceptible to a variety of intracellular pathogens and is an excellent model for a number of human infectious diseases. The molecular basis for this high level of susceptibility is unknown, and immunological studies related to this model have been limited b...

journal_title：Infection and immunity

authors： Melby PC,Tryon VV,Chandrasekar B,Freeman GL

更新日期：1998-05-01 00:00:00

abstract：:The enzymes responsible for reducing H2O2 were surveyed in 49 strains of Leptospira by using semiquantitative assays for catalase and peroxidase. The survey revealed a differential distribution of catalase and peroxidase activities between the two leptospiral complexes. The pathogenic Leptospira interrogans strains ga...

journal_title：Infection and immunity

authors： Corin RE,Boggs E,Cox CD

更新日期：1978-12-01 00:00:00

abstract：:The data presented indicate that in experimental Pseudomonas aeruginosa infection of mice, protease enhances the virulence of the organism. Anesthetized CBA/Lü mice were subjected to a 15-s flame burn and infected with a wild-type protease-producing strain and two of its protease-deficient mutants. The average bacteri...

journal_title：Infection and immunity

authors： Pavlovskis OR,Wretlind B

更新日期：1979-04-01 00:00:00

abstract：:Mannheimia haemolytica, a commensal organism of the upper respiratory tract in cattle, is the principal bacterial pathogen associated with the bovine respiratory disease complex. Adherence to the respiratory mucosa is a crucial event in its pathogenesis. However, the bacterial components that contribute to this proces...

journal_title：Infection and immunity

authors： Kisiela DI,Czuprynski CJ

更新日期：2009-01-01 00:00:00