Abstract:
:Suitability of the rhesus monkey (Macaca mulatta) as an experimental host for evaluation of vaccines against airborne infection with Mycobacterium tuberculosis strain H37Rv was investigated. Nonvaccinated monkeys were exposed to estimated doses of 12, 25, or 49 units of H37Rv in a modified Henderson apparatus, and the course of the disease was followed by chest X rays, skin testing with purified protein derivative, body-weight determinations, and autopsy 8 weeks postinfection. These animals developed progressive and extensive tuberculosis with pathological changes proportional to the infecting dose. Four of seven monkeys vaccinated intravenously with 1 mg of live BCG 8 weeks prior to challenge with 40 units of H37Rv had no gross evidence of disease at autopsy 13 weeks postinfection; the other three monkeys had minimal disease. These data demonstrated that (i) reproducible and progressive infection could be induced in rhesus monkeys infected in a manner which simulated natural infection of man and (ii) a high level of resistance to infection could be induced by BCG vaccine in the rhesus monkey, which in nature is highly susceptible to tuberculous infection.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Barclay WR,Anacker RL,Brehmer W,Leif W,Ribi Edoi
10.1128/IAI.2.5.574-582.1970keywords:
subject
Has Abstractpub_date
1970-11-01 00:00:00pages
574-82issue
5eissn
0019-9567issn
1098-5522journal_volume
2pub_type
杂志文章abstract::Membrane glycolipids contain the lactose sequence (galactose linked to glucose), and the oligosaccharide is variously extended such that there is a cell-type-specific repertoire. In this study, binding of Pseudomonas aeruginosa M35 to lipid-linked lactose (Gal beta 1-4Glc [structure 1]), lacto-N-neotetraose (Gal beta ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.12.5078-5084.1992
更新日期:1992-12-01 00:00:00
abstract::The protective immunity conferred by T-cell subsets against infection with Treponema pallidum subsp. pertenue was studied. We demonstrated that hamster T cells can be separated into two subsets by monoclonal antibody (MAb) GK 1.5 (anti-L3T4) and MAb 38. Eighty-five percent of hamster thymocytes were L3T4+ and 87% were...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.2.529-536.1991
更新日期:1991-02-01 00:00:00
abstract::In a double-blind, randomized, and placebo-controlled previous trial, the efficacy of Vi-rEPA for typhoid fever in 2- to 5-year-olds was 89.0% for 46 months. Vi-rEPA contained 25 microg of Vi and induced a greater-than-eightfold rise in immunoglobulin G (IgG) anti-Vi in all of the vaccinees tested. In this investigati...
journal_title:Infection and immunity
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1128/IAI.72.11.6586-6588.2004
更新日期:2004-11-01 00:00:00
abstract::A major problem in the study of chlamydial genital infections in animal models has been the use of varied doses of chlamydiae for infection in different laboratories. It is clearly desirable to use a dose which approximates that of natural sexual infection, but that dose to date has not been determined because of the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.11.6148-6154.2003
更新日期:2003-11-01 00:00:00
abstract::We compared a cryptococcal culture filtrate antigen referred to as CneF with chemically defined cryptococcal antigen fractions isolated by Cherniak and co-workers by using double immunodiffusion gels, polyacrylamide gel electrophoresis, immunoblots, and footpad reactivity of immunized mice. The three previously descri...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.2.424-431.1988
更新日期:1988-02-01 00:00:00
abstract::A multigene family of 58- to 60-kDa proteins, which are designated rhoptry-associated protein 1 (RAP-1) and which come from the parasites Babesia bigemina and Babesia bovis, is a target for vaccine development. The presence of multiple gene copies and conserved sequences and epitopes of RAP-1 implies that these protei...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.6.2079-2087.1996
更新日期:1996-06-01 00:00:00
abstract::Escherichia coli strains produce at least two heat-stable enterotoxins, STa and STb. STa is well known to be important in the pathogenesis of human diarrheal disease; the role of STb has not been defined. Fifty-two E. coli strains recovered from human diarrheal illness in northeast Brazil or Bangladesh were examined i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.52.1.323-325.1986
更新日期:1986-04-01 00:00:00
abstract::To define the role of nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide (LOS) in the induction of proinflammatory cytokine gene expression during otitis media, we compared the abilities of formalin-killed NTHI strain 2019 and its LOS htrB and rfaD mutants to stimulate human middle ear epithelial (HMEE) cel...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.6.3678-3684.2001
更新日期:2001-06-01 00:00:00
abstract::The ability of Toxoplasma gondii tachyzoites to differentiate into latent bradyzoite forms is essential for pathogenesis of clinical disease. We examined the effects of cyclic nucleotides on T. gondii bradyzoite differentiation in vitro. Differentiation of tachyzoites to bradyzoites was measured in an immunofluorescen...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.1.148-153.2001
更新日期:2001-01-01 00:00:00
abstract::Guinea pig peritoneal or alveolar macrophages were inoculated with Mycoplasma pneumoniae cells. Extracellular mycoplasms were killed by complement treatment, and the effect of macrophage action on the number of the remaining viable mycoplasmas was observed. The complement killing was to some extent inhibited by the pr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.1.11-15.1979
更新日期:1979-07-01 00:00:00
abstract::Modification of three or four of the five histidine residues in the toxic shock syndrome toxin 1 (TSST-1) with diethylpyrocarbonate did not inhibit the precipitin reaction of the modified TSST-1 with polyvalent antisera to the toxin. Monoclonal antibody 7T did not react with the modified TSST-1, but monoclonal antibod...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.7.1901-1905.1989
更新日期:1989-07-01 00:00:00
abstract::Iron is an important element for the growth of microorganisms as well as in the defense of the host by serving as a catalyst for the generation of free radicals via the Fenton/Haber-Weiss reactions. The iron transporter natural resistance-associated macrophage protein 1 (Nramp1) confers resistance to the growth of a v...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.11.6618-6624.2001
更新日期:2001-11-01 00:00:00
abstract::Stenotrophomonas maltophilia is a ubiquitous bacterium and an emerging nosocomial pathogen. This bacterium is resistant to many antibiotics, associated with a number of infections, and a significant health risk, especially for immunocompromised patients. Given that Caenorhabditis elegans shares many conserved genetic ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00711-15
更新日期:2015-12-07 00:00:00
abstract::We used inhibitors of receptor-mediated endocytosis to study the mechanisms of infectivity, especially the uptake mechanism, of Chlamydia trachomatis for cultured cells. The effect of methylamine and monodansylcadaverine on the different stages of the chlamydial growth cycle in McCoy cells was examined. There was a do...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.2.534-541.1983
更新日期:1983-05-01 00:00:00
abstract::The response of the intracellular pathogen Rhodococcus equi to H(2)O(2) treatment, a situation potentially encountered after the oxidative burst of alveolar macrophages, was analyzed. Compared to other bacteria, including Deinococcus radiodurans, R. equi showed exceptionally high resistance to this stress. A proteomic...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.7.3768-3776.2002
更新日期:2002-07-01 00:00:00
abstract::The yeast form of the dimorphic fungus Histoplasma capsulatum survives within macrophages after phagocytosis. To do so, it must avoid, inhibit, or resist a variety of toxic oxygen metabolites. Using ferricytochrome c reduction to assay superoxide release, we examined the response of mouse macrophages to the yeast form...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.1.29-34.1987
更新日期:1987-01-01 00:00:00
abstract::The antiinflammatory cytokine response during urosepsis was determined by measurement of concentrations of soluble tumor necrosis factor receptor (sTNFR) types I and II, interleukin 1 receptor antagonist (IL-1ra), soluble IL-1 receptor type II (sIL-1RII), and interleukin 10 in sera and urine of 30 patients with cultur...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.8.3527-3534.1998
更新日期:1998-08-01 00:00:00
abstract::Avian pathogenic Escherichia coli (APEC) cause extraintestinal disease in avian species via respiratory tract infection. Virulence factors associated with APEC include type 1 and P fimbriae, curli, aerobactin, lipopolysaccharide (LPS), K1 capsular antigen, temperature-sensitive hemagglutinin (Tsh), and an uncharacteri...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.1.494-503.2003
更新日期:2003-01-01 00:00:00
abstract::The intraerythrocytic apicomplexan Babesia microti, the primary causative agent of human babesiosis, is a major public health concern in the United States and elsewhere. Apicomplexans utilize a multiprotein complex that includes a type I membrane protein called apical membrane antigen 1 (AMA1) to invade host cells. We...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00168-15
更新日期:2015-10-01 00:00:00
abstract::We report on the colonization of murine trigeminal ganglia after sequential infection of mice by herpes simplex viruses (HSVs). In preliminary studies, we have established that whereas the HSV-1(F) strain efficiently colonizes ganglia when inoculated by either the ear or eye routes, the HSV-1 X HSV-2 recombinant C7D c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.2.702-708.1983
更新日期:1983-08-01 00:00:00
abstract::The gastric spirillum Helicobacter felis, originally isolated from the cat stomach, colonizes the stomachs of germfree rats. Studies were designed to examine the pathological and serological responses of germfree rats inoculated orally with H. felis. At 2 weeks postinoculation, the gastric mucosa of germfree rats had ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.3.785-791.1991
更新日期:1991-03-01 00:00:00
abstract::Serum from rabbits immunized with either heat-killed or live nonencapsulated Staphylococcus aureus failed further to enhance phagocytosis and intracellular killing of the homologous organism by either normal rabbit polymorphonuclear leukocytes or monocytes, when compared with normal rabbit serum. These immune sera did...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.2.6.742-749.1970
更新日期:1970-12-01 00:00:00
abstract::The pathogenic role of staphylococcal coagulase and clumping factor was investigated in the rat model of endocarditis. The coagulase-producing and clumping factor-producing parent strain Staphylococcus aureus Newman and a series of mutants defective in either coagulase, clumping factor, or both were tested for their a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.12.4738-4743.1995
更新日期:1995-12-01 00:00:00
abstract::The enzymes responsible for reducing H2O2 were surveyed in 49 strains of Leptospira by using semiquantitative assays for catalase and peroxidase. The survey revealed a differential distribution of catalase and peroxidase activities between the two leptospiral complexes. The pathogenic Leptospira interrogans strains ga...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.22.3.672-675.1978
更新日期:1978-12-01 00:00:00
abstract::Because combined administration of intramuscular and intravenous interferon has been partially successful in the incubationary treatment of rabies, the effect of direct interferon administration into the cerebrospinal fluid space was tested. After injecting 1,800 U of interferon into the cisterna magna or the lateral ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.2.286-293.1974
更新日期:1974-02-01 00:00:00
abstract::Cimetidine is a powerful H2 receptor antagonist that eliminates histamine's effects on chemotaxis, phagocytosis, and superoxide anion production by phagocytes. The purpose of this study was to analyze the clinical and histopathological changes associated with experimental periodontitis in rabbits in response to topica...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.4.2402-2414.2006
更新日期:2006-04-01 00:00:00
abstract::The humoral and cell-mediated immune responses of murine lymphocytes exposed to lead in vivo and in vitro were investigated. In vivo Pb was administered via the drinking water (0 to 10 mM) for 1 to 10 weeks. In vivo exposure of the mice to Pb did not alter significantly their plaque-forming cell response to sheep eryt...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.31.1.136-143.1981
更新日期:1981-01-01 00:00:00
abstract::Streptococcus suis serotype 2 is a porcine and human pathogen with adhesive and invasive properties. In other streptococci, large surface-associated proteins (>100 kDa) of the MSCRAMM family (microbial surface components recognizing adhesive matrix molecules) are key players in interactions with host tissue. In this s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00359-06
更新日期:2006-11-01 00:00:00
abstract::The relationship of catalase, cystinase, and deoxyribonuclease activity to toxinogeny in Corynebacterium diphtheriae was examined. Mutants deficient in each activity were isolated after mutagenization of strain C4 with nitrosoguanidine. All mutants were converted to toxinogeny after lysogenization with beta-converting...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.3.442-445.1973
更新日期:1973-09-01 00:00:00
abstract::Little is known about the underlying mechanisms that result in a sexually dimorphic response to Vibrio vulnificus endotoxic shock. V. vulnificus is a gram-negative bacterium, considered one of the most invasive and rapidly fatal human pathogens known. However, 85% of individuals that develop endotoxic shock from V. vu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.10.6119-6122.2001
更新日期:2001-10-01 00:00:00