Abstract:
:The antiinflammatory cytokine response during urosepsis was determined by measurement of concentrations of soluble tumor necrosis factor receptor (sTNFR) types I and II, interleukin 1 receptor antagonist (IL-1ra), soluble IL-1 receptor type II (sIL-1RII), and interleukin 10 in sera and urine of 30 patients with culture-proven urinary tract infections before and 4, 24, 48, and 72 h after initiation of antibiotic therapy and in 20 healthy individuals. In serum, the levels of sTNFR types I and II, IL-1ra, and IL-10 were higher in patients than in controls. In urine, only sTNFR type I and II levels were elevated in patients. The ratios of concentrations of both types of sTNFR in urine to concentrations in serum were higher in patients than in controls. These findings indicate that during urosepsis, the antiinflammatory cytokine response is generated predominantly at the systemic level.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Olszyna DP,Prins JM,Buis B,van Deventer SJ,Speelman P,van der Poll Tdoi
10.1128/IAI.66.8.3527-3534.1998subject
Has Abstractpub_date
1998-08-01 00:00:00pages
3527-34issue
8eissn
0019-9567issn
1098-5522journal_volume
66pub_type
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