O antigen protects Bordetella parapertussis from complement.

Abstract:

:Bordetella pertussis, a causative agent of whooping cough, expresses BrkA, which confers serum resistance, but the closely related human pathogen that also causes whooping cough, Bordetella parapertussis, does not. Interestingly, B. parapertussis, but not B. pertussis, produces an O antigen, a factor shown in other models to confer serum resistance. Using a murine model of infection, we determined that O antigen contributes to the ability of B. parapertussis to colonize the respiratory tract during the first week of infection, but not thereafter. Interestingly, an O antigen-deficient strain of B. parapertussis was not defective in colonizing mice lacking the complement cascade. O antigen prevented both complement component C3 deposition on the surface and complement-mediated killing of B. parapertussis. In addition, O antigen was required for B. parapertussis to systemically spread in complement-sufficient mice, but not complement-deficient mice. These data indicate that O antigen enables B. parapertussis to efficiently colonize the lower respiratory tract by protecting against complement-mediated control and clearance.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Goebel EM,Wolfe DN,Elder K,Stibitz S,Harvill ET

doi

10.1128/IAI.01629-07

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

1774-80

issue

4

eissn

0019-9567

issn

1098-5522

pii

IAI.01629-07

journal_volume

76

pub_type

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