Reactivation of latent Herpes simplex virus after pneumococcal pneumonia in mice.

Abstract:

:In attempts to reactivate latent herpes simplex virus, we instilled Diplococcus pneumoniae intratracheally into mice harboring latent infections in sacrosciatic spinal ganglia. All mice developed a severe pneumonia within 24 h and were given penicillin therapy. Representative mice that survived the penumonia were sacrificed at daily intervals, and appropriate tissues were examined for evidence of viral reactivation. Herpes simplex virus was reactivated in the ganglia and appeared to travel both proximally and distally in associated nerve trunks. Clinically apparent disease due to the virus was not detected in any mice.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Stevens JG,Cook ML,Jordan MC

doi

10.1128/IAI.11.4.635-639.1975

subject

Has Abstract

pub_date

1975-04-01 00:00:00

pages

635-9

issue

4

eissn

0019-9567

issn

1098-5522

journal_volume

11

pub_type

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