Epithelial cell invasion and survival of Bordetella bronchiseptica.

abstract：:Botulinum neurotoxins (BoNTs) and tetanus toxin (TeNT) are the most potent toxins for humans and elicit unique pathologies due to their ability to traffic within motor neurons. BoNTs act locally within motor neurons to elicit flaccid paralysis, while retrograde TeNT traffics to inhibitory neurons within the central ne...

journal_title：Infection and immunity

authors： Zuverink M,Chen C,Przedpelski A,Blum FC,Barbieri JT

更新日期：2015-07-01 00:00:00

abstract：:Modulation of myelopoiesis by three synthetic muramyl peptides was investigated in vivo. Two adjuvant-active compounds (N-acetylmuramyl dipeptide [MDP] and MDP-butyl-ester) elicited significant responses in DBA/2 mice characterized by a rise in the level of monocyte-macrophage colony-stimulating activity in serum, a p...

journal_title：Infection and immunity

authors： Galelli A,Chedid L

更新日期：1983-12-01 00:00:00

abstract：:Vibrio cholerae V86 El Tor Inaba caused experimental cholera in germfree ICR suckling mice. Sucklings born of gnotobiotic mothers monoassociated with the same strain were completely protected against live oral homologous challenge. ...

journal_title：Infection and immunity

authors： Shimamura T,Tazume S,Hashimoto K,Sasaki S

更新日期：1981-10-01 00:00:00

abstract：:The etiology of recurrent vulvovaginal candidiasis in otherwise healthy women of child-bearing age remains an enigma. To date, results from both clinical studies and a murine model of vaginal candidiasis indicate that Candida vaginitis can occur in the presence of Candida-specific Th1-type cell-mediated immunity expre...

journal_title：Infection and immunity

authors： Fidel PL Jr,Lynch ME,Sobel JD

更新日期：1995-07-01 00:00:00

abstract：:Streptococcus pneumoniae is a leading cause of bacterial pneumonia, meningitis, and sepsis in children. Human immunity to pneumococcal infections has been assumed to depend on anticapsular antibodies. However, recent findings from murine models suggest that alternative mechanisms, dependent on T helper cells, are also...

journal_title：Infection and immunity

authors： Olliver M,Hiew J,Mellroth P,Henriques-Normark B,Bergman P

更新日期：2011-10-01 00:00:00

abstract：:Legionnaires' disease is clinically manifested as severe pneumonia caused by Legionella pneumophila. However, the dendritic cell (DC)-centered immunological framework of the host defense against L. pneumophila has not been fully delineated. For this study, we focused on a potent chemoattractant for lymphocytes, fracta...

journal_title：Infection and immunity

authors： Kikuchi T,Andarini S,Xin H,Gomi K,Tokue Y,Saijo Y,Honjo T,Watanabe A,Nukiwa T

更新日期：2005-09-01 00:00:00

abstract：:The Chagas' disease parasite Trypanosoma cruzi commonly infects humans through skin abrasions or mucosa from reduviid bug excreta. Yet most studies on animal models start with subcutaneous or intraperitoneal injections, a distant approximation of the skin abrasion route. We show here that atraumatic placement of T. cr...

journal_title：Infection and immunity

authors： Caradonna K,Pereiraperrin M

更新日期：2009-04-01 00:00:00

abstract：:In order to plan for the wide-scale introduction of meningococcal C conjugate (MCC) vaccine for United Kingdom children up to 18 years old, phase II trials were undertaken to investigate whether there was any interaction between MCC vaccines conjugated to tetanus toxoid (TT) or a derivative of diphtheria toxin (CRM(19...

journal_title：Infection and immunity

authors： Burrage M,Robinson A,Borrow R,Andrews N,Southern J,Findlow J,Martin S,Thornton C,Goldblatt D,Corbel M,Sesardic D,Cartwight K,Richmond P,Miller E

更新日期：2002-09-01 00:00:00

abstract：:Gardnerella vaginalis, the bacterial species most frequently isolated from women with bacterial vaginosis (BV), produces a cholesterol-dependent cytolysin (CDC), vaginolysin (VLY). At sublytic concentrations, CDCs may initiate complex signaling cascades crucial to target cell survival. Using live-cell imaging, we obse...

journal_title：Infection and immunity

authors： Randis TM,Zaklama J,LaRocca TJ,Los FC,Lewis EL,Desai P,Rampersaud R,Amaral FE,Ratner AJ

更新日期：2013-12-01 00:00:00

abstract：:Rabbit-specific enteropathogenic Escherichia coli (REPEC) is an attaching and effacing pathogen of young rabbits. Using signature-tagged mutagenesis, we identified several known colonization factors of REPEC as well as a gene predicted to encode a novel autotransporter protein. This novel gene was termed rpeA for REPE...

journal_title：Infection and immunity

authors： Leyton DL,Adams LM,Kelly M,Sloan J,Tauschek M,Robins-Browne RM,Hartland EL

更新日期：2007-09-01 00:00:00

abstract：:Monoclonal antibodies have been generated to the unique distal sugar epitopes on the oligosaccharide haptens of the glycopeptidolipid antigens of clinically prominent members of the Mycobacterium avium serocomplex. Thus, antibodies are described that recognize the distal O-acetyl-alpha-L-rhamnopyranosyl residue of the...

journal_title：Infection and immunity

authors： Rivoire B,Ranchoff BJ,Chatterjee D,Gaylord H,Tsang AY,Kolk AH,Aspinall GO,Brennan PJ

更新日期：1989-10-01 00:00:00

abstract：:Sporothrix schenckii is a human pathogen that causes sporotrichosis, an important cutaneous mycosis with a worldwide distribution. It produces dark-brown conidia, which infect the host. We found that S. schenckii synthesizes melanin via the 1,8-dihydroxynaphthalene pentaketide pathway. Melanin biosynthesis in the wild...

journal_title：Infection and immunity

authors： Romero-Martinez R,Wheeler M,Guerrero-Plata A,Rico G,Torres-Guerrero H

更新日期：2000-06-01 00:00:00

abstract：:Salmonella spp. and Shigella spp. are responsible for millions of cases of enteric disease each year worldwide. While these pathogens have evolved distinct strategies for interacting with the human intestinal epithelium, they both induce significant proinflammatory responses that result in massive transepithelial migr...

journal_title：Infection and immunity

authors： Mumy KL,Bien JD,Pazos MA,Gronert K,Hurley BP,McCormick BA

更新日期：2008-08-01 00:00:00

abstract：:Mast cell-deficient W/Wv mice and their mast cell-sufficient littermates were given infections of Trichinella spiralis. W/Wv mice were slower than their littermates to expel adult T. spiralis. Repair of the mast cell deficiency of W/Wv mice by bone marrow grafting was accompanied by accelerated expulsion of T. spirali...

journal_title：Infection and immunity

authors： Ha TY,Reed ND,Crowle PK

更新日期：1983-07-01 00:00:00

abstract：:Protective immunity against pulmonary tuberculosis (TB) is characterized by the formation in the lungs of granulomas consisting of macrophages and activated T cells producing tumor necrosis factor alpha and gamma interferon, both required for the activation of the phagocytes. In 90% of immunocompetent humans, this res...

journal_title：Infection and immunity

authors： Kaplan G,Post FA,Moreira AL,Wainwright H,Kreiswirth BN,Tanverdi M,Mathema B,Ramaswamy SV,Walther G,Steyn LM,Barry CE 3rd,Bekker LG

更新日期：2003-12-01 00:00:00

abstract：:Eikenella corrodens normally inhabits the human respiratory and gastrointestinal tracts but is frequently the cause of abscesses at various sites. Using the N-terminal portion of the Moraxella nonliquefaciens pilin gene as a hybridization probe, we cloned two tandemly located pilin genes of E. corrodens 31745, ecpC an...

journal_title：Infection and immunity

authors： Tønjum T,Weir S,Bøvre K,Progulske-Fox A,Marrs CF

更新日期：1993-05-01 00:00:00

abstract：:The gene products from an 8-kb region adjacent to the 3' end of the ptx operon are required by Bordetella pertussis for the export of pertussis holotoxin. At least one of these gene products (PtlC) is specifically required for the export of assembled holotoxin from the periplasmic space. ptlC mutants exhibit a 20-fold...

journal_title：Infection and immunity

authors： Baker SM,Masi A,Liu DF,Novitsky BK,Deich RA

更新日期：1995-10-01 00:00:00

abstract：:Although it has been known for some time that Salmonella typhimurium is able to survive and even replicate in the normally bactericidal environment of the macrophage phagosome, the mechanisms by which this organism accomplishes this feat remain obscure. In this study, a murine macrophage cell line and confocal immunof...

journal_title：Infection and immunity

authors： Rathman M,Barker LP,Falkow S

更新日期：1997-04-01 00:00:00

abstract：:Cytoadherence-linked asexual gene 9 (Clag9), a conserved Plasmodium protein expressed during the asexual blood stages, is involved in the cytoadherence of infected red blood cells (RBCs) to the endothelial lining of blood vessels. Here, we show that Plasmodium falciparum Clag9 (PfClag9) is a component of the PfClag9-R...

journal_title：Infection and immunity

authors： Chourasia BK,Deshmukh A,Kaur I,Paul G,Panda A,Rathore S,Singh SK,Theisen M,Mohmmed A,Malhotra P

更新日期：2020-01-22 00:00:00

abstract：:Exohemagglutinin was found in the culture medium of Bacteroides gingivalis 381. Exohemagglutinin was purified 3,150-fold from culture fluid by ultracentrifugation followed by gel filtration on Sepharose CL-4B and by affinity chromatography on arginine-agarose. Examination of the final preparation of exohemagglutinin b...

journal_title：Infection and immunity

authors： Inoshita E,Amano A,Hanioka T,Tamagawa H,Shizukuishi S,Tsunemitsu A

更新日期：1986-05-01 00:00:00

abstract：:Streptococcus suis serotype 2 is a porcine and human pathogen with adhesive and invasive properties. In other streptococci, large surface-associated proteins (>100 kDa) of the MSCRAMM family (microbial surface components recognizing adhesive matrix molecules) are key players in interactions with host tissue. In this s...

journal_title：Infection and immunity

authors： Baums CG,Kaim U,Fulde M,Ramachandran G,Goethe R,Valentin-Weigand P

更新日期：2006-11-01 00:00:00

abstract：:The gastric spirillum Helicobacter felis, originally isolated from the cat stomach, colonizes the stomachs of germfree rats. Studies were designed to examine the pathological and serological responses of germfree rats inoculated orally with H. felis. At 2 weeks postinoculation, the gastric mucosa of germfree rats had ...

journal_title：Infection and immunity

authors： Fox JG,Lee A,Otto G,Taylor NS,Murphy JC

更新日期：1991-03-01 00:00:00

abstract：:Listeria monocytogenes is a ubiquitous potentially pathogenic organism requiring iron for growth and virulence. Although it does not produce siderophores, L. monocytogenes is able to obtain iron by using either exogenous siderophores produced by various microorganisms or natural catechol compounds widespread in the en...

journal_title：Infection and immunity

authors： Coulanges V,Andre P,Ziegler O,Buchheit L,Vidon DJ

更新日期：1997-07-01 00:00:00

abstract：:Previous studies have noted that the prevalence of certain gonococcal colony types is influenced by the physiological state of the human host. Consequently eight different gonococcal strains were passed on clear typing medium, and opaque (Op) and transparent (Tr) variants of heavily pilated (P++) bacteria were selecte...

journal_title：Infection and immunity

authors： Salit IE,Gotschlich EC

更新日期：1978-11-01 00:00:00

abstract：:Tuberculosis remains the leading cause of death among infectious diseases, accounting for more than two million deaths annually. The incidence of the disease is increasing globally, partially because of the resurgence of drug-resistant strains of Mycobacterium tuberculosis. Calixarenes are macrocyclic oligomers, some ...

journal_title：Infection and immunity

authors： Colston MJ,Hailes HC,Stavropoulos E,Hervé AC,Hervé G,Goodworth KJ,Hill AM,Jenner P,Hart PD,Tascon RE

更新日期：2004-11-01 00:00:00

abstract：:Nontypeable Haemophilus influenzae (NTHi) causes repeated respiratory infections in patients with chronic lung diseases. These infections are characterized by a brisk inflammatory response which results in the accumulation of polymorphonucleated cells in the lungs and is dependent on the expression and secretion of pr...

journal_title：Infection and immunity

authors： Clemans DL,Bauer RJ,Hanson JA,Hobbs MV,St Geme JW 3rd,Marrs CF,Gilsdorf JR

更新日期：2000-08-01 00:00:00

abstract：:We have recently reported Bacillus anthracis attenuated live vaccine strains efficiently expressing recombinant protective antigen (rPA) and have shown a direct correlation between the level of rPA secreted by these cells and efficacy (S. Cohen, I. Mendelson, Z. Altboum, D. Kobiler, E. Elhanany, T. Bino, M. Leitner, I...

journal_title：Infection and immunity

authors： Gat O,Inbar I,Aloni-Grinstein R,Zahavy E,Kronman C,Mendelson I,Cohen S,Velan B,Shafferman A

更新日期：2003-02-01 00:00:00

abstract：:While several diseases associated with Chlamydia psittaci infection have been reported in Phascolarctos cinereus (koala), it is still unclear whether one or more chlamydial strains are responsible. In this study, we provide evidence, obtained by restriction enzyme and gene probe analysis, that two quite distinct strai...

journal_title：Infection and immunity

authors： Girjes AA,Hugall AF,Timms P,Lavin MF

更新日期：1988-08-01 00:00:00

abstract：:Cholera toxin (CT) is a potent adjuvant for mucosal vaccination; however, its mechanism of action has not been clarified completely. It is well established that peripheral monocytes differentiate into dendritic cells (DCs) both in vitro and in vivo and that monocytes are the in vivo precursors of mucosal CD103(-) proi...

journal_title：Infection and immunity

authors： Veglia F,Sciaraffia E,Riccomi A,Pinto D,Negri DR,De Magistris MT,Vendetti S

更新日期：2011-03-01 00:00:00

abstract：:Deciphering the mechanisms by which Borrelia burgdorferi controls the synthesis of proteins associated with mammalian infection will be an important step toward understanding the pathogenic properties of Lyme disease-causing bacteria. We present results of studies indicating that B. burgdorferi senses a wide variety o...

journal_title：Infection and immunity

authors： Babb K,El-Hage N,Miller JC,Carroll JA,Stevenson B

更新日期：2001-06-01 00:00:00