Delayed-type hypersensitivity and immunity against aerogenic tuberculosis in guinea pigs.

abstract：:Shiga-like toxins (SLTs), which are produced by certain strains of Escherichia coli, are composed of enzymatically active A and B subunit multimers responsible for the toxin's binding. We have previously purified large amounts of the SLT-I B subunit by using a hyperexpression vector in Vibrio cholerae under the contro...

journal_title：Infection and immunity

authors： Acheson DW,De Breucker SA,Jacewicz M,Lincicome LL,Donohue-Rolfe A,Kane AV,Keusch GT

更新日期：1995-01-01 00:00:00

abstract：:Active immunization with Escherichia coli-expressed recombinant outer surface protein C (OspC) of Borrelia burgdorferi has been demonstrated to confer protection against a tick-transmitted infection on laboratory animals. A previous study in this laboratory showed that OspC antibody raised against a denatured immunoge...

journal_title：Infection and immunity

authors： Gilmore RD Jr,Mbow ML

更新日期：1999-10-01 00:00:00

abstract：:Antibodies against the class 4 outer membrane protein (OMP) from Neisseria meningitidis have been purified from sera from vaccinees immunized with the Norwegian meningococcal group B outer membrane vesicle vaccine. The human sera and purified antibodies reacted strongly with the class 4 OMP in immunoblots, whereas exp...

journal_title：Infection and immunity

authors： Rosenqvist E,Musacchio A,Aase A,Høiby EA,Namork E,Kolberg J,Wedege E,Delvig A,Dalseg R,Michaelsen TE,Tommassen J

更新日期：1999-03-01 00:00:00

abstract：:Haemophilus influenzae is a commensal and opportunistic pathogen of the human airways. A number of surface molecules contribute to colonization of the airways by H. influenzae, such as adhesins, including structures found in the lipooligosaccharide (LOS). A human bronchiolar xenograft model was employed to investigate...

journal_title：Infection and immunity

authors： Swords WE,Chance DL,Cohn LA,Shao J,Apicella MA,Smith AL

更新日期：2002-08-01 00:00:00

abstract：:Hamster (Mesocricetus auratus) neutrophil granules contain at least four microbicidal peptides belonging to the defensin family. These compounds were purified from granule acid extracts by reverse-phase chromatography and termed HaNP-1 to -4 (hamster neutrophil peptide). HaNP-1 and HaNP-3 revealed the most bactericida...

journal_title：Infection and immunity

authors： Mak P,Wójcik K,Thogersen IB,Dubin A

更新日期：1996-11-01 00:00:00

abstract：:Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P>0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P<0.05) over the deleted mutants....

journal_title：Infection and immunity

authors： Entenza JM,Foster TJ,Ni Eidhin D,Vaudaux P,Francioli P,Moreillon P

更新日期：2000-09-01 00:00:00

abstract：:We developed a human inhibition monoclonal enzyme-linked immunosorbent assay (HIMELISA) to investigate the human immune response to the lipooligosaccharides (LOS) of Neisseria meningitidis. Monoclonal antibodies (MAb) were used to define seven epitopes on four LOS molecules of a meningococcal strain (126E) previously ...

journal_title：Infection and immunity

authors： Estabrook MM,Mandrell RE,Apicella MA,Griffiss JM

更新日期：1990-07-01 00:00:00

abstract：:Streptococcus mutans produces several enzymes which metabolize sucrose. Three glucosyltransferase genes (gtfB, gtfC, and gtfD) and a single fructosyltransferase gene (ftf) encode enzymes which are important in formation of exopolysaccharides. Mutants of S. mutans V403 carrying single and multiple mutations of the gtfB...

journal_title：Infection and immunity

authors： Munro C,Michalek SM,Macrina FL

更新日期：1991-07-01 00:00:00

abstract：:In the absence of antiserum, rabbit polymorphonuclear leukocytes (PMNs) released lysosomal enzymes in response to Actinomyces viscosus (19246) but not to Streptococcus mutans (6715). Antibodies had a marked modulating influence on these reactions. PMN hydrolase release was significantly enhanced to both organisms when...

journal_title：Infection and immunity

authors： McArthur WP,Baehni P,Taichman NS

更新日期：1976-12-01 00:00:00

abstract：:Previous studies found that normal human serum (NHS) contains an immunoglobulin G (IgG) antibody that mediates initiation of the classical complement pathway by nonencapsulated Cryptococcus neoformans. The present study used an enzyme-linked immunosorbent assay with whole nonencapsulated yeast cells as solid-phase ant...

journal_title：Infection and immunity

authors： Keller RG,Pfrommer GS,Kozel TR

更新日期：1994-01-01 00:00:00

abstract：:The pathogenesis of middle ear inflammation caused by Streptococcus pneumoniae was explored in the chinchilla model with different pneumococcal cell wall (CW) preparations, including isolated native CW, M1 muramidase CW (M1-CW) digest, amidase CW digest, and M1 peptidoglycan (M1-PG) digest. Inflammatory cell and lysoz...

journal_title：Infection and immunity

authors： Carlsen BD,Kawana M,Kawana C,Tomasz A,Giebink GS

更新日期：1992-07-01 00:00:00

abstract：:The 23-membered Esx protein family is involved in the host-pathogen interactions of Mycobacterium tuberculosis. These secreted proteins are among the most immunodominant antigens recognized by the human immune system and have thus been used to develop vaccines and immunodiagnostic tests for tuberculosis (TB). Gene pai...

journal_title：Infection and immunity

authors： Uplekar S,Heym B,Friocourt V,Rougemont J,Cole ST

更新日期：2011-10-01 00:00:00

abstract：:By crossed immunoelectrophoresis and Western blotting (immunoblotting), it was shown that Borrelia burgdorferi expresses the 60-kilodalton Common Antigen (CA) that is cross-reactive with an equivalent antigen in a wide range of remotely related bacteria. B. burgdorferi CA is strongly immunogenic. A B. burgdorferi geno...

journal_title：Infection and immunity

authors： Hansen K,Bangsborg JM,Fjordvang H,Pedersen NS,Hindersson P

更新日期：1988-08-01 00:00:00

abstract：:Growth in colonies with type 1 morphology and the presence of pili are characteristics that have been associated with virulence of gonococci for humans. To determine whether the presence of pili per se might be responsible for colony type 1 morphology, the relationship of pili to colony type was examined in various sp...

journal_title：Infection and immunity

authors： McGee ZA,Dourmashkin RR,Gross JG,Clark JB,Taylor-Robinson D

更新日期：1977-02-01 00:00:00

abstract：:One of the chromosomal segments associated with the virulence of Shigella flexneri and transferred to Escherichia coli K-12 by conjugation has been shown to code for the production of aerobactin and for the synthesis of an iron-regulated 76,000-dalton (76K) outer membrane protein. Analysis of various E. coli K-12-S. f...

journal_title：Infection and immunity

authors： Griffiths E,Stevenson P,Hale TL,Formal SB

更新日期：1985-07-01 00:00:00

abstract：:The attachment and invasion of chicken ovarian granulosa cells by Salmonella enteritidis was examined in vitro. The attachment was inhibited by preincubation of granulosa cells with anti-chicken fibronectin antibody (approximately 70% reduction in attachment) or preincubation with a 14-kDa fimbrial protein isolated fr...

journal_title：Infection and immunity

authors： Thiagarajan D,Saeed M,Turek J,Asem E

更新日期：1996-12-01 00:00:00

abstract：:Suitability of the rhesus monkey (Macaca mulatta) as an experimental host for evaluation of vaccines against airborne infection with Mycobacterium tuberculosis strain H37Rv was investigated. Nonvaccinated monkeys were exposed to estimated doses of 12, 25, or 49 units of H37Rv in a modified Henderson apparatus, and the...

journal_title：Infection and immunity

authors： Barclay WR,Anacker RL,Brehmer W,Leif W,Ribi E

更新日期：1970-11-01 00:00:00

abstract：:To determine whether an ongoing response to Leishmania major would affect the response to a non-cross-reacting, non-leishmanial antigen, susceptible BALB/c mice and resistant C3H mice were infected with L. major parasites expressing Escherichia coli beta-galactosidase (beta-GAL); this parasite was designated L. major-...

journal_title：Infection and immunity

authors： Chakkalath HR,Siddiqui AA,Shankar AH,Dobson DE,Beverley SM,Titus RG

更新日期：2000-02-01 00:00:00

abstract：:Bacteria have evolved strategies to resist killing by antimicrobial peptides (APs), important effectors of innate immunity. The sap (sensitivity to antimicrobial peptides) operon confers resistance to AP-mediated killing of Salmonella. We have recently shown that sapA gene expression is upregulated in the middle ear i...

journal_title：Infection and immunity

authors： Mason KM,Munson RS Jr,Bakaletz LO

更新日期：2005-01-01 00:00:00

abstract：:A hemolysin that appears to be responsible for the zones of beta-hemolysis surrounding colonies of group B streptococci (Streptococcus agalactiae) on blood agar plates has been isolated and partially purified. No soluble hemolysin was detectable in the supernatants of streptococcal cultures grown in several types of m...

journal_title：Infection and immunity

authors： Marchlewicz BA,Duncan JL

更新日期：1980-12-01 00:00:00

abstract：:Brucella abortus and polyacrylic acid, two agents whose interferon-inducing capacity in the mouse has been well established, failed to stimulate circulating interferon production in rabbits, yet protected rabbits against local vaccinia virus infection. ...

journal_title：Infection and immunity

authors： De Clercq E,De Somer P

更新日期：1973-10-01 00:00:00

abstract：:The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in ...

journal_title：Infection and immunity

authors： Lembo A,Kalis C,Kirschning CJ,Mitolo V,Jirillo E,Wagner H,Galanos C,Freudenberg MA

更新日期：2003-10-01 00:00:00

abstract：:Immune responses of mice to Streptococcus mutans serotype c were analyzed by means of the enzyme-linked immunospot assay to determine the predominant specificities of the antibodies developed. In general, the numbers of splenic antibody-secreting cells correlated with serum antibody levels. A low dose (10(8) CFU) of k...

journal_title：Infection and immunity

authors： Russell MW,Czerkinsky C,Moldoveanu Z

更新日期：1986-08-01 00:00:00

abstract：:The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did n...

journal_title：Infection and immunity

authors： Daemer RJ,Feinstone SM,Alexander JJ,Tully JG,London WT,Wong DC,Purcell RH

更新日期：1980-11-01 00:00:00

abstract：:Polymicrobial intra-abdominal infections (IAI) are clinically prevalent and cause significant morbidity and mortality, especially those involving fungi. Our laboratory developed a mouse model of polymicrobial IAI and demonstrated that coinfection with Candida albicans and Staphylococcus aureus (C. albicans/S. aureus) ...

journal_title：Infection and immunity

authors： Lilly EA,Yano J,Esher SK,Hardie E,Fidel PL Jr,Noverr MC

更新日期：2019-07-23 00:00:00

abstract：:Intracellular survival of Chlamydia psittaci is in part dependent on the ability of the organism to thwart phagolysosome formation. Circumvention of phagolysosome fusion could be either localized to chlamydia-laden vacuoles or generalized to all phagosomes in the host cell. To determine which of these modes is in oper...

journal_title：Infection and immunity

authors： Eissenberg LG,Wyrick PB

更新日期：1981-05-01 00:00:00

abstract：:The protein P2 comprises a large proportion of the outer membrane of nontypable Haemophilus influenzae and functions as a porin. In view of the importance of the protein as a surface antigen, the present study was designed to purify and analyze P2 with particular emphasis on detection of antigenic determinants express...

journal_title：Infection and immunity

authors： Murphy TF,Bartos LC

更新日期：1988-05-01 00:00:00

abstract：:We have isolated plasma cell hybridomas which secrete monoclonal antibodies directed against Haemophilus ducreyi. Two of these monoclonal antibodies recognize all strains of H. ducreyi tested to date and are capable of detecting the presence of H. ducreyi in skin lesions produced by this pathogen in experimental anima...

journal_title：Infection and immunity

authors： Hansen EJ,Loftus TA

更新日期：1984-04-01 00:00:00

abstract：:Antiserum and purified immunoglobulin directed against Mycoplasma pneumoniae membrane protein P1 were examined for their influence on mycoplasma viability, metabolism, and cytadsorption. Anti-P1 immunoglobulin inhibited adherence of M. pneumoniae to hamster tracheal rings in vitro by up to 80% and inhibited hemadsorpt...

journal_title：Infection and immunity

authors： Krause DC,Baseman JB

更新日期：1983-03-01 00:00:00

abstract：:Killing of Salmonella minnesota and Salmonella typhimurium S and R strains in serum of nonimmune humans and guinea pigs was drastically reduced in the selective absence of C1q, C1r, Ca2+, C4, or C2, the components of the classical complement pathway. Binding of C1 and C1q to the S form and six different core-deficient...

journal_title：Infection and immunity

authors： Clas F,Loos M

更新日期：1982-09-01 00:00:00