Relationship of pili to colonial morphology among pathogenic and nonpathogenic species of Neisseria.

abstract：:The biochemical properties of polymorphonuclear neutrophils from blood and peritoneal exudates of rabbits were compared. All enzymes measured showed almost identical activities in both types of cells, except for alkaline phosphodiesterase, the activity of which was seven times higher in peritoneal neutrophils. During ...

journal_title：Infection and immunity

authors： Takamori K,Yamashita T

更新日期：1980-08-01 00:00:00

abstract：:Previous studies have demonstrated antigenic differences among the pili expressed by various strains of Haemophilus influenzae type b (Hib). In order to understand the molecular basis for these differences, the structural gene for pilin was cloned from Hib strain Eagan (p+) and the nucleotide sequence was compared to ...

journal_title：Infection and immunity

authors： Forney LJ,Marrs CF,Bektesh SL,Gilsdorf JR

更新日期：1991-06-01 00:00:00

abstract：:The purpose of the present study was to evaluate the effectiveness of an attenuated Salmonella enterica serovar Typhimurium vaccine strain expressing the saliva-binding region (SBR) of the Streptococcus mutans antigen I/II adhesin, either alone or linked with the mucosal adjuvant cholera toxin A2 and B subunits (CTA2/...

journal_title：Infection and immunity

authors： Huang Y,Hajishengallis G,Michalek SM

更新日期：2001-04-01 00:00:00

abstract：:Cytotoxic necrotizing factor type 1 (CNF1) and CNF2 are toxins of pathogenic Escherichia coli that share 85% identity over 1,014 amino acids. Although both of these toxins modify GTPases, CNF1 is a more potent inducer of multinucleation in HEp-2 cells, binds more efficiently to HEp-2 cells, and, despite the conservati...

journal_title：Infection and immunity

authors： Grande KK,Meysick KC,Rasmussen SB,O'Brien AD

更新日期：2009-01-01 00:00:00

abstract：:The LuxS protein is required for the biosynthesis of the type 2 autoinducer (AI-2), which is involved in quorum sensing in a wide range of bacterial species. We have determined the effects of a defined luxS mutation on the virulence of Streptococcus pneumoniae. Although the luxS mutant displayed reduced virulence rela...

journal_title：Infection and immunity

authors： Stroeher UH,Paton AW,Ogunniyi AD,Paton JC

更新日期：2003-06-01 00:00:00

abstract：:Studies with animal models have demonstrated that viral respiratory tract infections suppress bacterial clearance processes in the lung and that this alteration in host defenses appears to explain the excessive mortality from bacterial pneumonia during influenza epidemics. However, since the pathogenesis of postinflue...

journal_title：Infection and immunity

authors： Nugent KM,Pesanti EL

更新日期：1983-12-01 00:00:00

abstract：:Defensins are antibiotic peptides expressed in human and animal myeloid and epithelial cells. Due to the limited availability of natural peptides, the properties of human epithelial defensins have not been studied. We assayed the microbicidal activity of recombinant human intestinal defensin 5 (rHD-5) in the presence ...

journal_title：Infection and immunity

authors： Porter EM,van Dam E,Valore EV,Ganz T

更新日期：1997-06-01 00:00:00

abstract：:Tritrichomonas foetus is a serious veterinary pathogen, causing bovine trichomoniasis, a sexually transmitted disease leading to infertility and abortion. T. foetus infects the mucosal surfaces of the reproductive tract. Infection with T. foetus leads to apoptotic cell death of bovine vaginal epithelial cells (BVECs) ...

journal_title：Infection and immunity

authors： Singh BN,Lucas JJ,Hayes GR,Kumar I,Beach DH,Frajblat M,Gilbert RO,Sommer U,Costello CE

更新日期：2004-07-01 00:00:00

abstract：:The mig gene of Streptococcus dysgalactiae, a major bovine mastitis pathogen, encodes two plasma protein-binding receptors, alpha2-macroglobulin (alpha2-M) and immunoglobulin G (IgG). In this study, the mig gene from one S. dysgalactiae isolate was cloned and expressed in Escherichia coli. The IgG receptor region enco...

journal_title：Infection and immunity

authors： Song XM,Perez-Casal J,Bolton A,Potter AA

更新日期：2001-10-01 00:00:00

abstract：:Previous studies have indicated that the ability to bind to fibronectin is a key feature in successful cell invasion by Campylobacter jejuni. Given the spatial distribution of fibronectin and the architecture of the epithelium, this suggests the possibility that C. jejuni cell invasion might preferentially occur at th...

journal_title：Infection and immunity

authors： Monteville MR,Konkel ME

更新日期：2002-12-01 00:00:00

abstract：:The Plasmodium falciparum liver-stage antigen 3 (LSA3), a recently identified preerythrocytic antigen, induces protection against malaria in chimpanzees. Using antibodies from individuals with hyperimmunity to malaria affinity purified on recombinant or synthetic polypeptides of LSA3, we identified four non-cross-reac...

journal_title：Infection and immunity

authors： Brahimi K,Badell E,Sauzet JP,BenMohamed L,Daubersies P,Guérin-Marchand C,Snounou G,Druilhe P

更新日期：2001-06-01 00:00:00

abstract：:An effective vaccine for Vibrio cholerae is not yet available for use in the developing world, where the burden of cholera disease is highest. Characterizing the proteins that are expressed by V. cholerae in the human host environment may provide insight into the pathogenesis of cholera and assist with the development...

journal_title：Infection and immunity

authors： LaRocque RC,Krastins B,Harris JB,Lebrun LM,Parker KC,Chase M,Ryan ET,Qadri F,Sarracino D,Calderwood SB

更新日期：2008-09-01 00:00:00

abstract：:Early-onset periodontitis (EOP) is characterized by rapidly progressive alveolar bone loss, chemotactic defects of neutrophils, and significant familial aggregation. We found immature myeloid lineage cells, defined as promyelocytes, in the peripheral blood in patients with EOP. A hematological examination of periphera...

journal_title：Infection and immunity

authors： Nemoto E,Nakamura M,Shoji S,Horiuchi H

更新日期：1997-09-01 00:00:00

abstract：:Mice (BALB/cJ, C3H/HeN, and C3H/HeJ) primed with actinomycin D became highly susceptible to lethal intoxication with staphylococcal enterotoxin B (SEB). The mice underwent toxicosis and toxic shock and died. Actinomycin D-primed C3H/HeN and C3H/HeJ mice showed equal sensitivity to SEB, suggesting that bacterial lipopo...

journal_title：Infection and immunity

authors： Chen JY,Qiao Y,Komisar JL,Baze WB,Hsu IC,Tseng J

更新日期：1994-10-01 00:00:00

abstract：:Neutrophils are the main inflammatory cell present in lesions involving the central nervous system (CNS) during human and murine listeriosis. In this study, administration of the neutrophil-depleting monoclonal antibody RB6-8C5 during experimental murine listeriosis facilitated the multiplication of Listeria monocytog...

journal_title：Infection and immunity

authors： López S,Marco AJ,Prats N,Czuprynski CJ

更新日期：2000-08-01 00:00:00

abstract：:Chlamydia pneumoniae is a causative agent for many respiratory infections and has been associated with cardiovascular diseases in humans. The pathogenicity of C. pneumoniae is thought to depend on its ability to cause persistent infection and to evade host defense. Genome sequence analysis indicates that C. pneumoniae...

journal_title：Infection and immunity

authors： Fan P,Dong F,Huang Y,Zhong G

更新日期：2002-01-01 00:00:00

abstract：:Escherichia coli O157:H7 causes food and waterborne enteric infections that can result in hemorrhagic colitis and life-threatening hemolytic uremic syndrome. Intimate adherence of the bacteria to intestinal epithelial cells is mediated by intimin, but E. coli O157:H7 also possess several other putative adhesins, inclu...

journal_title：Infection and immunity

authors： Lloyd SJ,Ritchie JM,Rojas-Lopez M,Blumentritt CA,Popov VL,Greenwich JL,Waldor MK,Torres AG

更新日期：2012-03-01 00:00:00

abstract：:The two enteropathogens Yersinia pseudotuberculosis and Yersinia enterocolitica penetrate eukaryotic cells in vitro through invasin, a surface-exposed protein. In contrast, Yersinia pestis, the causative agent of plague, is unable to enter mammalian cell lines, although the inv gene is present on its chromosome. Altho...

journal_title：Infection and immunity

authors： Simonet M,Riot B,Fortineau N,Berche P

更新日期：1996-01-01 00:00:00

abstract：:The opacity (Opa) proteins mediate a variety of interactions between the bacterium Neisseria meningitidis and its human host. These interactions are thought to be of central importance in both the asymptomatic colonization of the nasopharynx and the sporadic occurrence of meningococcal disease. The receptor specificit...

journal_title：Infection and immunity

authors： Callaghan MJ,Jolley KA,Maiden MC

更新日期：2006-09-01 00:00:00

abstract：:It has been reported that Neisseria gonorrhoeae possesses a very high level of catalase activity, but the regulation of catalase expression has not been investigated extensively. In Escherichia coli and Salmonella enterica serovar Typhimurium, it has been demonstrated that OxyR is a positive regulator of hydrogen pero...

journal_title：Infection and immunity

authors： Tseng HJ,McEwan AG,Apicella MA,Jennings MP

更新日期：2003-01-01 00:00:00

abstract：:To develop targeted gene integration in the periodontal pathogen Actinobacillus actinomycetemcomitans, a ColE1-based, spectinomycin-resistant plasmid containing a segment of the leukotoxin gene was electroporated into strain JP2. In all of the stable spectinomycin-resistant transformants that arose, the plasmid had re...

journal_title：Infection and immunity

authors： Kolodrubetz D,Phillips LH,Ezzo PJ,Kraig E

更新日期：1995-07-01 00:00:00

abstract：:Lesions caused by Leishmania amazonensis normally heal, but relapses occur due to parasite persistence in host tissues. It has been proposed that infection of fibroblasts plays an important role in this process by providing the parasites with a safe haven in which to replicate. However, most previous studies have focu...

journal_title：Infection and immunity

authors： Morehead J,Coppens I,Andrews NW

更新日期：2002-08-01 00:00:00

abstract：:The heparin-binding hemagglutinin (HBHA) of Mycobacterium tuberculosis is a surface-expressed adhesin that can affect binding to host cells via a unique, methylated, carboxyl-terminal, lysine-, alanine-, and proline-rich repeat region. It has been implicated in extrapulmonary dissemination of M. tuberculosis from the ...

journal_title：Infection and immunity

authors： Parra M,Pickett T,Delogu G,Dheenadhayalan V,Debrie AS,Locht C,Brennan MJ

更新日期：2004-12-01 00:00:00

abstract：:Five mutagens were used to induce mutants of Candida albicans. Ultraviolet light, N-nitroso-N'-methyl-N-nitrosoguanidine, and N-nitroso-N-methylurethane were effective mutagens which induced stable auxotrophs. N-nitroso-N-methylurethane produced the largest number and variety of mutants. Nitrous acid and hydroxylamine...

journal_title：Infection and immunity

authors： Savage N,Balish E

更新日期：1971-01-01 00:00:00

abstract：:When inoculated orally, Escherichia coli strain 1056 caused acute enteritis in 7 of 22 weanling hamsters. E. coli strain 1056 was isolated from the ileum of a hamster with proliferative ileitis. It was lactose negative, nonmotile, and anaerogenic. By electron microscopy and indirect fluorescent-antibody techniques, E....

journal_title：Infection and immunity

authors： Frisk CS,Wagner JE,Owens DR

更新日期：1981-03-01 00:00:00

abstract：:Current vaccination against Streptococcus pneumoniae uses vaccines based on capsular polysaccharides from selected serotypes and has led to nonvaccine serotype replacement disease. We have investigated an alternative serotype-independent approach, using multiple-antigen vaccines (MAV) prepared from S. pneumoniae TIGR4...

journal_title：Infection and immunity

authors： Chan WY,Entwisle C,Ercoli G,Ramos-Sevillano E,McIlgorm A,Cecchini P,Bailey C,Lam O,Whiting G,Green N,Goldblatt D,Wheeler JX,Brown JS

更新日期：2019-02-21 00:00:00

abstract：:The presence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs), hepatitis B e antigen (HBeAg) and antibody (anti-HBe), the nature of T-cell function, and specific cell-mediated immunity to HBsAg were determined and evaluated serially in groups of subjects with chronic HBsAg carrier states and in seronegat...

journal_title：Infection and immunity

authors： Beutner KR,Tiku ML,Ogra PL

更新日期：1978-08-01 00:00:00

abstract：:Purified Escherichia coli type 1 fimbriae have been shown previously to stimulate T-cell-independent proliferation of human B lymphocytes. The response is mediated by the mannose-specific, lectin-like adhesin protein FimH. Here we show that type 1 fimbriae also stimulate immunoglobulin (Ig) secretion by B cells. The r...

journal_title：Infection and immunity

authors： Ponniah S,Abraham SN,Endres RO

更新日期：1992-12-01 00:00:00

abstract：:The interferon-inducing capabilities of the three molecular segments of bacteriophage phi6 double-stranded ribonucleic acid increased with increasing molecular weight. ...

journal_title：Infection and immunity

authors： Kleinschmidt WJ,Van Etten JL,Vidaver AK

更新日期：1974-07-01 00:00:00

abstract：:A simple and convenient method was developed for the preparation of Streptococcus pneumoniae type 14 polysaccharide (Pn14PS)-tetanus toxoid (TT) conjugate vaccines, using terminally linked Pn14PS fragments of different lengths. Native Pn14PS was simultaneously depolymerized and activated for conjugation by partial N-d...

journal_title：Infection and immunity

authors： Laferriere CA,Sood RK,de Muys JM,Michon F,Jennings HJ

更新日期：1998-06-01 00:00:00