Lipopolysaccharide hyperreactivity of animals infected with Trypanosoma lewisi or Trypanosoma musculi.

abstract：:Cathepsin G (CatG) is a serine protease found in the azurophilic granules of monocytes that is known to have antimicrobial properties, but its role in Mycobacterium tuberculosis infection is unknown. We found that M. tuberculosis infection of human THP-1 monocytic cells induced the down-regulation of CatG mRNA express...

journal_title：Infection and immunity

authors： Rivera-Marrero CA,Stewart J,Shafer WM,Roman J

更新日期：2004-10-01 00:00:00

abstract：:Phorbol myristate acetate stimulated oxidative metabolism in alveolar macrophages and blood neutrophils. This compound also stimulated lysozyme release from neutrophils but not from alveolar macrophages. These findings suggest that the regulation of lysozyme release from alveolar macrophages is different than for poly...

journal_title：Infection and immunity

authors： Biggar WD

更新日期：1978-08-01 00:00:00

abstract：:Escherichia coli strains isolated from newborn infants were injected intraperitoneally into infant rats. Strains possessing the K1 capsular polysaccharide antigen were significantly more virulent than strains lacking this antigen. When 5-day-old animals were injected with 1.2 X 10(1) colony forming units of a K1 E. co...

journal_title：Infection and immunity

authors： Bortolussi R,Ferrieri P,Wannamaker LW

更新日期：1978-11-01 00:00:00

abstract：:Potential vaccine components for protection against atrophic rhinitis in pigs were developed. This was achieved by deletion mutagenesis of the gene encoding the Pasteurella multocida toxin. Four purified toxin derivatives lacking different and widely separated regions in the amino acid sequence were characterized by a...

journal_title：Infection and immunity

authors： Petersen SK,Foged NT,Bording A,Nielsen JP,Riemann HK,Frandsen PL

更新日期：1991-04-01 00:00:00

abstract：:Polymorphonuclear leukocytes from 46 adults (age 18 to 35), 19 adults (age 70 to 91), 10 children (age 1 to 3), and 22 neonates (cord blood samples) were tested for their chemiluminescence response to opsonized zymosan. Results indicated that both cord blood leukocytes and those from individuals over 70 were significa...

journal_title：Infection and immunity

authors： Van Epps DE,Goodwin JS,Murphy S

更新日期：1978-10-01 00:00:00

abstract：:The character of the antibody response in the rabbit to Salmonella typhimurium somatic (O) antigen was similar to the response to each of several serotypes of Shigella flexneri O antigens, namely a predominance of production of immunoglobulin M (IgM) antibody. Lipopolysaccharide protein (LPSP) and lipopolysaccharide (...

journal_title：Infection and immunity

authors： Fukazawa Y,Shinoda T,Yomoda T,Tsuchiya T

更新日期：1970-03-01 00:00:00

abstract：:Polyprotein allergens are a family of structurally homologous molecules from parasitic nematodes which induce specific immunoglobulin E in infected individuals. We show here that both H-2 and non-H-2 factors determine the ability of mice to generate T- and B-cell responses to the filarial polyprotein allergen (Brugia ...

journal_title：Infection and immunity

authors： Allen JE,Lawrence RA,Maizels RM

更新日期：1995-08-01 00:00:00

abstract：:In vivo expression of pili by Escherichia coli in the urine of 41 adults with lower urinary tract infections was analyzed by immunostaining with polyclonal antiserum to type 1 and P pili. Type 1 pili were detected in 31 of 41 urine specimens, while P pili were detected in 6 of 18 specimens. The piliation status of bac...

journal_title：Infection and immunity

authors： Kisielius PV,Schwan WR,Amundsen SK,Duncan JL,Schaeffer AJ

更新日期：1989-06-01 00:00:00

abstract：:Borrelia burgdorferi sensu stricto is the major causative agent of Lyme disease in the United States, while B. garinii and B. afzelii are more prevalent in Europe. The highly complex genome of B. burgdorferi is comprised of a linear chromosome and a large number of variably sized linear and circular plasmids. Many pla...

journal_title：Infection and immunity

authors： Chan K,Casjens S,Parveen N

更新日期：2012-04-01 00:00:00

abstract：:Chromosomes from Cryptococcus neoformans, an encapsulated yeast pathogen, were separated by contour-clamped homogeneous field gel electrophoresis. Seven strains representing all four serotypes were studied. It was found that each strain had a unique, reproducible pattern of chromosome bands which could potentially be ...

journal_title：Infection and immunity

authors： Perfect JR,Magee BB,Magee PT

更新日期：1989-09-01 00:00:00

abstract：:Invasive fungal infections represent an increasing problem associated with high mortality. The present study was undertaken to identify leukocyte subsets that are activated by hyphal fragments in a whole-human-blood model, as well as to examine the involvement of CD14 and Toll-like receptors (TLRs) in activation of mo...

journal_title：Infection and immunity

authors： Wang JE,Warris A,Ellingsen EA,Jørgensen PF,Flo TH,Espevik T,Solberg R,Verweij PE,Aasen AO

更新日期：2001-04-01 00:00:00

abstract：:Upon infection of a host, the pathogenic fungus Aspergillus fumigatus is attacked by the reactive oxygen species produced by phagocytic cells. Detoxification of hydrogen peroxide by catalases was proposed as a way to overcome this host response. A. fumigatus produces three active catalases; one is produced by conidia,...

journal_title：Infection and immunity

authors： Paris S,Wysong D,Debeaupuis JP,Shibuya K,Philippe B,Diamond RD,Latgé JP

更新日期：2003-06-01 00:00:00

abstract：:The type III secretion system (TTSS) of Pseudomonas aeruginosa is induced in vivo upon contact with eukaryotic cells and in vitro by calcium depletion in culture medium. We have observed a previously identified protein, PsrA, necessary for full activation of TTSS gene expression in P. aeruginosa. Electrophoretic mobil...

journal_title：Infection and immunity

authors： Shen DK,Filopon D,Kuhn L,Polack B,Toussaint B

更新日期：2006-02-01 00:00:00

abstract：:Ninety-six Aeromonas hydrophila isolates were tested for cytotoxin and hemolysin production. Sixty-six (69%) of the isolates were both cytotoxic and hemolytic, whereas the rest produced neither cytotoxin nor hemolysin. No evidence of a separate cytotonic activity could be found in any of the isolates. Cytotoxin activi...

journal_title：Infection and immunity

authors： Cumberbatch N,Gurwith MJ,Langston C,Sack RB,Brunton JL

更新日期：1979-03-01 00:00:00

abstract：:Heart and muscle tissues appear to be specific target organs for the in vivo inhibition of protein synthesis by diphtheria toxin. ...

journal_title：Infection and immunity

authors： Bowman CG,Imhoff JG,Bonventre PF

更新日期：1970-11-01 00:00:00

abstract：:A superoxide dismutase (SOD) gene from the obligate intracellular bacterium Coxiella burnetii has been cloned, and its DNA sequence has been determined and expressed in Escherichia coli. The gene was identified on pSJR50, a pHC79-derived genomic clone, by using the polymerase chain reaction with degenerate oligonucleo...

journal_title：Infection and immunity

authors： Heinzen RA,Frazier ME,Mallavia LP

更新日期：1992-09-01 00:00:00

abstract：:Analysis of the partition in a two-polymer phase system of Salmonella typhimurium R mutants with different susceptibility to phagocytosis distinguished between the mutants. Close to 80% of the R mutants least resistant to phagocytosis accumulated in the dextran-rich phase, whereas more phagocytosis-resistant mutants s...

journal_title：Infection and immunity

authors： Stendahl O,Tagesson C,Edebo M

更新日期：1973-07-01 00:00:00

abstract：:Bacillus anthracis, the causative agent of anthrax, relies on multiple virulence factors to subvert the host immune defense. Using Caenorhabditis elegans as an infection model, we screened approximately 5,000 transposon mutants of B. anthracis Sterne for decreased virulence. One of the attenuated mutants resulted in l...

journal_title：Infection and immunity

authors： Franks SE,Ebrahimi C,Hollands A,Okumura CY,Aroian RV,Nizet V,McGillivray SM

更新日期：2014-03-01 00:00:00

abstract：:The endothelium is a specific target for Bartonella henselae, and endothelial cell infection represents an important step in the pathogenesis of cat scratch disease and bacillary angiomatosis. Mechanisms of Bartonella-endothelial cell interaction as well as signaling pathways involved in target cell activation were an...

journal_title：Infection and immunity

authors： Fuhrmann O,Arvand M,Göhler A,Schmid M,Krüll M,Hippenstiel S,Seybold J,Dehio C,Suttorp N

更新日期：2001-08-01 00:00:00

abstract：:This study was carried out to determine the role of nitric oxide (NO) in Staphylococcus aureus infection in mice. NO production in spleen cell cultures was induced by heat-killed S. aureus. Expression of mRNA of the inducible isoform of NO synthase (iNOS) was induced in the spleens and kidneys of S. aureus-infected mi...

journal_title：Infection and immunity

authors： Sasaki S,Miura T,Nishikawa S,Yamada K,Hirasue M,Nakane A

更新日期：1998-03-01 00:00:00

abstract：:One major outer membrane protein (P1) of Haemophilus influenzae type b (Hib), with an apparent molecular weight of 34,000 (34K) as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), has been shown to be heat modifiable. After heating at 100 degrees C for 5 min in 2% SDS, the P1 protein...

journal_title：Infection and immunity

authors： Gonzales FR,Leachman S,Norgard MV,Radolf JD,McCracken GH Jr,Evans C,Hansen EJ

更新日期：1987-12-01 00:00:00

abstract：:The involvement of tumor necrosis factor (TNF) in resistance to Toxoplasma gondii infection was examined by means of experiments in which mice were treated with anti-TNF antibodies prior to infection with ME49, a low-virulence Toxoplasma strain. In (BALB/cBy x C57BL/6J)F1 (CB6F1) mice, which are highly resistant to in...

journal_title：Infection and immunity

authors： Johnson LL

更新日期：1992-05-01 00:00:00

abstract：:Recruitment of neutrophils to lung tissue and airspaces is a hallmark of inflammatory events following inhalation of endotoxins. We studied the role of different lymphocyte subsets in this inflammation, which is assumed to primarily involve the innate immune system. Inhalation of aerosolized Escherichia coli lipopolys...

journal_title：Infection and immunity

authors： Larsson R,Rocksén D,Lilliehöök B,Jonsson A,Bucht A

更新日期：2000-12-01 00:00:00

abstract：:In the murine model of urinary tract infections (UTI), cystitis by uropathogenic Escherichia coli (UPEC) occurs through an intimate relationship with the bladder superficial umbrella cell entailing cycles of adherence, invasion, intracellular bacterial community (IBC) formation, and dispersal (fluxing) from the intrac...

journal_title：Infection and immunity

authors： Wright KJ,Seed PC,Hultgren SJ

更新日期：2005-11-01 00:00:00

abstract：:Toxic protein(s) neutralized with anti-C2 toxic serum was extracted from Clostridium botulinum type C spores treated with an alkaline mercaptoethanol solution. C2 toxicity in the spores was located in the spore coat fraction and was more heat stable than that found in culture fluid. ...

journal_title：Infection and immunity

authors： Yamakawa K,Nishida S,Nakamura S

更新日期：1983-08-01 00:00:00

abstract：:The vast majority of cases of gram-negative meningitis in neonates are caused by K1-encapsulated Escherichia coli. The role of the K1 capsule in the pathogenesis of E. coli meningitis was examined with an in vivo model of experimental hematogenous E. coli K1 meningitis and an in vitro model of the blood-brain barrier....

journal_title：Infection and immunity

authors： Hoffman JA,Wass C,Stins MF,Kim KS

更新日期：1999-07-01 00:00:00

abstract：:Most strains of Shigella flexneri 2a and enteroaggregative Escherichia coli carry a highly conserved chromosomal locus which encodes a 109-kDa secreted mucinase (called Pic) and, on the opposite strand in overlapping fashion, an oligomeric enterotoxin called ShET1, encoded by the setA and setB genes. Here, we characte...

journal_title：Infection and immunity

authors： Behrens M,Sheikh J,Nataro JP

更新日期：2002-06-01 00:00:00

abstract：:Vitamin D(3) (1,25-dihydroxycholecalciferol) induced the phagocyte oxidative burst and intracellular killing of Salmonella enterica serovar Typhimurium in a phosphatidylinositol 3-kinase-dependent manner. The antimicrobial effect was more pronounced for Salmonella SodCI and SodCII mutants, confirming the role of the p...

journal_title：Infection and immunity

authors： Sly LM,Guiney DG,Reiner NE

更新日期：2002-09-01 00:00:00

abstract：:In the present study, the role of virulence factors in and the effect of opsonization on the interactions between Bordetella pertussis and human monocytes were investigated. The methods used facilitated the distinction between attachment and ingestion of bacteria by monocytes. Nonopsonized virulent B. pertussis cells ...

journal_title：Infection and immunity

authors： Hazenbos WL,van den Berg BM,van't Wout JW,Mooi FR,van Furth R

更新日期：1994-11-01 00:00:00

abstract：:We have previously demonstrated that protection from allergic inflammation by Ascaris suum infection was characterized by a global increase in interleukin-10 (IL-10) and the development of protective CD4(+)/CD25(+) T cells (L. Schopf, S. Luccioli, V. Bundoc, P. Justice, C. C. Chan, B. J. Wetzel, H. H. Norris, J. F. Ur...

journal_title：Infection and immunity

authors： McConchie BW,Norris HH,Bundoc VG,Trivedi S,Boesen A,Urban JF Jr,Keane-Myers AM

更新日期：2006-12-01 00:00:00