Virulence factors determine attachment and ingestion of nonopsonized and opsonized Bordetella pertussis by human monocytes.

abstract：:Infection with gram-negative monocytotropic Ehrlichia strains results in a fatal toxic shock-like syndrome characterized by a decreased number of Ehrlichia-specific CD4(+) Th1 cells, the expansion of tumor necrosis factor alpha (TNF-alpha)-producing CD8(+) T cells, and the systemic overproduction of interleukin-10 (IL...

journal_title：Infection and immunity

authors： Ismail N,Crossley EC,Stevenson HL,Walker DH

更新日期：2007-09-01 00:00:00

abstract：:The antigenicity of Erysipelothrix rhusiopathiae T28 (serotype 2) was investigated. Antigens were solubilized from the cell surface with detergents. By means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting it was shown that the molecular weight of the main antigenic component--a nonprot...

journal_title：Infection and immunity

authors： Lachmann PG,Deicher H

更新日期：1986-06-01 00:00:00

abstract：:Cryptococcus neoformans laccase expression during murine infection was investigated in lung tissue by immunohistochemistry and immunogold electron microscopy. Laccase was detected in the fungal cell cytoplasm, cell wall, and capsule in vivo. The amount of laccase found in different sites varied as a function of the ti...

journal_title：Infection and immunity

authors： Garcia-Rivera J,Tucker SC,Feldmesser M,Williamson PR,Casadevall A

更新日期：2005-05-01 00:00:00

abstract：:The cyst cell wall β-glucans of Pneumocystis have been shown to stimulate immune responses in lung epithelial cells, dendritic cells, and alveolar macrophages. Little is known about how the trophic life forms, which do not have a fungal cell wall, interact with these innate immune cells. Here, we report differences in...

journal_title：Infection and immunity

authors： Evans HM,Bryant GL 3rd,Garvy BA

更新日期：2016-11-01 00:00:00

abstract：:Development of hemolytic uremic syndrome (HUS) after infection by Shigella dysenteriae 1 or enterohemorrhagic Escherichia coli has been associated with the production of Shiga toxins (verotoxins). The putative target of Shiga toxins in HUS is the renal microvascular endothelium. This report shows that preincubation of...

journal_title：Infection and immunity

authors： Kaye SA,Louise CB,Boyd B,Lingwood CA,Obrig TG

更新日期：1993-09-01 00:00:00

abstract：:The outer membrane proteins of Bordetella avium were examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Sarkosyl-insoluble outer membrane protein-enriched profiles from 50 virulent B. avium isolates, containing major 21,000- and 37,000-molecular-weight proteins (21K and 37K proteins, respectively) ...

journal_title：Infection and immunity

authors： Leyh R,Griffith RW

更新日期：1992-03-01 00:00:00

abstract：:We demonstrate that a mucoid, alginate-producing strain of Pseudomonas aeruginosa isolated from the lungs of a cystic fibrosis (CF) patient secretes multiple enzymes with nucleoside diphosphate kinase (Ndk), ATPase, adenylate kinase, 5'-nucleotidase, and ATP-modifying enzymatic activities. The secretion is triggered a...

journal_title：Infection and immunity

authors： Zaborina O,Misra N,Kostal J,Kamath S,Kapatral V,El-Idrissi ME,Prabhakar BS,Chakrabarty AM

更新日期：1999-10-01 00:00:00

abstract：:The phenotypic and functional changes of glycolipid presented by CD1d(glycolipid/CD1d) specific Valpha14+ T cells in the liver of mice at early stages of bacterial infection were investigated. After Listeria monocytogenes infection or interleukin-12 (IL-12) treatment, alpha-galactosylceramide/CD1d tetramer-reactive (a...

journal_title：Infection and immunity

authors： Emoto M,Yoshizawa I,Emoto Y,Miamoto M,Hurwitz R,Kaufmann SH

更新日期：2006-10-01 00:00:00

abstract：:For pathogens to survive in the human oral cavity, they must identify a suitable niche in the complex multispecies biofilm that exists on oral tissues. The periodontal pathogen Porphyromonas gingivalis adheres to Streptococcus gordonii by interacting with a specific region of the streptococcal SspB polypeptide, design...

journal_title：Infection and immunity

authors： Demuth DR,Irvine DC,Costerton JW,Cook GS,Lamont RJ

更新日期：2001-09-01 00:00:00

abstract：:Salmonella infection can cause gastroenteritis in healthy individuals or a serious, systemic infection in immunocompromised patients and has a global impact. CD4 Th1 cells represent the main lymphocyte population that participates in bacterial clearance during both primary and secondary infections in mice of the H-2b ...

journal_title：Infection and immunity

authors： Labuda JC,Depew CE,Pham OH,Benoun JM,Ramirez NA,McSorley SJ

更新日期：2019-10-18 00:00:00

abstract：:Lung dendritic cells were identified by immunohistochemistry in lung tissue sections from C57BL/6 mice. Following isolation from the lungs using CD11c magnetic beads, the flow cytometric analysis of I-A(b+) and CD11c(+) cells indicated a mixed population of dendritic cells at different stages of maturation, with most ...

journal_title：Infection and immunity

authors： Gonzalez-Juarrero M,Orme IM

更新日期：2001-02-01 00:00:00

abstract：:Yersinia pestis evolved from Y. pseudotuberculosis to become the causative agent of bubonic and pneumonic plague. We identified a homolog of the Salmonella enterica serovar Typhimurium lipoprotein (lpp) gene in Yersinia species and prepared lpp gene deletion mutants of Y. pseudotuberculosis YPIII, Y. pestis KIM/D27 (p...

journal_title：Infection and immunity

authors： Sha J,Agar SL,Baze WB,Olano JP,Fadl AA,Erova TE,Wang S,Foltz SM,Suarez G,Motin VL,Chauhan S,Klimpel GR,Peterson JW,Chopra AK

更新日期：2008-04-01 00:00:00

abstract：:Four glycoproteins of Treponema pallidum were identified by intrinsic [14C]glucosamine labeling. Only two glycoproteins were demonstrated in T. phagedenis biotype Reiter with the same technique. Glycoproteins of both treponemes were characterized as antigens and shown to be localized within the outer membranes of the ...

journal_title：Infection and immunity

authors： Moskophidis M,Müller F

更新日期：1984-12-01 00:00:00

abstract：:Antigen preparations derived from Plasmodium falciparum-infected erythrocytes (but not from uninfected erythrocytes) can stimulate the in vitro proliferation of peripheral blood lymphocytes from malaria-sensitized as well as nonsensitized donors. The possibility that the nonspecific responses might be due to a parasit...

journal_title：Infection and immunity

authors： Wyler DJ,Herrod HG,Weinbaum FI

更新日期：1979-04-01 00:00:00

abstract：:Lipooligosaccharide (LOS) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the pathogenesis of human infections caused by this organism. The presence of LOS on the bacterium is an obstacle to the development of vaccines derived from whole cells or outer membrane components of th...

journal_title：Infection and immunity

authors： Peng D,Hong W,Choudhury BP,Carlson RW,Gu XX

更新日期：2005-11-01 00:00:00

abstract：:A high-molecular-weight, immunogenic form of the lipopolysaccharide O side chain of Pseudomonas aeruginosa Fisher immunotype 4 (type 4, International Antigenic Typing System 1, Lanyi O:6) was isolated and characterized. Analysis by nuclear magnetic resonance spectroscopy confirmed the structural similarity of this hig...

journal_title：Infection and immunity

authors： Pier GB,Pollack M

更新日期：1989-02-01 00:00:00

abstract：:Immunologically competent mice and mice with defined immunological deficiencies were infected with Plasmodium yoelii. Splenomegaly, enhanced phagocytosis, and anemia were most marked in infected mice having intact thymic tissue. Whereas the spleens of infected nude mice increased minimally in size, the relative blood ...

journal_title：Infection and immunity

authors： Roberts DW,Weidanz WP

更新日期：1978-06-01 00:00:00

abstract：:Three strains of Lactobacillus, identified as Lactobacillus acidophilus, Lactobacillus gasseri, and Lactobacillus jensenii, were selected from among 70 isolates from the vaginas of healthy premenopausal women for properties relevant to mucosal colonization or antagonism. All three self-aggregated and adhered to epithe...

journal_title：Infection and immunity

authors： Boris S,Suárez JE,Vázquez F,Barbés C

更新日期：1998-05-01 00:00:00

abstract：:Naegleria fowleri produces fatal meningoencephalitis in humans and in experimentally infected laboratory animals. The course of the disease in mice is dependent upon the infecting dose of amoebae, route of inoculation, and prior exposure to Naegleria antigens. DUB/ICR mice were immunized by various routes and antigen ...

journal_title：Infection and immunity

authors： John DT,Weik RR,Adams AC

更新日期：1977-06-01 00:00:00

abstract：:The Gram-negative intracellular pathogen Burkholderia pseudomallei is the causative agent of melioidosis, an important cause of sepsis in Southeast Asia. Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is essential for an appropriate immune response during pathogen invasion. In pati...

journal_title：Infection and immunity

authors： Birnie E,Weehuizen TAF,Lankelma JM,de Jong HK,Koh GCKW,van Lieshout MHP,Roelofs JJTH,Budding AE,de Vos AF,van der Poll T,Wiersinga WJ

更新日期：2019-07-23 00:00:00

abstract：:Streptococcal pyrogenic exotoxin B (SpeB), a conserved cysteine protease expressed by virtually all Streptococcus pyogenes strains, has recently been shown to be an important virulence factor (S. Lukomski, S. Sreevatsan, C. Amberg, W. Reichardt, M. Woischnik, A. Podbielski, and J. M. Musser, J. Clin. Invest. 99:2574-2...

journal_title：Infection and immunity

authors： Lukomski S,Burns EH Jr,Wyde PR,Podbielski A,Rurangirwa J,Moore-Poveda DK,Musser JM

更新日期：1998-02-01 00:00:00

abstract：:Studies were carried out to determine whether the in vitro capacity of adherent peritoneal cells to replicate herpes simplex virus type 1 (HSV-1) might correlate with the in vivo susceptibility of mice genetically resistant, moderately susceptible, or very susceptible to HSV-1 infection. Unstimulated and proteose pept...

journal_title：Infection and immunity

authors： Lopez C,Dudas G

更新日期：1979-02-01 00:00:00

abstract：:Helicobacter infections are present in approximately 50% of humans, causing severe illnesses such as gastritis and malignancies. Dendritic cells (DC) are critical antigen-presenting cells which link innate and adaptive immune responses. The mechanism of dendritic cell regulation in Helicobacter-induced gastritis is po...

journal_title：Infection and immunity

authors： Drakes ML,Czinn SJ,Blanchard TG

更新日期：2006-08-01 00:00:00

abstract：:Although there appears to be little if any role for specific antibodies in protection against intracellular bacteria, such as the model pathogen F. tularensis live vaccine strain (LVS), the role of B cells themselves in primary and secondary infection with such bacteria has not been examined directly. We show here tha...

journal_title：Infection and immunity

authors： Elkins KL,Bosio CM,Rhinehart-Jones TR

更新日期：1999-11-01 00:00:00

abstract：:Newly hatched chicks were vaccinated orally with a genetically defined Salmonella enteritidis aroA candidate, strain CVL30. In chickens immunized with 10(5) or 10(9) CFU and challenged by the intravenous route with 10(8) CFU of S. enteritidis 109 Nalr at 8 weeks old, there were similar reductions in colonization of th...

journal_title：Infection and immunity

authors： Cooper GL,Venables LM,Woodward MJ,Hormaeche CE

更新日期：1994-11-01 00:00:00

abstract：:Antibodies to Escherichia coli O and K antigens were raised in rabbits by repeated immunizations with whole, Formalin-killed and, later, liver bacteria. The serum antibody levels were determined with the ammonium sulfate precipitation technique after radioiodinating the antigens. The K antigens had to be conjugated to...

journal_title：Infection and immunity

authors： Kaijser B,Ahlstedt S

更新日期：1977-08-01 00:00:00

abstract：:Human multidrug efflux transporters are known for their ability to extrude antibiotics and toxic compounds out of cells, yet accumulating data indicate they have additional functions in diverse physiological processes not related to drug efflux. Here, we show that the human multidrug transporter P-glycoprotein (P-gp) ...

journal_title：Infection and immunity

authors： Sigal N,Kaplan Zeevi M,Weinstein S,Peer D,Herskovits AA

更新日期：2015-06-01 00:00:00

abstract：:Polyprotein allergens are a family of structurally homologous molecules from parasitic nematodes which induce specific immunoglobulin E in infected individuals. We show here that both H-2 and non-H-2 factors determine the ability of mice to generate T- and B-cell responses to the filarial polyprotein allergen (Brugia ...

journal_title：Infection and immunity

authors： Allen JE,Lawrence RA,Maizels RM

更新日期：1995-08-01 00:00:00

abstract：:The mechanism of complement-mediated killing of seven serum-sensitive Pseudomonas aeruginosa strains was examined. All seven strains were sensitive to the bactericidal activity of 20% pooled normal human serum (PNHS) containing magnesium EGTA, which blocks the classical complement pathway (CCP), or 20% PNHS preheated ...

journal_title：Infection and immunity

authors： Schiller NL

更新日期：1988-03-01 00:00:00

abstract：:Immunization with Plasmodium sporozoites can elicit high levels of sterile immunity, and neutralizing antibodies from protected hosts are known to target the repeat region of the circumsporozoite (CS) protein on the parasite surface. CS-based subunit vaccines have been hampered by suboptimal immunogenicity and the req...

journal_title：Infection and immunity

authors： Carapau D,Mitchell R,Nacer A,Shaw A,Othoro C,Frevert U,Nardin E

更新日期：2013-12-01 00:00:00