Genetic characterization of DNA region containing the trh and ure genes of Vibrio parahaemolyticus.

abstract：:Brucella spp. are intracellular bacteria that cause the most frequent zoonosis in the world. Although recent work has advanced the field of Brucella vaccine development, there remains no safe human vaccine. In order to produce a safe and effective human vaccine, the immune response to Brucella spp. requires greater un...

journal_title：Infection and immunity

authors： Durward MA,Harms J,Magnani DM,Eskra L,Splitter GA

更新日期：2010-01-01 00:00:00

abstract：:Experimental infection of mice with a virulent strain of Mycobacterium avium leads to a slowly progressive disease, which we have previously shown culminates in loss of gamma interferon (IFN-gamma) production by T lymphocytes and death of the animals approximately 40 weeks after infection. Here we investigated the cha...

journal_title：Infection and immunity

authors： Mannering SI,Cheers C

更新日期：2002-01-01 00:00:00

abstract：:Recently, our laboratory and others have demonstrated that human peripheral blood T and NK lymphocytes directly inhibit the growth of Cryptococcus neoformans. In this study, we further define the conditions under which lymphocyte-mediated fungistasis against C. neoformans occurs and examine whether mechanisms implicat...

journal_title：Infection and immunity

authors： Levitz SM,North EA,Dupont MP,Harrison TS

更新日期：1995-09-01 00:00:00

abstract：:As part of a study of virulence gene regulation in Streptococcus pneumoniae, we have identified a gene encoding a homologue of the staphylococcal catabolite control protein CcpA in the pneumococcal genome sequence. The pneumococcal protein, designated RegM, has significant similarity to members of the LacI/GalR family...

journal_title：Infection and immunity

authors： Giammarinaro P,Paton JC

更新日期：2002-10-01 00:00:00

abstract：:The intraerythrocytic apicomplexan Babesia microti, the primary causative agent of human babesiosis, is a major public health concern in the United States and elsewhere. Apicomplexans utilize a multiprotein complex that includes a type I membrane protein called apical membrane antigen 1 (AMA1) to invade host cells. We...

journal_title：Infection and immunity

authors： Moitra P,Zheng H,Anantharaman V,Banerjee R,Takeda K,Kozakai Y,Lepore T,Krause PJ,Aravind L,Kumar S

更新日期：2015-10-01 00:00:00

abstract：:Sephadex G-200 filtration was used for fractionating dengue type 2 (DEN-2)-infected suckling mouse brain (SMB) supernatant fluids. The high-molecular-weight fraction, which was eluted in the void volume, showed no increase in type specificity when tested against immune ascitic fluid to the four prototype dengue viruse...

journal_title：Infection and immunity

authors： Cornesky RA,Hammon WM,Atchison RW,Sather GE

更新日期：1972-12-01 00:00:00

abstract：:Experiments outlined here investigate the role of nitric oxide (NO) in the pathogenesis of Plasmodium falciparum-induced malarial anemia (MA). The results show that ex vivo and in vitro NO synthase (NOS) activity in peripheral blood mononuclear cells (PBMCs) is significantly elevated in children with MA and inversely ...

journal_title：Infection and immunity

authors： Keller CC,Kremsner PG,Hittner JB,Misukonis MA,Weinberg JB,Perkins DJ

更新日期：2004-08-01 00:00:00

abstract：:Serotypes A and B of the relapsing fever spirochete Borrelia turicatae produce different disease manifestations in infected mice. Whereas serotype B causes more severe arthritis and reaches higher densities in the blood of mice than serotype A, serotype A invades the central nervous system earlier than serotype B duri...

journal_title：Infection and immunity

authors： Pennington PM,Cadavid D,Barbour AG

更新日期：1999-09-01 00:00:00

abstract：:The gene encoding Clostridium sordellii phospholipase C (Csp) was cloned and expressed as a histidine-tagged (His-tag) protein, and the protein was purified to compare its enzymatic and biological activities with those of Clostridium perfringens phospholipase C (Cpa) and Clostridium bifermentans phospholipase C (Cbp)....

journal_title：Infection and immunity

authors： Karasawa T,Wang X,Maegawa T,Michiwa Y,Kita H,Miwa K,Nakamura S

更新日期：2003-02-01 00:00:00

abstract：:The serum antibody response and four different cellular immune responses (cytotoxic T cells, delayed-type hypersensitivity T cells, natural killer cells, and cytotoxic macrophage levels) induced in CBA/H mice were measured at different times after intranasal inoculation of a cold-adapted (ca) variant of influenza A vi...

journal_title：Infection and immunity

authors： Mak NK,Zhang YH,Ada GL,Tannock GA

更新日期：1982-10-01 00:00:00

abstract：:Random-bred mice were immunized with a nonliving antigen prepared from mixed-blood forms of Plasmodium berghei, strain NYU-2, in combination with Corynebacterium parvum and/or living BCG. A high proportion of intravenously immunized mice survived virulent challenge, but subcutaneous vaccination was less effective. Vac...

journal_title：Infection and immunity

authors： Murphy JR,Lefford MJ

更新日期：1978-12-01 00:00:00

abstract：:Mortality associated with acute lung injury (ALI) induced by lipopolysaccharide (LPS) remains high in humans, warranting improved treatment and prevention strategies. ALI is characterized by the expression of proinflammatory mediators and extensive neutrophil influx into the lung, followed by severe lung damage. Under...

journal_title：Infection and immunity

authors： Jeyaseelan S,Chu HW,Young SK,Worthen GS

更新日期：2004-12-01 00:00:00

abstract：:The development of immunological responsiveness to a soluble cercarial antigenic preparation (CAP) from Schistosoma mansoni was analyzed in inbred CBA/J mice infected with cercariae, one or multiple times, or sensitized using CAP. Repeated exposure to 75 cercariae at three weekly intervals (3X-75) or subcutaneous admi...

journal_title：Infection and immunity

authors： Katz SP,Colley DG

更新日期：1976-08-01 00:00:00

abstract：:We identified a gene (atlA) encoding autolytic activity from Streptococcus mutans Xc. The AtlA protein predicted to be encoded by atlA is composed of 979 amino acids with a molecular weight of 107,279 and has a conserved beta-1,4-N-acetylmuramidase (lysozyme) domain in the C-terminal portion. Sodium dodecyl sulfate ex...

journal_title：Infection and immunity

authors： Shibata Y,Kawada M,Nakano Y,Toyoshima K,Yamashita Y

更新日期：2005-06-01 00:00:00

abstract：:We investigated the cytokine/chemokine secretions and alteration of protein expression from peripheral blood mononuclear cells (PBMCs) cocultured with adult liver flukes (Opisthorchis viverrini) for 6 to 24 h. PBMC-derived proteins were identified by two-dimensional electrophoresis and mass spectrometry, and the cytok...

journal_title：Infection and immunity

authors： Hongsrichan N,Intuyod K,Pinlaor P,Khoontawad J,Yongvanit P,Wongkham C,Roytrakul S,Pinlaor S

更新日期：2014-05-01 00:00:00

abstract：:Chlamydia trachomatis is a strict human pathogen producing infections that cause medically important chronic inflammatory diseases, such as blinding trachoma and tubal factor infertility. Isolates exist as serotypes that fall into distinct biologic and pathological groups corresponding to differences in infection tiss...

journal_title：Infection and immunity

authors： Carlson JH,Hughes S,Hogan D,Cieplak G,Sturdevant DE,McClarty G,Caldwell HD,Belland RJ

更新日期：2004-12-01 00:00:00

abstract：:Previous work in our laboratory has shown that corticosterone increases the susceptibility of macrophages from Bcgs mice to the growth of Mycobacterium avium. The innate antimycobacterial activity of macrophages from Bcgr mice was not affected by corticosterone. In contrast to the differential effect of corticosterone...

journal_title：Infection and immunity

authors： Brown DH,LaFuse W,Zwilling BS

更新日期：1995-08-01 00:00:00

abstract：:Humoral and cellular immune responses to several antigens were compared in control and hypercholesterolemic groups of monkeys. Chronic hypercholesterolemia, with concomitant hyperphospholipidemia and hypotriglyceridemia, was produced experimentally by feeding monkeys a high-fat, high-cholesterol diet. When studied pri...

journal_title：Infection and immunity

authors： Fiser RH Jr,Denniston JC,McGann VG,Kaplan J,Alder WH 3rd,Kastello MD,Beisel WR

更新日期：1973-07-01 00:00:00

abstract：:The outcome of coccidioidomycosis depends to a large extent on the effectiveness of the T-cell-mediated immune (CMI) response to the fungal pathogen. For this reason, identification of Coccidioides immitis antigens which stimulate T cells is important for understanding the nature of host defense against the organism a...

journal_title：Infection and immunity

authors： Kirkland TN,Thomas PW,Finley F,Cole GT

更新日期：1998-02-01 00:00:00

abstract：:Escherichia coli strain RDEC-1 causes a diarrheagenic infection in rabbits with AF/R1 fimbriae, which have been identified as an important colonization factor in RDEC-1 adherence leading to disease. The AF/R1-mediated RDEC-1 adherence model has been used as a model systems for E. coli diarrheal diseases. In this study...

journal_title：Infection and immunity

authors： Ryu H,Kim YS,Grange PA,Cassels FJ

更新日期：2001-02-01 00:00:00

abstract：:Early-onset periodontitis (EOP) is characterized by rapidly progressive alveolar bone loss, chemotactic defects of neutrophils, and significant familial aggregation. We found immature myeloid lineage cells, defined as promyelocytes, in the peripheral blood in patients with EOP. A hematological examination of periphera...

journal_title：Infection and immunity

authors： Nemoto E,Nakamura M,Shoji S,Horiuchi H

更新日期：1997-09-01 00:00:00

abstract：:Coxiella burnetii is the causative agent of Q fever, a zoonotic disease that threatens both human and animal health. Due to the paucity of experimental animal models, little is known about how host factors interface with bacterial components and affect pathogenesis. Here, we used Drosophila melanogaster, in conjunctio...

journal_title：Infection and immunity

authors： Bastos RG,Howard ZP,Hiroyasu A,Goodman AG

更新日期：2017-06-20 00:00:00

abstract：:ExoU, a phospholipase injected into host cells by the type III secretion system of Pseudomonas aeruginosa, leads to rapid cytolytic cell death. Although the importance of ExoU in infection is well established, the mechanism by which this toxin kills host cells is less clear. To gain insight into how ExoU causes cell d...

journal_title：Infection and immunity

authors： Rabin SD,Veesenmeyer JL,Bieging KT,Hauser AR

更新日期：2006-05-01 00:00:00

abstract：:Suitability of the rhesus monkey (Macaca mulatta) as an experimental host for evaluation of vaccines against airborne infection with Mycobacterium tuberculosis strain H37Rv was investigated. Nonvaccinated monkeys were exposed to estimated doses of 12, 25, or 49 units of H37Rv in a modified Henderson apparatus, and the...

journal_title：Infection and immunity

authors： Barclay WR,Anacker RL,Brehmer W,Leif W,Ribi E

更新日期：1970-11-01 00:00:00

abstract：:Although certain helminth infections preferentially induce type 2 T-cell responses, the immunological mechanisms responsible for type 2 T-cell polarization remain unclear. In the present study, we investigated the effects of excretory-secretory (ES) antigen from the nematode Nippostrongylus brasiliensis on cytokine pr...

journal_title：Infection and immunity

authors： Uchikawa R,Matsuda S,Arizono N

更新日期：2000-11-01 00:00:00

abstract：:Phase 1 and 2 clinical trials of group B streptococcal (GBS) capsular polysaccharide (CPS)-protein conjugate vaccines in healthy adults have demonstrated their safety and improved immunogenicity compared with uncoupled CPSs. Two recent trials sought to determine (i) whether adsorption of conjugate vaccine to aluminum ...

journal_title：Infection and immunity

authors： Paoletti LC,Rench MA,Kasper DL,Molrine D,Ambrosino D,Baker CJ

更新日期：2001-11-01 00:00:00

abstract：:Three monoclonal antibodies (MAbs), all of the immunoglobulin G1 subclass, were raised against Cryptococcus neoformans by using the technique of cyclophosphamide ablation of B-cell responses against shared epitopes of the cross-reactive fungus Trichosporon beigelii. MAb 3C2 was reactive against the encapsulated and no...

journal_title：Infection and immunity

authors： Hamilton AJ,Jeavons L,Hobby P,Hay RJ

更新日期：1992-01-01 00:00:00

abstract：:After aerosol deposition of Serratia marcescens in mice, initial delayed pulmonary clearance was followed between 4 and 24 hr later by progressive elimination. ...

journal_title：Infection and immunity

authors： Southern PM,Pierce AK,Sanford JP

更新日期：1971-01-01 00:00:00

abstract：:Oral spirochetes possess many potential virulence factors, including the capacity for tissue invasion and persistence despite a vigorous host immune response. In an attempt to identify treponemal immunoreactive components, sera derived from individuals with advanced periodontal disease were used as a reagent to isolat...

journal_title：Infection and immunity

authors： Heinzerling HF,Olivares M,Burne RA

更新日期：1997-06-01 00:00:00

abstract：:A cytoplasmic 75-kDa immunogen from Chlamydia trachomatis serovar L2 has previously been characterized as being similar to the Escherichia coli heat shock protein DnaK. We have localized a linear epitope for one monoclonal antibody specific for C. trachomatis DnaK. By use of a recombinant DNA technique, the epitope wa...

journal_title：Infection and immunity

authors： Birkelund S,Larsen B,Holm A,Lundemose AG,Christiansen G

更新日期：1994-05-01 00:00:00